Celecoxib (Celebrex)

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Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID), which relieves pain and swelling. It is used to treat arthritis, ankylosing spondylitis, menstrual pain, acute pain, and discomfort. It works by blocking the enzyme (COX-2) that makes prostaglandins which are responsible for inflammation.

Celecoxib is sold under the brand name Celebrex which belongs to a drug class called Cox-2 inhibitors (McCormack, P.L., 2011).

How to Buy Celebrex (Celecoxib) Online?

Celecoxib is a prescription-based medication to treat pain and inflammation. A lot of pharmacies provide celecoxib online by accepting prescription and with offers on it. They provides on the go customer service which helps in grievance support. There are also pharmacies that provide Celebrex over the counter when you show up with a prescription or related letter. An important part is played by us in this segment of getting the proper information across and building trust through our reliable sources to get your satisfaction at new levels.

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Warning

Celecoxib is linked with the increased risk of a fatal heart attack or stroke, even if there are no pre-existing risks. We suggest you not take this medicine just before or right after heart bypass surgery.

Celecoxib can also cause stomach or intestinal bleeding, which can be dangerous to health. This can happen, especially in older adults.

How To Use Celecoxib?

This medication is taken orally, usually once or twice a day, as prescribed by your doctor. Always read the medication guide properly before using any medicine. You can contact your pharmacist or the doctor if you have any doubts or concerns.

To reduce the chance of an upset stomach, use the drug after eating food. The lowest effective dose for the prescribed duration of the medication must be used.

The medication can be taken with a full glass of water unless your doctor advises you differently. Do not lie down right after taking medicine (Clemett, D. and Goa, K.L., 2000).

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Forms and Strengths

Celebrex and Celecoxib (Generic Form) are both available in an oral capsule form in the strengths 50mg, 100mg, 200mg and 400mg
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Dosage:

  • Adult dose for pain: 400 mg initial dose, followed by two doses of 200 mg.
  • Adult dose for Dysmenorrhea: 400 mg initial dose, followed by two doses of 200 mg.
  • Adult dose for Osteoarthritis: Daily dose of 200 mg once or two doses of 100 mg twice a day.
  • Adult dose for Rheumatoid Arthritis: 100 or 200 mg twice daily.
  • Adult dose for Familial Adenomatous Polyposis: 400 mg daily.
  • Pediatric dose for Juvenile Rheumatoid Arthritis: 10 years old with 25 kg or less should take 50 mg orally two times a day. 10-year-olds with 50 kg or more can take 100 mg orally two times a day.
  • (Note: Always follow the proper dosage as prescribed by your doctor) (Goa, K.L., 2000).

Storage

Keep the drug between 20°C and 25°C in a closed container at room temperature. You can store it at temperatures between 15°C and 30°C, away from heat, from time to time. Do not put the medicine in the freezer. This medication should not be kept in a moist or damp environment, such as a restroom.

Who Can Use Celecoxib?

Adults who suffer from pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, and menstrual pain or discomfort typically use Celecoxib. 

Celecoxib can also be used for children who are at least two years old and weigh 25 kg or more suffering from juvenile rheumatoid arthritis. 

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Side Effects

There can be some side effects caused during the treatment of Celecoxib in some people (Stollberger, C. and Finsterer, J., 2004). You must call your doctor if you have the following side effects:
  • Allergic reaction (difficulty in breathing, swelling in face or throat)
  • Severe skin reaction (skin rash, blistering, and peeling)
  • Fever
  • Sudden numbness or weakness on one side of the body
  • Slurred speech
  • Signs of stomach bleeding (bloody or tarty stools, coughing up blood)
  • Kidney problems (little or no urination, feeling tired or short of breath)
  • Low red blood cells (pale skin, feeling light-headed, cold hands and feet)
  • Liver problems (nausea or stomach pain)
  • Dizziness

What Additional Medications will have an Effect on Celebrex?

Celebrex has the potential to interact with a number of different drugs. Different encounters can have various outcomes. Some interactions, for example, can impair a drug’s effectiveness. Other interactions can increase the number of or make the severity of side effects worse.

Celebrex belongs to the class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) (NSAID). Other NSAIDs should not be taken with Celebrex. This can put you at risk for major intestinal issues. Certain NSAIDs may be found in over-the-counter pain medicines and cold and flu drugs. It’s crucial to always consult your doctor before taking any other medications while using Celebrex.

When you use Celebrex with blood thinners, you run the risk of bleeding, particularly in your stomach and intestines. Celebrex can cause blood pressure to rise. When you take Celebrex with some blood pressure drugs, your blood pressure may become more difficult to control.

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Study

A study on Efficacy and Safety of Celecoxib Therapy in Osteoarthritis was conducted in Beijing, China. The objective was to study the effect of Celecoxib on patients suffering from Osteoarthritis. Many studies were pooled together, and the mean difference, relative risk, and corresponding 95% confidence interval were calculated. Fifteen relevant articles were included in this study for meta-analysis. The study found improved results by using Celecoxib than that of placebo alone.

Conclusion

Celecoxib is a nonsteroidal anti-inflammatory drug and can be used to treat pain and inflammation. It is an effective drug and should be taken as prescribed by your doctor or pharmacist. Consult your doctor for any side effects. Keep the medication away from the reach of children and do not share medicines with others (Crawford, M., 2017).
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