Tizanidine for back pain

Tizanidine for back pain

Tizanidine is a medicine used as a muscle relaxant. It works on different muscle pains. It tends to make the drug more powerful to use it. Muscle spasms are more painful for people; they act as a reliever for them. It has a drug class of skeletal muscle relaxants. Tizanidine is a Generic name, whereas the brand name is Zanaflex.

The drug is a muscle relaxant; it works as a pain reliever and is the cure for the pain. It works by obstructing the sensation of pain, which creates and passes to the brain. It helps block the pain through the spinal cord and makes the person more comfortable in the senses of pain (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

Study on the Effectiveness of Tizanidine for Back Pain

Study: A study was conducted by H Berry et al. to observe the back pain relief with Tizanidine and placebo with ibuprofen.

Aim: The study aims at observing the process of medicines and their safety and effectiveness for back pains.

Method: This study was conducted for 7 days, including 105 patients., They were divided into different groups to observe the effectiveness of Tizanidine and placebo with ibuprofen. Half the patients were given 4mg tizanidine 3 times a day and 400mg of ibuprofen 3 times a day. This process was observed on the 3rd day and the 7th day to strictly observe the reliever’s comments on the process of getting them cured. This was followed by giving a daily diary to the patients to note down their pain levels. Patients who were there as volunteers were already having back pains, which helped the researcher know efficiently.

Results: After the two intervals of observation, the outcome came as Tizanidine working more efficiently and quicker than ibuprofen and placebo. This study shows that Tizanidine is more effective and works well on back pains. It can rely on curing back pains from moderate to mild (Berry H, Hutchinson DR)

study of tizanidine explained in infographics

How and When to take Tizanidine for Back Pain?

As Tizanidine comes in two forms: capsules and tablets, both have the same similarity of taking medicine orally. Medicine can be consumed without food and can be taken with food.

Tizanidine is a medicine that can be consumed at any time. But with a time gap of at least 6-8 hours. Tizanidine should be consumed as per the doctor’s recommendation (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

Dosage

Adults

  • At the Start of the dose- The doctor may prescribe you to take 2mg at every 6-8 hours of interval.
  • Continuity of dose- The doctor may prescribe you to increase the dosage by 2 to 4mg. Until the symptoms are controlled, you need to be under the doctor’s guidance.
  • Highest dose- A person should not exceed 3 doses within 24 hours

Pediatric

  • People below 18 years should not consume Tizanidine. It may cause side effects if consumed.

Senior citizen (65 years and more)

  • The doctor does not always recommend it to consume Tizanidine as it is a powerful drug that might affect the kidneys more than the age of 65. It is a risk to give it to people who already have kidney issues that cannot be worked as other normal adults. Their kidneys might get weak to process the medicine.
  • If required, only after the doctor’s consultation, the doctor might prescribe to take the dose at the lowest power possible.

Every medication should be taken under the doctor’s guidance only. Otherwise, there could be worse situations build-up would not be suitable for health (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

What if I Skipped a Dose or Overdose?

It is ok if you skip the dose or miss a dose. An important thing to keep in mind, you should not have two doses at one time to cover up the previously missed dose.

There would be some of the effects found within you, such as fainting or having lightheadedness which can lead to headaches or getting confused about what you are doing, your body can get weak, and the biggest reason could be slow heart rate.

Who should avoid taking Tizanidine?

These people should avoid taking Tizanidine

  • If the person is already using fluvoxamine (medicine which is used for treating obsessive-compulsive disorder)
  • If the person is consuming ciprofloxacin (medication which is used in treating bacterial infections)
  • If the person is in the process of toning the muscles
  • If the person uses antidepressant medicines.
  • Before consuming medicine, you should inform the doctor about
  • If the person has any kidney-related issues
  • If the person has any liver-related issues
  • If the person has any heart-related issues

Pros and Cons

  • It helps in curing the muscles
  • It helps in making the muscle lose
  • It helps in taking off spasms
  • It helps in curing the spinal problems
  • People below 18 are not recommended to consume Tizanidine.
  • There might be a liver injury.
  • Psychotic symptoms can make the person more brain drained.
  • There might be allergies to the body.

Warnings

There are different medicines that affect the body if you take Tizanidine with it. There are possibilities of Tizanidine acting as a tool for death if taken with other drugs. It can also make the person feel sleepy a lot, which can also be unsuitable for body function.

You need to inform the doctor if you are using medication like:

  • Acyclovir: This medicine is used to treat different infections, as it’s an antiviral medicine
  • Ticlopidine: – This medicine is used to treat strokes and coronary stents.
  • Zileuton: This medicine is used in the treatments of asthma
  • Birth control pills: this medicine is used for not having babies and to control the birth of a child.
  • Antibiotics: These medicines are used for treating different bacterias in the body.
  • Blood pressure: These medicines are used to control blood pressure problems.
  • Heart rhythm medicine: These medicines are used for treating when the heart causes slow blood flow
  • Stomach acid medicine: These medicines are used for treating stomach-related issues.

Conclusion

Tizanidine works more efficiently for the back pains and cures them in the safest way possible. There are side effects too, which always have to be kept in mind; it might get a reaction if consumed without the doctor’s prescription. It works well for curing muscles and pains.

Zanaflex vs Flexeril

Zanaflex vs Flexeril

Muscle relaxants such as Flexeril (cyclobenzaprine) and Zanaflex (tizanidine) are used to relieve muscle tension and cramping (spasm) caused by acute, painful musculoskeletal diseases. Flexeril is used to treat muscle spasms as an addition to rest and physical therapy, whereas Zanaflex is used to treat disorders like multiple sclerosis or spinal damage(Dickerson, L.M., 2010).

Strength and Dosage for Zanaflex

Zanaflex is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg. The initial dose is recommended to be 2 mg. Because Zanaflex’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours. To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg (Barnes, M., 2000).
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Strength and Dosage for Flexeril

Tablet for adults and children – 5mg, 7.5mg, 10mg Capsule, extended use for adults only – 15mg, 30mg The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets(Zegarra, M., 2010).
Zanaflex-vs-Flexeril

Side Effects for Zanaflex

  • dry mouth
  • drowsiness
  • dizziness
  • muscle weakness
  • back pain
  • increased muscle tone or spasms
  • sweating
  • nervousness
  • numbness or tingling
  • stomach pain
  • diarrhea
  • constipation
  • vomiting

Side Effects for Flexeril

Zanaflex vs Flexeril
  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision

Drug Interactions for Zanaflex

  • Zanaflex is mostly metabolized in the liver by the CYP1A2 enzyme. Zanaflex levels in the body can be increased by drugs that block or inhibit this enzyme. 
  • Increased medication levels might cause sleepiness and dizziness, among other side effects. 
  • CYP1A2 inhibitors like ciprofloxacin and cimetidine and birth control pills containing Ethinyl estradiol should be avoided when taking Zanaflex.
  • Zanaflex may interact with drugs that depress the central nervous system. Barbiturates, opioids, and benzodiazepines are examples of these medications. 
  • Zanaflex might intensify their effects, causing dizziness and sedation.
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Study on the effectiveness of Zanaflex and Flexeril

Cyclobenzaprine has been evaluated in most clinical trials with evidence to support its usage, according to a meta-analysis. Tizanidine has been shown to help with spasticity caused by multiple sclerosis. For musculoskeletal problems, such as acute neck or back pain, both cyclobenzaprine and tizanidine were proven to be helpful. Over 100 trials comparing muscle relaxants such as Lioresal (baclofen), Soma (carisoprodol), Robaxin (methocarbamol), Skelaxin (metaxalone), and Valium were included in the meta-analysis (diazepam). Overall, the study discovered that the efficacy and safety of these medications are equal. Muscle relaxants, according to certain guidelines, produce drowsiness and should only be used for a short period. Both Zanaflex and Flexeril are efficient muscular spasm and pain relievers. On a case-by-case basis, they are used depending on which one is most appropriate. There is currently no clinical evidence that shows a direct comparison between these two medicines (Chou R, Peterson K, Helfand M)

Is there a difference between Zanaflex and Flexeril?

Flexeril and Zanaflex are not the same things. Flexeril has an average half-life of 18 hours, while Zanaflex has a half-life of roughly 2.5 hours. Flexeril is only available in extended-release capsules, whilst Zanaflex is only available in immediate-release oral tablets and capsules(Peterson, K. and Helfand, M., 2004).

Is it better to take Zanaflex or Flexeril?

Zanaflex is a relatively new medicine that has been licensed by the FDA to treat muscle spasticity caused by multiple sclerosis and spinal cord injury. Flexeril is an older medication that has been examined extensively for musculoskeletal pain and spasms. The better medicine is the one that is most effective for your condition. Consult a doctor for assistance in determining the best course of action for you(Dickerson, L.M., 2010).

Does Tizanidine Make You Sleepy?

Does Tizanidine Make You Sleepy?

Tizanidine sold under the brand name Zanaflex possesses the effect of making the patient sleepy, dizzy, and tired, slowing down their reaction. It is not advisable to take the medicine if you are going to engage in an activity that requires you to be alert, such as driving, using tools or machines, etc.

Tizanidine belongs to a category of drugs called muscle relaxants. Drinking alcohol over Tizanidine is not recommended as it can increase the risk of side effects such as sleepiness and drowsiness. Tizanidine can also be used to treat refractory sleep disturbance (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

conversation between two people on tizanidine make you sleepy

Study on Tizanidine Used To Treat Sleep Disturbance

Purpose of the study: To study the Effects of Tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia.

Method: 21 spastic quadriplegic children with severe sleep disturbance not improved by conventional therapies were administered Tizanidine. All these patients showed abnormalities of both the induction and maintenance of sleep.

Dosage: Tizanidine was given in doses of 0.1 to 0.2 mg/kg per day, divided into two or three doses. If the drowsiness was significant during the day, Tizanidine was only given just before bedtime.

Findings: The study found that in 13 patients (61.9%), the induction and maintenance of sleep were improved. No detectable side effects were found except a facial pallor in a couple of patients (9.5%) whose treatment was discontinued.

Conclusions: The study concluded that Tizanidine directly affects the induction of sleep and promotes muscular relaxation, which promotes good sleep. It stated that Tizanidine could be used to treat refractory sleep disturbance in spastic quadriplegic patients (Tanaka H, Fukuda I, Miyamoto A, Oka R, Cho K, Fujieda K).

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When to Take Tizanidine?

The ideal time to take Tizanidine is at night, right before going to bed. The most common side effect of Tizanidine is sleepiness and can cause you to lose your concentration and focus. Users of Tizanidine have stated that they had to be in bed right after taking the drug as it kicks in your body quickly.

Mixing Tizanidine with Other Substances

Tizanidine (Zanaflex) can make you sleepy and impair your ability to concentrate and focus. If you’re over 65 or using other sedative medications, this is more likely to happen. While using this medicine, avoid drinking alcohol. Avoid tasks that need alertness, such as driving or operating machinery, until you better understand how the medication affects you.

Tizanidine has been known to interact with several drugs, including some OTC products. Some of these interactions are potentially hazardous. Before starting Tizanidine (Zanaflex), make sure to tell your healthcare provider and pharmacist about all drugs and over-the-counter products you’re taking, even if you only take them occasionally or as needed.

Common Side Effects

Common side effects include

Common side effects include,

  • dry mouth
  • urinary tract infection
  • constipation
  • vomiting
  • sore throat
  • vision problems

Serious side effects include a light-headed feeling, like you might pass out; weak or shallow breathing; confusion, hallucinations; pain or burning when you urinate. Call your doctor immediately if you notice any of these symptoms.

Conclusion

Tizanidine is a muscle relaxant medication sold under the brand name Zanaflex. Tizanidine’s most common Side effect is sleepiness. Tizanidine can cause you to feel drowsy and lose concentration

Mixing alcohol can increase the risk factors related to symptoms like sleepiness and drowsiness. A study found that tizanidine can be used to treat refractory sleep disturbance

Is Tizanidine the Right Option for Anxiety

Is Tizanidine the Right Option for Anxiety

Tizanidine is a muscle relaxant used to treat spasticity. It acts by interrupting the transmission of nerve impulses (pain sensations) to the brain. Tizanidine should only be used for daily tasks that require muscle spasm alleviation. Tizanidine is a pain-relieving central muscle sedative that relieves pain and relieves pain-induced anxiety (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

A Study on Tizanidine Withdrawal Syndrome in Stress

A study conducted by the Pharmacy Department by IDIBELL and Hospital Universitario de Bellvitge, Barcelona, Spain, stated that; Most medicines that act on the central nervous system (CNS) require dose titration to avoid withdrawal symptoms. Tizanidine withdrawal syndrome is marked by hypertension, reflex tachycardia, hypertonicity, and anxiety and is induced by adrenergic discharge due to its 2-agonist action.

Although Tizanidine withdrawal syndrome is a possible adverse effect of discontinuation, it is uncommon, and only a few reports have been made. We discuss the case of a 31-year-old lady who had Tizanidine withdrawal syndrome after stopping a muscular contracture treatment (Tizanidine). With nausea, vomiting, widespread tremor, Dysthermia, hypertension, anxiety, and tachycardia, she displayed significant adrenergic activity.

By beginning Tizanidine followed by a moderate downward titration, symptoms were reversed, and successful reweaning was achieved. When medicines that target the CNS are abruptly withdrawn, withdrawal syndrome should be considered. Acute withdrawal effects should be thoroughly monitored during reducing regimens.

Hence stating that titration of Tizanidine can reverse the withdrawal symptoms that also induce anxiety (Management of Tizanidine Withdrawal Syndrome: A Case Report).

Tizanidine-for-anxiety-(1)

Dosages

Tizanidine is available in 2- or 4-mg pills and 2, 4, or 6mg capsules. A single dose of 8 mg can ease spasticity for several hours. The effects are strongest 1–2 hours after the dose and fade away after 3–6 hours.

Due to the possibility of dose-related side effects, most people will begin with a lower dose of 2 or 4 mg. A doctor can gradually increase the dose by 2–4 mg every 1–4 days to achieve the best benefit with the least side effects. People can repeat the dose every 6–8 hours, but they should never take more than three doses in 24 hours, totalling 36 mg.

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What Happens If I Forget to Take a Dose?

As soon as you recall, take the missed dose. If your next scheduled dose is approaching, skip the missing dose. To make up for a missed dose, do not take more medicine.

What Happens If I Overdose?

Seek medical help right away. Overdose symptoms include light-headedness, drowsiness, disorientation, sluggish heart rate, shallow breathing, and fainting.

Who Should Not Take it

This drug shouldn’t be consumed if you have the following conditions:

  • Injured Liver
  • Hypotension
  • Kidney problems
  • Allergic reaction
Side Effects

Side Effects

Tizanidine has the potential to induce adverse effects:

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Sleepiness

Conclusion

You might get withdrawal symptoms (such as anxiety, tremor, elevated blood pressure/heart-rate/muscle tenseness) if you suddenly stop using this medicine. To prevent withdrawal, your doctor may gradually reduce your dose. If you’ve been using Tizanidine for a long period or in high quantities, you’re more prone to experiencing withdrawal symptoms. If you develop withdrawal symptoms, contact your doctor or pharmacist right away. 

Zanaflex (Tizanidine) vs Soma (Carisoprodol)

Zanaflex (Tizanidine) vs Soma (Carisoprodol)

What Is Tizanidine?

Tizanidine is a medication used to treat spasms and elevated muscular tone caused by multiple sclerosis, stroke, or a brain or spinal injury. Tizanidine belongs to the skeletal muscle relaxant class of drugs. It works by allowing the brain and nerve system to slow down their actions, relaxing the muscles.

What is Soma?

Soma is a prescription medication that doctors usually given to people who have muscle spasms, discomfort, or other related issues. Soma is a muscle relaxant that acts on the central nervous system. While it is well recognized that the medication is efficient in reducing the amount of muscle pain a patient may be experiencing, medical specialists do not appear to completely understand how the drug works to achieve these results.

conversation of two people which is better

Tizanidine vs Soma: Which one is better?

There is a scarcity of data comparing skeletal muscle relaxants to one another. A systematic review looked at 46 trials, most of which were focused on low back pain or neck disorders. The placebo-controlled trials were completed more than 15 years ago and included 17 on cyclobenzaprine, six on Tizanidine, four on carisoprodol, and four on orphenadrine. (See S, Ginzburg R).

Soma was found to be more effective than diazepam at reducing muscle spasms and improving overall and functional status in patients with low back pain in one research of moderate quality. Another trial that compared Tizanidine to chlorzoxazone for back spasms found no significant differences.

Some studies of good quality were included in a different systematic review. There was no difference in outcomes (muscle spasms, muscle discomfort, tension, tenderness, and functional status) between cyclobenzaprine and carisoprodol, chlorzoxazone, and Tizanidine, and diazepam and Tizanidine in these trials.

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Strength and Dosage for Tizanidine

Tizanidine is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg tablets.

 

The initial dose is recommended to be 2 mg. Because Tizanidine’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours.

 

To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg.

Strength and Dosage for Soma

Strength and Dosage for Soma

Soma is available in two strengths: 250mg and 350mg tablets.

 

Soma should be taken in doses of 250 mg to 350 mg three times a day and at bedtime. 


Soma should be used for no more than two or three weeks at a time.

Drug Interactions for Tizanidine

Tizanidine is primarily metabolized in the liver by the CYP1A2 enzyme. Tizanidine levels in the body can be increased by drugs that block or inhibit this enzyme. Increased medication levels might cause sleepiness and dizziness, among other side effects. CYP1A2 inhibitors like ciprofloxacin and cimetidine and birth control pills containing Ethinyl estradiol should be avoided when taking Zanaflex.

Drug Interactions for Soma

Consult your doctor before taking any other sleep-inducing medication, such as allergy medications or narcotic pain relievers. Other substances that slow the brain’s functions, such as alcohol, barbiturates, benzodiazepines, and opioids, interact with Soma. Do not consume alcohol while taking this medication. This drug has the potential to become addictive. Do not exceed the recommended dosage.

Can you take Tizanidine and Soma Together?

When the drugs Zanaflex (Tizanidine) and Soma (carisoprodol) are taken together, they might cause addictive side effects such as drowsiness and cognitive impairment. Both are categorized as muscle relaxants; therefore, taking both is termed a “double therapy.”

 

Nonetheless, while Zanaflex and Soma are both muscle relaxants, their mechanisms of action are slightly different, and it’s possible that using both could provide additional benefits. However, before combining the two, you should consult your doctor.

Conclusion

Both these medications- Tizanidine and Soma are used for muscle spasms. According to the study conducted, it was observed that Soma was more effective as compared to Tizanidine. But before taking any of these medications, please consult your doctor and tell them about your medical history in order to prevent negative effects.

Does Tizanidine Cause Weight Gain or Weight Loss

Does Tizanidine Cause Weight Gain or Weight Loss

According to various studies, Tizanidine can cause both weight gain and weight loss. Several factors like loss of appetite and slowed metabolism affect and cause weight gain and loss for a Tizanidine user.

Tizanidine is a short-acting muscle relaxer that works by blocking the nerve impulses or the pain sensations sent to your brain, and there are some side effects to it, including weight gain, which is rare, and weight loss which a common.

Weight gain can be found among people who take Tizanidine, especially females 50-59 years old and who have been taking the drug for around 1-6 months. eHealthMe conducted a study where reported 2,547 people taking Tizanidine, and their side effects regarding weight were recorded.

conversation on weightgain

Time on Tizanidine Hydrochloride when people have Weight Gain:

  • < 1 month: 20%
  • 1-6 months: 40%            
  • 6-12 months: 0.0%
  • 1-2 years: 0.0%
  • 2-5 years: 20%
  • 10+ years: 20%

Gender of People who have Weight Gain while taking Tizanidine Hydrochloride

Does Tizanidine Cause Weight Gain or Weight Loss
  • Male: 12.82%
  • Female: 87.18%

Dosage

Adults: Initial dose: 2mg/day to 8mg/day Maximum dose: 8mg/day to 24mg/day Painful muscle spasms associated with musculoskeletal conditions: 2-4mg 3 times/day(Sergay, S. and Richardson, M., 2001).

Tizanidine Side Effects

Tizanidine has side effects ranging from standard to rare; some of these side effects are mentioned below(Weightman, D. and Hudgson, P., 1982).

Common side effects

  • Dizziness 
  • weight loss
  • Blurred vision
  • Feeling nervous
  • Sore throat 
  • Dry mouth
  • Vomiting
  • Uncontrolled muscle movement

These Are Some of the Rare Side Effects of Tizanidine

  • Pain or burning sensation while urination
  • Weight gain
  • Confusion
  • Hallucinations 
  • I feel like you might pass out.
  • Shallow breathing

How To Effectively Tackle Weight Gain or Weight Loss?

If you are taking Tizanidine and experience weight gain or weight loss after a while, you must immediately consult your doctor and seek professional help. Your doctor might give you medications to tackle your weight gain or weight loss that might suit you(Lombard, C.B. and Cicuttini, F.M., 2013).

Conclusion

In the end, Tizanidine, when taken as prescribed by your doctor and if followed all the guidelines for taking the drug then it can be incredibly beneficial for the user. It can help the user with their problem by avoiding as many side effects as possible.

Is Zanaflex a Controlled Substance?

Is Zanaflex a Controlled Substance?

Spasms and increased muscle tone caused by sclerosis, stroke, or brain or spinal injury are treated with Zanaflex (Tizanidine). Zanaflex belongs to the skeletal muscle relaxant class of drugs. It works by allowing the brain and nerve system to slow down and relax the muscles.

According to the DEA, Zanaflex is not a controlled substance. Some people, like those who abuse other muscle relaxants, may abuse this one as well. Zanaflex is a therapy option for a brief period of time. Long-term use can develop into abuse and dependency, as well as addictive habits(Leonard, P. and Valaer, C., 2014).

What Schedule Class is Tizanidine?

Zanaflex belongs to the Central Alpha-2-Adrenergic Agonist class of medicines. Alpha-2 agonists that operate centrally stimulate the central nervous system’s alpha-2 adrenoceptors. Sympathetic nervous system activity reduces when alpha-2 receptors are activated.

conversation of two people on zanaflex is controlled substance or not

Is Tizanidine a Narcotic?

The fact that Tizanidine is not a narcotic appeal to many people who require relief from muscle spasms. Despite the fact that Tizanidine is not a narcotic, it does cause some people to get addicted to it. The way it acts in your body distinguishes it from a narcotic. Instead of attaching directly to pain receptors, it inhibits nerve receptors at the muscle level. This creates the erroneous impression that Tizanidine cannot be abused(Levy, R.M., 1995).

Is Tizanidine a Strong Muscle Relaxer?

A systematic review compared and contrasted 46 trials (both randomized and placebo-controlled), the majority of which focused on low back pain or neck disorders. The placebo-controlled trials were largely completed more than 15 years ago and included 17 on cyclobenzaprine, six on Tizanidine, four on carisoprodol, and four on orphenadrine.

In general, all of the medications were found to be beneficial in some way. There was no significant difference between Tizanidine and chlorzoxazone (Parafon Forte) for back spasms in a fair-quality trial.

To summarise, Tizanidine is a powerful muscle relaxant; however, there is little evidence to suggest that it is superior to other muscle relaxants(Bryson, H.M., 1997).

Strength and Dosage

Is Zanaflex a Controlled Substance

Zanaflex is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg.

The initial dose is recommended to be 2 mg. Because Zanaflex’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours

To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg.

Side Effects

  • Dry mouth
  • Drowsiness
  • Dizziness
  • Muscle weakness
  • Back pain
  • Increased muscle tone or spasms
  • Sweating
  • Nervousness
  • Numbness or tingling
  • Stomach pain
  • Diarrhea
  • constipation
  • vomiting

Drug Interactions

Zanaflex is mostly metabolizd in the liver by the CYP1A2 enzyme. Zanaflex levels in the body can be increased by drugs that block or inhibit this enzyme. Increased medication levels might cause sleepiness and dizziness, among other side effects. CYP1A2 inhibitors like ciprofloxacin and cimetidine, as well as birth control pills containing Ethinyl estradiol, should be avoided when taking Zanaflex. Zanaflex may interact with drugs that depress the central nervous system. Barbiturates, opioids, and benzodiazepines are examples of these medications. Zanaflex might intensify their effects, causing dizziness and sedation(Bouchard, S., Tansey, C., Gendron, D., Barkas, W.J. and Francis, G.S., 1987).
How long does Zanaflex Stay in your System?

How long does Zanaflex Stay in your System?

Tizanidine, sold under the brand name Zanaflex, is a prescription medication used to treat the symptoms of muscle spasticity due to multiple sclerosis or spinal cord injury. The medication belongs to a class of drugs called Central Alpha-2-Adrenergic Agonist. It can be used along with other medicines or alone too. The drug was approved by FDA in 1996 in the United States for medical use. Zanaflex is available as a generic medication. With more than 8 million prescriptions, it was the 86th most commonly prescribed medication in the United States in 2018. Zanaflex is a central alpha-2-adrenergic receptor agonist & it reduces the spasticity by increasing the presynaptic inhibition of motor neurons. The effects of the medication are most remarkable on the polysynaptic pathways. The complete impact of these actions is thought to alleviate the simplification of spinal motor neurons. While oral administration of the drug, it is completely absorbed. (Kaddar, N., Vigneault, P., Pilote, S., Patoine, D., Simard, C. and Drolet, B., 2012)
two people conversation on how long zanalflex stay in your system

Half-life of Zanaflex

The active ingredient in Zanaflex is Tizanidine and is used in treating antispastic in multiple sclerosis and spinal cord injury. The half-life of Zanaflex is approximately 2.5 hours, but its metabolites have a half-life of about 20 hours to 40 hours. Hence, a single dose of the medication will take approximately 80-90 hours to get out of the system completely. .After taking either a tablet or capsule of Zanaflex, the peak plasma concentrations occur an hour after ingestion. The half-life of the drug is about two hours to two and a half. Almost 95% of the dose is metabolized. With a half-life varying between 20 to 40 hours, the metabolites of Zanaflex are not known to be active. The half-life of Zanaflex is not influenced by food, but it does affect the peak plasma concentration. In the fasting state, the peak plasma concentrations. In a fasting state, the peak plasma concentration is one hour after ingestion & a half-life of about two hours.  However, Zanaflex, when administered with food, the plasma concentration rises by 30% to one hour and 25 minutes. (Granfors, M.T., Backman, J.T., Neuvonen, M. and Neuvonen, P.J., 2004)
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Factors that Affect how long Zanaflex Stay in your System

Though the half-life of Zanaflex is approximately 2 to 2.5 hours, it varies from person to person; how long will it stay in your system depending on several factors and variables? The healthcare physician must explain the mechanism of Zanaflex, how long it will remain in your system, urine, blood, or Saliva, and the factors that play a vital role in the drug’s presence in the body.

 

How long does Zanaflex Stay in your System

The factors include:

  • Age
  • Metabolism rate
  • Body mass and weight
  • Food intake
  • Co-administered drug
  • Kidney and liver health
  • Frequency of administration 

Zanaflex in Urine: It has a short half-life; approximately 95% of the dose gets metabolized, out of which 60% is recovered in urine. Therefore a single dose of 4mg can be detected in urine from 5 to 13 days.

Zanaflex in Blood: A blood test is requested when an individual is suspected to be under the influence of drugs. When taken from blood, Zanaflex is found maximum on day 1 & falls below the detectable limit by day 5 after ingestion.

Zanaflex stay in hair: Zanaflex can be detected in hair & is the most promising alternative test as it is perfect for examining long-term use of the drug. A hair follicle test can help detect the drug for up to 90 days.

Zanaflex stay in Saliva: A saliva drug test can detect the presence of drugs within a few hours after ingestion. Oral secretions may be able to show if you’ve been using for up to 24-48 hours, depending on how long it’s been used.

How to remove Zanaflex from the System Safely?

Knowing the mechanism of Zanaflex and what Zanaflex is can help us understand the working and efficiency of the medicine and how long it will remain in your system. For the individual who worries about the Zanaflex testing, there are many things they can do to help in order to get the medication eliminated from the system at a faster rate. Precautions are required, and these should be considered only under the guidance of your healthcare physician. Following are the methods-
  • Calcium D Glucarate
  • Activated Charcoal
  • Hydration
  • Acidification
It is always advised to talk or consult your healthcare physician regarding every concern about dependence on this drug. Seek immediate medical help if you are experiencing dry mouth, hypertension, dizziness, or other symptoms after administering the drug. Your healthcare physician might consider replacing it with any other medication. (Suárez-Lledó, A., Padullés, A., Lozano, T., Cobo-Sacristán, S., Colls, M. and Jódar, R., 2018)
Zanaflex vs Robaxin

Zanaflex vs Robaxin

The generic name for Zanaflex is tizanidine, and it acts as a short-acting muscle relaxer. It mainly works by blocking the pain sensations, i.e., nerve impulses directed to your brain. 

Conditions like cerebral palsy or other neurological disorders are treated by Zanaflex, which is a prescription medicine. The symptoms like muscle stiffness (spasticity) are associated with the neurological disorder is treated by this drug. Zanaflex may be safe and effective for children, but it’s not known if they work because there has never been a clinical trial on them before. The safety and effectiveness data explicitly related to children under 18 has not yet been published; however, this does not mean you shouldn’t give them one chance if your child falls.

The generic name of Robaxin is methocarbamol which is also a muscle relaxer to treat skeletal muscle conditions such as injury.mRobaxin is a prescription medicine used to treat the symptoms of muscle spasms caused by pain or injury and Tetanus. 

They belong in a group known as Skeletal Muscle Relaxants, which includes Valium, among others; not only does it help relieve your discomfort, there has been some evidence suggesting these drugs can actually decrease seizures from epilepsy conditions such as Lennox Gas taut Syndrome.

Zanaflex-vs-robaxin

Are Robaxin and Zanaflex the same thing?

Zanaflex and Robaxin are both muscle relaxants which is used for relaxing the muscles in slightly different ways. Robaxin can be used with therapy and rest to treat skeletal muscle conditions such as injury and pain.

If your muscles suffer cramping after a workout or swimming, then you could use Zanaflex to treat them. It also uses for muscle tightness, the condition like spasm is caused by conditions such as spinal injury.

You may see similar side effects of Zanaflex and Robaxin, including dizziness, skin rash, drowsiness, vomiting, and constipation. It’s not like there are only similar side effects of Robaxin and Zanaflex; some side effects of Robaxin are different from Zanaflex that includes:

  • Nausea
  • Stomach upset
  • Confusion
  • Loss of balance or co-ordination
  • Headache
  • Blurred vision
  • Memory problems
  • Eye redness
  • Spinning sensation
  • Stuffy nose
  • Itching
  • Sleep problems
  • Double vision
  • Diarrhea
  • Dry mouth
  • Fever
  • Muscle weakness
  • Sweating
  • Fatigue
  • Numbness or tingling
  • Back pain
  • Increased muscle tone or spasms
  • Nervousness
  • Anxiousness

Studies have shown that both drugs Zanaflex and Robaxin may interact with some other medicines that can make your breathing slow and could make you dizzy and sleepy. Other drugs may include prescription cough medicines, anxiety, sleeping pills, and depression, narcotics, and muscle relaxers. It is seen that if consumption of Zanaflex stops suddenly after long-term use, then you may have some withdrawal symptoms like anxiety, fast heartbeats, tremors, and dizziness.

For both, Robaxin and Zanaflex at a reduced cost

Strength of Robaxin and Zanaflex

Strength of Robaxin and Zanaflex
  • Robaxin is available in round, a light orange film-coated tablet that contains 500 mg of methocarbamol and USP for oral administration.
  • Zanaflex capsules are available in three strengths containing tizanidine hydrochloride, a two-piece hard gelatin capsule. It has 2.29 mg. 4.58 mg and 6.87 mg, equivalent to 2 mg, 4 mg, and 6 mg tizanidine base.

How is Robaxin taken?

Doctors have recommended the doses of Robaxin so that you may not overdose on it. The recommended started dose is six grams a day for the first 48 to 72 hours of the treatment; after some time, you may reduce these doses to approximately 4 grams a day which might not affect you adversely.

If you are using the medicines regularly, tell your doctor or healthcare provider about all over-the-counter prescriptions, medications, and supplements you use.

Robaxin is prescribed for women during pregnancy, but research has not proven whether this drug passes into breast milk? So consult a doctor if you’re using this drug and breastfeeding.

How is Zanaflex taken?

consume robaxin

Zanaflex is a strong drug, and it should be taken only if recommended and precisely as prescribed; you can take it with or without food and be aware that you do not switch between capsules and tablets.

Patients must be informed about this drug that they should not consume Zanaflex more than prescribed because there might be a risk of adverse effects at single doses greater than 8 mg or total daily doses greater than 36 mg.

Like Robaxin, the patient must be informed about the Zanaflex that it should be suddenly stopped because tachycardia and rebound hypertension may occur.

Robaxin Precautions

First to remember, if you’re allergic to Robaxin, then tell your doctor or pharmacist about it to suggest you some advice. The drug may contain some inactive ingredients that may be harmful or cause some allergic reactions or other problems to your health. Talk to your pharmacist for more details.

If you’re suffering from any liver disease, telling your doctor must be the first thing to do before using this medication. If you’re taking Robaxin regularly, it may make you feel dizzy or make your vision blurry.

Do not drive or use machinery when you consume this medicine or do not do such activity that needs alertness until you can do it safely. Avoid alcohol or marijuana after or before taking Robaxin; if you take it, get ready to visit your doctor.

Zanaflex Precautions

Zanaflex Precautions

Precautions are almost similar to Robaxin; if you’re allergic to Zanaflex, consult your doctor and get the required information about the drug. If you’re suffering from any issue regarding low blood pressure, kidney disease, or liver disease, then ask your doctor for any help regarding the consumption of Zanaflex.

If you’re having any tooth surgery or body surgery, then tell your doctor or dentist about all the products you are taking, which may include herbal products, prescription drugs, and non-prescription drugs.

Studies have seen that side effects of this drug are more affected to the older adults as they are more sensitive to it, especially the effects may include drowsiness and dizziness, which may lead to a risk of falling.

Conclusion

Both Robaxin and Zanaflex are muscle relaxants and are prescribed by the doctors in proper proportion. These drugs may damage your health after being taken in excess proportion, so be aware of this condition and be in contact with your doctor for any issues.

References

  1. Poudel, R.R. and Kafle, N.K., 2015. Tizanidine-induced acute severe cystitis in a female taking famotidine. Clinical pharmacology: advances and applications7, p.83. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524377/ Accessed on 01/10/2021
  2. Forsyth, H.F., 1958. Methocarbamol (Robaxin) in orthopedic conditions: Preliminary report of one hundred cases. Journal of the American Medical Association167(2), pp.163-168. Available at: https://jamanetwork.com/journals/jama/article-abstract/323874 Accessed on 01/10/2021
  3. McLain, D., 2002. An open label dose finding trial of Tizanidine [Zanaflex™] for treatment of fibromyalgia. Journal of Musculoskeletal Pain10(4), pp.7-18. Available at: https://www.tandfonline.com/doi/abs/10.1300/J094v10n04_02 Accessed on 01/10/2021