Tizanidine is a muscle relaxant used to treat spasticity. It acts by interrupting the transmission of nerve impulses (pain sensations) to the brain. Tizanidine should only be used for daily tasks that require muscle spasm alleviation. Tizanidine is a pain-relieving central muscle sedative that relieves pain and relieves pain-induced anxiety (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

A Study On Tizanidine Withdrawal Syndrome In Stress

A study conducted by the Pharmacy Department by IDIBELL and Hospital Universitario de Bellvitge, Barcelona, Spain, stated that; Most medicines that act on the central nervous system (CNS) require dose titration to avoid withdrawal symptoms.

Tizanidine withdrawal syndrome is marked by hypertension, reflex tachycardia, hypertonicity, and anxiety and is induced by adrenergic discharge due to its 2-agonist action.

Although Tizanidine withdrawal syndrome is a possible adverse effect of discontinuation, it is uncommon, and only a few reports have been made. We discuss the case of a 31-year-old lady who had Tizanidine withdrawal syndrome after stopping a muscular contracture treatment (Tizanidine).

With nausea, vomiting, widespread tremor, Dysthermia, hypertension, anxiety, and tachycardia, she displayed significant adrenergic activity. By beginning Tizanidine followed by a moderate downward titration, symptoms were reversed, and successful reweaning was achieved.

When medicines that target the CNS are abruptly withdrawn, withdrawal syndrome should be considered. Acute withdrawal effects should be thoroughly monitored during reducing regimens.

Hence stating that titration of Tizanidine can reverse the withdrawal symptoms that also induce anxiety. You can buy Zanaflex  online from the certified online pharmacy taking a doctor’s prescription before consuming any medications (Management of Tizanidine Withdrawal Syndrome: A Case Report).


Tizanidine is available in 2- or 4-mg pills and 2, 4, or 6mg capsules. A single dose of 8 mg can ease spasticity for several hours. The effects are strongest 1–2 hours after the dose and fade away after 3–6 hours.

Due to the possibility of dose-related side effects, most people will begin with a lower dose of 2 or 4 mg. A doctor can gradually increase the dose by 2–4 mg every 1–4 days to achieve the best benefit with the least side effects. People can repeat the dose every 6–8 hours, but they should never take more than three doses in 24 hours, totalling 36 mg.

What Happens If I Forget to Take a Dose?

As soon as you recall, take the missed dose. If your next scheduled dose is approaching, skip the missing dose. To make up for a missed dose, do not take more medicine.

What Happens If I Overdose?

Seek medical help right away. Overdose symptoms include light-headedness, drowsiness, disorientation, sluggish heart rate, shallow breathing, and fainting.

Who Should Not Take it

This drug shouldn’t be consumed if you have the following conditions:

  • Injured Liver
  • Hypotension
  • Kidney problems
  • Allergic reaction

Side Effects

Tizanidine has the potential to induce adverse effects:

Dry mouth


You might get withdrawal symptoms (such as anxiety, tremor, elevated blood pressure/heart-rate/muscle tenseness) if you suddenly stop using this medicine. To prevent withdrawal, your doctor may gradually reduce your dose. If you've been using Tizanidine for a long period or in high quantities, you're more prone to experiencing withdrawal symptoms. If you find Zanaflex highly addictive, contact your doctor or pharmacist right away. 


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