Can You Take Gabapentin And Tylenol Together?

gabapentin and tylenol together
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If you have epilepsy, chances are that you are on Gabapentin. Add fever to this and most likely you will be considering consuming Tylenol to take care of that. Tylenol is the brand name for Acetaminophen. So the obvious question that will hit your mind will be can you take Gabapentin and Tylenol together? Will there be any Gabapentin and Tylenol interaction? Let us first get an understanding of each drug.

What is Gabapentin?

Gabapentin is an anticonvulsant and anti-epileptic medication. It affects the chemicals and neurons that produce seizures and some forms of pain. Gabapentin is a prescribed medication available under the brand name Neurontin. It is mainly used to treat partial seizures that occurs because of epilepsy. It also has antihyperalgesic, that is pain-reducing properties.

What is Tylenol?

Tylenol, also known as acetaminophen, is a pain reliever and fever reducer. Acetaminophen is also called Paracetamol in some countries. Colds, flu, headaches, muscular pains, arthritis, menstrual cramps, and fevers are all treated with Tylenol

It is an OTC medication, you can buy Tylenol online from a certified pharmacy. Tylenol is a brand name that belongs to the drug class of analgesics or opioids. Both, Gabapentin and Acetaminophen reduce pain but in a different way

Taking Gabapentin and Tylenol together

Taking both, Gabapentin and Tylenol together should not be a problem for you, if your doctor prescribes it. Gabapentin is commonly used with OTC medications for pain relief and is usually safe to take. No drug interaction has been observed between Gabapentin and Acetaminophen.

Please consult your doctor for any detected symptoms of the side effects or health issues occurring after taking Gabapentin and Tylenol together.


A study published in the Journal of Anaesthesiology Clinical Pharmacology observed the use of Gabapentin, Tylenol, and a combination of Gabapentin and Tylenol together as a protective premedication for post-operative pain.

It was a randomized, double-blind study conducted on 120 consenting patients. The drugs were given 2 hours before the induction. Time, number, VAS score at rest, and side effects were noted.

The study stated that premedication with antihyperalgesic and analgesic medications could help reduce postoperative pain. In simple words, a combination of Gabapentin and Tylenol helps in reducing pain post-surgery.

However, while Gabapentin premedication is successful in delivering superior postoperative pain management, it induces more nausea and vomiting episodes as well as greater degrees of drowsiness. (Syal, K., Goma, M., Dogra, R. K., Ohri, A., Gupta, A. K., & Goel, A. (2010).)

How Does Gabapentin And Tylenol Work?

Gabapentin appears to work by affecting the activity of molecules called neurotransmitters, which convey information between nerve cells and modify electrical activity in the brain. Gabapentin relieves pain by changing the way the body senses pain. This medication is also used to treat nerve pain.

Tylenol reduces pain by raising the pain threshold, When used together, both these drugs can reduce pain and amplify side effects in some people.

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Forms And Strengths Of Gabapentin And Tylenol

Gabapentin comes in capsules, tablets, and liquid forms. 


Capsules: 100, 300 and 400 mg.

Tablets: 600 and 800 mg.

Liquid: 250 mg per 5 mL.

Tylenol comes in capsules, tablets, and liquid forms.


Capsules: 325 mg and 500 mg.

Tablets: 325 and 500 mg.

Liquid: 160 and 500 mg per 5 mL.

How to Administer Gabapentin and Tylenol together?

Gabapentin pills, tablets, and oral solutions are commonly given three times a day, with or without meals.

Gabapentin can be started as a single 300 mg dosage on Day 1, 600 mg twice a day on Day 2, and 900 mg twice a day on Day 3 in individuals with postherpetic neuralgia (300 mg three times a day).

After then, the dose can be titrated up to 1800 mg per day as needed for pain management (600 mg three times a day) (Goa, K.L. and Sorkin, E.M., 1993. Gabapentin).

Tylenol is also available in the form of tablets or an oral solution. It can also be taken with or without meals. Tylenol Regular Strength is usually taken in two 650 mg pills or capsules every four to six hours.

In a 24-hour period, adults and adolescents aged 12 and above should not consume more than 10 Tylenol tablets (3,250 mg). Use for a maximum of 10 days.

Regular strength Tylenol can be taken by children aged 6 to 11. (325 mg). Children under the age of six should only be given Tylenol under the supervision of a doctor or other healthcare professional.

The recommended dose of Tylenol for young children is decided by the child’s weight and age (Sahajwalla, C.G. and Ayres, J.W., 1991).

If you have a sensitive stomach, we would suggest you eat food before taking these medicines as it may lessen the effects of an upset stomach. 

As mentioned above in the article published by the Journal of Anaesthesiology Clinical Pharmacology, the study studied the effects of Acetaminophen 1000 mg and 1200 mg of Gabapentin when taken together.

Can You Take Gabapentin And Tylenol Together

Who cannot take Gabapentin or Tylenol?

Gabapentin can cause life-threatening breathing issues, especially if you already have a respiratory disease or are taking other medications that make you sleepy or slow your breathing. If your breathing is sluggish, get medical help right once.

While using Gabapentin, some patients have suicidal ideation or behavioral problems. Keep an eye on your mood and symptoms for any changes. Notify your doctor if you develop new or worsening symptoms.

If you have severe liver disease, you should avoid using Tylenol. An acetaminophen overdose can harm your liver or perhaps cause death. Adults and teens weighing at least 110 pounds should not consume more than 1000 mg at a time or 4000 mg in 24 hours.

Children under the age of 12 should not take more than five doses in 24 hours and should only take the quantity of mg per dosage suggested for their weight and age. Strictly follow the directions on the label.

We strongly suggest you not to drink alcohol, use heavy machinery or drive when under the influence of either of these two medicines. 

Side Effects

Side Effects

Some side effects of these medications are:


  • Weak or shallow breathing
  • Blue colored skin
  • Confusion
  • Increased seizures
  • Fever
  • Headache
  • Nausea and vomiting
  • Fatigue
  • Dizziness
  • Instability in body movements
  • Unusual eye movements
  • Blurred vision

Some side effects of these medications are:


  • Stomach pain
  • Loss of appetite
  • Tiredness
  • Jaundice
  • Dark urine
  • Itching
  • Rashes
  • Dark urine
  • Clay-coloured stools
  • Jaundice
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Interractions Of Gabapentin and Tylenol With Other Drugs

Gabapentin is known to interact with:

  • Aspirin
  • Flexeril
  • Lexapro
  • Tylenol
  • Vitamins

Gabapentin interacts with 262 known medications.

Tylenol is known to interact with:

  • Aspirin
  • Gabapentin
  • Ibuprofen
  • Metformin
  • Omeprazole

Tylenol interacts with 105 known medications.

These medications are known to interact with alcohol, vitamin, and herbal drugs.  


In a nutshell, you can take Gabapentin and Tylenol together for pain relief under proper guidance. As per most studies, it is perfectly safe to take Gabapentin and Tylenol together. Gabapentin and Tylenol work differently on your body. There may be certain minor side effects such as nausea and drowsiness.

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