Tylenol is a medication used for the treatment of pain. Acetaminophen is the generic name of Tylenol. It is a member of the drug class called Analgesics. It works against the pain caused due to cold and fever, headaches, and menstrual cramps.

Tylenol and Celebrex are both medications used to treat pain caused due to various reasons in the body. There are no significant drug interactions observed between these two medications. One can take Tylenol with Celebrex to treat pain after consulting the medical practitioner (Gunasingha, R.M., Niloy, I.L., Wetstein, B.B., Learn, P.A. and Turza, L.C., 2021).

Study Of Effectiveness Of Taking Tylenol With Celebrex

A study was conducted by Tijani Issioui et al. to compare the individual efficacy of Tylenol and Celebrex and take it together against pain after surgery.

The total number of participants was 112, and the study was divided into 4 groups:

  • Group 1. Placebo (500 mg)
  • Group 2. Tylenol (2000 mg)
  • Group 3. Celebrex (200 mg)
  • Group 4. Tylenol and Celebrex (2000 mg and 200 mg respectively).

It was observed that Group 4 was more effective in reducing the pain compared to the other groups. Taking Tylenol with Celebrex was observed more effective in reducing the pain after the surgery.

It can be observed that Tylenol can be taken with Celebrex and get effective results.

How Does Tylenol Work?

Tylenol blocks the prostaglandin-producing enzymes. Prostaglandin is the chemical that gives the feeling and sensation of pain in the body. The level of prostaglandin decreases due to the blocking of enzymes. It helps to reduce the pain. 

How Does Celebrex Work?

Celebrex blocks COX-2 enzymes and relieves pain. COX-2 enzymes produce prostaglandins that cause pain and inflammation in the body. This helps to decrease the level of prostaglandin and provides relief from pain and inflammation (Chiang, P.C., Ran, Y., Chou, K.J., Cui, Y., Sambrone, A., Chan, C. and Hart, R., 2012).

Celebrex is a medicine that requires a prescription, so before consuming these medications, consult a doctor, and you can buy Celebrex over the counter online from a certified online pharmacy.

Forms And Strengths


Tylenol is available in tablets, capsules, caplets, chewable tablets, and liquid forms.

  • Capsule: 325 mg, 500 mg
  • Tablet: 325 mg, 500 mg
  • Chewable tablet: 80 mg
  • Liquid solution: 160 mg/5 ml
  • Caplet extended release: 650 mg
  • Tablet oral-disintegrating: 80 mg, 160 mg
  • Caplet 325 mg, 500 mg, 650 mg


Celebrex is an oral medication available in capsules. It comes in strengths of 50,100,200, and 400 mg capsules.

How To Take Them?


Tylenol can be taken with water before or after a meal. Do not crush or break the tablets. For oral Tylenol, one should use a proper measuring spoon.

It should be taken only as directed and not change the dose without consulting the doctor. Take medical help if you face a problem while taking medicine.


Celebrex can be taken with or without eating food. If you face the problem of stomach upset, it is better to take it with food. It should be taken only as per the directions of a medical practitioner. This medication can be taken at any time, but one should take it regularly.



  • The normal adult dose of Tylenol extended-release is 1300 mg every 8 hours.
  • The maximum daily dose should not be more than 3900 mg.
  • The regular tablet dose is 325-650 mg, taken 4 hours daily.
  • The maximum dose is 3250-4000 mg daily.


  • The initial adult daily dose is 200 mg, taken twice daily.
  • The maximum daily dose is 400 mg twice daily.

Who Should Not Take It?


One should not take Tylenol if:

  • Cirrhosis
  • Diabetes
  • Allergic to acetaminophen
  • Addicted to alcohol

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.


One should not take Celebrex if:

  • Allergic to Celecoxib
  • Asthma
  • Heart diseases like stroke and high blood pressure
  • Liver and kidney problems
  • Bleeding and stomach ulcers
  • Allergic to NSAIDs

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.

Side Effects


Following are some common side effects of Tylenol:

  • Nausea- make you feel uneasy
  • Stomach pain- discomfort in the abdomen.
  • Headaches- severe headache leading to disturbance in sleep.
  • Constipation- leading to digestion problems
  • Loss of appetite- may lead to weakness

These are severe side effects associated with the medication of Tylenol:

  • Jaundice- pale yellow urine and weakness
  • Swelling – complicating some muscle movements
  • Difficulty in breathing- suffocation, and restlessness
  • Redness of the skin- constant feeling of itching


Following are some common side effects of Celebrex:

  • Dizziness- feeling sleepy most of the time
  • Nausea- feeling like vomiting.
  • Heartburn- pain in the chest after eating.
  • Stuffy nose- runny nose and cough problems.
  • Stomach pain- unable to eat as discomfort in the abdomen.
  • Constipation- problem in stools.

These are some adverse side effects after using Celebrex:

  • Signs of heart attack- chest pain, sweating.
  • Difficulty in breathing- restlessness, suffocation.
  • Stomach bleeding- vomiting blood, blood in urine and stools.
  • Anaemia- cold hands, pale skin, weakness.
  • Swelling- restricting muscle movements.

Take immediate medical help if you face these side effects to prevent further risks.

Other Precautions While Taking These Medications 

  • Drinking alcohol can lead to more dizziness and bleeding problems. Thus, it is advised not to consume alcohol.
  • Other medicines for pain and fever can interact and have a negative impact on health. Therefore, do not consume or ask your medical health practitioner before taking such medicines.
  • Do consult your doctor before taking Tylenol with Celebrex, as it might affect your health and lead to severe side effects.


Tylenol and Celebrex are medications for pain and fever. It is observed that Tylenol can be taken with Celebrex, as no major drug interaction was observed between them. Take precautionary medical help before taking it.


Get Celecoxib (Celebrex)

Or Write To US