A recipe is made with a combination of different ingredients, and each component has its quality that makes the dish unforgettable and fulfills the taste buds' needs.

In the world of medicine, the word recipe refers to the active ingredients used for making the treatment more effective, in short a combination. For your information, 1 out of 6 Americans undergo migraine conditions, especially women.

Sumatriptan and Naproxen are such an example of a combination for the treatment of Migraine.

Sumatriptan is not available over the counter as it is not an OTC medication also you can buy sumatriptan online from a certified online pharmacy or you can get over the counter sumatriptan but it is recommended to get a doctor's prescription first.

Naproxen is available both over-the-counter (OTC) and by prescription. you can also buy Naproxen online from online pharmacy.

The combination consists of two active medicines in respective quantities.

Fusion of these medicines is proven very well for treating migraines. You might have heard about this duo. Why not learn it in a detailed and straightforward way to manage and enhance our health.

The Successful Combination- (Sumatriptan And Naproxen)

Sumatriptan is generally used for managing headaches, and it works by blocking the signals and thus decreasing the pain. In drug class terms, it is identified as a selective serotonin receptor.

Naproxen is a Non-steroidal Anti-Inflammatory drug that stops the production of pain-inducing substances to relieve the nuisance.

Till now we got a bit of an idea of Sumatriptan And Naproxen.

The combination is used for treating migraines/Migraine attacks. It is mainly for acute treatment and not for chronic issues, but the success rate of pain-relieving is higher than Migraine. It should be taken when the Migraine has just begun.

Sumatriptan and Naproxen combinations are well balanced, as both the drugs are closely connected through relieving pain. The mechanism plays a vital role in this mixture (Winner, P., Ricalde, O., Le Force, B., Saper, J. and Margul, B., 1996).

What Makes The Sumatriptan Plus Naproxen Effective?

These medicines are reasonably related to each other, and both relieve pain. The point of similarity is they both treat headaches and migraine pain. A user can feel the effect in just 2 hours. The quick mechanism of action plays a significant role.

Sumatriptan And Naproxen work together in respective working procedures in the body.

The National Center For Biotechnology Information did a study to see the effectiveness of Sumatriptan plus Naproxen on acute treatment of Migraine.

The result was positive, with a higher output of combination medication (Law S, Derry S, Moore RA. 2016 Apr).

Mechanism Of Action (Sumatriptan And Naproxen)

Sumatriptan works by relaxing the blood vessels by widening them. It also blocks the hormones reaching the brain. The Naproxen starts work by stopping the production of COX1 and COX2 enzymes, which produce pain in the head and further inflammation caused by Migraine.

In simple terms, Sumatriptan calms through serotonin or blood vessels, and Naproxen covers the inflammation pain caused by Migraine.

Thus, there is no precise mechanism of action, and the whole working procedure is a combination of serotonin receptors and inflammatory hormones (Smith, T.R., Sunshine, A., Stark, S.R., Littlefield, D.E., Spruill, S.E. and Alexander, W.J., 2005).

Essential Information You Should Know About Sumatriptan And Naproxen


It is always better to know more about what you are interested in. Some information will be helpful before taking the combination of Sumatriptan And Naproxen.

  • Pregnant ladies in their third trimester should not use it, as it can adversely affect the fetus and infants after breastfeeding.
  • High blood pressure, Asthma patients should take guidance from a medical expert.
  • People who are allergic to Sumatriptan and Naproxen should avoid their usage of it.
  • Liver problems and gastrointestinal issues can arise.

How To Take Sumatriptan And Naproxen (Dosage)?

Sumatriptan And Naproxen is available in tablet form with the strength of 85 mg of Sumatriptan and 500 mg of Naproxen. You can take this medication with food and water, and there is no interaction between them.

If your Migraine doesn't stop after your 1st dose, the patient can take the second dose with the recommendation of your health expert. (especially for small children)

Usual Dosage Used For Migraine In-

Adults (Age more than 18): Twice in 24 hours, about 85 mg/500 mg

Age (12 to 17): Once a day, strength is decided by the physician

Pediatric: Age less than 12: It is not recommended for children under this age group. The combination does not guarantee the safety of the kids.

Interactions Still Exist! (Sumatriptan and Naproxen)

When we are creating a recipe, sometimes the unwanted ingredients can cause severe damage to the rapport of the dish. So it is necessary to know about the other elements that disrupt the system.

  • Blood pressure or Hypertension medicines
  • Isocarboxazid, Lithium, blood thinners, steroids
  • Cyclosporine

Side-Effects You Can Come Across for Sumatriptan And Naproxen

Side effects of combination medicine can cause a mixture of both sides and result in unknown consequences.

  • Nausea and vomiting
  • Dizziness and Drowsiness
  • Dry Mouth
  • Heartburn
  • Gastrointestinal damages
  • Numbness in parts of the body
  • Headaches
  • Chest pain, Hypertension

Are There Any Brands Related To Sumatriptan And Naproxen Combination?

Brands like Treximet, Somatratn, Napsort Tablet, and Hedfree Tablet are available. While choosing brands, please see that the combination contains naproxen or naproxen sodium, as it does not matter that much, but still.

The difference is in the absorption time of Naproxen sodium. All the medicines are available only under expert prescription.

Can We Overdose?

Overdose can be accidental or voluntary. No overdose has been found, but the dependency can create overdose as there will be an urge to take medicine when the Migraine arises again. Use some natural methods to control Migraines attacks.


A combination can result in a superb approach to treat a particular condition. Sumatriptan and Naproxen worked effectively due to their procedure and working behavior. It is not a permanent solution for long-term migraines but it is a short treatment for acute migraines and headaches.

Although some points are vital while using this combination of medicine, if followed, then the medication can be a good treatment.


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