Is Zanaflex a Controlled Substance?

Is Zanaflex a Controlled Substance?

Spasms and increased muscle tone caused by sclerosis, stroke, or brain or spinal injury are treated with Zanaflex (Tizanidine). Zanaflex belongs to the skeletal muscle relaxant class of drugs. It works by allowing the brain and nerve system to slow down and relax the muscles.

According to the DEA, Zanaflex is not a controlled substance. Some people, like those who abuse other muscle relaxants, may abuse this one as well. Zanaflex is a therapy option for a brief period of time. Long-term use can develop into abuse and dependency, as well as addictive habits(Leonard, P. and Valaer, C., 2014).

What Schedule Class is Tizanidine?

Zanaflex belongs to the Central Alpha-2-Adrenergic Agonist class of medicines. Alpha-2 agonists that operate centrally stimulate the central nervous system’s alpha-2 adrenoceptors. Sympathetic nervous system activity reduces when alpha-2 receptors are activated.

conversation of two people on zanaflex is controlled substance or not

Is Tizanidine a Narcotic?

The fact that Tizanidine is not a narcotic appeal to many people who require relief from muscle spasms. Despite the fact that Tizanidine is not a narcotic, it does cause some people to get addicted to it. The way it acts in your body distinguishes it from a narcotic. Instead of attaching directly to pain receptors, it inhibits nerve receptors at the muscle level. This creates the erroneous impression that Tizanidine cannot be abused(Levy, R.M., 1995).

Is Tizanidine a Strong Muscle Relaxer?

A systematic review compared and contrasted 46 trials (both randomized and placebo-controlled), the majority of which focused on low back pain or neck disorders. The placebo-controlled trials were largely completed more than 15 years ago and included 17 on cyclobenzaprine, six on Tizanidine, four on carisoprodol, and four on orphenadrine.

In general, all of the medications were found to be beneficial in some way. There was no significant difference between Tizanidine and chlorzoxazone (Parafon Forte) for back spasms in a fair-quality trial.

To summarise, Tizanidine is a powerful muscle relaxant; however, there is little evidence to suggest that it is superior to other muscle relaxants(Bryson, H.M., 1997).

Strength and Dosage

Is Zanaflex a Controlled Substance

Zanaflex is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg.

The initial dose is recommended to be 2 mg. Because Zanaflex’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours

To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg.

Side Effects

  • Dry mouth
  • Drowsiness
  • Dizziness
  • Muscle weakness
  • Back pain
  • Increased muscle tone or spasms
  • Sweating
  • Nervousness
  • Numbness or tingling
  • Stomach pain
  • Diarrhea
  • constipation
  • vomiting

Drug Interactions

Zanaflex is mostly metabolizd in the liver by the CYP1A2 enzyme. Zanaflex levels in the body can be increased by drugs that block or inhibit this enzyme. Increased medication levels might cause sleepiness and dizziness, among other side effects. CYP1A2 inhibitors like ciprofloxacin and cimetidine, as well as birth control pills containing Ethinyl estradiol, should be avoided when taking Zanaflex. Zanaflex may interact with drugs that depress the central nervous system. Barbiturates, opioids, and benzodiazepines are examples of these medications. Zanaflex might intensify their effects, causing dizziness and sedation(Bouchard, S., Tansey, C., Gendron, D., Barkas, W.J. and Francis, G.S., 1987).
Is Flexeril a Controlled Substance?

Is Flexeril a Controlled Substance?

Flexeril, recognized by its generic name cyclobenzaprine, is a muscle relaxant. Flexeril is used along with physical therapy to treat skeletal muscle conditions such as pain injury or spasms. It works by blocking the nerve impulses or pain sensations that are being sent to the brain.

Flexeril side effects are minimal, but there are few long terms risks. Flexeril is currently not categorized as a controlled substance by the Drug Enforcement Administration (DEA). The drug has a slight potential for abuse due to its sedating effects.

People sometimes abuse Flexeril for its subjective high, categorized by feelings of sedations, relaxations, and mild euphoria. Flexeril is abused along with CNS depressants such as Alcohol, Benzodiazepines (Kaye, A.M. and Kaye, A.D., 2015).

coversation about flexeril a controlled substance
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Study on the Effects of Flexeril

A study on the effects of cyclobenzaprine in animals showed that cyclobenzaprine reduced or eliminated skeletal muscle hyperactivity. Cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle.

According to this research, cyclobenzaprine works mainly in the central nervous system at the brain stem level rather than the spinal cord. Still, its action on the latter may add to its total skeletal muscle relaxant activity. Evidence suggests that cyclobenzaprine has a net effect of reducing tonic somatic motor activity, affecting both the gamma and alpha motor systems (Linden, C.H., Mitchiner, J.C., Lindzon, R.D. and Rumack, B.H., 1983)

Flexeril Abused

Is Flexeril a Controlled Substance

Although Flexeril isn’t a controlled substance, it does possess slight abuse potential. The side effects of Flexeril abuse include:

  • Elevated heart rate.
  • Nausea.
  • Excessive drowsiness.
  • Dizziness.
  • Dry mouth.
  • Headache.
  • Confusion.
  • Impaired cognitive function.
  • Physiological dependence.

Data of Muscle Relaxers Being Abused

A search of skeletal muscle relaxant exposures reported to the Florida Poison Information Center Network from 2009 to 2012 was done to explore the potential shift in abuse or misuse of drugs after carisoprodol was categorized as a controlled substance. Intentional abuse of carisoprodol, cyclobenzaprine, and a combination of additional muscle relaxants were among the data gathered.

After carisoprodol was categorized as a controlled substance in 2012, there were 75 occurrences of carisoprodol exposure, compared to an average of 132 cases per year between 2009 and 2011. Surprisingly, the instances of cyclobenzaprine poisoning fell to 27 in 2012, down from an average of 36 per year between 2009 and 2011 (Witenko C, Moorman-Li R, Motycka C, et al).

Is Robaxin (Methocarbamol) a Controlled Substance?

Is Robaxin (Methocarbamol) a Controlled Substance?

Robaxin was approved on 6th October 1959 by the FDA (Food and Drug Administration). The effect of the drug generally begins within half an hour after consumption. One can take it by mouth or by injection. Geriatric patients should not take the drug. FDA labels the medication as a pregnancy C category.

Methocarbamol interacts with other central nervous system depressants (prescription painkillers, cough and cold medications, sedatives, sleeping pills, and anxiety medications) to enhance their effect when taken orally. Methocarbamol is not an opioid, benzodiazepine, or other prescription medicines used to treat pain or convulsions. Methocarbamol is not a controlled substance in the United States, so its potential for abuse or addiction is low. Like any substance, however, it can be misused and used in ways that are not intended.

Diseases such as kidney or liver disease can also influence the metabolic processes of methocarbamol. A 2014 review of skeletal muscle relaxants found that the first-line drugs were not as effective as muscle relaxants at first. Muscle relaxants were more effective than placebos for short-term relief, but the risk of side effects was 50%.
In 2018, it was the 120th most commonly directed medicine in the United States, with higher than 5 million prescriptions.

Robaxin and Carisoprodol is schedule IV drug used to relieve pain in muscles and relax them. Robaxin got approval in the year 1959 by FDA (Food and Drug Administration).

two people conversation on robaxin a controlled substance
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What kind of drug is Robaxin?

What kind of drug is Robaxin

Robaxin belongs to the drug group called Skeletal Muscle Relaxants. It is sold under the brand names of other medicines and is used for short-term musculoskeletal pain.
The medicine is prescribed to treat the symptoms of muscle spasms caused by pain or injury. It is used along with some rest, physical therapy, and other treatment to support it. It acts to relax the muscles to relieve the pain.
It can be injected intravenously and has positive effects in controlling neuromuscular spasms caused by tetanus.

Robaxin injection is at times utilized in the treatment of tetanus, which produces painful tightening of the muscles.
The mechanism of action in humans is not yet established. It is assumed to operate, depressing the central nervous system, leading to the relaxation of muscles.
It is not beneficial in chronic neurological diseases, such as cerebral palsy or different dyskinesia’s.

Does Robaxin make you high?

According to studies, and observation under clinic trials, the drug can induce dizziness and drowsiness as they are some of its general side effects and can be misinterpreted as high. Considering the dizziness, one should take care that after using Robaxin, the person should not be involved or get included in any task that demands mental alertness, for example, driving or activity on any hazardous machine.
The medicine is not frequently abused.
People with a history of substance abuse or addiction are more likely to be abused and become dependent on Robaxin. Such as Snorting or smoking Carisoprodol can increase their effectiveness and deliver a strong high. Patients with a history of substance abuse are more likely to be addicted. Robaxin can be purchased without a prescription, and it can be misused to make a habit.

Is Robaxin a Narcotic?

Robaxin is not a narcotic. It is a muscle relaxant and is used to cure pain. According to studies and proven clinical trials, the drug can make you dizzy and drowsy, which can be misunderstood as high on the drug.


Robaxin is utilized to treat the symptoms of muscle spasms caused by pain. The safety and effectiveness of the drug in kids older than 16 years have not been authenticated yet.
Every drug has its benefits and limitations. Likewise, every drug has specific side effects; some get improved on time, but some get worse; in such cases, medical help should be taken, and conditions should not be taken for granted. Drug abuse should not be done as it may lead to a serious impact on the body. Never share or take medicine from other people, even if there is a similarity in symptoms. Use the drugs only when prescribed by doctors.
For some, the drug may not be the fittest option. Talk to your doctor about your concerns and brief them about your medical conditions. After conducting a proper check-up and examination, the physician will direct the most suitable prescription for you.


Witenko, C., Moorman-Li, R., Motycka, C., Duane, K., Hincapie-Castillo, J., Leonard, P., & Valaer, C. (2014). Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P & T: a peer-reviewed journal for formulary management39(6), 427–435. Available at: Accessed on 14/08/2021 Accessed on 14/08/2021

Is Carisoprodol (Soma) a Controlled Substance in the USA

Is Carisoprodol (Soma) a Controlled Substance in the USA

A controlled substance is a drug or medication that is labeled as illicit due to its addictive nature. The government restricts its manufacture, use, and possession. Such medications can only be acquired through a doctor’s prescription that too when is considered extremely necessary.

Because of Soma’s potential for abuse, Soma is a controlled substance in 18 U.S. states: 

  • Alabama       
  • Arizona
  • Arkansas
  • Florida
  • Georgia
  • Hawaii
  • Indiana
  • Kentucky
  • Louisiana
  • Nevada
  • New Mexico
  • Oklahoma
  • Oregon
  • Texas
  • Utah
  • Washington
  • West Virginia
  • Wyoming. 

The U.S. drug enforcement agency listed Soma as a drug of concern and is conducting hearings to determine whether it should be classified at the federal level as a control substance. 


Is Soma a Schedule 1 drug?

is soma a schedule one drug

In December 2011, the Drug Enforcement Agency decided to control the drug as a Schedule I controlled substance under the Controlled Substances Act (C.S.A.). The D.E.A. (Drug Enforcement Agency) published a final rule (76 FR 77330) in the federal register that makes carisoprodol a Class I controlled substance.

Later on January 11, 2012, the D.E.A. (Drug Enforcement Agency) classified carisoprodol as a schedule IV controlled substance at the federal level. The final rule is that as of January 11, 2012, all prescription drugs containing carisoprodol must comply with 21 C.F.R. SS 130604. The medicines must also contain the information required under 21CFR. 
Schedule I drugs consist of medications or substances guaranteed to cause extreme addiction and pose a high risk of abuse.

What kind of drug is Carisoprodol?

Carisoprodol is a muscle relaxant that blocks pain sensations in the nerves of the brain. It is often used in resting and physiotherapy to treat skeletal muscles such as pain and injury. It is also used for recovery, physical therapy, and other measures to relax muscle strains and sprained muscle injuries. 

Carisoprodol is the most active and prominent substance present in Soma. Carisoprodol subject is to abuse, dependence, withdrawal, abuse, and criminal diversion. As Soma induces a calming effect, other C.N.S. depressants like alcohol, benzodiazepines, opioids, and tricyclic antidepressants may be additives.

For high quality Soma (Carisoprodol) at a reasonable cost

Is Carisoprodol 350 mg a Narcotic?

is soma narcotic

The typical 350 mg dose is unlikely to cause any prominent side effects except drowsiness, mild to significant euphoria, and dysphoria, but these effects are short-lived due to the rapid metabolism of carisoprodol with meprobamate and other metabolites and are largely due to its inherent anxiolytic solid effect, strong enough to produce its primary metabolite meprobamate, which is falsely blamed for the intense effects of the metabolite.

Although Soma is not a narcotic such as opioids, benzodiazepines, or barbiturates as a controlled substance, it can be used with these drugs in combination to enhance its effect with significant negative effects.

The overconsumption of carisoprodol and other medications will make you drowsy or decrease your breathing rate and can cause severe side effects, which could even lead to death. Some medications may affect your blood level or other medications you take, which may exacerbate side effects or make the medication less effective.

Suddenly halting the use of carisoprodol will make you experience severe withdrawal symptoms like insomnia, vomiting, abdominal pain, headaches, tremors, twitching, ataxia, hallucinations, and psychosis.

Does Carisoprodol make you high?

Yes, carisoprodol can get you high, but the effects won’t be severe as Soma does not fall in the narcotics category of medications. 

When utilized for the treatment of musculoskeletal pain will give a brief euphoric phase while taking effect to relieve muscle tension. The intensity of its speedy action provides users a high, euphoric feeling known as a soma-high feeling. Due to its toxic effects, doctors usually prescribe carisoprodol for up to three weeks.
Misuse of the drug carries the risk of overdose, leading to death due to C.N.S. depression (respiratory diseases), hypotension, seizures, and other overdose disorders. 


Yan Li, Chris Delcher, Joshua D. Brown, Yu-Jung Wei, Gary M. Reisfield, Almut G. Winterstein, Impact of Schedule IV controlled substance classification on carisoprodol utilization in the United States: An interrupted time series analysis,
Drug and Alcohol Dependence,