Metaxalone vs Baclofen

Metaxalone vs Baclofen

Metaxalone and Baclofen are muscle relaxants. Both these medications are widely used to treat muscle pains and spasms caused in the body.

What is Metaxalone?

Metaxalone belongs to the drug class called Skeletal muscle relaxants. Metaxalone is a medication used to treat muscle pain. It works against the pain caused due to muscle strains and injuries and provides relief (Bruce, R.B., Turnbull, L., Newman, J. and Pitts, J., 1966).

What is Baclofen?

Baclofen belongs to the drug class called Skeletal muscle relaxants. Baclofen can be used as a medication to relieve pain and muscle spasms. It can also be used against stiffness caused due to sclerosis or spinal injury (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Metaxalone vs. Baclofen: Which is More Effective?

Both these medications- Metaxalone and Baclofen are muscle relaxants. They work as effective medication against muscle pain and spasms.

There is no specific study comparing the efficacy of Metaxalone and Baclofen for the treatment of muscle pain and spasms. But it is observed that both these medicines are equally effective against pain and spasms.

Metaxalone has few side effects and is thus preferred in older people, while Baclofen has fewer sedative effects on the body during treatment. Therefore, it is suggested that both medications are equally effective and can be selected by the doctor depending upon the health conditions.

Conversation of two people on flexeril and baclofen

How does Metaxalone work?

Metaxalone works against pain by affecting nerve impulses. Metaxalone affects these nerve impulses by working on the CNS and blocking these impulses. This action results in stopping the pain signals from reaching the brain (Bruce, R.B., Turnbull, L., Newman, J. and Pitts, J., 1966).

How does Baclofen work?

It works by acting on the spinal cord nerves. It helps to decrease the action of these nerves, which cause the problem of pain and spasm. Due to the decreased activity of these nerves, the pain gets relieved, and the muscle spasms get stopped (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

How to take Metaxalone?

Metaxalone can be taken before or after food. It is advisable to take medicine after a light meal to reduce the sedation effect. It should be consumed only as advised by the doctor.

The doctor can change the dosage depending upon the responsiveness and tolerability (Bruce, R.B., Turnbull, L., Newman, J. and Pitts, J., 1966).

How to take Baclofen?

Baclofen can be taken orally with or without food. It is taken 3 times a day, depending upon the responsiveness. The doctor may gradually increase the dose. A proper measuring spoon should be used for the liquid Baclofen. It should be consumed only as advised by the doctor (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Dosage of Metaxalone

The normal dose for adults and children is 800 mg, which must be taken 3-4 times daily.

People below 12 are not allowed to take this medicine.

Dosage of Baclofen

The initial daily dose of Baclofen is 5 mg, taken 3 times a day.

The dosage can be gradually increased daily to 10,20 mg per dose.

The maximum daily dose limit is 80 mg per day.

Who should not take Metaxalone?

One should not take Metaxalone if:

  • Allergic to Metaxalone
  • Seizures
  • Consumed MAO inhibitors in last two weeks
  • Blood disorders
  • Liver problems
  • Kidney disorders
  • Consuming alcohol regularly

Pregnant and breastfeeding women should not take Metaxalone as it can have adverse effects on the health of women and children. It can be taken only in necessary conditions as prescribed by the doctor.

Who should not take Baclofen?

One should not take Baclofen if:

  • Allergic to Baclofen
  • Kidney disorder
  • Below the age of 12
  • Stroke
  • Parkinson’s disease
  • Epilepsy
  • Nervous system problems

Pregnant and breastfeeding women should not take Baclofen. It can be taken only in necessary conditions as prescribed by the doctor.

Side effects of Metaxalone:

Following are some of the common side effects observed after taking Metaxalone:

  • Nausea
  • Headache
  • Drowsiness
  • Upset stomach
  • Vomiting

There are severe side effects that one may face after taking Metaxalone:

  • Agitation
  • Problem in breathing
  • Jaundice
  • Skin rashes
  • Fever
  • Anemia

Take emergency medical help if any side effects are observed to prevent negative risks.

Side effects of Baclofen:

Following are some of the common side effects observed after taking Baclofen:

  • Nausea
  • Constipation
  • Vomiting
  • Tiredness
  • Increase in urine

There are severe side effects associated with the medication of Baclofen. Following are some of them:

  • Depression and confusion
  • Hallucinations
  • Seizures
  • Itching
  • Low blood pressure

Consult your doctor if any of these side effects are experienced. The doctor can terminate or change the dosage to reduce further risks.

Difference between Metaxalone and Baclofen

  • Metaxalone is used to treat short-term to cure pain, while Baclofen can be used for long-term pain and spasms.
  • Anemia, Jaundice are some side effects of Metaxalone, which are not similar to the side effects of Baclofen.
  • Low blood pressure, confusion, depression are side effects of Baclofen which are different from the side effects of Metaxalone.
  • Metaxalone is mostly preferred in older people as no major side effects are associated with older people.
  • Baclofen has fewer sedative effects than Metaxalone and other muscle relaxants.


Metaxalone and Baclofen are muscle relaxants. These medications are widely used and equally effective against muscle spasms and pain. It is advisable to consult your medical health practitioner before taking this medication to prevent the risk of adverse effects and get better results.

Skelaxin For Menstrual Cramps

Skelaxin For Menstrual Cramps

Skelaxin is a muscle relaxant with a generic name, Metaxalone. It works by blocking the pain-sensitive nerve impulses in the brain. It is generally prescribed with physiotherapy and rest. Skelaxin is used to treat the symptoms of pain erupting in the skeletal muscles. It was approved by FDA in 1962.

Skelaxin cannot be used to relieve menstrual cramps. This is because, unlike other cramps, during a menstrual cramp, there is an inflammatory reaction that could only interact with an anti-inflammatory drug such as Ibuprofen to relieve the sensation of the contractions happening in the uterus to pass out the broken blood lining.

Half-Life and How long does it take to work?

The average half-life of Skelaxin extends from 4.4 to 14 hours at peak. The average concentration reaches about 9.2 hours. The effect of Skelaxin starts to show within an hour of consumption. However, the peak concentration is reached after about 3 hours of consumption.

How To Consume Skelaxin?

Swallow the tablets. Avoid chewing, crushing, or sucking on them as it might irritate your throat. Make sure you consume plenty of water to make swallowing easier.

Do NOT increase or stop the dose abruptly without the consultation of your doctor.

It is advised to consume Skelaxin on either an empty stomach or a light meal.

Who Should Not Take Skelaxin?

Do NOT consume Skelaxin if you suffer or have suffered the following conditions:

  • Anemia
  • Severe liver infection
  • Severe kidney infection

Side Effects Of Skelaxin

The common side effects of Skelaxin include:

  • Dizziness
  • Drowsiness
  • Upset stomach
  • Nausea
  • Vomiting
  • Nervousness
  • Fatigue
  • Weakness
  • Headache
  • Irritability


Your doctor must track your progress. It is NOT advised to consume Skelaxin while pregnant or breastfeeding as it would severely affect the fetus and infant, respectively.

Do not consume Skelaxin right before you are about to drive or do something which requires a lot of attention as it could lead to accidents. Consult your doctor if you face any doubts or confusion (Poklis, J.L., Ropero-Miller, J.D., Garside, D. and Winecker, R.E., 2004).

What To Do If You Missed A Dose?

Skelaxin is used only when needed unless prescribed otherwise. Skip the dose that is missed if you are close to the next dosage. Do NOT consume a double dose to even it out.

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing in the case of Skelaxin could be fatal (Poklis, J.L., Ropero-Miller, J.D., Garside, D. and Winecker, R.E., 2004).


Skelaxin is a type of muscle relaxant used to treat the symptoms of pain erupting in the skeletal muscles, prescribed with physiotherapy and rest. It is NOT suitable for menstrual cramps. However, it could be used for the skeletal muscle cramps that erupt along with menstrual cramps.

Metaxalone Vs Flexeril

Metaxalone Vs Flexeril

Both Skelaxin and Flexeril are FDA-approved medicines for treating muscular spasms. They’re part of a class of drugs known as skeletal muscle relaxants.

The generic versions of Skelaxin and Flexeril are metaxalone and cyclobenzaprine, which are the most routinely prescribed. It’s unclear how they function; however it could be linked to the central nervous system (CNS) depression and sedative effects. These drugs have no direct effect on the muscles or nerves.

What are the differences between Metaxalone and Flexeril?

Metaxalone is a muscle relaxant used to treat sprains, strains, and other ailments that produce muscle spasms and pain. Skelaxin is a brand name for a generic medication called Metaxalone. Other brand names for this metaxalone are Metaxall, Metaxall CP.

Flexeril is a muscle relaxant that can be used to relieve skeletal, muscular spasms. Flexeril’s generic name is cyclobenzaprine.

Strength and Dosage

For Flexeril

  • Tablet for adults and children – 5mg, 7.5mg, 10mg
  • Capsule, extended use for adults only – 15mg, 30mg
The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets (Tofferi, J.K., Jackson, J.L. and O’Malley, P.G., 2004).

For Metaxalone

Tablet for adults and children – 400mg and 800mg Adults and children aged 13 and up should take 800 milligrams (mg) three to four times a day. Children under the age of 12 must have their use and dose determined by their doctor (Gabhane, K.B., Kasture, A.V., Shrikhande, V.N., Barde, L.N. and Wankhade, V.P., 2009).

Side Effects

 For Flexeril 

  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision

For Metaxalone

  • Dizziness
  • drowsiness
  • Stomach upset
  • Nervousness
  • irritability
  • Blurred vision
  • Headache

Is Metaxalone the same as Flexeril?

Despite the fact that Metaxalone and Flexeril belong to the same pharmacological class (skeletal muscle relaxants), they have some distinctions in terms of adverse effects, dosage, and cost.

Is it Safe for me to use Metaxalone vs Flexeril while Pregnanancyt?

Although there has been no evidence of fetal impairment in the post-marketing experience, this does not rule out the possibility of occasional or subtle damage to the human baby. The safe usage of metaxalone in terms of potential fetal development side effects has not been proven. As a result, unless your healthcare practitioner determines that the benefits exceed the risks, Skelaxin is not indicated for use in pregnant women or women who may become pregnant. There are no adequate, well-controlled trials in pregnant women, according to the Flexeril manufacturer’s statement. As a result, Flexeril should only be taken on pregnant women if absolutely necessary (Di Martino, A., Russo, F., Denaro, L. and Denaro, V., 2017).

Which one is more effective?

According to American Family Physician, there is very little evidence comparing muscle relaxants and their efficacy. They advise that muscle relaxants be chosen based on the risk of side effects, drug interactions, and abuse, as well as patient preference. 

Your healthcare professional will be able to tell you if metaxalone or Flexeril is right for you. Your symptoms, medical problems, medical history, and any drugs you’re taking that could interact with Skelaxin or Flexeril will all be taken into account.

Snorting Metaxalone

Snorting Metaxalone

Metaxalone is a medication used for the treatment of musculoskeletal pain. It is a member of the drug class called Skeletal muscle relaxants. It helps relax muscles and gives relief from pain caused due to muscle injuries and strains. It is sold under the brand name Skelaxin.

Is It A Good Idea To Snort Metaxalone

Snorting Metaxalone is not a good idea as it will quickly start reacting in the body. As Metaxalone affects the CNS, snorting it can amplify the effects very quickly. It may give an instant feeling of pain relief and increase the feeling of relaxation and sedation. But, snorting Metaxalone can have adverse effects on the body. It can damage the nasal cavity, giving rise to respiratory problems. Also, snorting muscle relaxants creates a feeling of high, so snorting Metaxalone makes a person feel high. (Holman, C.M., 2020)
Grab Meataxalone At A Fanatstic Price

How It Works:

Metaxalone works by affecting the nerve impulses which are sent to the brain. Metaxalone works on the CNS to relax the muscle and block the pain signals. Because of this action, these pain signals do not reach the brain and cannot communicate with the brain.

Forms And Strengths:

Metaxalone is an oral medication, and it is available in tablets form.

Metaxalone is available in the strength of 800 mg tablets.

How To Take It:

One should take Metaxalone only as advised by the doctor. The medicine can be consumed with or without food. It should be taken as a whole without crushing or chewing. It is generally preferred to take this medicine after a light meal or empty stomach to reduce the chance of side effects such as sedation and high blood pressure. The dosage may depend upon the health conditions and tolerability. One should not increase or decrease the dose without consulting the doctor. (Derington, C.G., Choi, D.K. and Trinkley, K.E., 2019)


The normal adult dose is 800 mg, taken 3 to 4 times daily.

The same dose of 800 mg taken 3-4 times daily is followed for children aged 13-18.

This medicine is not prescribed for children below the age of 12.

If you miss the dose, take the dose immediately only if the next dose is after a long time. Do not mix up two doses to compromise the missed dose. Taking double dosages can lead to more adverse effects on health.

If you overdose on Metaxalone, seek immediate medical help, which may cause negative effects. It can be fatal too, as it will cause extreme drowsiness.

Snorting Metaxalone

Who Should Not Take It?

One should not take Metaxalone:

  1. Below the age of 12
  2. Allergic to Metaxalone
  3. Kidney and liver disorder
  4. Regular consumption of alcohol
  5. Blood disorder
  6. Seizure
  7. Taken MAO inhibitor 2 weeks before

Pregnant and breastfeeding women should not take Metaxalone as it can affect the health of both woman and the child. The doctor can only prescribe it in necessary extreme conditions.


Side Effects:

Snorting Metaxalone

Following are the common side effects:

  1. Drowsiness
  2. Nausea
  3. Headache
  4. Vomiting
  5. Nervousness
  6. Upset stomach

Following Are The Severe Side Effects:

  1. Difficulty in breathing
  2. Loss of appetite
  3. Agitation
  4. Jaundice
  5. Allergic reactions like rashes
  6. Fever
  7. Extreme weakness

One should get emergency medical help after noticing any of these side effects to prevent further risk to the health.

Is Metaxalone a Controlled Substance?

Metaxalone might be an addictive medication, but it is not a controlled substance. Metaxalone works by affecting the central nervous system and thus has the potential of getting abused but not a controlled substance.

Pros And Cons:


  1. It helps to relieve pain along with rest and therapy.
  2. It helps to treat pain as well as stiffness and strains.
  3. It starts working quickly against the pain.


  1. It interacts with most of the medications.
  2. It can be addictive.
  3. It may lead to many side effects.
  4. Everyone cannot take it.


Snorting Metaxalone should not be done as it has adverse effects on an individual’s overall health. One should take it as prescribed by the medical practitioner and not increase the dose and take it for a long time.

Consult the doctor before taking medicine to reduce the risk of negative side effects.