Methocarbamol for Menstrual Cramps

Methocarbamol for Menstrual Cramps

Methocarbamol is used for the treatment of muscle pain and injuries. It is used to deal with pain for a short period of time. Robaxin is the brand name of Methocarbamol. It helps deal with various types of pain, such as back pain and tooth pain.

Can Methocarbamol be used for Menstrual Cramps?

Methocarbamol is used against various pain. It is observed that Methocarbamol can be used as an off-label treatment for menstrual cramps as it is not mainly used for it.

Magnesium plays an important role in dealing with menstrual cramps. Medications used for menstrual cramps have magnesium as their ingredient, and it is observed effective. Similarly, Methocarbamol also has magnesium as one of its ingredients and can be used to relieve menstrual cramps or period pain.

After getting medical advice, one can take Methocarbamol for menstrual pain only because it is an off-label treatment and not prescribed primarily for menstrual cramps (Guerrera, M.P., Volpe, S.L. and Mao, J.J., 2009).

Conversation of two people on methocarbamol for menstrual cramps

How it Works?

Methocarbamol works by affecting nerve impulses. These nerve impulses travel to the brain to inform about the pain. But because of Methocarbamol, these nerve signals get blocked from reaching the brain.

This results in the relaxing of muscles and slows down the central nervous system’s activity, and relieves pain (Sibrack, J. and Hammer, R., 2020).

Forms and strengths

Methocarbamol is available as tablets and oral solutions to be taken orally. It is also in injectable solutions that can be taken intramuscularly or intravenously.

Methocarbamol tablets are available in 500 mg and 700 mg strengths, while injectable solution strength is 100 mg/ml.

How to take it?

Methocarbamol can be consumed before or after eating food. The tablet form should be taken as a whole without crushing or breaking it. The injection should be appropriately taken intravenously or intramuscularly.

The medicine should be taken only as directed by the doctor. The dosage can be increased or decreased depending on the treatment response (Sibrack, J. and Hammer, R., 2020).


Tablet dosage for adults:

1500 mg is the initial dose which has to be taken 4 times a day. This dosage has to be followed for 3 to 4 days.

1000 mg per day is the maintenance dose, taken 4 times daily.

Injection dosage for adults:

The initial dose is 1 g taken intravenously or intramuscularly every 8 hours.

The maximum injection limit should not be more than 3 g per day.

Injections should not be used for more than 3 days.

Who should not take it?

One should not take Methocarbamol if:

  • Below the age of 16
  • Liver and kidney disorders
  • Allergic to Methocarbamol
  • Seizures
  • Suffering from Myasthenia Gravis
  • Breastfeeding women

Taking Methocarbamol can lead to adverse effects if you face any of these problems. Get medical help before taking it.

Side Effects

Following are some severe side effects which are associated with Methocarbamol:

  • Blood clots
  • Skin rashes
  • Seizures
  • Change in the heartbeat pattern
  • Breathing problems
  • Swelling

It is advised to take emergency medical help on observing such side effects to prevent further risks.


Please inform your doctor if you are taking the following medicines:

  • Pain relief medicines
  • Sleeping pills
  • Medications for depression-like Valium and Zoloft.
  • OTC medicines
  • Herbal medicines

These medicines may interact with Methocarbamol and cause trouble with side effects.


Methocarbamol is an effective muscle relaxer and is widely used for muscle pain and spasms. It can be used for menstrual cramps as an off-label treatment. Please consult your doctor before taking Methocarbamol for menstrual cramps to know whether it is safe or not for you to take.

Can you take Methocarbamol and Tylenol Together?

Can you take Methocarbamol and Tylenol Together?

A combination of Methocarbamol and Tylenol can be taken as per the doctor’s advice. It doesn’t have many side effects, but to be in a safe zone, a person should consult a doctor before having it. This might have side effects such as a feeling of headache, feeling of having a deep sleep, fainting, and maybe lightheadedness.

Methocarbamol is a drug used for making the muscles relax. It is used in treating pains more effectively on body muscles. It treats various issues in the body like injuries, spasms, and different muscle-related problems. Methocarbamol is a generic name, whereas the brand name is Robaxin; muscle relaxers are a drug class.

 Tylenol is used in treating various aches in the body, which causes pains. It helps in lessening the pains and fevers. Tylenol has a generic name as Acetaminophen, whereas Tylenol is a brand name. It is mainly known in the USA. It is an over-the-counter drug, which can be readily available.

Why Methocarbamol is used for?

Methocarbamol is a relaxer for muscle pains and spasms. It is used in the treatment for getting the muscles cured. Spasms and muscle pains happen for overusing weights or any aches which are caused due to various reasons.

Why Tylenol is used for?

Tylenol is a medicine used for mild pains; it even cures fevers and colds in the body. It helps cure different aches and works for headaches, period cramps, and even arthritis.

A Study on Methocarbamol and Acetaminophen Together

Study: J Clin conducted this study from the Korean Society for Clinical Laboratory Science.

Aim: To observe the relaxation of pains after taking Methocarbamol + Ibuprofen compared to Methocarbamol + Acetaminophen.

Method: There were patients involved in the study who were facing different issues. This study was made for 7 days. Pains varied from mild to high. People were divided into 3 groups; the first group was given the combination of Acetaminophen and Ibuprofen consisting of 325mg tablets and 200mg tablets. The second group was given Acetaminophen, methocarbamol, and Ibuprofen which consisted of 325mg+500mg+200mg tablets. The third group was given methocarbamol and Acetaminophen consisting of 325mg+500mg, including body stretches 3 times a day.

Results: After all the completion of observing patients, the conclusion was like; Body pains were similar to every other combination included in the study. In other senses, Consuming Methocarbamol and Tylenol (Acetaminophen) showed the same results in curing pains by stretching the body parts and managing the pains.

How does Methocarbamol work?

As Methocarbamol is a muscle relaxer, it works by the feeling of pain, which can cause many aches to the body and muscles by stopping it and obstructing it to send signals to the brain. It helps in curing the pains caused by various reasons.

How does Tylenol work?

As Tylenol is a pain reliever, it helps cure the pains throughout the body. It works by stopping the body from creating various pains. It works in lowering the body temperature; it is an analgesic and even antipyretic. 

What is Methocarbamol treated for?

Methocarbamol is treated for various muscle spasms in the body to which the person might have pains. It is mainly used in physical therapy and other related treatments.

What is Tylenol treated for?

Tylenol is a drug used in treating different body pains ranging from mild to moderate. It helps cure issues such as headaches, toothaches, fever, and cold.

Forms and strengths






Tablet form

500mg, 700mg


Injection form

100mg, per ml


Tablet form

325mg, 500mg, 625mg


Liquid form


How should you take Methocarbamol?

For taking methocarbamol, a person should take all the required guidelines from a doctor or read the package. It is said that a person can take medicine with food or without food intake.

How should you take Tylenol?

Before taking medicine, you should keep in mind the procedure and how to have it by the doctor’s consultation. It is said that a person can take the medication with or without food intake, but the person should have enough water intake. 

Ways to take Methocarbamol

There is one type of medicine, whereas the other form is an injection

  • Tablet form can be taken by swallowing with a water
  • The doctor can only give the injection form of treatment.

Ways to take Tylenol

There are two forms of taking a medicine

  • Tablet form which has to be swallowed with water
  • The liquid form has to be placed at the point of pain.


Methocarbamol (Tablet)

Adult (18-64 years)

Pediatric (16-17 years)

Senior Citizen (65 years and more)


Dosing at the start-

It has to be taken 1500mg per dose (6000mg per day)

Starting dosage-

It can be taken (6000mg dose) 1500mg per dose

As per the age

Senior citizens have a weaker body, It leads to kidney issues

Continuation of dose- A person can take 4000mg -4500 mg per day (Dividing as per the doctor’s recommendation)

Continuation of Dose-

The person is recommended to have 4000-4500mg per day

Kidney doesnt work fast Due to the age, which will make the medicine in stomach stay for a longer time

In severe cases- 8000mg can be used.

It might vary from patient to patient.

Doctor would recommend it as per the patient’s condition.

Doctor might recommend only if needed, that too at a very low dose.

Methocarbamol (Tetanus)



Dosing at start-

1 to 2g followed by 1 to 2g

(should not exceed 3g)

Dosing at Start-

At every interval of 4-6 hours, 15mg can be given

It can also be given by diluting into water and inserting into the body

Maximum dose can be continuously taken at 1.8 g/m2/day IV for 3 days.

24mg should be the maximum dose according to the body reaction

If needed further, a doctor’s recommendation is mandatory.





In every 4-6 hours, 2 medicines can be consumed of 500mg

In every 4-6 hours 325mg to 650mg can be consumed

Max Dosage should not increase 4000mg per day

Max dosage should not  increase 3250mg per day

Only 10 days advisable

(Consult a doctor)

Dosage may vary from their age and weight

Side effects (Methocarbamol)

Usual side effects which can be seen after consuming Methocarbamol

  • The person might feel having a mild headache
  • The person might feel sleepy or out of energy
  • The person might feel their head getting a little heavy
  • The person might feel sober

Serious side effects which can be seen after consuming Methocarbamol

  • The person might feel breathlessness, and even chest might pain
  • The person might feel specific areas getting swollen up
  • The person might feel having a heart attack or low blood pressure
  • The person might get the place swollen where the injection was inserted.
  • The person might feel things in yellow, maybe eyes and body
  • The person might think that his memory is getting lost or forgetting things
  • The person might have visionary issues, such as blurring

If the person faces any issues within them, the first duty is to consult a doctor for immediate guidance. Mild matters can be ignored but not up to the mark till you get those things to worsen for yourself. Get a medical emergency. It is always good to consult a doctor for a better purpose and health.

Side effects (Tylenol)

Usual side effects which can be seen after consuming Tylenol

  • The person might face allergic issues
  • The person might see rashes on their body
  • The person might feel itchiness in the body
  • The person might think that their mouth and throat are getting swollen up
  • The person might feel sleepy all day and tired
  • The person might face urinating dark in color
  • The person might get pains which have never been caused before
  • The person might think that the body and eyes are getting yellow

Severe effects which can be seen after consuming Tylenol

  • The person might feel unstable in their stomach
  • The person might start getting a feeling of kidney issues
  • The person might feel reduced in blood count because of insufficient oxygen flow into the body.

Severe effects should be first consulted to the doctor, to which it can get into control. Normal effects also be known to the doctor to prevent more issues on the person’s body.

What if I Overdose on Methocarbamol?

Overdose can result in panic and getting drowsy. If it happens to you, you should first consult a doctor for a proper dose.

What if I overdose on Tylenol?

Overdose can result in a person’s life and death. As it’s a pain reliever, it has many issues if you overdose on it. It’s good to consult a doctor immediately.


According to the study, there are no interactions with the medicines if combined. This tends to be safe, but the person might visit a doctor before consuming a medicine. Every drug can be good, but only after a doctor’s prescription.

Methocarbamol For Anxiety

Methocarbamol For Anxiety

Methocarbamol, a muscle relaxant, is used along with physiotherapy to treat conditions of skeletal muscles such as pain and injury. It is a type of central nervous system (CNS) depressant approved by the FDA in July 1957. Methocarbamol works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. Methocarbamol can be used for anxiety. In addition, the medication can affect the symptoms of depression (Jung, H. and Chae, H.K., 2019).

Study of Methocarbamol in the Treatment of Depression

In a study conducted to observe the effect of Meprobamate and Methocarbamol over anxiety and depression, it was noted that Methocarbamol was more suited for the treatment of depression than Meprobamate. A likely cause for depression could be stiff and tense muscles, especially the skeletal muscles. As Methocarbamol is a muscle relaxant, it also eases the CNS into a slightly light-headed mood, in turn helping an individual relax. Therefore, by easing the skeletal muscles, it is noted to be effective in diminishing the symptoms of depression (Numazawa, T. (2016) Treating Depression with the Mephenesin Analog Skeletal Muscle Relaxant Methocarbamol).

Mechanism Of Methocarbamol

Although the exact mechanism of Methocarbamol is unknown, it is observed to be dependent upon the CNS depressant activity. This could be mediated by inhibiting or blocking spinal polysynaptic reflexes, inhibiting nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the muscle cells’ refractory period.

It is observed that Methocarbamol does not affect the contraction of nerve and muscle fibers and motor endplates (Jung, H. and Chae, H.K., 2019).

Half life and how long does it take to work?

For an average human, the half-life of Methocarbamol is 1.14 hours. For patients with renal insufficiency, the half-life extends to 1.24 hours, and for older adults, 1.6-2.15 hours.

The effects of Methocarbamol are seen within 30 minutes of consumption, and its peak concentration is reached within 2 hours (Jung, H. and Chae, H.K., 2019).

How To Consume Methocarbamol?

The consumption of Methocarbamol is totally dependent upon your age, condition, medical history, and your response to the initial dosage.

Methocarbamol is generally available in the form of tablets to be taken by mouth. The usual dosage is four times a day initially, and then it may change to three to six times a day. In case of any doubts, you could consult your doctor (Jung, H. and Chae, H.K., 2019).

Side Effects Of Methocarbamol

Common side effects of the consumption of Methocarbamol include:

  • Dizziness
  • Headache
  • Drowsiness
  • Fever
  • Confusion
  • Interruption in memory
  • Vomiting 
  • Nausea
  • Bad stomach
  • Pixelated vision
  • Blurred vision
  • Insomnia
  • Flushing feeling
  • Lack of coordination

Seek urgent medical attention in case you observe any of the given side effects to Methocarbamol:

  • The feeling of passing out
  • Decreasing heartbeats
  • Seizures
  • Jaundice
  • Pain, swelling, bruising, stiffening, or skin reactions in the area where the medicine was injected

Who Should Not Take Methocarbamol?

Do not use Methocarbamol if you are allergic to it.

Consult your doctor if you are facing or have undergone any of the following conditions:

  • Seizures
  • Kidney failure
  • Kidney disease
  • Myasthenia gravis


Consumption of Methocarbamol can cause severe skin allergies. In case you notice any of the following symptoms or conditions, report to your doctor at once:

  • Rash 
  • Hives
  • Swelling up of either tongue, throat or both
  • Trouble breathing

Note: Do not consume Methocarbamol again if you have ever had any of such allergies before. In case you are pregnant or are planning to, consult your doctor before the consumption of Methocarbamol.

If you are a breastfeeding mother, there are chances that the drug might pass on through milk into the infant, leading to adverse side effects. Consult your doctor before the consumption (Jung, H. and Chae, H.K., 2019).

What To Do If You Missed A Dose?

Methocarbamol is used only when needed unless prescribed otherwise. Skip the missed dose if you are close to the next dosage. Do NOT consume a double dose to even it out (Jung, H. and Chae, H.K., 2019).

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing symptoms may include nausea, blurry vision, drowsiness, seizures, and /or coma (Jung, H. and Chae, H.K., 2019).


Methocarbamol is a type of muscle relaxant that works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. It helps with anxiety and depression by soothing out the root cause of the symptoms, i.e., the tension in the skeletal muscles.

Is Methocarbamol a Blood Thinner?

Is Methocarbamol a Blood Thinner?

Methocarbamol is a drug that used for making the muscle normal. It is used as a muscle reliever. It helps in making the pain less effective on the body muscles. It treats the symptoms such as muscle spasms, injury, or tetanus, with a generic name, whereas the familiar brand is Robaxin. It has a drug class of muscle relaxers.

Relieving blood clots is done by blood thinners. Blood thinners are medicines that substantially impact blood clots to make them accessible. It also acts as a solution for the clots to get bigger (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Is Methocarbamol a Blood Thinner?

No, Methocarbamol is used to relieve pain in the muscles. It is used in different physical therapy, which works as a muscle reliever. Methocarbamol can be used alone without other medicines if the person wants to get rid of muscle pain. Another drug (aspirin) or (methocarbamol plus) works as a blood thinner (Jildeh, T.R., Khalil, L.S., Abbas, M.J., Moutzouros, V. and Okoroha, K.R., 2021).

Why is Methocarbamol used?

Methocarbamol is a drug used as a muscle reliever and used for muscle spasms. A muscle spasm occurs when the muscle is overused or any stress built up. Muscle pain is even caused due to over-exercising as well, and the problems related to muscle pain and stiffness (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Ways to take Methocarbamol?

For the very first, you should read the ways of having medicine on the package or even get a recommendation from a doctor.

There are two forms of drugs in this

  • Tablet form which has to be eaten orally
  • The injection form has to be taken under medical practitioner guidance.



1- Tablet form

500mg, 700mg

2- Injection form

100mg (per ml)

Side effects for Methocarbamol

Types of side effects:

  • Normal effects which can be seen after consuming
  • The person might feel a headache
  • The person might feel fainting out or sleepy
  • A slight feeling of the head being heavy
  • Feeling sober

Serious effects

  • If the person has any allergic reactions such as rashes over the body, itching, face getting swollen up, breathlessness, Chest might have mild pain.
  • Suppose the person is facing symptoms of Angioedema. This includes swelling at specific places on the face or other parts of the body, swelling on the throat, and pain in the abdomen.
  • If the person is facing a slow heartbeat, lower blood pressure.
  • If the person faces a swelling on the muscle or where the injection has been injected.
  • Jaundice, which means the eyes and skin getting yellowish.
  • If the person is fainting or feels lazy, it can lead to low white blood count, which will not fight against the medicine injected.
  • If the person feels like memory loss.
  • If the person is facing vision issues, the person starts to get his vision blurred or doubled vision.
  • Eyes might become watery, and the eyes would get itchy.
  • If the person is facing any brain-related issues such as seizures.

If the person faces any severe issues, they should quickly contact their doctor before making the situation worse. You should always consult the doctor, which can be easy to not get into some serious trouble (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

What if you Overdose?

If you have overdosed or have a feeling of passing out, or any other severe happenings with your body, then you should consult a doctor as soon as possible (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

What if you missed a Dose?

You should not panic or have any other thoughts in your mind; it’s okay if you miss a dose. You should remember that you should not double up the amount if one is forgotten (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Pros of having a Methocarbamol

  • You can have an intense relief
  • You can feel that your muscle pains getting low
  • Muscle spasm can state in relief mode.

Cons of having methocarbamol

  • The person might feel to sleep every time
  • The person might get a fever
  • Heartbeats could be a little low
  • The vision could be effected
  • Not valid for the people who have allergies, which can be taken only after a doctors prescription 


Methocarbamol is not used as a blood thinner. Other variants of medicines add to the methocarbamol, which can be used in a blood thinner process.

Is Methocarbamol Good For Headaches?

Is Methocarbamol Good For Headaches?

Methocarbamol may help with neck pain present in 70% of migraine patients. It can be used as an abortive treatment of migraine, is not available over the counter, and can be prescribed by doctors or pharmacists. Depending on the frequency, severity, and severity of your impairment and other medical concerns, your doctor will help you select the most effective migraine abortion technique.

For best results, take an abortion drug as soon as you notice any signs or symptoms of migraine. Some medications work at the beginning of a headache, while many oral medications are not well absorbed when the stomach is slowed or paralyzed for effect. I have a gastrointestinal migraine.

Brand Name of methocarbamol is Robaxin, Carbacot, Skelex

How Methocarbamol To Be Taken

Methocarbamol could be taken orally with or without food as directed by the doctor. Do not raise the dose or take this medication more frequently or longer than recommended. Your illness will not facilitate any faster, and you will be at a higher risk of experiencing negative side effects. The dosage is prescribed based on medical condition and response to treatment. The doctor should be informed if the condition doesn’t improve or worsen. (Minai-Tehrani, D., Masoudnia, A., Alavi, S., Osmani, R., Lotfi, L., Asghari, M., Pirsalehi, M. and Sobhani-Damavandifar, Z., 2012)

Mechanism Of Action

In theory, a musculus spasm is caused by a protective reflex that prevents movement that would otherwise result in harm. The cramp may become excruciating and incapacitating in some circumstances. This occurrence, known as the “pain-spasm-pain cycle,” has yet to be proven in clinical or electrophysiologic studies. 

Methocarbamol’s creation and development, like that of other muscle relaxants, was aided by animal experiments that showed lowered tone without a reduction in motor activity. The respite supplied by SMRs is assumed to be the outcome of global central system depression—anticholinergic suppression of the midbrain’s reticular activation system, resulting in diminished polysynaptic reflexes and tension. Indirect suppression of interneuronal transmission is a term used to describe this phenomenon.


Precautions to be Taken While Taking Methocarbamol

Before using methocarbamol, speak to your doctor or pharmacist if you have any allergies alternatively if you have any other allergies. Indolent chemicals in this product may cause allergic reactions and other complications. For further information, please get in touch with your pharmacist.

Before taking this medicine, tell your doctor or pharmacist about your medical history, especially if you have liver disease.

Dizziness, sleepiness, and blurred vision are all possible side effects of this medication. You may become dizzy or sleepy if you consume alcohol or marijuana. Do not drive, use machinery, or perform any other activity that requires alertness or clear vision until you can do so safely. Alcoholic beverages should be avoided.

Tell your doctor about all the products you consume before surgery, including prescription drugs, nonprescription drugs, and herbal products. The drug’s adverse effects, particularly disorientation, dizziness, and lightheadedness, may be particularly harmful to the elderly. Falls are more likely as a result of these side effects.

This medication should only be taken during pregnancy if it is absolutely essential. Consult your doctor about the risk and advantages.

This medicine is not known to be excreted in breast milk. Before you start nursing, consult your doctor. (Looke, T.D., and Kluth, C.T., 2013)

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Interaction with Other Drugs

Keep a list of all the products you use (prescription, over-the-counter, and herbal) and provide it to your doctor and pharmacist. Do not begin, stop, or change your medication without consulting your doctor. 

Suppose you take any other drowsy drugs, such as opioid pain relievers and cough suppressants, alcohol, marijuana, sleeping pills, or anxiolytics. In that case, you should not take this medication Other muscle relaxants or antihistamines. All drugs should be checked for chemicals that can cause drowsiness on the label. Consult your pharmacist for advice on how to use these products safely.

This medication can cause false test results in some laboratory tests, such as the VMA or 5HIAA urine screening tests. Ensure that your laboratory personnel and your doctors are aware that you are taking this medication.


If you are allergic to methocarbamol, do not use this medication. Before taking methocarbamol, tell your doctor if you have myasthenia gravis.

After the first two or three days of treatment, the dose may need to be reduced. Follow your doctor’s recommendations for how many tablets you should take each day.

Methocarbamol has the ability to influence your thoughts and reactions. Be cautious when driving a car or doing anything else that requires your full attention. Specific side effects of this drug can be exacerbated by drinking alcohol.

Side Effects of Methocarbamol

Is Methocarbamol Good For Headaches

Some of the serious side effects of Methocarbamol and would require immediate doctor consultation are;

  • A dizzy feeling, like you, might pass out
  • Slow heartbeats
  • A seizure
  • Jaundice 
  • Pain, bruising, swelling, or skin changes where the injection was given.

Common methocarbamol side effects may include:

  • Headache, dizziness, drowsiness
  • Fever
  • Confusion, problems with memory
  • Nausea, vomiting, upset stomach
  • Blurred vision, double vision
  • Insomnia

Overdose or Missed Dose

Nausea, excessive sleepiness, fainting, convulsions, or coma are signs of an overdose. Call your doctor in case you experience such symptoms of overdose.

If you forget to take a dose, do so as soon as you remember. Please do not take the dose that you missed. Take the following doses as directed at regular intervals. To catch up, do not extend the dose.

Key Take Away

Painkillers are frequently the first drug a doctor gives for migraine headaches and migraines. While many of these medications can be procured over-the-counter or without a prescription, some require a prescription. Avoid caffeine-rich items and other over-the-counter headache relievers when using these headache medications. 

Does Methocarbamol Make You Sleepy?

Does Methocarbamol Make You Sleepy?

Methocarbamol is a muscle relaxant medication sold under the brand name Robaxin. Robaxin is used along with rest and physical therapy for short-term musculoskeletal pain.

It relaxes muscles and relieves pain and discomfort caused by sprains, strains, and other muscle injuries/conditions. It works by slowing down the activity in the nervous system to allow the body to relax (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Does Methocarbamol Make You Sleepy?

Yes, methocarbamol can make you sleepy if taken in huge quantities and if taken with other sedative medication. Drowsiness/sleepiness is a common side effect of methocarbamol.

It is not advisable to take alcohol or other central nervous system depressant medication along with methocarbamol as it can enhance the side effect of drowsiness and can affect your concentration and focus.

Muscle relaxers are often suggested to be taken at night due to their high sedative effects. Driving and taking other important decisions should be avoided by patients if they are taking any muscle relaxers (Jung, H. and Chae, H.K., 2019).

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Does It Affect Sleeping Patterns?

Robaxin can influence your sleeping pattern. Almost all muscle relaxants have drowsiness as their side effects and cause sleepiness in patients. People suffering from muscle pain usually face difficulty getting sleep at night due to pain.

Methocarbamol is usually prescribed to be taken at night due to its sedative effects and can help a patient sleep well.Taking methocarbamol during the day is not advised as it can cause a person to lose their concentration and focus and also affect their sleeping patterns (Jung, H. and Chae, H.K., 2019).


How Does Methocarbamol Work?

The exact mechanism of methocarbamol is not known. However, it is presumed that Methocarbamol works by depressing the central nervous system. This leads to the relaxation of muscles.

Although the drug isn’t an opioid drug, it does produce effects of drowsiness and dizziness, which users mistake for a high. Methocarbamol causes sleep problems such as insomnia during the initial stages of treatment as your body adjusts to this medication.

For light sleepers, they find it hard to sleep with muscle pain. Methocarbamol is prescribed for such patients as it can induce sleep. For deep sleepers, methocarbamol can enhance the drowsiness effect; hence it is usually prescribed to take during the night or when they aren’t going to engage in activities that require focus and concentration (Jung, H. and Chae, H.K., 2019).

Withdrawing From Methocarbamol

Stopping any medication abruptly can cause dangerous side effects. Speak with your healthcare provider before discontinuing methocarbamol. Methocarbamol has little to no evidence of withdrawal symptoms; however gradual decrease in the medication is advised for discontinuing the drug to prevent severe side effects.

As mentioned, Robaxin does not cause any withdrawal symptoms; however, methocarbamol abusers and addicts who take the medication in large quantities for recreational purposes can find it hard to discontinue the medication. Professionals have facilitated a methocarbamol detox program to provide a safe and effective transition to sobriety (Jung, H. and Chae, H.K., 2019).

Methocarbamol Levels of Usage and Effects

Methocarbamol is usually prescribed for a short time, along with rest and physical therapy to treat musculoskeletal conditions.

For beginners or initial users, methocarbamol usage in low dosages can cause insomnia (difficulty in sleeping).
For mild to average users, methocarbamol can produce effects of drowsiness/ sleepiness and can cause impaired motor controls if mixed with alcohol or other CNS depressant/sedative medication.

Methocarbamol usually isn’t prescribed for long-term use or in heavy doses. However, methocarbamol abusers take the drug in high dosages, which causes extreme drowsiness and sleepiness, which the users misunderstand for a high. Although Methocarbamol abuse is not very common.


Methocarbamol is a muscle relaxant medication that calms the central nervous. Methocarbamol does make a user sleepy. Drowsiness is a common side effect of methocarbamol.

Methocarbamol causes insomnia in the initial stages of treatment as the body tries to adapt to the drug. Methocarbamol shouldn’t be used with alcohol or other sedative medications as it can double the drowsiness side effect. Methocarbamol is usually prescribed at night because of the drowsiness side effects.

Methocarbamol causes loss of focus and concentration. Methocarbamol is usually not abused; however, users often misunderstand the drowsiness side effect of the drug as a “high.”

Methocarbamol for Back Pain

Methocarbamol for Back Pain

Methocarbamol is a muscle relaxer drug. It is used as a medication to treat muscle pain and injury. It is sold under the brand name Robaxin, and it is an oral medication as well as injectables. It is mainly used in the short-term treatment of pain. Methocarbamol can be used for the treatment of back pain. It has been observed as an effective medicine for back pain as well as other musculoskeletal pain (Sibrack, J. and Hammer, R., 2020. Methocarbamol).


Study of effectiveness of Methocarbamol in Lower Back Pain

A study was conducted by Oliver M D Emrich et al. to observe whether Methocarbamol is effective for lower back pain or not.

The study was observed on participants suffering from lower back pain for at least 24 hours. The participants were categorized into 2 groups where 98 participants were given Methocarbamol while the other 104 were given a placebo for a span of 8 days. The treatment was stopped as soon as relief was observed for every individual.

It was observed that 44% of patients from the methocarbamol group got pain relief and thus pre-terminated the process, while it was 18 % in the placebo group.

A total of 67% of participants methocarbamol group and 35% of participants placebo group found the treatment effective as the pain was relieved and no major side effects were associated during the study.

Thus, this study shows that Methocarbamol is an effective medicine for lower back pain and can be used depending on medical conditions (Methocarbamol in acute low back pain. A randomized double-blind controlled study).

Methocarbamol for Back Pain
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How it works

Methocarbamol reduces pain by affecting the nerve impulses which travel to the brain. Methocarbamol decreases these nerve signals by blocking them and stopping them from reaching the brain. It also helps to slow down the activity of the CNS and promotes the muscles to relax, thus reducing the pain (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

How to take Methocarbamol

One can take methocarbamol with or without meals. The medicine should be taken only as prescribed by the doctor. The amount of dosage can vary from person to person depending upon an individual’s tolerance and health conditions. The methocarbamol tablets should not be crushed or broken and taken as a whole. The methocarbamol injection should be taken into the muscle or infused into veins by a proper medical practitioner. One should consult the doctor before taking or stopping the medication from preventing severe side effects (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Forms and strengths

Methocarbamol is an oral medication. It is in the form of tablets and oral solutions. Methocarbamol can also be taken via injectable solutions- intramuscular or intravenous.

  • The strength of tablets is available in 500 and 700 mg.
  • The strength of the injectable solution of methocarbamol is 100 mg/ml.


Adult dosage for muscle pain and back pain:

  • The initial daily dose is 1500 mg which can be taken 4 times a day, followed for 3-4 days.
  • The maintenance dose is 1000 mg per day, taken 4 times.

Adult dosage of injection:

  • The initial dose should be 1 g given intramuscularly or intravenously every 8 hours.
  • The maximum dose limit is 3 g per day.
  • Injections should not be administered for more than 3 days.

The doctor can change the dosage depending upon the tolerability and response to the treatment. Nausea, fainting, and sleepiness are some of the symptoms of overdosage of Methocarbamol. One should seek emergency medical help on observing such symptoms.

In case you miss the dose, take the dose immediately only if the next dose is after a long time. Taking two doses together to compensate for the missed dose will not help but increase the risk of adverse effects.

Who should not take Methocarbamol


One should not take Methocarbamol if:

  • Seizures
  • Kidney problems
  • Below the age of 16
  • Allergic to methocarbamol
  • Liver diseases
  • Neuromuscular disease like Myasthenia Gravis
  • Consuming alcohol regularly
  • Pregnant women should not take Methocarbamol as it can harm the unborn baby.

Breastfeeding women can take Methocarbamol only after the doctor’s guidance. The doctor can prescribe methocarbamol to them only if necessary.

Side effects of Methocarbamol

These are some common side effects which one might experience after taking Methocarbamol:
  • Nausea
  • Headache
  • Difficulty in sleeping
  • Vomiting
  • Fever
But along with the common side effects, the following are some severe side effects that can be observed after consuming Methocarbamol:
  • Seizures
  • Difficulty in breathing
  • Change in heartbeats
  • Swelling
  • Rashes and itching
  • Blood clots
You should take medical help if you observe any of these symptoms. The doctor can change the dosage or terminate the medication depending upon the health condition (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Pros and Cons of Methocarbamol


  • It can be used to treat Tetanus spasm also.
  • Effective medicine against muscle pain and spasms.
  • It can be used as a combination medication.


  • If taken with alcohol, it can cause dizziness and make the person feel dizzier.
  • Not for use under the age of 16 for back pain.
  • Higher doses can create complications in people above 60.
  • Some severe side effects can trouble the individual (Sibrack, J. and Hammer, R., 2020. Methocarbamol).


Methocarbamol can interact with the following drugs and medications:

  • OTC medicines
  • Herbal medicines and vitamins
  • Sleeping pills
  • Antidepressants such as Zoloft, Prozac, Imipramine, Valium
  • Other muscle pain reliever drugs

These interactions may harm health and suffer from adverse side effects. If you take any of these medications, it is essential to inform your doctor.

Is Methocarbamol addictive?

Methocarbamol is not addictive. Even though Methocarbamol works by affecting the central nervous system, it is not an addictive or narcotic drug. It can turn into an addictive substance when consumed with alcohol as it will make the person feel sleepier and loss of coordination.


Being a muscle relaxer, Methocarbamol is an effective medicine for back pain. It can be used to get relief from back pain after consulting the doctor. Before taking this medication, one should consult the doctor and take the doses as per the directions.

Can you take Diazepam and Methocarbamol together?

Can you take Diazepam and Methocarbamol together?

No, it is not advisable to take Diazepam and Methocarbomol together. Diazepam and Methocarbamol together can lead to adverse symptoms such as impairment in thinking and muscle coordination. These medications are interactive and can be lethal. It is hence, suggested to consult the doctor before taking both the medicines together.

Diazepam is a medication that was first sold as Valium used to treat conditions such as muscle spasm, anxiety, withdrawal symptoms, benzodiazepine withdrawal syndrome, insomnia. Methocarbamol is marketed as Robaxin and used to treat short-term musculoskeletal pain.

Diazepam and Methocarbomol work by blocking the naturally occurring nerve impulses in the brain, which are the pain-causing sites.  Thus, to avoid any side effects, it is recommended to take both the medications separately, however, under the medical expert’s surveillance (Crankshaw, D.P. and Raper, C., 1968).

Side effects of taking Diazepam and Methocarbomol Together?

Taking both Diazepam and Methocarbomol can lead to common side effects, namely:

Common Side Effects: 

These are the side effects that can fade away in a few days. If not, then do consult the doctor regarding the case. 

  • Nausea or vomiting 
  • Downiness or dizziness                  
  • Lack of concentration 
  • Impairment of thinking 
  • Lack of motor coordination 

These are a few common side effects.  

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Warning of taking Diazepam and Methocarbomol together?

It is not advised to take any of these medications if allergic to them.

  • Do not consume this medication together if you are undergoing the following conditions: 
  • Do not take Diazepam and Methocarbomol if diagnosed with any recent heart conditions such as heart attack.
  • Do not take any of these medications if have any liver issues.
  • It is not advisable to take this medication if you have kidney issues. 
  • Do not consume both of these drugs with alcohol as it can lead to side effects or further adverse issues. 
  • Do not take the medications if diagnosed with mental health issues such as depression, anxiety, or suicidal tendency. 

These are a few instructions to follow. It is wise to connect with the doctor before taking any medications.  

Precautions to Follow

  • Before taking Diazepam and Methocarbamol, do follow these precautions: 
  • It is not advisable to take both the medications together and indulge in any high-intensity activity as taking it can decrease motor coordination.
  • Don’t take both the medications together with alcohol as it can make the side effects even adverse. 
  • It is not advised to take this drug if you have any allergies in general or are allergic to Methocarbamol or diazepam. 
  • Do consult the doctor before taking any of the medications with Diazepam or Methocarbamol such as any antidepressants or sleeping pills to avert any further interactions or any prescription or OTC drugs. 
  • Confront the medical practitioner regarding any history of ailments or issues such as alcohol abuse, depression, suicidal thoughts, anxiety, and furthermore. 
  • It is safe to take methocarbamol or diazepam during pregnancy; however, consult the medical expert before taking any further action. 
  • Consult the medical practitioner if taking any other tablets, herbs, or vitamins can lead to interactions. 

How to Administer Methocarbamol or Diazepam


Methocarbamol is a medication that can be taken orally with water. The medication can be taken with or without food. And can be divided to 4 times a day in the beginning and can be further changed to 3-6 times a day. In any case, consult the doctor and follow the given instructions (Preston, K.L., Guarino, J.J., Kirk, W.T. and Griffiths, R.R., 1989)


Methocarbamol is a medication that can be taken orally with water. The medication can be taken with or without food. And can be divided to 3 times a day. In any case, consult the doctor and follow the given instructions (Cereghino, J.J., Mitchell, W.G., Murphy, J., Kriel, R.L., Rosenfeld, W.E. and Trevathan, E., 1998)

Strength of Methocarbamol and Diazepam


Strength and form of Methocarbamol

  • Form:The dosage comes in the form of a tablet and injectable solution.
  • Strength:The strength of Methocarbamol is 500mg and 750mg, respectively. 

 Strength and form of Diazepam:

  • Form:Diazepam comes in three states, namely oral solution, tablet, and oral concentrate.
  • Strength: The oral dosage comes in 2 mg, 5 mg, or 10 mg.

Strength and form of Methocarbamol

  • Form:The dosage comes in the form of a tablet and injectable solution.
  • Strength:The strength of Methocarbamol is 500mg and 750mg, respectively. 

 Strength and form of Diazepam:

  • Form:Diazepam comes in three states, namely oral solution, tablet, and oral concentrate.
  • Strength: The oral dosage comes in 2 mg, 5 mg, or 10 mg.

Dosage of Methocarbamol and Diazepam

Dosage of Methocarbamol 

The recommended dosage of Methocarbamol is as follows: 

In the case of muscle spasms: 

  • Adult Dosage:The initial dosage of Methocarbamol IS 1500mg 4 times per day.
  • Pediatric Dosage:The minimum pediatric dosage is about 15mg or 500mg every 6 hours. 

Dosage of Diazepam: 

  • Adult dosage: 2mg to 10mg is the dosage for diazepam, which should be taken three to four times a day.
  • Pediatric dosage:The pediatric dosage is about 1.5 to 2.5mg orally.


Both Methocarbamol and Diazepam treat muscle-skeletal pain and cannot be taken together. It can lead to side effects such as Lack of concentration, Impairment of thinking, lack of motor coordination, nausea, and furthermore.

Consult the doctor before taking any other medication and take the drug only when prescribed. Do not forget to follow the prescribed dosage and instructions before taking the medication. 

How Long Does Robaxin Stay In Your System

How Long Does Robaxin Stay In Your System

Robaxin remains in the urine for up to four hours, from the time of ingestion. However, the range of presence varies depending on the age and health condition of the patient. Robaxin is a brand name of the generic medication methocarbamol. Methocarbamol is a central nervous system depressant used to treat involuntary muscle spasms. Robaxin is sometimes used in the treatment of tetanus. Robaxin belongs to a class of drugs called Skeletal Muscle Relaxants. Robaxin is used with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

How long does robaxin stay in the body

Half Life Of Robaxin

The plasma clearance of Robaxin ranges between 0.20 and 0.80 L/h/kg. The mean plasma excretion half-life ranges between 1 and 2 hours and the plasma protein binding ranges between 46% and 50%.

Robaxin is metabolized through dealkylation and hydroxylation. Essentially all changed and unchanged Robaxin metabolites are eliminated in the urine.(See, S. and Ginzburg, R., 2008)

Factors That Influence Robaxin Stay in The System

Robaxin has a relatively short half-life. In healthy individuals, nearly all Robaxin metabolites are excreted in the urine within four hours of ingesting the drug. The metabolism of Robaxin in the body is influenced by patients’ age and the health of their kidneys and liver. Elderly people in the age range of 69 years take a slightly longer time to eliminate Robaxin in the urine. In other words, methocarbamol has a shorter half-life in elderly persons. Patients in the age range of 69 years take 1.5 hours to excrete Robaxin, while patients in the age range of 53 years take 1.1 hours to get rid of the drug.

Also, it is found that older patients display a decreased fraction of bound Robaxin in the blood, which means that the younger patients utilize the drug more effectively. Patients with kidney problems and are on hemodialysis utilize Robaxin less efficiently and eliminate only 40 percent compared to healthy patients; those who eliminate 46 to 50 percent. Patients with liver cirrhosis due to alcohol misuse have similar efficacy, with only 40 to 45 percent of Robaxin bounding to plasma protein. It is found that only 2 percent of Robaxin will remain in the blood for 24 hours following the final dose in most individuals.(Lu, Y. and Bertoncini, E., 2019)

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How long Robaxin Stays in Urine, Hair and Blood

A considerable amount of Robaxin metabolites may be found in one or two hours of ingestion. Robaxin can remain in the urine for up to four hours from the time of ingestion. These ranges depend on the age and health of the patient. In most of the patients, only 2 percent of absorbed Robaxin will remain in the blood for 24 hours, while it could be tested via hair within 90 days, following the final dose.(Tagliaro, F., Carli, G., Cristofori, F., Campagnari, G. and Marigo, M., 1988)

How Long Robaxin takes to Respond

Robaxin starts working in about 30 minutes and its full effects are seen within 2 hours. It is relatively short-acting and needs to be taken three or four times a day, as prescribed by a doctor.

Possible Side effects Of Robaxin

How Long Does Robaxin Stay In Your System

Robaxin may cause serious side effects, that includes:

  • Headache
  • Slow heartbeats
  • Fever
  • Chills
  • Flu symptoms
  • Seizure(convulsions)
  • Yellowing of your skin or eyes (jaundice)

 These are not all the possible side effects of Robaxin, but there may be many more side effects that may not be severe. But for any side effects, you must consult your doctor.(Forsyth, H.F., 1958)

Who Should Avoid Robaxin

Robaxin is a prescription medicine and is not available over-the-counter. It could only be taken in consultation with a general practitioner. Patients under several conditions should avoid taking Robaxin, which are;(See, S. and Ginzburg, R., 2008).

  • Pregnant women should avoid taking Robaxin due to an increased likelihood of the infant being born with a physical abnormality.
  • Robaxin should be avoided by lactating mothers, too, as it is found in the milk of the mother receiving treatment with the drug. But it is not clear whether it affects the infant adversely on not. 
  • It should be avoided by elders also as it may increase the risk of falls. 
  • It is also not suitable for those who have an allergic reaction to Robaxin.
  • Sedation caused by Robaxin may affect driving or operating heavy machinery of a person.
  • An alcoholic person should also avoid taking this medicine.
  • Patients already on medication of opioids, benzodiazepines, and sedating antihistamines should avoid taking Robaxin.
  • Safety and effectiveness in children below 16 years of age are still to be established.  
  • People who have a history of narcotic abuse and addiction are more likely to abuse Robaxin and become psychologically addicted.
Is Robaxin (Methocarbamol) a Controlled Substance?

Is Robaxin (Methocarbamol) a Controlled Substance?

Robaxin was approved on 6th October 1959 by the FDA (Food and Drug Administration). The effect of the drug generally begins within half an hour after consumption. One can take it by mouth or by injection. Geriatric patients should not take the drug. FDA labels the medication as a pregnancy C category.

Methocarbamol interacts with other central nervous system depressants (prescription painkillers, cough and cold medications, sedatives, sleeping pills, and anxiety medications) to enhance their effect when taken orally. Methocarbamol is not an opioid, benzodiazepine, or other prescription medicines used to treat pain or convulsions. Methocarbamol is not a controlled substance in the United States, so its potential for abuse or addiction is low. Like any substance, however, it can be misused and used in ways that are not intended.

Diseases such as kidney or liver disease can also influence the metabolic processes of methocarbamol. A 2014 review of skeletal muscle relaxants found that the first-line drugs were not as effective as muscle relaxants at first. Muscle relaxants were more effective than placebos for short-term relief, but the risk of side effects was 50%.
In 2018, it was the 120th most commonly directed medicine in the United States, with higher than 5 million prescriptions.

Robaxin and Carisoprodol is schedule IV drug used to relieve pain in muscles and relax them. Robaxin got approval in the year 1959 by FDA (Food and Drug Administration).

two people conversation on robaxin a controlled substance
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What kind of drug is Robaxin?

What kind of drug is Robaxin

Robaxin belongs to the drug group called Skeletal Muscle Relaxants. It is sold under the brand names of other medicines and is used for short-term musculoskeletal pain.
The medicine is prescribed to treat the symptoms of muscle spasms caused by pain or injury. It is used along with some rest, physical therapy, and other treatment to support it. It acts to relax the muscles to relieve the pain.
It can be injected intravenously and has positive effects in controlling neuromuscular spasms caused by tetanus.

Robaxin injection is at times utilized in the treatment of tetanus, which produces painful tightening of the muscles.
The mechanism of action in humans is not yet established. It is assumed to operate, depressing the central nervous system, leading to the relaxation of muscles.
It is not beneficial in chronic neurological diseases, such as cerebral palsy or different dyskinesia’s.

Does Robaxin make you high?

According to studies, and observation under clinic trials, the drug can induce dizziness and drowsiness as they are some of its general side effects and can be misinterpreted as high. Considering the dizziness, one should take care that after using Robaxin, the person should not be involved or get included in any task that demands mental alertness, for example, driving or activity on any hazardous machine.
The medicine is not frequently abused.
People with a history of substance abuse or addiction are more likely to be abused and become dependent on Robaxin. Such as Snorting or smoking Carisoprodol can increase their effectiveness and deliver a strong high. Patients with a history of substance abuse are more likely to be addicted. Robaxin can be purchased without a prescription, and it can be misused to make a habit.

Is Robaxin a Narcotic?

Robaxin is not a narcotic. It is a muscle relaxant and is used to cure pain. According to studies and proven clinical trials, the drug can make you dizzy and drowsy, which can be misunderstood as high on the drug.


Robaxin is utilized to treat the symptoms of muscle spasms caused by pain. The safety and effectiveness of the drug in kids older than 16 years have not been authenticated yet.
Every drug has its benefits and limitations. Likewise, every drug has specific side effects; some get improved on time, but some get worse; in such cases, medical help should be taken, and conditions should not be taken for granted. Drug abuse should not be done as it may lead to a serious impact on the body. Never share or take medicine from other people, even if there is a similarity in symptoms. Use the drugs only when prescribed by doctors.
For some, the drug may not be the fittest option. Talk to your doctor about your concerns and brief them about your medical conditions. After conducting a proper check-up and examination, the physician will direct the most suitable prescription for you.


Witenko, C., Moorman-Li, R., Motycka, C., Duane, K., Hincapie-Castillo, J., Leonard, P., & Valaer, C. (2014). Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P & T: a peer-reviewed journal for formulary management39(6), 427–435. Available at: Accessed on 14/08/2021 Accessed on 14/08/2021