Clotrimazole vs Nystatin

Clotrimazole vs Nystatin
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What is Clotrimazole?

Clotrimazole is an antifungal cream that prevents the growth of fungus. Clotrimazole is used to treat different skin infections such as ringworm, jock itch, candidiasis, athlete’s foot and fungal infections (Crowley, P.D).

What is Nystatin?

Nystatin belongs to the drug class called Polyenes- antifungal medications. Its working is also similar to Clotrimazole. Nystatin is also used in the treatment of fungal infections, especially internal fungal infections (G.W., 1977).

Forms and Strength


Clotrimazole is available as – Cream, Powder, lotion, ointment, Gel.

Strengths – 15GM of 1%, 28GM of 1%, 30GM of 1%, 45GM of 1%


Nystatin is available as – Cream, Powder, Ointment, Tablet, and Liquid.

Strengths – 15gm and 30gm (tube), 15gm, 30gm and 60gm (bottle), 500,000units (tablet), 60ml and 480ml (bottle)



The amount of dosage may vary depending on the condition. Depending on the nature and severity, you can apply the cream around the infected area for 2 to 8 weeks up to two times a day.

You can order Clotrimazole online from a certified online pharmacy but before consuming contact your health care provider.


Tablet – Adults and children over the age of 5 can take 1-2 pills for about 3 to 5 times a day.

Liquid – 1 teaspoon full is the standard dosage

Side Effects


It can cause minor side effects like burning, itching, or irritation when applied. Following are the severe side effects associated with Clotrimazole (Crowley, P.D):

  • Fever
  • Chills
  • Nausea
  • Rash
  • Hives
  • stomach pain


Like Clotrimazole, even Nystatin may irritate, stinging, or burning where it is applied. Following are the adverse effects (Bissell, M.J., 1974).

  • Allergic reaction
  • Slow heart rate
  • Bronchospasm
  • Facial swelling
  • Muscle pain
  • Vomiting
  • Hypersensitivity reactions
  • Skin irritation or redness
  • Mouth irritation
  • Rash
  • Hives
  • Diarrhea
  • Nausea
  • Stomach pain or upset
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Drug Warnings


Once you have applied the medication, don’t apply cosmetics on it.

Also, do not use any other creams on the area where you have applied Clotrimazole.

The liquid form may be flammable so take appropriate precautions with it.

Do not breastfeed or use it during pregnancy without consulting your healthcare professional.

Do not use clotrimazole if you have had allergic reactions to other antifungal medications before.


Consult your healthcare professional if you are using any OTC medications, prescription medications, or herbal medicines before using Nystatin.

Can you use Clotrimazole and Nystatin together?

No interactions between Clotrimazole and Nystatin have been discovered yet. Still, there have been no studies implying that you can use them together. Always consult your healthcare professional before mixing medications.

Scientific Study on Clotrimazole and Nystatin

A study was conducted to compare the efficacy and safety of Clotrimazole and Nystatin in the treatment of Diaper dermatitis in infants. Diaper dermatitis is a common type of irritative dermatitis in infancy.

Ninety-six infants were included in this study which was multi-center, controlled, and randomized. The infants were treated with either Nystatin or Clotrimazole two times a day for 14 days straight.

Both medications helped in decreasing the symptoms. However, the clinical cure rate and global assessment of clinical response were higher in Clotrimazole. The frequency of side effects was minimal in both the medications.

In conclusion, Clotrimazole was better in this trial than Nystatin.

Which one is better?

Based on various studies conducted on Clotrimazole and Nystatin, clotrimazole ointment was found to be significantly more effective than Nystatin. However, depending on your condition, one might be better than the other, so speak to your healthcare professional, and he will help you decide which one is suited for you.