Both Skelaxin and Flexeril are FDA-approved medicines for treating muscular spasms. They're part of a class of drugs known as skeletal muscle relaxants.

The generic versions of Skelaxin and Flexeril are Metaxalone and Cyclobenzaprine, which are the most routinely prescribed. It's unclear how they function; however it could be linked to the central nervous system (CNS) depression and sedative effects. These drugs have no direct effect on the muscles or nerves.

What are the differences between Metaxalone and Flexeril?

Metaxalone is a muscle relaxant used to treat sprains, strains, and other ailments that produce muscle spasms and pain. Skelaxin is a brand name for a generic medication called Metaxalone. Other brand names for this metaxalone are Metaxall, Metaxall CP.

Before consuming these medicines you should always consult for a doctor's prescription, you can buy Metaxalone online from a certified online pharmacy.

Flexeril is a muscle relaxant that can be used to relieve skeletal, muscular spasms. Flexeril's generic name is cyclobenzaprine.

Strength and Dosage

For Flexeril

  • Tablet for adults and children - 5mg, 7.5mg, 10mg
  • Capsule, extended use for adults only - 15mg, 30mg

The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets (Tofferi, J.K., Jackson, J.L. and O'Malley, P.G., 2004).

For Metaxalone

  • Tablet for adults and children - 400mg and 800mg
  • Adults and children aged 13 and up should take 800 milligrams (mg) three to four times a day.

Children under the age of 12 must have their use and dose determined by their doctor (Gabhane, K.B., Kasture, A.V., Shrikhande, V.N., Barde, L.N. and Wankhade, V.P., 2009).

Side Effects

Flexeril Metaxalone
Unpleasant taste Dizziness
Nervousness drowsiness
Acid reflux Stomach upset
Abdominal pain or discomfort Nervousness
Dry mouth irritability
Fatigue Blurred vision
Blurred vision Headache

Is Metaxalone the same as Flexeril?

Despite the fact that Metaxalone and Flexeril belong to the same pharmacological class (skeletal muscle relaxants), they have some distinctions in terms of adverse effects, dosage, and cost.

Is it Safe for me to use Metaxalone vs Flexeril while Pregnancy?

Although there has been no evidence of fetal impairment in the post-marketing experience, this does not rule out the possibility of occasional or subtle damage to the human baby.

The safe usage of metaxalone in terms of potential fetal development side effects has not been proven. As a result, unless your healthcare practitioner determines that the benefits exceed the risks, Skelaxin is not indicated for use in pregnant women or women who may become pregnant.

There are no adequate, well-controlled trials in pregnant women, according to the Flexeril manufacturer's statement. As a result, Flexeril should only be taken on pregnant women if absolutely necessary (Di Martino, A., Russo, F., Denaro, L. and Denaro, V., 2017).

Metaxalone Vs Flexeril: Which one is more effective?

According to American Family Physician, there is very little evidence comparing muscle relaxants and their efficacy. They advise that muscle relaxants be chosen based on the risk of side effects, drug interactions, and abuse, as well as patient preference. 

Your healthcare professional will be able to tell you if metaxalone or Flexeril is right for you. Your symptoms, medical problems, medical history, and any drugs you're taking that could interact with Skelaxin or Flexeril will all be taken into account.


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