Tizanidine vs Methocarbamol

tizanidine vs methocarbamol
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What is Tizanidine?

Tizanidine is a muscle relaxer that treats muscle spasms and pain caused due to spinal injuries. It is a quick-acting drug and belongs to the drug class called Skeletal muscle relaxants.

Zanaflex is the brand name of Tizanidine. It can be used with other medicines as a combination medication.

You can get Tizanidine online from certified pharmacy (Tizanidine (Zanaflex) A Muscle Relaxant).

What is Methocarbamol?

Methocarbamol is a muscle relaxer, and it is used for muscle spasms and pain. It is a part of the drug class called Skeletal muscle relaxants.

Robaxin is the brand name of Methocarbamol. This medication is used along with the therapy to deal with muscle pain and muscle spasms.

you can also buy Methacarbamol online from certified pharmacy (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

How does Zanaflex vs Robaxin Works?


Tizanidine works by affecting the nerve signals which travel to the brain. Tizanidine blocks these signals from reaching the brain and helps to reduce the nerve activity in the spinal cord. This helps to relieve pain and to relax the muscles (Tizanidine (Zanaflex) A Muscle Relaxant).


Methocarbamol affects the nerve signals which travel to the brain. These nerve impulses carry information and are sent to the brain. These signals are blocked due to Methocarbamol, which relaxes the muscles (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

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Tizanidine vs. Methocarbamol: Which is better?

Tizanidine and Methocarbamol are muscle relaxants used to treat muscle pain and spasms. Both the medications work against the exact cause and work in the same manner.

It is observed that both medications are effective against muscle pain and spasms. There isn’t any specific evidence denoting which is better, but both drugs give relief from muscle pain.

The selection of the medicine can be decided by the doctor depending upon the health conditions and which treatment can give you better results (Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions).

Forms and strengths


Tizanidine is an oral medication in the form of tablets and capsules.

The tablet’s strengths are 2 mg and 4 mg, while the capsule is available in the strength of 2,4 and 6 mg.


Methocarbamol is an oral medication. It is available as tablets, oral solutions, and injectable solutions.

The strength of Methocarbamol tablets is 500 mg and 700 mg, and that of the injectable solution is 100 mg/ml.

How to Administer?


Tizanidine can be consumed before or after eating food. It is advised to take medicine at the same time every day and in the same manner. The doctor may change the dose depending upon the response to the treatment.

The effect of taking capsules and tablets with food and without food is different, and thus choose the best option to get better results after consulting a doctor (Tizanidine (Zanaflex) A Muscle Relaxant).


Methocarbamol should be used as directed by the doctor. The dosage can be changed depending upon the treatment and response.

It can be used with or without food. Take the tablets without crushing or breaking. The injection should be administered carefully. If you face any problem while taking it, inform your doctor (Sibrack, J. and Hammer, R., 2020. Methocarbamol).



The initial dose of Tizanidine is 2 mg which is taken 3 times a day.

The maximum limit of Tizanidine should not be more than 36 mg in a day.

The time difference between the two doses should be about 6-8 hours.


Adult dosage of the tablet

The initial dose is 1500 mg which can be taken 4 times a day. It can be followed for 3-4 days.

The maintenance dose is 1000 mg per day which is taken 4 times.

Side Effects


Common Side Effects

Severe Side Effects








Dry mouth

Difficulty in breathing



Passing out


Vision problems

Urination problems












Blood clots


Stuffy nose

Change in heartbeats



Difficulty in breathing


Problem with memory


If you face any of the side effects, do consult your doctor to prevent further negative risks. The doctor may change the dose or terminate the medication depending upon the situation.

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Who should not take it?


  • Allergic to Tizanidine
  • Liver diseases
  • Low blood pressure
  • Taking antidepressant-like Fluvoxamine
  • Kidney disorders

Pregnant and breastfeeding women should not take Tizanidine as it can harm the child as well as the mother (Tizanidine (Zanaflex) A Muscle Relaxant).


  • Below 16 years
  • Liver diseases
  • Kidney disorder
  • Seizures
  • Neuromuscular disease like Myasthenia Gravis

Taking Methocarbamol can cause harm to pregnant and breastfeeding women. It can be taken only in necessary conditions after the doctor’s advice (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Similarities between Tizanidine and Methocarbamol

  1. Tizanidine and Methocarbamol are both muscle relaxers and belong to the same drug class, Skeletal muscle relaxants.
  2. Both these medicines work by blocking the nerve signals from reaching the brain.
  3. Similar side effects of Tizanidine and Methocarbamol are dizziness, constipation, vomiting, and drowsiness.
  4. Both medicines may interact with antidepressant medications and alcohol.
  5. Pregnant and breastfeeding should not take any of these medicines.

Differences between Tizanidine and Methocarbamol

  1. Methocarbamol is also available as tablets and injections, while Tizanidine is available as tablets and capsules.
  2. One might experience withdrawal symptoms after stopping the consumption of Tizanidine suddenly.
  3. Nervousness and back pain are some side effects of Tizanidine that are different from Methocarbamol.
  4. Memory problems, blood clotting, insomnia are some side effects of Methocarbamol different from Tizanidine.


Tizanidine and Methocarbamol are muscle relaxers used for muscle spasms and pain. Both are effective pain medicines and can be used for treatment.

It is essential to discuss with the medical health practitioner before taking any medicine to prevent any harmful effects on the health and get effective results.