Methocarbamol, a muscle relaxant, is used along with physiotherapy to treat conditions of skeletal muscles such as pain and injury. It is a type of central nervous system (CNS) depressant approved by the FDA in July 1957.

Methocarbamol works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. Methocarbamol can be used for anxiety. In addition, the medication can affect the symptoms of depression.

You can also get Methocarbamol online  from a certified online pharmacy also it is advised to take a doctor's prescription before consuming any medications.

Study of Methocarbamol in the Treatment of Depression

Meprobamate and Methocarbamol were compared in a study to examine how they affected anxiety and depression, and it was found that methocarbamol was more effective in treating depression than meprobamate.

In a study conducted to observe the effect of Meprobamate and Methocarbamol over anxiety and depression, it was noted that Methocarbamol was more suited for the treatment of depression than Meprobamate.

A likely cause for depression could be stiff and tense muscles, especially the skeletal muscles. As Methocarbamol is a muscle relaxant, it also eases the CNS into a slightly light-headed mood, in turn helping an individual relax.

Therefore, by easing the skeletal muscles, it is noted to be effective in diminishing the symptoms of depression.

Mechanism Of Methocarbamol

Although the exact mechanism of Methocarbamol is unknown, it is observed to be dependent upon the CNS depressant activity. This could be mediated by inhibiting or blocking spinal polysynaptic reflexes, inhibiting nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the muscle cells’ refractory period.

It is observed that Methocarbamol does not affect the contraction of nerve and muscle fibers and motor endplates.

Half-life and how long does it take to work?

For an average human, the half-life of Methocarbamol is 1.14 hours. For patients with renal insufficiency, the half-life extends to 1.24 hours, and for older adults, 1.6-2.15 hours.

The effects of Methocarbamol are seen within 30 minutes of consumption, and its peak concentration is reached within 2 hours.

How To Consume Methocarbamol?

Methocarbamol consumption depends on your age, condition, medical history, and response to the initial dosage.

Methocarbamol is generally available in the form of tablets to be taken by mouth. The usual dosage is four times a day initially, and then it may change to three to six times a day. In case of any doubts, you could consult your doctor.

Side Effects Of Methocarbamol

Common side effects of the consumption of Methocarbamol include:

  • Dizziness
  • Headache
  • Drowsiness
  • Fever
  • Confusion
  • Interruption in memory
  • Vomiting 
  • Nausea
  • Bad stomach
  • Pixelated vision
  • Blurred vision
  • Insomnia
  • Flushing feeling
  • Lack of coordination

Seek urgent medical attention in case you observe any of the given side effects to Methocarbamol:

  • The feeling of passing out
  • Decreasing heartbeats
  • Seizures
  • Jaundice
  • Pain, swelling, bruising, stiffening, or skin reactions in the area where the medicine was injected

Who Should Not Take Methocarbamol?

Do not use Methocarbamol if you are allergic to it.

Consult your doctor if you are facing or have undergone any of the following conditions:

  • Seizures
  • Kidney failure
  • Kidney disease
  • Myasthenia gravis


Consumption of Methocarbamol can cause severe skin allergies. In case you notice any of the following symptoms or conditions, report to your doctor at once:

  • Rash 
  • Hives
  • Swelling up of either tongue, throat or both
  • Trouble breathing

Note: Do not consume Methocarbamol again if you had allergies before. In case you are pregnant or are planning to, consult your doctor before the consumption of Methocarbamol.

If you are a breastfeeding mother, there are chances that the drug might pass on through milk into the infant, leading to adverse side effects. Consult your doctor before the consumption.

What To Do If You Missed A Dose?

Methocarbamol is only used only when needed unless prescribed otherwise. Skip the missed dose if you are close to the next dosage. Do NOT consume a double dose to even it out.

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing symptoms may include nausea, blurry vision, drowsiness, seizures, and /or coma.


Methocarbamol is a type of muscle relaxant that works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. It helps with anxiety and depression by soothing out the root cause of the symptoms, i.e., the tension in the skeletal muscles.

  • Numazawa, T., 2016. Treating depression with the mephenesin analog skeletal muscle relaxant methocarbamol. Open Journal of Depression5(04), p.40. From 10.4236/ojd.2016.54005  Accessed on 15 January 2022.
  • Zhang, Y., Otto, P., Qin, L., Eiber, N., Hashemolhosseini, S., Kröger, S. and Brinkmeier, H., 2021. Methocarbamol blocks muscular Nav1. 4 channels and decreases isometric force of mouse muscles. Muscle & Nerve63(1), pp.141-150. From Accessed on 16 January 2022.


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