The Efficacy of Naproxen on Headaches

The Efficacy of Naproxen on Headaches

Naproxen is a medication used for relieving pain. Naproxen can be used for the treatment of headaches, back pains, and muscle pain. Naproxen is the generic name of Aleve, and it belongs to the drug class Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). It can also be used to treat fever and menstrual discomfort in women.

As it is used to tackle pain, Naproxen is an effective medicine for headaches and migraine. Aleve can be used to treat headaches and give better results (Todd, P.A. and Clissold, S.P., 1990).

Effectiveness of Naproxen for Headache

infographic on the study of naproxen for headaches

A research was conducted by Simon Law et al. to study the effectiveness of Naproxen on people suffering from headaches and migraine. 6 studies from about 2700 participants were collected by assigning 275mg, 500mg, and 825 mg doses. The participants were given doses of Naproxen and a placebo.

It was observed that Naproxen was more effective in relieving headaches and migraine. People relived after taking Naproxen was more than people taking placebo. There were adverse effects with mild intensity observed when high doses were administered. Thus, Naproxen with lower doses can better effective results against headaches and migraines (Naproxen with or without an antiemetic for acute migraine headaches in adults).

How does Naproxen Work?

Naproxen affects the enzymes which produce prostaglandins- substances causing inflammation and pain. Aleve restricts the prostaglandin-producing enzymes and thus reduces the headache (Todd, P.A. and Clissold, S.P., 1990).

Forms and strengths of Naproxen

Aleve, also known as Naproxen, is an oral medication available in the form of tablets, gel caps, and caplets. The Aleve tablets and caplets are available in the strength of 220 mg (Todd, P.A. and Clissold, S.P., 1990).

How to Administer Naproxen?

Aleve should be taken as prescribed by the doctor only. Taking a higher dose to tackle headaches quickly should not be done as it will lead to severe side effects and create a threat to life.

The medicine can be taken with or without food. One can take it with milk or food to prevent stomach upset. One should not consume alcohol while taking Aleve. It may lead to stomach bleeding. Taking antacids along with Aleve can act as a barrier in the working of Aleve (Todd, P.A. and Clissold, S.P., 1990).

Dosage of Naproxen

Type Of Dosage

Dose Amount

Initial Dose

220-440 mg

Standard Dose

220 mg every 8-12 hours

Maximum Dose

440 mg every 8-12 hours OR

660 mg every 24 hours

Most of the time, Aleve doesn’t follow a specific schedule. But one should take the dose at the time prescribed by the doctor. One should not take a double dose to compromise the missed dose. Some people take a higher amount to get more effectiveness. But it will cause harm. 

If observed overdose, one should seek emergency medical help to prevent further risk. Difficulty in breathing, seizures, and stomach pain are some of the overdosage symptoms (Todd, P.A. and Clissold, S.P., 1990).

Who should not take Naproxen

One should not take Naproxen if:

  • Used MAO inhibitor in past 2 weeks
  • Allergic to Naproxen
  • Asthma attack
  • Below the age of 12
  • Blood pressure and other heart diseases
  • Stomach ulcers and bleeding issues
  • Kidney and liver disorders
  • Addicted to alcohol

It is advised for breastfeeding and pregnant women not to take Aleve as it can harm the woman and child both. It can be taken only if prescribed by the doctor.

Side effects of Naproxen

Following are the common side effects which one can experience after taking Aleve:

  • Heartburn
  • Swelling
  • Dizziness
  • Nausea
  • Ringing in ears
  • Abdominal pain

There are some severe side effects associated too with the medication of Aleve, which require emergency medical help or even termination of drugs. Following are the severe side effects:

  • Anemia
  • Breathlessness
  • Chest pain or stroke symptoms
  • A quick change in weight
  • Skin rashes
  • Stomach bleeding


Naproxen is an effective medicine for headaches if taken in smaller dosages. Aleve can be taken for other pains too. Proper medical guidance should be taken before taking Aleve in order to prevent the risk of adverse effects.

The Efficacy and Safety of Naproxen for Treating Pain

The Efficacy and Safety of Naproxen for Treating Pain

Naproxen is a pain reliever to treat illnesses like arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, and menstrual cramps. It can also treat acute pain caused by disorders that aren’t covered in this drug guide. Over-the-counter Naproxen is sold under the brand name Aleve.

Does Naproxen help with Pain Relief?

Yes, Naproxen is used to treat headaches, muscle aches, tendonitis, tooth pain, and menstrual cramps, among other things. It also helps to relieve the pain, swelling, and stiffness associated with arthritis, bursitis, and gout episodes(Todd, P.A. and Clissold, S.P., 1990).

Scientific Study on the Effectiveness of Naproxen

Pain after surgery is frequently mismanaged. A variety of pharmacological therapy is available, including non-steroidal anti-inflammatory medications (NSAIDs), of which Naproxen is one. Naproxen is used to treat a wide range of painful disorders, including acute postoperative pain, and is frequently coupled with sodium to increase its oral solubility. The objective of this study was to see how effective, safe, and long a single oral dose of Naproxen or naproxen sodium was at treating immediate postoperative pain in adults. Naproxen 200 mg and naproxen sodium 220 mg, according to two small trials, may give good postoperative pain management. When compared to placebo, there was no significant difference in the number of patients who experienced an adverse event while on therapy.

Forms and Strength of Naproxen

Naproxen is available in tablet, liquid capsule, and liquid form. The amount of Naproxen required is dictated by the reason for taking the medication. Naproxen is available in a range of strengths and formulations. There are three main strengths of naproxen tablets: 250 mg, 375 mg, and 500 mg. Naproxen sodium is available in OTC capsules and tablets with a dose of 220 mg, as well as prescription pills with doses of 275 mg and 550 mg. Low-dose Naproxen is available in pill or capsule form. Children and those who have difficulty swallowing tablets can use naproxen suspension. Each milliliter of Naproxen suspension contains 25 milligrams of the medication (ml) (Musa, K.A. and Eriksson, L.A., 2008).
Rush Today To Buy Discounted Naproxen Medicines


If you have a fever, you should only use OTC naproxen for 3–5 days for the pain and no longer than three days if you have a fever. If people need to continue treatment, they should first see their doctor. For children aged 2–12 years, the maximum daily dose is 20 mg/kg. In a 24-hour period, they should not consume more than 1,000 mg. In a 24-hour period, children aged 12 and up should not ingest more than 660 mg of OTC medications.(Bliss, C.I., 1935)

How Naproxen works

These drugs operate by preventing your body from manufacturing prostaglandins, which are responsible for reducing pain and temperature. When your body’s tissues are damaged, your body produces prostaglandins. These molecules are responsible for many of the symptoms of inflammation, including swelling, fever, and discomfort. Prostaglandin synthesis inhibition can help you prevent pain and other inflammatory side effects. It does, however, have the potential to cause problems with other functions(Roshandel, M.R., 2021).

Side Effects of Naproxen

If you exhibit symptoms of an allergic response to Naproxen, get immediate medical attention: sneeze, runny, or stuffy nose; wheezing or difficulty breathing; hives; swelling of the cheeks, lips, tongue, or throat.

Get emergency medical help if you have chest discomfort that spreads to your jaw or shoulder, numbness or weakness on one side of your body, slurred speech, or shortness of breath.

Side Effects of Naproxen
  • stomach ache
  • constipation
  • dizziness 
  • drowsiness
  • headache
  • heartburn
  • nausea and vomiting, as well as abdominal hemorrhage
  • perforation of the abdomen
  • lightheadedness
  • ulceration in the stomach
  • retaining fluid
  • diarrhea

These adverse effects can be fatal and come on suddenly. If you get severe stomach pain while taking Naproxen, stop using it right once and see your doctor. To limit the risk of digestive system side effects, use the lowest effective dosage for the shortest time.

Blood pressure has been shown to rise when using Naproxen. There’s a chance you won’t notice any signs that your blood pressure is rising. Furthermore, if you already have high blood pressure, Naproxen could make it worse. Before taking Naproxen, talk to your doctor if you have high blood pressure.

Drug Interactions

Some drugs can interfere with Naproxen’s effectiveness. If you use any of the following, tell your doctor:

The Efficacy and Safety of Naproxen for Treating Pain
  • Digoxin
  • Cholestyramine
  • Cyclosporine
  • Lithium
  • Methotrexate
  • Blood pressure medicine
  • Blood thinner
  • Diuretic
  • Medicine to treat depression
  • Probenecid
  • Sucralfate
  • Antacids

Unless your doctor says it’s acceptable, don’t take any additional NSAIDs. Aspirin, celecoxib, diclofenac, diflunisal, ibuprofen, and salsalate are some of the NSAIDs. Do not consume alcohol while taking this medication (Moore, N., Pollack, C. and Butkerait, P., 2015).

Is it Safe to Drink Alcohol while taking Naproxen?

Is it Safe to Drink Alcohol while taking Naproxen?

Drinking Alcohol with Naproxen is undoubtedly not recommended. Mixing Naproxen with alcohol may cause severe side effects and damage a person’s health. To understand the severity of the two, together, we should understand Naproxen as a medicine.

Naproxen As A drug

Is it Safe to Drink Alcohol while taking Naproxen

Naproxen is a non-steroidal anti-inflammatory drug that is taken to treat pain and tenderness associated with 

  • Muscle aches 
  • Joint aches 
  • Menstrual pains
  • Various forms of arthritis such as rheumatoid arthritis, osteoarthritis, and gout.  

Naproxen is most commonly sold under the brand name Aleve but can also be manufactured and sold as Anaprox, Flanax, and Naprosyn. Naproxen is available over the counter in tablet and liquid form. It could also be prescribed to children.


Non-steroidal anti-inflammatory drugs (NSAIDs) are known to increase the risk of gastrointestinal complications. Excessive alcohol consumption may further increase this risk. The study’s objective was to evaluate the risk of NSAID-related gastrointestinal events for persons with a history of alcohol abuse. This case-control study used data from Saskatchewan Health. Thus with both risk factors present, the resulting risk ratio is greater than the additive risk of the separate risk factors. The present study presents the effect of long-term alcohol abuse. Further research is needed to separate these two issues to allow physicians to provide the best advice to their patients.

Drinking Alcohol While On Naproxen

It is not recommended to drink alcohol while on Naproxen. Prostaglandin thickens and protects the stomach lining. Naproxen reduces prostaglandin in the body, which is responsible for inflammatory reactions.

Alcohol also suppresses the body’s ability to make blood cells, especially platelets. When a person gets a cut, platelets are activated, which helps to stop bleeding. However, when the person has been drinking alcohol for a long time, the body has trouble making new platelets. If a person is injured and the body can’t stop the bleeding, they may continue to bleed. This situation can be dangerous, especially if the bleeding is on the inside of the body.

So taking Naproxen and alcohol can increase the risk of bleeding even more when used together than when used separately. It is suspected that alcohol and Naproxen have an additive risk. When a person has taken Naproxen and drinks alcohol, they are likely to bleed for longer than if they had not consumed alcohol(Neutel, C.I. and Appel, W.C., 2000).

Is it safe to drink alcohol with Naproxen

Other Side Effects of Naproxen And Alcohol Taken Together

Both alcohol and Naproxen have side effects that increase people’s risk of bleeding. So, not only do they both make it more likely for a person to bleed when they’re injured, but they also put the body at risk of damage in the first place. This damage is often not on the outside of the body; instead happens inside the body.

One of the most common side effects is gastritis. Gastritis is an inflammation of the stomach lining. It can be caused both by alcohol and Naproxen. Therefore, if someone uses alcohol and Naproxen together, they are at a higher risk of getting gastritis(Subuddhi, U., 2013).

Other Serious Problems That Can Arise From A Mixture Of Naproxen And Alcohol:

  • Ulcers in the stomach and intestines
  • Permanent damage to the stomach lining
  • Low blood iron, which means blood cells are not able to carry oxygen to the rest of the body
  • Vitamin B12 deficiency, which can lead to permanent nerve damage and mental changes
  • Growths in the stomach which may be cancerous in some cases
  • Potential chance of becoming addicted to alcohol
  • Increased risk of overdose


For most people, Naproxen is an effective medication for mild pain and fever for short-term use. If you have a history of stomach ulcer, kidney, heart, or liver disease, talk to your doctor before use. The best way to avoid gastritis and bleeding from alcohol and Naproxen is not to use them together(ogel, U., Christensen, J., Dybdahl, M., Friis, S., Hansen, R.D., Wallin, H., Nexø, B.A., Raaschou-Nielsen, O., Andersen, P.S., Overvad, K. and Tjønneland, A., 2007).

Aleve (Naproxen) for Back and Muscle Pain?

Aleve (Naproxen) for Back and Muscle Pain?

Yes, Aleve is the medication that can temporarily cure Backaches, muscle aches, headaches, mild arthritis, and other joint pain. It can also aid menstruation discomfort, toothaches fever for a short time. Aleve is a non-steroidal anti-inflammatory drug that treats rheumatoid arthritis, gout, and fever.

How does Aleve work for Back and Muscle pain?

Naproxen sodium is a pain reliever that acts both at the site of the pain and in the central nervous system (CNS). It is known to function by inhibiting the formation of prostaglandins, which are responsible for inflammation and blocking the pain-causing substances.

Study: Aleve for back pain

A meta-analysis of six studies (500 patients) comparing naproxen sodium 550 mg against placebo found that naproxen sodium 550 mg had an RR of at least 50% pain reduction over 4 to 6 hours. The quality of the research included in this analysis was acceptable. Naproxen 200 mg and naproxen sodium 220 mg were shown to be beneficial in two minor trials for pain management. Compared to placebo, there was no significant difference in the number of patients who experienced an adverse event while on therapy. The weighted mean time to remediation for naproxen sodium 550 mg was 7.6 hours, whereas the placebo took 2.6 hours. Result: Orally given naproxen sodium 550 mg, naproxen sodium 400 mg, and naproxen sodium 440 mg are effective analgesics for treating acute postoperative pain in adults (Mason, L., Edwards, J. E., Moore, R. A., & McQuay, H. J. (2004).

How Long does It take Aleve to Work?

Aleve is the medication that primarily treats pain and inflammation-related issues. It activates and takes about 45 minutes to start working. It takes two to three hours to begin its full effect efficiently.

Dosage for back and muscle pain

Aleve comes in oral as well as capsule form. Aleve is available as a pill or a gel. OTC Aleve includes 220 mg naproxen and 20 mg sodium in each dosage. In accordance with the label should be taken as follows:

Side effects of Aleve

The side effects of taking Aleve can be common as well as adverse, which are as follows:

Side effects of Aleve

Common side effects:

  • Constipation,
  • Diarrhea and stomach discomfort
  • Gas
  • Heartburn
  • Vomiting or nausea

Adverse side effects:

  • Severe stomach pains
  • Stools that are black and tarry.
  • Asthma
  • Rash on the skin 
  • Heart attack
  • Stroke


Aleve can cure back and muscle pain but temporarily. However, consult the doctor before consuming this medication in any case. Make sure to consult with the physician regarding your medical history, as this medication can lead to interactions. Do not consume this drug if suffering from any heart, kidney, or liver disease as it can be lethal; thus, use it with proper guidance. 

Toradol vs Naproxen

Toradol vs Naproxen

Toradol and Naproxen are medications used to treat pain and inflammation. Toradol and Naproxen belong to the Nonsteroidal anti-inflammatory (NSAID) drug group.

What is Toradol?

Toradol is a medication used for the treatment of pain and inflammation. Ketorolac is the generic name of Toradol. It is used for a short period to treat moderately severe pains. It works by reducing the pain and inflammation-causing hormones in the body.

What is Naproxen?

Naproxen is used for pain management during the treatment of many diseases such as Gout, Tendonitis, and Arthritis. It can be used to reduce the pain caused by menstrual cramps. It works by blocking the enzyme, which produces chemicals causing pain and inflammation.

conversation of two people on toradol and naproxen

Difference Between Toradol and Naproxen

Toradol is mainly used for short-term pains and to control pain caused after surgery. Naproxen is used to deal with acute pain caused due to menstrual cramps and arthritis, inflammation, and fever.

Toradol is no longer available over-the-counter medication, while Naproxen is available as both generic and over-the-counter medication.

Toradol can be used by pregnant women only if needed, and it is not advisable to use Naproxen during pregnancy.

Toradol can be taken by adults and children. On the other hand, Naproxen is not prescribed to individuals below the age of 18.

Toradol cannot be used for the treatment of arthritis for a longer duration, unlike Naproxen.

Similarities between Toradol and Naproxen

Toradol and Naproxen are NSAID drugs used to treat pain and inflammation.

Common side effects of Toradol and Naproxen are headaches, dizziness, rash, nausea, abdominal pain, and heartburn.          

Study: Toradol vs Naproxen

The study was conducted by Pérola Grinberg Plapler et al. in 2016.

Aim: To study and compare the efficacy of Toradol and Naproxen in the treatment of acute lower back pain.

Procedure: The study was conducted on people suffering from lower back pain for a duration of 10 days.

Two groups were prepared and were assigned daily dosages of Toradol and Naproxen.

The dosage of Toradol was 10 mg three times a day, while the dosage of Naproxen was 250 mg three times per day.

The study’s primary aim was to study the efficacy by observing the reduction in lower back pain.


Toradol & Naproxen

Results: The number of people administered with Toradol experiencing pain relief after the first dose was more than the number of people administered with Naproxen. 24.2 % of participants from the Toradol group and 6.5% participants from the Naproxen group got pain relief after 60 minutes of dosage.

Conclusion: Toradol provides fast pain relief for lower back pain than Naproxen.      



The duration of therapy should not be more than 5 days.

Injectable dosage: 30mg single dosage intravenous or 60 mg single dosage intramuscular. The maximum dose should not exceed 120mg.

Oral Dosage: 20 mg once after intramuscular or intravenous therapy. The maximum dose should not be more than 40mg per day.    


Immediate-release oral tablet: The normal dosage is 500-1000 mg daily in 2 dosages. The maximum daily dosage is 1500 mg.

Delayed-release oral tablet: The normal dosage is 375-500 mg, given two times a day. The maximum dosage per day is 1500 mg.

Side effects


Toradol Side Effects

Common side effects after medication of Toradol are as follows:

  • Nausea
  • Dizziness
  • Swelling
  • Headache
  • Indigestion

There are some severe side effects of Toradol which may require emergency medical help or termination of medication, such as:

  • Chest pain
  • Short of breath
  • Stomach bleeding
  • Rapid change in weight
  • Anemia
Can You Take Ibuprofen And Naproxen Together?

Can You Take Ibuprofen And Naproxen Together?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces certain chemicals that cause pain and inflammation in the body. It reduces fever and treats pain or inflammation caused by headache, back pain, toothache, arthritis, or minor injury. It is safe for use in adults or children six months or older.

Naproxen is also a nonsteroidal anti-inflammatory drug. Like Ibuprofen, it works by blocking the chemicals that cause pain and inflammation in the body. It is used to treat inflammation or pain caused by arthritis, tendinitis, bursitis, gout, or menstrual cramps. It is safe for use in children 12 years and older.

Ibuprofen is a short-acting drug, while naproxen is a long-acting drug. Naproxen is more likely to cause an upset stomach. Both these drugs are NSAIDs and are similar in many ways, but there are some differences. It is generally not advised to take Ibuprofen with Naproxen or with any other NSAIDs.

Conversation on ibuprofen and naproxen

What Happens When You Take Ibuprofen And Naproxen Together?

Combining these two medications may increase the risk of side effects. It can affect the gastrointestinal tract and cause bleeding, inflammation, ulcer, and in some rare cases, can also cause perforation. Gastrointestinal perforation can be fatal, which causes holes in your stomach and intestine. We suggest you take these drugs with food to reduce any risks.

You can always talk to your doctor if you have any questions or concerns. Your doctor may prescribe other medications that may not interact with these medications. 


Can You Take Ibuprofen And Naproxen Together

Seek immediate medical attention if you experience any symptoms of bleeding such as:

  •  Dizziness
  •  Lightheadedness
  •  Red or Black Stools
  •  Coughing or Vomiting blood 
  •  Headache and Weakness

Do not stop using any medications without consulting your doctor first.

Avoid taking Aspirin, Ibuprofen, or Naproxen within 8 to 12 hours of each other. These NSAIDs may be taken in combination with acetaminophen for additional pain relief. If you have pre-existing medical conditions, tell your doctor.(Polat, O., Karaman, A.I. and Durmus, E., 2005)

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A study published by the department of pharmacology at the University of Bordeaux, France, studied NSAID drugs, their safe and effective use, and adverse side effects due to drug-drug reactions. The study reported adverse drug reactions (ADRs), including gastrointestinal bleeding and cardiovascular and renal effects due to NSAID use. In many cases, ADRs may occur due to drug-drug interaction between the NSAID and other medications. When assessing potential risks of ADRs, it is crucial to consider the dose and duration of NSAID use and the type or class of comedication administered (Pacheco, D.P., Manrique, Y.J. and Martinez, F., 2007).

Health care professionals can be crucial in educating patients to use the lowest effective dose for the shortest required duration for good balance and safety. Refer to the link to read the entire study.

Does Naproxen Make You Sleepy?

Does Naproxen Make You Sleepy?

Naproxen is a nonsteroidal anti inflammatory drug(NSAID) Naproxen is used to treat

Naproxen is a nonsteroidal anti-inflammatory drug(NSAID). Naproxen is used to treat:

  • headaches
  • dental aches
  • muscle aches
  • muscle cramps

It also reduces pain, swelling, and stiffness in joints for those who have arthritis. It can also help treat insomnia in some cases.

A study conducted at the Bowling Green State University (Ohio) demonstrated that some nonsteroidal anti-inflammatory drugs (NSAIDs) have adverse effects on sleep. Thirty-seven male and female subjects slept in a sleep laboratory for two nights, recorded on a polygraph. The study stated that the mechanisms of sleep disruption after taking NSAIDs might relate to direct or indirect consequences of prostaglandin synthesis resulting in changes in body temperature and suppression of nighttime melatonin levels.

Melatonin is a sleep hormone and is an essential part of the body’s sleep-wake cycle. The prostaglandin synthesis, which causes melatonin suppression, can make you feel tired or sleepy. However, the study did not specifically test Naproxen; the two drugs used were aspirin and ibuprofen(Brown, G.M., 1994).

Another study in the International Journal of Clinical Practice Published by John Wiley & Sons Ltd evaluated sleep aid and analgesic combination of Naproxen sodium and diphenhydramine in dental pain with patients with transient insomnia. The study aimed to demonstrate the added benefit and optimal dosages of the mixture of Naproxen and Diphenhydramine over individual ingredients alone in improving sleep and pain. 

There were two studies conducted, and the subjects were randomized, double-blind, and double-dummy trialed. The subjects in both studies were given a combination of Naproxen and Diphenhydramine in different dosages. The primary end-points in both studies were wake time after sleep onset and sleep latency which was measured by actigraphy. Other sleep and pain end-points were also assessed. There were no serious or unexpected events reported in the study besides 1 type of dosage (NS 440 mg/ DPH 50 mg)improving sleep quality (Simpson, K. and Jarvis, B., 2000).

It is generally advised to take medicine at nighttime before going to bed. 

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conversation of two people on naproxen making them sleep

Things You Shouldn’t Do Under The Influence Of Naproxen


Avoid drinking alcohol. It may increase the risk of stomach bleeding. Consult your doctor if you get the symptoms of stomach or intestine bleeding. Some of the signs to look for are black or bloody stools, coughing up blood, or vomiting.

Use of Heavy Machinery/ Drive:

You shouldn’t operate heavy machinery or drive when under the influence of Naproxen as it causes fatigue and drowsiness. Also, try to avoid other activities that require alertness and attention, especially outdoors. 

In short, there is no concrete evidence of Naproxen showing adverse effects on sleep-cycle, but some other NSAIDs are found to affect sleep negatively up to some degree. Naproxen may cause drowsiness and fatigue, and hence you shouldn’t operate on heavy machines or drive.(Thomas, R.G. and Thal, L.J., 2003)

Can You Take Naproxen and Tylenol?

Can You Take Naproxen and Tylenol?

Naproxen is a non-steroidal anti-inflammatory drug (NSAID). Naproxen is used for the treatment of painful conditions such as arthritis, sprains and strains, backache, menstrual pain, and gout pain.

Tylenol is an over-the-counter medicine used to treat reduce symptoms of pain and fever. Tylenol belongs to a class of drugs called Analgesics. Tylenol could be taken by adults and children above the age of 12.   

Can Naproxen And Tylenol Be Taken Together?

Naproxen and Tylenol could be taken together and found to be safe. However, it is advisable to take both medicines at different times for more effective results. Staggering the medication can help to extend relief from pain. In case the pain is severe Tylenol alone may not be effective. Doses of Naproxen could be added. A combination of both the medicine may work better than either drug alone.(Akhter, T., BAQAI, R. and Aziz, M., 2010)
conversation of two people on naproxen and tylenol

Difference Between Naproxen And Tylenol

                                                  Naproxen                                                    Tylenol

Naproxen works well for treating mild to moderate pain or inflammation.

Tylenol effectively reduces fever and relieves pain, but it doesn’t lower inflammation and swelling.

Naproxen is good for relieving pain from common conditions like menstrual cramps, toothaches, and arthritis.

Works well to relieve pain and fevers. Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.

Naproxen causes fewer stomach problems and is generally safe to use. Naproxen is not safe for pregnant women and people who are above the age of 60. Could cause kidney problems and stomach bleeding if taken for a longer period.

Tylenol causes less upset stomach, ulcers, bruising, and bleeding than other pain medications. It doesn’t cause kidney damage and is also safe to use for people suffering from heart problems or in case of pregnancy.

Naproxen can raise the risk of getting blood clots, heart attack, or stroke.

Drinking alcohol while taking Tylenol can damage the liver

Comparison of Side Effects of Naproxen And Tylenol

The utility of Tylenol and Naproxen are largely defined by their side effects. The side effects of Tylenol are minor and may include stomach upset, nausea, loss of appetite, and headache. On occasion, itchiness and rash can also develop. By contrast, Naproxen can cause heartburn, stomach pain, and peptic ulcers. Long-term or excessive use can affect blood pressure and clotting and increase the risk of bleeding, hypertension, peripheral edema (leg swelling), heart attack, and stroke. Tylenol is neither associated with cardiovascular nor peptic ulcer risk. It can, however, cause serious liver damage if used in excess (more than 4,000 milligrams per day) or taken with alcohol. While Naproxen can also hurt the liver if used in excess, the risk is far smaller. The same applies to the kidneys but usually only when there is an underlying kidney disorder.(Leuschen, M.P., Filipi, M. and Healey, K., 2004)
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Whom Should Avoid Naproxen

Some medicines under certain conditions are not suitable for people and may only be used after taking advice from a doctor or pharmacist. Those conditions may be;
  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
  • If you have a heart condition or a problem with your blood vessels or circulation.
  • If you have high blood pressure.
  • If you have ever had blood clotting problems.
  • If you have high blood sugar or cholesterol levels.
  • If you are a smoker.
  • If you have a connective tissue disorder, such as systemic lupus erythematosus (an inflammatory condition also called lupus or SLE).
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to any other NSAID.(Risser, A., Donovan, D., Heintzman, J., and Page, T., 2009)



The recommended dosage of Naproxen, for adults, is one pill every 8–12 hours. However, this depends on the strength of the medication. While, Tylenol generally comes in 325 mg, 500 mg, or 650 mg pills.

  • 1 or 2 325 mg pills every 4–6 hours, taking no more than 8–10 pills per day
  • 1 or 2 500 mg pills every 4–6 hours, taking no more than 6 pills per day
  • 1 or 2 650 mg extended-release pills every 8 hours, taking no more than 4–6 pills per day