Naproxen is a non-steroidal anti-inflammatory drug (NSAID). Naproxen is used for the treatment of painful conditions such as arthritis, sprains and strains, backache, menstrual pain, and gout pain. Buy Naproxen online from a certified online pharmacy.

Tylenol is an over-the-counter medicine used to treat reduce symptoms of pain and fever. Tylenol belongs to a class of drugs called Analgesics. Tylenol could be taken by adults and children above the age of 12.   

Can Naproxen And Tylenol Be Taken Together?

Naproxen and Tylenol could be taken together and found to be safe. However, it is advisable to take both medicines at different times for more effective results.

Staggering the medication can help to extend relief from pain. In case the pain is severe Tylenol alone may not be effective. Doses of Naproxen could be added. A combination of both the medicine may work better than either drug alone.(Akhter, T., BAQAI, R. and Aziz, M., 2010)

Difference Between Naproxen And Tylenol

Naproxen Tylenol

Naproxen works well for treating mild to moderate pain or inflammation.

Tylenol effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.

Naproxen is good for relieving pain from common conditions like menstrual cramps, toothaches, and arthritis.

Works well to relieve pain and fevers. Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.

Naproxen causes fewer stomach problems and is generally safe to use. Naproxen is not safe for pregnant women and people who are above the age of 60. Could cause kidney problems and stomach bleeding if taken for a longer period.

Tylenol causes less upset stomach, ulcers, bruising, and bleeding than other pain medications. It doesn't cause kidney damage and is also safe to use for people suffering from heart problems or in case of pregnancy.

Naproxen can raise the risk of getting blood clots, heart attack, or stroke.

Drinking alcohol while taking Tylenol can damage the liver

Comparison of Side Effects of Naproxen And Tylenol

The utility of Tylenol and Naproxen are largely defined by their side effects.

The side effects of Tylenol are minor and may include stomach upset, nausea, loss of appetite, and headache. On occasion, itchiness and rash can also develop.

By contrast, Naproxen can cause heartburn, stomach pain, and peptic ulcers. Long-term or excessive use can affect blood pressure and clotting and increase the risk of bleeding, hypertension, peripheral edema (leg swelling), heart attack, and stroke.

Tylenol is neither associated with cardiovascular nor peptic ulcer risk. It can, however, cause serious liver damage if used in excess (more than 4,000 milligrams per day) or taken with alcohol.

While Naproxen can also hurt the liver if used in excess, the risk is far smaller. The same applies to the kidneys but usually only when there is an underlying kidney disorder.(Leuschen, M.P., Filipi, M. and Healey, K., 2004)

Who Should Avoid Naproxen?

Some medicines under certain conditions are not suitable for people and may only be used after taking advice from a doctor or pharmacist. Those conditions may be;

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you have a heart condition or a problem with your blood vessels or circulation.
  • If you have high blood pressure.
  • If you have ever had blood clotting problems.
  • If you have high blood sugar or cholesterol levels.
  • If you are a smoker.
  • If you have a connective tissue disorder, such as systemic lupus erythematosus (an inflammatory condition also called lupus or SLE).
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to any other NSAID.(Risser, A., Donovan, D., Heintzman, J., and Page, T., 2009)


The recommended dosage of Naproxen, for adults, is one pill every 8–12 hours. However, this depends on the strength of the medication. While, Tylenol generally comes in 325 mg, 500 mg, or 650 mg pills.

  • 1 or 2 325 mg pills every 4–6 hours, taking no more than 8–10 pills per day
  • 1 or 2 500 mg pills every 4–6 hours, taking no more than 6 pills per day
  • 1 or 2 650 mg extended-release pills every 8 hours, taking no more than 4–6 pills per day


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