Whenever you are suffering from a disease, you are always concerned about the side effects of the prescribed medicines. In the medical world, many drugs cause insomnia as a side effect. Here we are concerned with the relation of a specific treatment named Celebrex with insomnia as its side effect.

Celebrex is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug which relieves pain and inflammation. Celebrex is prescribed against osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and polyps. It can be used to relieve and ease the pain of stomach cramps. Celecoxib is a prescription based medicine that can be bought online through telehealth sites, Celebrex over the counter can be purchased only with a doctors prescription or recommendation.

During inflammation, prostaglandins are produced and increase body temperature and make nerve endings sensitive to pain transmission. Celebrex indirectly inhibits the production of prostaglandins which relieves pain. Now, what is insomnia? In simple words, insomnia is the inability to sleep. It is a sleep disorder issue that makes it hard for you to sleep or causes you to wake up early in the morning and are not able to get back to sleep again. There are several reasons for Insomnia.

Top Reason For Insomnia

Several reasons may cause insomnia. Here we have a list of reasons to help you know if you have insomnia.


Stress may be the reason for your insomnia. Stress regarding different things can keep your brain active all night and can cause insomnia. Stressful events, including the death of your loved ones, any trauma from the past, or divorce, can lead you to dreadful conditions.

Irregular Sleeping Habits:

Irregular sleeping habits such as an irregular bedtime schedule or napping during the daytime can disturb your sleep cycle, causing insomnia.

Mental Disorder:

Patients suffering from mental disorders may also have insomnia. Mental disorders such as Anxiety, depression, schizophrenia, bipolar disorder, and ADHD can cause insomnia.


People who take alcohol may have insomnia, along with many other adverse effects on their health. Alcohol reduces REM sleep, disturbs the sleep cycle, and makes it difficult to sleep for the person.

Bad Eating Habits:
Bad eating habits can also disturb the sleep cycle. Eating late at night can make you physically uncomfortable while lying down. You will also have an awkward feeling in the morning.

Neurological Problems:

Many neurodegenerative disorders, such as dementia and Alzheimer's, can interact with the person's circadian rhythm and cause insomnia. For your better understanding, circadian rhythms control the sleep-wake cycle.


Many medicines, such as antidepressants, medications for allergies, asthma, blood pressure disorders, and pain, can interfere with sleep and can cause insomnia. Here we will dig into the details of how medications cause insomnia.

Can Celebrex Cause Insomnia?

Many types of research have proved that Celebrex has nothing to do with sleep. It has nothing connected with the circadian rhythm.

The significant side effects of Celebrex are stomach pain, heartburn, gas, diarrhea, nausea, and dizziness. These side effects can indirectly make it hard for you to sleep. Some COX-2 inhibitors also increase the risk of heart attacks which can be very dangerous and life-threatening. Insomnia can be called an occasional or rare Side effect of celebrex. So, technically it's not Celebrex that directly causes insomnia. It's its side effects that make all the trouble.

Why Does Insomnia Happens Due To Medication?

Insomnia caused by medications is known as DRUG-INDUCED INSOMNIA. Drug-induced insomnia can be caused by certain medicines that act as stimulants and disrupt sleep by their mode of action, dose, and treatment length.

Some medications may also lower the melatonin hormone levels in our body, which are responsible for controlling circadian rhythms. Some drugs cause insomnia by antagonizing central adenosine receptors and reducing physiological sleepiness. Some medications increase dopaminergic and noradrenergic neurotransmission. So, different drugs have different mechanisms by which they cause insomnia. 

How To Avoid Sleeplessness Caused By Medication?

Does this question also roam in your mind? You can visit your healthcare provider for that. He may reduce your dose, prescribe you an alternative medicine, or some supplements such as Melatonin hormone gums that can help induce sleep.


By all counts, it is no wonder that insomnia can be a hazardous condition for some. There are a plethora of reasons that can cause insomnia and make you feel restless. You can get rid of insomnia by changing your routine habits. It would help if you had good sleeping and eating habits. Here we have discussed how celebrex indirectly can cause insomnia.


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