Flexeril vs Baclofen

Flexeril vs Baclofen

What is Flexeril?

Flexeril is a muscle relaxant that is used in conjunction with rest, physical therapy, and other treatments to relieve pain and suffering caused by muscle strains, sprains, and other injuries. Cyclobenzaprine belongs to the skeletal muscle relaxant class of drugs. It works by allowing the muscles to relax by acting on the brain and nerve system (RELAXANT, S.M., 1981. FLEXERIL).

What is Baclofen? 

Baclofen is a prescription pain reliever that is used to treat pain and spasticity caused by spinal cord injuries, multiple sclerosis, and other spinal cord illnesses. Baclofen belongs to the skeletal muscle relaxant class of drugs. Baclofen works by acting on the nerves in the spinal cord, reducing the amount and intensity of muscular spasms caused by multiple sclerosis or other spinal disorders. It also helps with pain relief and muscle movement (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Forms and Strength

For Flexeril

  • Tablet for adults and children – 5mg, 7.5mg, 10mg
  • Capsule, extended use for adults only – 15mg, 30mg

For Baclofen

Oral Tablet – 10mg, 20mg


For Flexeril

The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets (RELAXANT, S.M., 1981. FLEXERIL).

For Baclofen

For people with spasticity, the usual starting dose of oral baclofen is 5 mg three times daily. The amount can be increased by 5 mg every three days, up to a maximum of 80 mg/day in divided doses, depending on the reaction (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Side Effects


  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision


  • Vomiting
  • Low blood pressure (hypotension)
  • Respiratory depression
  • Weakness
  • Seizures
  • Inability to sleep (insomnia)
  • Increased urinary frequency or urinary retention

Drug Interactions


  • MAO inhibitors and FLEXERIL may have life-threatening interactions. 
  • Alcohol, barbiturates, and other CNS depressants may be amplified by Flexeril.
  • Antihypertensive effects of guanethidine and related substances may be blocked by tricyclic antidepressants. 
  • Tricyclic antidepressants may amplify the risk of seizures in tramadol users (RELAXANT, S.M., 1981. FLEXERIL).


  • The use of baclofen plus MAO inhibitors can lead to a decrease in brain function and a drop in blood pressure.
  • Anti-diabetic medicine doses may need to be modified when baclofen is started because it can raise blood sugar.
  • The use of baclofen and tricyclic antidepressants combined may produce muscle weakness, in addition to the danger of reducing brain function.
  • Baclofen with monoamine oxidase inhibitors can cause brain function to be depressed as well as low blood pressure (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Which one is better?

If you have acute back or neck pain due to a musculoskeletal injury or fibromyalgia, cyclobenzaprine is the best treatment option. If you have spasticity or persistent pain as a result of neurological disease or injury, such as multiple sclerosis or a spinal cord injury, baclofen may be the best option for you.

Always talk to your healthcare professional about your medical history to figure out which medications are the safest for you to use. Any medication’s apparent benefits should always outweigh the potential hazards.

Metaxalone Vs Flexeril

Metaxalone Vs Flexeril

Both Skelaxin and Flexeril are FDA-approved medicines for treating muscular spasms. They’re part of a class of drugs known as skeletal muscle relaxants.

The generic versions of Skelaxin and Flexeril are metaxalone and cyclobenzaprine, which are the most routinely prescribed. It’s unclear how they function; however it could be linked to the central nervous system (CNS) depression and sedative effects. These drugs have no direct effect on the muscles or nerves.

What are the differences between Metaxalone and Flexeril?

Metaxalone is a muscle relaxant used to treat sprains, strains, and other ailments that produce muscle spasms and pain. Skelaxin is a brand name for a generic medication called Metaxalone. Other brand names for this metaxalone are Metaxall, Metaxall CP.

Flexeril is a muscle relaxant that can be used to relieve skeletal, muscular spasms. Flexeril’s generic name is cyclobenzaprine.

Strength and Dosage

For Flexeril

  • Tablet for adults and children – 5mg, 7.5mg, 10mg
  • Capsule, extended use for adults only – 15mg, 30mg
The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets (Tofferi, J.K., Jackson, J.L. and O’Malley, P.G., 2004).

For Metaxalone

Tablet for adults and children – 400mg and 800mg Adults and children aged 13 and up should take 800 milligrams (mg) three to four times a day. Children under the age of 12 must have their use and dose determined by their doctor (Gabhane, K.B., Kasture, A.V., Shrikhande, V.N., Barde, L.N. and Wankhade, V.P., 2009).

Side Effects

 For Flexeril 

  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision

For Metaxalone

  • Dizziness
  • drowsiness
  • Stomach upset
  • Nervousness
  • irritability
  • Blurred vision
  • Headache

Is Metaxalone the same as Flexeril?

Despite the fact that Metaxalone and Flexeril belong to the same pharmacological class (skeletal muscle relaxants), they have some distinctions in terms of adverse effects, dosage, and cost.

Is it Safe for me to use Metaxalone vs Flexeril while Pregnanancyt?

Although there has been no evidence of fetal impairment in the post-marketing experience, this does not rule out the possibility of occasional or subtle damage to the human baby. The safe usage of metaxalone in terms of potential fetal development side effects has not been proven. As a result, unless your healthcare practitioner determines that the benefits exceed the risks, Skelaxin is not indicated for use in pregnant women or women who may become pregnant. There are no adequate, well-controlled trials in pregnant women, according to the Flexeril manufacturer’s statement. As a result, Flexeril should only be taken on pregnant women if absolutely necessary (Di Martino, A., Russo, F., Denaro, L. and Denaro, V., 2017).

Which one is more effective?

According to American Family Physician, there is very little evidence comparing muscle relaxants and their efficacy. They advise that muscle relaxants be chosen based on the risk of side effects, drug interactions, and abuse, as well as patient preference. 

Your healthcare professional will be able to tell you if metaxalone or Flexeril is right for you. Your symptoms, medical problems, medical history, and any drugs you’re taking that could interact with Skelaxin or Flexeril will all be taken into account.

Flexeril (Cyclobenzaprine) vs Valium (Diazepam)

Flexeril (Cyclobenzaprine) vs Valium (Diazepam)

Muscle spasms are treated with Flexeril (cyclobenzaprine) and Valium (diazepam). Valium is also prescribed for anxiety, seizures, and alcohol withdrawal symptoms. Valium and Flexeril belong to separate drug classes. Valium is a benzodiazepine, while Flexeril is a muscle relaxant (Basmajian, J.V., 1978).

Which One is Better?

Cyclobenzaprine is a common treatment for muscular spasms that is also available as a generic, although it should not be used for an extended period. Valium is beneficial for anxiety and muscle spasm when used infrequently or for a short period. Valium is particularly fast-acting when compared to cyclobenzaprine.

Difference between Cyclobenzaprine and Valium

Valium and cyclobenzaprine belong to separate pharmacological classes. Valium is a benzodiazepine and cyclobenzaprine is a muscle relaxant.

Diarrhea, rash, exhilaration, loss of balance, excitability, muscle spasm, lack of sleep, rage, and speech issues are some of the side effects of Valium that differ from cyclobenzaprine (Aker, P., 2004).

Similarities between Cyclobenzaprine and Valium

Cyclobenzaprine and Valium are both used to treat muscle spasms. Side effects of cyclobenzaprine and Valium that are similar include drowsiness, fatigue, vision problems, and confusion (Elenbaas, J.K., 1980).

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Age Restrictions

For Cyclobenzaprine-Cyclobenzaprine is not recommended for children under the age of 15.

For Diazepam- Use is not recommended for children under the age of six months.

Conditions Treated

By Cyclobenzaprine

  • Relaxes muscles
  • Relives pain from strains
  • Relives pain caused by sprains
  • Relives pain caused by muscle injuries
  • Chronic Myofascial Pain
  • Fibromyalgia
  • Migraine

By Valium 

  • panic disorder
  • a feeling of restlessness with the inability to sit still
  • symptoms from alcohol withdrawal
  • psychosis caused by sudden alcohol withdrawal
  • inducing of a relaxed, easy state
  • muscle spasm
  • anxiety

Availability and Cost

Flexeril (Cyclobenzaprine) vs Valium (Diazepam)


Cyclobenzaprine pills are available in three dosage strengths.

  • 5 milligrammes (mg)
  • 7.5 milligrammes (mg)
  • 10 milligrammes (mg) tablets

Cyclobenzaprine is also available as a generic or under the brand name Amrix in 15 mg or 30 mg extended-release capsules.

Dosage for muscle spasms 

For adults and teenagers 15 years and older – For muscle spasms, take 5–10 mg up to three times per day as required for up to three weeks.

Maximum recommended dosage – For a maximum of three weeks, take no more than 10 mg three times each day.

Amrix and Fexmid are two brand names for cyclobenzaprine. Depending on the drugstore you visit, cyclobenzaprine oral tablet 10 mg costs roughly $10 for a supply of three tablets.


Valium (diazepam) comes as an intramuscular injection, an intravenous injection, and a tablet. It’s usually prescribed as a tablet, and it’s taken that way.

The tablet is available in the strength of

  • 2mg
  • 5mg
  • 10mg

Intramuscular injection: the amount varies. Intravenous injection: the amount varies.


For Adults to treat muscle spasms – 3-4 times a day, take a 2-10 mg pill.

For children six months and older – The standard dose is 0.1 to 10mg a day, and the maximum dose is 30mg.

Diazepam is a generic name for Valium. Valium oral tablet 2 mg costs roughly $364 for a 100-tablet supply, depending on the drugstore you go to.

Mechanism of Action


Cyclobenzaprine is a centrally acting skeletal muscle relaxant with a tricyclic antidepressant-like structure. Cyclobenzaprine reduces localized skeletal, muscular spasms without impairing muscle function.

According to research, it predominantly functions in the brain stem of the central nervous system. Although an overlapping action on the spinal cord may contribute to its total skeletal muscle relaxant activity, cyclobenzaprine does not work directly on skeletal muscle or the neuromuscular junction. 

The evidence suggests that cyclobenzaprine causes a decrease in tonic somatic motor activity, impacting both the gamma() and alpha() motor systems. According to recent research, cyclobenzaprine is a (5-HT2) receptor antagonist, and its antispasmodic activity is due to this extra action.


Valium is a benzodiazepine that has anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnestic properties. The majority of these effects are assumed to be due to a facilitation of the action of gamma-aminobutyric acid (GABA), a central nervous system inhibitory neurotransmitter.

How to take them?


Cyclobenzaprine is available as a tablet and an extended-release capsule for oral administration. The tablet is normally taken three times a day, with or without food. 

The extended-release capsule is typically taken once a day, with or without food. Do not take this medication for longer than three weeks without consulting your healthcare professional. 

Follow the instructions on your prescription label carefully, and if there is anything you don’t understand, ask your doctor or pharmacist to explain it to you. 

Take cyclobenzaprine exactly as prescribed by your healthcare professional. Do not take more or less of it, or take it more frequently than your doctor has suggested.


With a glass of water, take diazepam tablets or liquid. They can be consumed with or without meals.

Typically, you’ll take your medicine one to three times per day.

Your healthcare professional will determine the most appropriate dose for you. It’s critical to take diazepam exactly as prescribed by your doctor (Hall, A.M., 2017).

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Common Side Effects


  • Blurred vision, Dry mouth, or Throat.
  • Headache.
  • Fatigue.
  • Loss of appetite.
  • Stomach pain.
  • Drowsiness.
  • Dizziness.


  • Drowsiness
  • Tiredness
  • Dizziness
  • spinning sensation
  • Exhaustion
  • Constipation
  • ataxia (loss of balance)
  • memory issues
  • Constipation

Drug Warnings


Serotonin syndrome is a potentially fatal side effect of this medication. This occurs when your body produces too much serotonin due to your drugs. If you have any signs of this ailment, contact your doctor immediately. Agitation, hallucinations, convulsions, and nausea are some of these symptoms. If you combine cyclobenzaprine with other drugs that enhance the risk of serotonin syndrome, such as antidepressants, your risk may be increased.

This medication has the potential to cause cardiac arrhythmias. If you use a depressive medication or already have cardiac problems, your risk may be increased. These problems can lead to a heart attack or stroke if they aren’t addressed.


Diazepam has the potential to become addictive. Do not take a higher dose, take it more frequently, or take it for a longer period than your doctor recommends.

Tell your doctor if you’ve ever drunk a lot of alcohol, if you use or have used illicit drugs, or if you’ve ever taken too many prescription prescriptions.

During your treatment, refrain from drinking alcohol or using illegal substances. When you drink alcohol or use illegal substances while taking diazepam, you increase your chances of developing these significant, life-threatening side effects.

Also, tell your doctor if you are currently suffering from or have ever suffered from depression or a similar mental disorder.

Diazepam, especially if taken for several days to weeks, can create physical dependency. Do not stop taking this drug or reduce your doses without consulting your doctor.

Stopping diazepam abruptly might aggravate your health and create withdrawal symptoms that can last anywhere from a few weeks to over a year. Your healthcare professional will most likely progressively reduce your diazepam dosage (Hincapie-Castillo).

Scientific Study

In patients with long-term intractable pain of cervical and lumbar origin increased by skeletal muscle spasm and soreness, the effectiveness of cyclobenzaprine hydrochloride, a novel tricyclic skeletal muscle relaxant, was demonstrated. The study compared cyclobenzaprine hydrochloride (10 mg three times a day) to diazepam (5 mg three times a day) and placebo in a double-blind, randomised trial.

The 16 patients in the cyclobenzaprine group showed an overall improvement in pain variables after two weeks of treatment, as did the 16 patients in the diazepam group. In the trial, no significant side effects from cyclobenzaprine were observed. However, the anticholinergic activity of cyclobenzaprine caused dry mouth and mild sleepiness, which were more common than with diazepam or placebo (Jackson, J.L. and O’Malley, P.G., 2001).

Zanaflex vs Flexeril

Zanaflex vs Flexeril

Muscle relaxants such as Flexeril (cyclobenzaprine) and Zanaflex (tizanidine) are used to relieve muscle tension and cramping (spasm) caused by acute, painful musculoskeletal diseases. Flexeril is used to treat muscle spasms as an addition to rest and physical therapy, whereas Zanaflex is used to treat disorders like multiple sclerosis or spinal damage(Dickerson, L.M., 2010).

Strength and Dosage for Zanaflex

Zanaflex is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg. The initial dose is recommended to be 2 mg. Because Zanaflex’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours. To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg (Barnes, M., 2000).
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Strength and Dosage for Flexeril

Tablet for adults and children – 5mg, 7.5mg, 10mg Capsule, extended use for adults only – 15mg, 30mg The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets(Zegarra, M., 2010).

Side Effects for Zanaflex

  • dry mouth
  • drowsiness
  • dizziness
  • muscle weakness
  • back pain
  • increased muscle tone or spasms
  • sweating
  • nervousness
  • numbness or tingling
  • stomach pain
  • diarrhea
  • constipation
  • vomiting

Side Effects for Flexeril

Zanaflex vs Flexeril
  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision

Drug Interactions for Zanaflex

  • Zanaflex is mostly metabolized in the liver by the CYP1A2 enzyme. Zanaflex levels in the body can be increased by drugs that block or inhibit this enzyme. 
  • Increased medication levels might cause sleepiness and dizziness, among other side effects. 
  • CYP1A2 inhibitors like ciprofloxacin and cimetidine and birth control pills containing Ethinyl estradiol should be avoided when taking Zanaflex.
  • Zanaflex may interact with drugs that depress the central nervous system. Barbiturates, opioids, and benzodiazepines are examples of these medications. 
  • Zanaflex might intensify their effects, causing dizziness and sedation.
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Study on the effectiveness of Zanaflex and Flexeril

Cyclobenzaprine has been evaluated in most clinical trials with evidence to support its usage, according to a meta-analysis. Tizanidine has been shown to help with spasticity caused by multiple sclerosis. For musculoskeletal problems, such as acute neck or back pain, both cyclobenzaprine and tizanidine were proven to be helpful. Over 100 trials comparing muscle relaxants such as Lioresal (baclofen), Soma (carisoprodol), Robaxin (methocarbamol), Skelaxin (metaxalone), and Valium were included in the meta-analysis (diazepam). Overall, the study discovered that the efficacy and safety of these medications are equal. Muscle relaxants, according to certain guidelines, produce drowsiness and should only be used for a short period. Both Zanaflex and Flexeril are efficient muscular spasm and pain relievers. On a case-by-case basis, they are used depending on which one is most appropriate. There is currently no clinical evidence that shows a direct comparison between these two medicines (Chou R, Peterson K, Helfand M)

Is there a difference between Zanaflex and Flexeril?

Flexeril and Zanaflex are not the same things. Flexeril has an average half-life of 18 hours, while Zanaflex has a half-life of roughly 2.5 hours. Flexeril is only available in extended-release capsules, whilst Zanaflex is only available in immediate-release oral tablets and capsules(Peterson, K. and Helfand, M., 2004).

Is it better to take Zanaflex or Flexeril?

Zanaflex is a relatively new medicine that has been licensed by the FDA to treat muscle spasticity caused by multiple sclerosis and spinal cord injury. Flexeril is an older medication that has been examined extensively for musculoskeletal pain and spasms. The better medicine is the one that is most effective for your condition. Consult a doctor for assistance in determining the best course of action for you(Dickerson, L.M., 2010).

Flexeril in the Treatment of Back Pain

Flexeril in the Treatment of Back Pain

Flexeril is a medication that can treat back pain and is considered a frequently prescribed medication. Flexeril treats pain, injury, or muscle spasm-related conditions as a muscle relaxant. This drug is primarily used during the resting period and ongoing physical therapy treatment. 

Flexeril for backpain

How Does Flexeril Treat Back Pain?

Flexeril is a medication that works by interrupting the transmission of nerve impulses (or pain sensations) to the brain. To treat muscle spasms produced by painful circumstances such as an injury, Flexeril is combined with rest and physical therapy. Thus, Flexeril treats pain-related issues ranging from back pain to joint pain through this mechanism of action.

Flexeril Dosage For Back Pain

The recommended dose of Flexeril is 5 mg three times a day. The dosage of the medication may increase to 10 mg three times a day, depending on the patient’s response. Flexeril should not be taken for more than two or three weeks at a time.
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Flexeril Efficiency In Treating Back Pain

Research: This study was conducted by the Department of Medicine, National Naval Medical Center, Bethesda, MD, USA.

Aim: To conduct a systematic observation of the efficacy of Flexeril in the treatment of back pain.

Method: This study was evaluated by Searched outcomes from MEDLINE, PsycLIT, CINAHL, EMBASE, AIDS LINE, HEALTH STAR, CANCERLIT, the Cochrane Library, Micromedex, Federal Research in Progress, and the references of reviewed articles for English-language, randomized, placebo-controlled trials of Flexeril in adults with back pain.

Result: In the treatment of back pain, cyclobenzaprine is more efficient than placebo; however, the benefit is limited and comes at the cost of additional side effects. The effect is most significant within the first four days of treatment, implying that shorter treatments may be preferable (Chaffee DM. Cyclobenzaprine in the Treatment of Low Back Pain).

Adverse Side Effects Of Flexeril

Adverse Side Effects Of Flexeril 

One might experience certain adverse effects after taking this medication however is a rare case. Suppose detected any contact the doctor as fast as possible. 

  • Dizziness
  • Drowsiness
  • Light-headedness
  • The mouth feels dry
  • Blurred vision

Common Side Effects Of Flexeril 

The common side effects are namely as follows:

  • Bloating and gas are less prevalent adverse effects.
  • Indigestion
  • Vomiting or nausea
  • Constipation or discomfort in the stomach
  • Constipation
  • Diarrhea
  • Nervousness or excitement
  • More frequent urination 
  • Headache


Flexeril, a muscle relaxer, is used in conjunction with rest and physical therapy to treat muscle spasms caused by acute muscle and skeletal disorders. It’s only meant to be taken for a few weeks. The muscle relaxant Flexeril) is a typical medicine for low back pain that is used to relieve muscular spasms in addition to non-narcotic analgesic pain management. However, studies have shown that improvements in low back pain symptoms occurred at all recorded periods, with a more significant effect observed in the first four days of therapy as unfavorable effects would indeed persist beyond the first few days. Thus, Flexeril treats back pain however comes with certain side effects (Chaffee DM. Cyclobenzaprine in the Treatment of Low Back Pain).
Is Flexeril a Controlled Substance?

Is Flexeril a Controlled Substance?

Flexeril, recognized by its generic name cyclobenzaprine, is a muscle relaxant. Flexeril is used along with physical therapy to treat skeletal muscle conditions such as pain injury or spasms. It works by blocking the nerve impulses or pain sensations that are being sent to the brain.

Flexeril side effects are minimal, but there are few long terms risks. Flexeril is currently not categorized as a controlled substance by the Drug Enforcement Administration (DEA). The drug has a slight potential for abuse due to its sedating effects.

People sometimes abuse Flexeril for its subjective high, categorized by feelings of sedations, relaxations, and mild euphoria. Flexeril is abused along with CNS depressants such as Alcohol, Benzodiazepines (Kaye, A.M. and Kaye, A.D., 2015).

coversation about flexeril a controlled substance
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Study on the Effects of Flexeril

A study on the effects of cyclobenzaprine in animals showed that cyclobenzaprine reduced or eliminated skeletal muscle hyperactivity. Cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle.

According to this research, cyclobenzaprine works mainly in the central nervous system at the brain stem level rather than the spinal cord. Still, its action on the latter may add to its total skeletal muscle relaxant activity. Evidence suggests that cyclobenzaprine has a net effect of reducing tonic somatic motor activity, affecting both the gamma and alpha motor systems (Linden, C.H., Mitchiner, J.C., Lindzon, R.D. and Rumack, B.H., 1983)

Flexeril Abused

Is Flexeril a Controlled Substance

Although Flexeril isn’t a controlled substance, it does possess slight abuse potential. The side effects of Flexeril abuse include:

  • Elevated heart rate.
  • Nausea.
  • Excessive drowsiness.
  • Dizziness.
  • Dry mouth.
  • Headache.
  • Confusion.
  • Impaired cognitive function.
  • Physiological dependence.

Data of Muscle Relaxers Being Abused

A search of skeletal muscle relaxant exposures reported to the Florida Poison Information Center Network from 2009 to 2012 was done to explore the potential shift in abuse or misuse of drugs after carisoprodol was categorized as a controlled substance. Intentional abuse of carisoprodol, cyclobenzaprine, and a combination of additional muscle relaxants were among the data gathered.

After carisoprodol was categorized as a controlled substance in 2012, there were 75 occurrences of carisoprodol exposure, compared to an average of 132 cases per year between 2009 and 2011. Surprisingly, the instances of cyclobenzaprine poisoning fell to 27 in 2012, down from an average of 36 per year between 2009 and 2011 (Witenko C, Moorman-Li R, Motycka C, et al).

How long does Flexeril Stay in your System?

How long does Flexeril Stay in your System?

Flexeril is a prescription-based muscle relaxant usually taken along with other medical treatments like rest and physical therapy. The way Flexeril works is by targeting the central nervous system. The drug causes the brain to change the way pain signals are sent across the body. The half-life of Flexeril is usually around 18 hours. It should generally leave your body after about four days since the last dose is taken. However, these are average numbers, and there can be differences. On average, Flexeril has a half-life range of 8037 hours. The amount of days Flexeril stays in your system depends on the half-life of Flexeril. If the half-life of Flexeril is around 8 hours, then it will usually take at least two days for the body to eliminate the drug completely; if the half-life is approximately 37 hours, then it will take 8 1/2 days for the body to eliminate the drug entirely. In most cases, it takes around four to five days for Flexeril to leave your system. (Darwish, M. and Xie, F., 2009)
two people conversation on how long does flexeril stay in your system

Factors Influencing the Stay of Flexeril

The stay of Flexeril can be influenced by various other factors, just like other drugs. The three main factors affecting how long Flexeril stays in your body are age, body weight, and hepatic functions. For example, it will take longer for an elderly patient and also patients with impaired hepatic function to eliminate Flexeril from the system. Metabolism rates of the body also affect the stay of Flexeril in your system. Usually, patients having a high metabolism rate eliminate the drug more quickly and people with higher body weights. Another factor that influences the stay is the amount of drug intake. If a patient is taking high dosages of Flexeril or is taking the drug more frequently, it will eliminate the drug more slowly than the usual rate because it accumulates in the body. (Winchell, G.A., King, J.D., Chavez‐Eng, C.M., Constanzer, M.L. and Korn, S.H., 2002)
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How does Flexeril Work?

Flexeril belongs to a class of medicines called muscle relaxants. Flexeril contains the active ingredient cyclobenzaprine, a muscle relaxer that works in the central nervous system (CNS), indirectly influencing the motor neurons. It relaxes the muscles by reducing the muscle hyperactivity on the motor system, the nerve cells that directly connect to the skeletal muscle and are responsible for muscle contraction. It effectively treats muscle strains and sprains by relaxing the ultra-tight muscles. (Cyclobenzaprine: a possible mechanism of action)

Side effects of Flexeril

Side effects of Flexeril

The common Flexeril side effects include:

  • Headache.
  • Dry mouth.
  • Drowsiness/ dizziness/ tiredness.
  • Upset stomach,
  • Constipation,
  • Nausea.

Severe symptoms you should look out for:

  • Chest pain
  • Pain/ pressure spreading to your jaw or shoulder.
  • Sudden numbness.
  • Balance problems.
  • Slurred speech.
  • Fast or irregular heartbeats.

Seek immediate medical help you see any of these symptoms to avoid any fatality. Apart from these, you should also seek help from a medical professional if you start getting an allergy or see symptoms of serotonin syndrome like agitation, hallucination, fever, sweating, shivering, twitching, loss of coordination, fast heartbeat, etc.


Flexeril is an effective medicine used in the short term to treat a musculoskeletal medical condition. The time taken for Flexeril to be eliminated from the body differs from person to person. There are various other elements too that influence the stay of Flexeril in the system. Although on average, it takes around 4-5 days for Flexeril to leave your system entirely. Although Flexeril is an excellent drug, it can get addictive after a point and hence should be used only if your doctor prescribes it.

The Risks of Mixing Flexeril and Alcohol

The Risks of Mixing Flexeril and Alcohol

Flexeril (Cyclobenzaprine) is a sedative.It belongs to a class of drugs called Skeletal muscle relaxants. It works by stopping pain feelings (nervous impulses) from reaching your brain. Flexeril is used in conjunction with rest and physical therapy to treat skeletal muscle disorders such as pain, damage, or spasms.

two people conversation about risk of mixing Flexeril and Alcohol

Effects Of Mixing Alcohol And Flexeril

Flexeril is an efficient pharmacological treatment for muscle spasms and discomfort, but it can raise the risk of side effects and dependency when used with alcohol. Both depress the central nervous system and produce sleepiness, dizziness, slower mental processing, and impaired motor coordination. However, mixing the two narcotics can dramatically intensify these and other symptoms and increase the risk of accidents. Both substances have a significant tendency to promote physiological dependence, and mixing the two substances enhances the risk of abuse and addiction. (Messiha, F.S. and Barnes, C.D., 1979)

Side effects of Mixing Flexeril and Alcohol

If you have hives, difficulty breathing, or swelling of your face, lips, tongue, or throat as a result of an allergic reaction to Flexeril, seek medical attention right away.

The Risks of Mixing Flexeril and Alcohol

The common side effects of Flexeril include: 

  • Blurred vision
  • Dizziness
  • Drowsiness
  • Lightheadedness
  • Dryness of the mouth

Flexeril can also have significant adverse effects, such as:

  • Fast or irregular heartbeats 
  • chest pain or pressure
  • pain spreading to your jaw or shoulder
  • abrupt numbness or weakness 
  • slurred speech
  • balance issues 

How to Consume Flexeril?

Read all drug guides or instruction sheets and follow all guidelines on your prescription label. As advised by your healthcare professional, take this medication by mouth with or without food. Do not raise your dosage or take this medication more frequently or for longer than recommended. Your condition won’t improve any faster, and you’ll be more vulnerable to side effects. Do not crush, chew, break, or open the capsule; instead, swallow it whole. Each day, take the drug at the same time. If your symptoms do not improve or worsen after three weeks, see your doctor. (Cimolai, N., 2009)

Safety Measures

  • Tell your healthcare professional if you are allergic to it or any of the substances in the tablet or capsule.
  • Tell your doctor if you have increased intraocular pressure or glaucoma, difficulty urinating, or liver disease.
  • If you’re 65 or older, consult your doctor about the dangers and advantages of taking this supplement. It is not advised for usage by older adults since it is not as safe or effective as other drugs for the same disease.
  • If you’ve recently had a heart attack or have an overactive thyroid gland, tell your doctor: heart failure, irregular heartbeat, heart block, or other electrical impulse abnormalities in your heart. Most likely, your healthcare professional will advise you not to take this medication.
  • If you are using or have just discontinued taking any of the medications, please tell your doctor.
  • Interactions between drugs can alter how they work or put you at risk for significant side effects. One substance that may interact with this drug is tricyclic antidepressants.
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Like Soma with alcohol and Robaxin with alcohol, While taking Flexeril, you should avoid or limit your alcohol consumption. Use Flexeril only as directed, and avoid tasks that need mental alertness, such as driving until you know how the medicine affects you. Talk to your healthcare professional, if you have any more queries.

Is it Safe to Consume Flexeril and Ibuprofen together?

Is it Safe to Consume Flexeril and Ibuprofen together?

Flexeril is a drug used as a medication for muscle spasms which is generically known as Cyclobenzaprine. It is an oral medication available in the form of tablets, capsules, and liquid. It was approved by the FDA in 1977 and has been used since then. It works against the pain and discomfort caused by muscle injuries and muscle strains. Flexeril fights against the pain by decreasing the incoming signals coming to the muscles from the brain about the pain. The main motive of Flexeril is to help the muscles to relax along with physical therapy and rest. (RELAXANT, S.M., 1981. FLEXERIL) On the other hand, Ibuprofen is an anti-inflammatory drug used to treat fever and pain caused due to headaches, dental pain, arthritis, or menstrual cramps. It is an oral medication that was approved in the year 1998. It is sold under the brand name Advil. It is available as tablets as well as gel. Ibuprofen can be used in combination with other medications as well.  Ibuprofen works by decreasing the Cyclooxygenase, the natural substance produced by the body that causes inflammation in the body. It also reduces minor aches and pains. (KANTOR, T.G., 1979. Ibuprofen)
two people talking about is it safe to consume Flexeril and Ibuprofen together

What if we Consume Flexeril and Ibuprofen together?

Flexeril is a muscle relaxer drug, while Ibuprofen is an anti-inflammatory drug. Using them together can cause no harm to the person. These two medications- Flexeril and Ibuprofen, don’t show any interactions. This does not imply that no interactions exist. Always seek the advice of your healthcare practitioner. When there is a large level of muscular discomfort, it is typical to combine a muscle relaxer with ibuprofen. Flexeril can make individuals sleepy throughout the day, so they only take it at night. The combination may cause some common side effects like drowsiness and lack of alertness. Thus, Flexeril and Ibuprofen can be used together as muscle relaxers and NSAIDs without harm. (Low-dose cyclobenzaprine versus combination therapy with ibuprofen)

What are the Uses of Flexeril and Ibuprofen?

Flexeril belongs to the drug class called Muscle relaxants. It works against the pain and discomfort caused by muscle injuries and muscle strains. Flexeril, also known as Cyclobenzaprine, can also be used with other medications as a combination.

Ibuprofen belongs to the drug class Nonsteroidal anti-inflammatory drug (NSAID), which helps treat fever and pain caused due to various disorders. It is available as tablets as well as gel. Ibuprofen can be used in combination with other medications as well. 

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What are the Warnings of Flexeril and Ibuprofen Together?

Warnings of flexeril and ibuprofen
  • Have heart block, congestive heart failure, heart disease, or had a recent heart attack.
  • Having a thyroid disorder.
  • Having difficulties while urinating.
  • Taken MAO inhibitor in the past 14 days.
  • Having high blood pressure
  • Having stomach problems and stomach ulcers
  • Having liver and kidney problems.
  • Over the age of 60.

What are the Side Effects?

Side Effects of flexeril and ibuprofen

Common side effects:

  • Drowsiness, tiredness
  • Headache, dizziness
  • Dry mouth
  • Upset stomach, nausea, constipation.

Serious side effects leading to termination of medication:

  • Chest pain, pain going in the shoulder and jaw.
  • Balance problems, numbness on one side of the body.
  • Irregular and fast heartbeats.


Consuming any medication together could be harmful for individual. Although this can lead to serious side effects like drowsiness and nausea. There is no interaction found between Flexeril and Ibuprofen together still you should always consult a doctor before consuming any medication. 

Does Flexeril Cause Weight Gain?

Does Flexeril Cause Weight Gain?

Flexeril is a medication used to treat muscle spasms from musculoskeletal conditions. The generic name of the drug is Cyclobenzaprine. It comes under the drug class called Skeletal muscle relaxants. FDA approved it in the year 1977 for medical purposes in the United States.

Flexeril is a muscle relaxant drug used to treat conditions related to skeletal muscle, such as pain, injury, or spasms. Flexeril works by blocking the pain sensations that are sent to your brain. Once the pain sensations are blocked on the way, the body starts feeling a sense of relief from the pain.

Flexeril is only available in the form of tablets of 5mg and 10 mg each. Most patients are recommended with a 5 mg of dose thrice a day. Based on patients’ condition and response, the dosage can be increased to 10 mg three times a day.

The dosage completely depends upon an individual’s health condition, age, gender, and medical history. Follow your doctor’s instructions while dosing.

two people conversation about Flexeril Cause Weight Gain

Flexeril and Weight Gain

Muscle relaxers like Carisoprodol and Flexeril depress your central nervous system and slow down many of the processes that make your body function. The medicine is generally prescribed for the short term of around 5-7 days.

Short-term use of these medications can begin a slight weight gain of 2 to 3 lbs. as you lessen your activities to recover from your injury. Prolong use or abuse of these medicines can provoke more significant weight gain as you remain to undergo a decrease in your overall physical activities.

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Can Muscle Relaxers Cause Weight Gain?

Can Muscle Relaxers cause Weight Gain

Weight gain can be one of the side effects of muscle relaxer. It does not directly affect the weight; the decreased mobility of the injury and the effects of the medicines can result in weight gain as a result of decreased activity to relax the body.

The medication slowdowns the process of the body that results in weight gain in the person.

Side Effects of Flexeril

Side Effects of Flexeril

Flexeril carries some side effects too. The side effects can be sometimes general and can be dangerous too. It is good to know all the side effects to take proper care of. Common side effects:

  • Drowsiness
  • tiredness
  • Headache
  • dizziness.
  • Dry mouth.
  • Upset stomach
  • nausea
  • constipation

Get medical assistance if you have allergic reactions like- hives, difficult breathing, swelling of your face, lips, tongue, or throat. Stop using the drug if you undergo side effects like:

  • Fast or irregular heartbeats
  • Chest pain or pressure, pain spreading to your jaw or shoulder
  • Sudden numbness or weakness, slurred speech, balance problems.

The above-mentioned is not the complete list of the side effects. If you are experiencing anything apart from the side effects mentioned, do not hesitate to visit your health care service provider.


  • Flexeril should not be used if your thyroid disorder, heart block, congestive heart failure, a heart rhythm disorder, or you have recently had a heart attack.
  • Do not consume if you have taken MAO inhibitor in the past 14 days.
  • Brief your physician about your health condition, especially if you have a thyroid disorder, heart block, heart rhythm disorder, congestive heart failure, or recently had a heart attack.
  • The safety of the medicine has not been established for people under 15 years old.
  • Avoid taking alcohol while on these medications.


Flexeril is the muscle relaxant. The drug helps people who are undergoing any muscle problems. Studies show that the drug can be the reason for the weight gain in your body, and it causes weight gain in the person taking the drug.

Always consult your doctor regarding any of the information, our physician is the best person to solve all your queries and support you in any health situation.

RELAXANT, S.M., 1979. FLEXERIL. CMA JOURNAL120. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1818972/ Accessed on 21/09/2021