Naproxen Vs Flexeril- The No1 Medicine Rumble

Naproxen Vs Flexeril- The No1 Medicine Rumble

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Competing and making difference is in our human genes. It’s the spark to create something new and effective. The medicine world is  not too unleft from this, many types of medicine in many formats and types, but which is the most effective?. Besides this some medicines should not be compared as they can be different in their core nature and the competition can become the usual fact-checker report.

Just as with Naproxen Vs Flexeril, the medicines have different core aspects and different perspectives towards the condition. This medicine can be confused as one relieves muscle pain and other pain from bone conditions. So let’s find out how well this rumble goes!

How Does Naproxen Vs Flexeril Works?

Naproxen is also available over the counter you can buy naproxen online from a certified pharmacy as well as you can buy Flexeril online from an online pharmacy. 

Naproxen And Flexeril are different medicines, naproxen is a pain reliever and Flexeril is muscle relaxer.  The core concept here is their different working mechanism.

Naproxen works by stopping the production of COX1 and COX2 (pain hormones) to relieve pain from arthritis, spondylitis ,gout etc. Hence the pain hormones are the main factor that causes distress and Naproxen hinders its production . Whenever you get pain these hormones are produced and you can feel the inflammation on muscles (Todd, P.A. and Clissold, S.P., 1990).

Flexeril has a different mechanism , it relaxes muscles through its action on the gamma and alpha motor system(nerves fibres connected to muscles). Flexeril does not directly work on muscles. It affects the spinal cord and brain to relax the nerves connected to the muscles (RELAXANT, S.M., 1979).

From the above round we can say it is difficult to compare them and declare who is the best, because every medicine has its own respected working technique. Moving on to the 2nd round.

Naproxen Vs Flexeril- How long Do They Stay In System?

The 2nd round of differentiation can be in terms of its elimination time.The elimination of medicines depends upon the absorption rate, metabolism , conditions and other medicines etc.

How Long Does Flexeril Stay in the System?

Flexeril has a Half life of about 18 hours . It takes about 5.5 to 16 days to get completely  eliminated from the body. It takes more time due to conditions such as low metabolism or other medicines.

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How Long Does Naproxen Stay In The System?

Naproxen is eliminated in half by 12-17 hours, it takes about 3 and half days to push it out of the system.It can also increase the time further if the user is undergoing gastric or stomach related problems.

Bioavailability Of Naproxen And Flexeril

Bioavailability is the ability of a drug to be absorbed and used in the body. Higher the bioavailability higher the nutrition absorption rate. Naproxen and Flexeril differs in bioavailability rate

Flexeril has bioavailability of 44 percent and naproxen has 95 percent. It says that Naproxen has the highest absorption rate and can work at a faster pace than Flexeril.

Can Naproxen Vs Flexeril be Naproxen Plus Flexeril?

Using Nsaid with Muscle relaxers can be a quiet treatment option for back pain, surgery pain etc. There were no Interactions found when Naproxen and Flexeril mixed together. 

Hence we can say that sometimes the competitors can work together as friends.

The Pregnancy And Breastfeeding (Naproxen Vs Flexeril)

Flexeril: Factually speaking there is no particular study on flexeril used in pregnancy. Please have a word with your medical authority. Although it should not be used in breastfeeding.

Naproxen: Naproxen or Nsaids should not be used in pregnancy and also in breastfeeding. It can cause severe damage to the fetus and increase the side effects.

Side Effects Of Naproxen And Flexeril

Below is the differentiated side effects of both medicines:


  • Drowsiness
  • Fatigue
  • Headache
  • Dizziness
  • Nausea
  • Seizures
  • Heartattack


  • Rash
  • Ringing in ears
  • Hypertension
  • Constipation
  • Gastrointestinal Ulcer
  • Headache
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Interactions Of Naproxen And Flexeril

When the above medicine mixed together there were no interactions found, as we discussed earlier. Though there are individual interactions can happen when mixed with elements such as:

Naproxen Interactions

  • Alcohol
  • Anticoagulants
  • Blood Thinners
  • Allergic reactions
  • Asthma

Flexeril Interactions

  • Benzos
  • Depressants
  • Abusive schedule 1 drugs
  • Hypertension medicines 


Medicines of different forms, size, shape, mechanism has its own area of treating conditions. It cannot be compared or competed. Naproxen and Flexeril cannot be completed as they belong to different classes and also used for different purposes, but they can be used together. So we can profoundly understand the winner is your perspective towards medicine.