Zanaflex (Tizanidine) vs Soma (Carisoprodol)

tizanidine vs soma
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What Is Tizanidine?

Tizanidine is a medication used to treat spasms and elevated muscular tone caused by multiple sclerosis, stroke, or a brain or spinal injury. Tizanidine belongs to the skeletal muscle relaxant class of drugs. It works by allowing the brain and nerve system to slow down their actions, relaxing the muscles.

What is Soma?

Soma is a prescription medication that doctors usually given to people who have muscle spasms, discomfort, or other related issues. Soma is a muscle relaxant that acts on the central nervous system. While it is well recognized that the medication is efficient in reducing the amount of muscle pain a patient may be experiencing, medical specialists do not appear to completely understand how the drug works to achieve these results.

conversation of two people which is better

Tizanidine vs Soma: Which one is better?

There is a scarcity of data comparing skeletal muscle relaxants to one another. A systematic review looked at 46 trials, most of which were focused on low back pain or neck disorders. The placebo-controlled trials were completed more than 15 years ago and included 17 on cyclobenzaprine, six on Tizanidine, four on carisoprodol, and four on orphenadrine. (See S, Ginzburg R).

Soma was found to be more effective than diazepam at reducing muscle spasms and improving overall and functional status in patients with low back pain in one research of moderate quality. Another trial that compared Tizanidine to chlorzoxazone for back spasms found no significant differences.

Some studies of good quality were included in a different systematic review. There was no difference in outcomes (muscle spasms, muscle discomfort, tension, tenderness, and functional status) between cyclobenzaprine and carisoprodol, chlorzoxazone, and Tizanidine, and diazepam and Tizanidine in these trials.

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Strength and Dosage for Tizanidine

Tizanidine is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg tablets.


The initial dose is recommended to be 2 mg. Because Tizanidine’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours.


To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg.

Strength and Dosage for Soma

Strength and Dosage for Soma

Soma is available in two strengths: 250mg and 350mg tablets.


Soma should be taken in doses of 250 mg to 350 mg three times a day and at bedtime. 

Soma should be used for no more than two or three weeks at a time.

Drug Interactions for Tizanidine

Tizanidine is primarily metabolized in the liver by the CYP1A2 enzyme. Tizanidine levels in the body can be increased by drugs that block or inhibit this enzyme. Increased medication levels might cause sleepiness and dizziness, among other side effects. CYP1A2 inhibitors like ciprofloxacin and cimetidine and birth control pills containing Ethinyl estradiol should be avoided when taking Zanaflex.

Drug Interactions for Soma

Consult your doctor before taking any other sleep-inducing medication, such as allergy medications or narcotic pain relievers. Other substances that slow the brain’s functions, such as alcohol, barbiturates, benzodiazepines, and opioids, interact with Soma. Do not consume alcohol while taking this medication. This drug has the potential to become addictive. Do not exceed the recommended dosage.

Can you take Tizanidine and Soma Together?

When the drugs Zanaflex (Tizanidine) and Soma (carisoprodol) are taken together, they might cause addictive side effects such as drowsiness and cognitive impairment. Both are categorized as muscle relaxants; therefore, taking both is termed a “double therapy.”


Nonetheless, while Zanaflex and Soma are both muscle relaxants, their mechanisms of action are slightly different, and it’s possible that using both could provide additional benefits. However, before combining the two, you should consult your doctor.


Both these medications- Tizanidine and Soma are used for muscle spasms. According to the study conducted, it was observed that Soma was more effective as compared to Tizanidine. But before taking any of these medications, please consult your doctor and tell them about your medical history in order to prevent negative effects.