Methocarbamol for Menstrual Cramps

Methocarbamol for Menstrual Cramps

Methocarbamol is used for the treatment of muscle pain and injuries. It is used to deal with pain for a short period of time. Robaxin is the brand name of Methocarbamol. It helps deal with various types of pain, such as back pain and tooth pain.

Can Methocarbamol be used for Menstrual Cramps?

Methocarbamol is used against various pain. It is observed that Methocarbamol can be used as an off-label treatment for menstrual cramps as it is not mainly used for it.

Magnesium plays an important role in dealing with menstrual cramps. Medications used for menstrual cramps have magnesium as their ingredient, and it is observed effective. Similarly, Methocarbamol also has magnesium as one of its ingredients and can be used to relieve menstrual cramps or period pain.

After getting medical advice, one can take Methocarbamol for menstrual pain only because it is an off-label treatment and not prescribed primarily for menstrual cramps (Guerrera, M.P., Volpe, S.L. and Mao, J.J., 2009).

Conversation of two people on methocarbamol for menstrual cramps

How it Works?

Methocarbamol works by affecting nerve impulses. These nerve impulses travel to the brain to inform about the pain. But because of Methocarbamol, these nerve signals get blocked from reaching the brain.

This results in the relaxing of muscles and slows down the central nervous system’s activity, and relieves pain (Sibrack, J. and Hammer, R., 2020).

Forms and strengths

Methocarbamol is available as tablets and oral solutions to be taken orally. It is also in injectable solutions that can be taken intramuscularly or intravenously.

Methocarbamol tablets are available in 500 mg and 700 mg strengths, while injectable solution strength is 100 mg/ml.

How to take it?

Methocarbamol can be consumed before or after eating food. The tablet form should be taken as a whole without crushing or breaking it. The injection should be appropriately taken intravenously or intramuscularly.

The medicine should be taken only as directed by the doctor. The dosage can be increased or decreased depending on the treatment response (Sibrack, J. and Hammer, R., 2020).

Dosage

Tablet dosage for adults:

1500 mg is the initial dose which has to be taken 4 times a day. This dosage has to be followed for 3 to 4 days.

1000 mg per day is the maintenance dose, taken 4 times daily.

Injection dosage for adults:

The initial dose is 1 g taken intravenously or intramuscularly every 8 hours.

The maximum injection limit should not be more than 3 g per day.

Injections should not be used for more than 3 days.

Who should not take it?

One should not take Methocarbamol if:

  • Below the age of 16
  • Liver and kidney disorders
  • Allergic to Methocarbamol
  • Seizures
  • Suffering from Myasthenia Gravis
  • Breastfeeding women

Taking Methocarbamol can lead to adverse effects if you face any of these problems. Get medical help before taking it.

Side Effects

Following are some severe side effects which are associated with Methocarbamol:

  • Blood clots
  • Skin rashes
  • Seizures
  • Change in the heartbeat pattern
  • Breathing problems
  • Swelling

It is advised to take emergency medical help on observing such side effects to prevent further risks.

Warnings

Please inform your doctor if you are taking the following medicines:

  • Pain relief medicines
  • Sleeping pills
  • Medications for depression-like Valium and Zoloft.
  • OTC medicines
  • Herbal medicines

These medicines may interact with Methocarbamol and cause trouble with side effects.

Conclusion

Methocarbamol is an effective muscle relaxer and is widely used for muscle pain and spasms. It can be used for menstrual cramps as an off-label treatment. Please consult your doctor before taking Methocarbamol for menstrual cramps to know whether it is safe or not for you to take.

Does Neurontin (Gabapentin) Cause Weight Gain?

Does Neurontin (Gabapentin) Cause Weight Gain?

Neurontin is an anticonvulsant and anti-epileptic medication. It works by affecting the chemicals and neurons that produce seizures and some forms of pain. The generic name of the brand Neurontin is Gabapentin.

Neurontin (Gabapentin) can cause weight gain to some people; however, this side effect is quite rare. Neurontin use may increase appetite and water retention, mainly in the arms, hands, legs, and feet, causing weight gain in some people. 

A study conducted at the neurology department in Miami, Florida, concluded that some people could gain weight. The study was conducted to see the changes in body weight with high doses of Neurontin. However, it also found that some people lost weight while many were unaffected in terms of weight changes (Changes in Body Weight With Chronic, High-Dose Gabapentin Therapy, Therapeutic Drug Monitoring)

Factors that Affect Weight Gain

A few factors might affect weight gain to some people while on Neurontin. The sudden increase in appetite is a significant contributing factor while taking this medication. Consuming more calories than you burn will increase body weight.  

Fluid retention is another side effect caused by Neurontin linked to weight gain. The use of Neurontin also causes fatigue which makes it harder to get out of bed for exercise. 

How much do people gain weight when on Neurontin?

According to the study mentioned in this article; the weight changes were as follows: Of the total 44 patients, ten patients gained 10% in body weight, 15 patients gained 5%-10% off in their body weight. 

How could I know if Neurontin is making me gain weight?

It is not always the same factors that affect everyone the same way to gain weight while on Neurontin. There are certain factors however that are common and mostly seen for weight gain.

Here are a few of the major reasons that affect weight gain:

  • Changes in Appetite

Some people may face an increase in appetite due to the use of Neurontin and certain antidepressants. That can result in people eating more than usual. Doing so can increase in weight especially if the person is not working out or eating unhealthy. 

  • Fluid retention

Certain medications can make our body hold sodium that makes the body hold fluids as well. This makes us gain weight as the water weight adds more pounds. Since edema is a possible side effect, it can be the reason for your weight gain.  

  • Difficulty in exercising

Neurontin and other antidepressants make us sleepy and fatigued. It is harder to exercise when you are fatigued which might contribute to an increase in weight. 

You can see to it if there are any changes or symptoms of weight gain occurring to you while on Neurontin. Self-diagnosis can sometimes be useful in such situations. However, when faced with severe levels of any side effects it is always better to see a doctor. 

How do other Medications like Neurontin cause weight gain?

There are certain types of medications similar to Neurontin that can cause weight gain. Here are the reasons why.

  • Increased fat storage

For example; medication like Insulin which shows an anti-depressant-like effect can make the cells in our body hold on and store fat. Insulin is a growth hormone that affects how our body stores fat. An increase in fat storage is bound to cause weight gain.

  • Fluid retention

Certain diabetic medications have the property to retain sodium. The retention of salt causes the body to hold on to water causing an increase in the water weight of a person.

  • Increased appetite

Like Neurontin, other antidepressants and corticosteroids are known to increase appetite in some people. If an individual does not pay attention to exercising and healthy eating, they are bound to gain weight.  

  • Slows the metabolism

Metabolism plays an important role in calorie breakdown. Certain medications like beta-blockers are found to slow down the metabolism of the body. This results in lowering the rate at which the calorie is broken down for energy. This causes weight gain in some people. 

  • Difficulty in exercising

Antidepressants and antihistamines have common side-effect of tiredness and dizziness. It makes it difficult to work out when you don’t feel like exercising. Skipping exercises and eating unhealthy causes weight gain. 

Other side effects caused by Neurontin

Some side effects of Neurontin are:

  • Weak or shallow breathing
  • Blue colored skin
  • Confusion
  • Increased seizures
  • Fever
  • Headache
  • Nausea and vomiting

There are other side effects not mentioned in this article. We advise you to consult a doctor if faced with any side effects. 

Precautions you need to take while using Neurontin

You must tell your doctor of any pre-existing health conditions or if you are allergic to Neurontin. This medication might have some ingredients that may cause side effects that you are unaware of. 

Drinking alcohol or using other drugs that cause dizziness is highly unadvised, while using Neurontin medication may increase its side effects. Avoid driving vehicles or operating heavy machinery that requires high alertness.

Having the habit of practicing healthy living and working out can help reduce the risk of any adverse side effects.  

Here are some conditions where you should be extra careful while using Neurontin:

  • Kidney diseases
  • Diabetes
  • Breathing problems
  • Depression
  • Any drug addiction
  • Seizures
  • Liver diseases
  • Heart diseases

Conclusion

Neurontin may indeed cause weight gain. However, it is an infrequent side effect. Studies have found Neurontin to cause weight gain and weight loss in few people. Most people do not show changes in weight after using Neurontin. 

Does Gabapentin Help with Anxiety?

Does Gabapentin Help with Anxiety?

Gabapentin is a drug used for people who have epilepsy, treating seizures. Neuropathic pains are treated with Gabapentin. There are different neuropathic pains caused by viral infections and herpes zoster in adults.

Gralise, Horizant, Neurontin, Gaborone. are the brand names for the medicine, whereas Gabapentin is a generic name. Drug class of Gabapentin is Gamma-aminobutyric acid analogs.

How does Gabapentin Help with Anxiety?

Gabapentin is a drug used in treating nerve pains. Anxieties have different issues involved, such as headaches, uneasiness in the body, fear of unrealistic things, and over imagination, leading to overthinking. Gabapentin works in a short form, which means Gabapentin does not operate fully on anxiety issues but works as a symptom reliever.

This study was made by Rachel K Berlin et al. for a psychiatric disorder. To study the Therapy in psychiatric disorders using Gabapentin.

There were 18 patients involved in this study. These 18 people are facing different anxiety disorders, in which one person was having Generalized Anxiety Disorder. These people were observed by giving the dosage of Gabapentin and diazepam every 3 months of follow-up. This study happened for 196 days keeping the patients in observation.

Gabapentin has a different mechanism that works for the body. It helps in overcoming anxiety issues but not wholly. It helps make the patients less effective with the anxiety issues but doesn’t solve the whole anxiety issues. It helps in curing a few disorders of anxiety (Berlin, R.K., Butler, P.M. and Perloff, M.D., 2015).

How Long Does Gabapentin Take to Work for Anxiety

Every person takes a different time process in curing themselves. Individuals take as per their body’s reaction to the drug, whereas the medicine can help the person heal within a week, or it may take months to get out of the situation depending on the reaction of the drug.

Gabapentin works around 6 hours after consuming, 3 to 4 times a day depending upon the doctor’s prescription (Khezri, M.B., Oladi, M.R. and Atlasbaf, A., 2013).

How Gabapentin Is Used to Treat Mixed Bipolar State

Gabapentin has antidepressant and anti-maniac properties. It helps in some way or another by stopping the nervous system by blocking the chemical cells, which is terrible for the brain. This helps by treating some disorders if gabapentin is taken (Khezri, M.B., Oladi, M.R. and Atlasbaf, A., 2013).

What if I Miss a Dose?

It’s ok to miss a dose, but consuming it two can lead to problems. Have medications with a time gap suggested by the doctor; if you miss, then have the next dose but not double the older dose.

What if I Overdose?

There are different serious conditions built up for the person who has consumed double or overdosed. There are issues such as the person might have a doubled vision focus and lack of concentration to which a person might fall off and face many other problems. If you overdosed, or see any issues, call the doctor as soon as possible.

Forms and strengths

Forms

Strengths

Tablet

600mg,800mg

Capsule

100mg, 200mg, 250mg

Liquid

250mg

Dosage (Partial onset seizures)

Adult (18-64 years)

Start of the dose-

900mg (300mg per dose)

 

Max dose- 2400mg- 3600mg per day

Child (12-17 years)

Start of the dose-

900mg (300mg per dose)

 

Continuity dose-

900mg – 1800mg (divided into 3 times a day)

 

Max dose-

2400mg- 3600mg per day

Child (3-11 years)

Start of the dose-

10mg-15mg per day

Child (0-2 years)

No dosage recommended

Senior Citizen (65+)

You will be prescribed as per doctors observation

Dosage (postherpetic neuralgia)

Adult (18-64 years)

Start of the dose-

Day1- 300mg

Day2- 600mg (300mg per dose)

Day3- 900mg (300mg per dose) (3 times)

 

Max Dose- 600mg per dose (1800mg per day)

Child (0-17 years)

There is no dosage recommended

Senior citizen (65+)

Dosage will be prescribed as per the doctor’s observation.

Consulting a doctor would be prescribed so that the doctor can thoroughly check and give the dosage accordingly.

Dosage (Stabilizing mood or antidepressant)

Adults (18-64 years)

900mg- 2000mg a day

 

Max dose may increase from person to person

Senior Citizen (65+)

Dosage will be prescribed as per doctor’s observation

Why is Gabapentin used for?

The Gabapentin drug treats nerve pains. It works against different problems such as rashes caused by chickenpox or viral infections, also called the herpes virus (Khezri, M.B., Oladi, M.R. and Atlasbaf, A., 2013).

How does Gabapentin work?

Gabapentin works by electrical changes in the brain and activities that happen through the chemicals in the brain known as neurotransmitters. It creates cells that fight against changes and pains created within (Khezri, M.B., Oladi, M.R. and Atlasbaf, A., 2013).

Ways to take Gabapentin?

Two forms of Gabapentin

  • Capsule and tablet form- It should be taken with water directly (You need to consume the medicine within a few days if you break into two)
  • Liquid form- A dosing cup should be used when taking the liquid state. (Do not measure with a normal housing spoon)

Before taking Medicines

For proper guidance of consuming medicine, you should inform a doctor of all the previous and present medications you’re taking.

  • Do not take Gabapentin if you are allergic to it.
  • If you’re facing any liver issues
  • If you are a diabetic person
  • If you are facing kidney issues
  • If you have lung disease
  • If you do not breathe normally or your breathing rate is low.

What to avoid

There are a few things that should be avoided before taking Gabapentin. It might lead to severe situations in life.

  • While consuming Gabapentin, You should not take antacids before 2 hours of gap.
  • When you are on gabapentin medication, you should not drink alcohol
  • You should know your body level, which goes ups and downs if you are driving , which can lead to problems
  • It might cause you problems if you’re using heavy machinery or lifting heavy weights when you have Gabapentin.

What Non-Medication Therapies Treat Anxiety?

  • The person has to avoid the consumption of caffeine.
  • The person has to avoid consuming nicotine and alcohol to treat
  • The person should have the proper diet which has all the healthy products and a balanced diet.
  • The person’s consumption of water should be high.
  • The person should make self fit by doing proper exercises and making the body strong.
  • The person should have a full-time sleep. (not less than 8 hours)
  • Muscles should be relaxed, for which the person has to get a massage.
  • A person should have a relaxed life to which the person should practice techniques such as meditation, breathing techniques, yoga, acupuncture.
  • People can take supplements given by doctors or suggested by the doctors.
Tizanidine for back pain

Tizanidine for back pain

Tizanidine is a medicine used as a muscle relaxant. It works on different muscle pains. It tends to make the drug more powerful to use it. Muscle spasms are more painful for people; they act as a reliever for them. It has a drug class of skeletal muscle relaxants. Tizanidine is a Generic name, whereas the brand name is Zanaflex.

The drug is a muscle relaxant; it works as a pain reliever and is the cure for the pain. It works by obstructing the sensation of pain, which creates and passes to the brain. It helps block the pain through the spinal cord and makes the person more comfortable in the senses of pain (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

Study on the Effectiveness of Tizanidine for Back Pain

Study: A study was conducted by H Berry et al. to observe the back pain relief with Tizanidine and placebo with ibuprofen.

Aim: The study aims at observing the process of medicines and their safety and effectiveness for back pains.

Method: This study was conducted for 7 days, including 105 patients., They were divided into different groups to observe the effectiveness of Tizanidine and placebo with ibuprofen. Half the patients were given 4mg tizanidine 3 times a day and 400mg of ibuprofen 3 times a day. This process was observed on the 3rd day and the 7th day to strictly observe the reliever’s comments on the process of getting them cured. This was followed by giving a daily diary to the patients to note down their pain levels. Patients who were there as volunteers were already having back pains, which helped the researcher know efficiently.

Results: After the two intervals of observation, the outcome came as Tizanidine working more efficiently and quicker than ibuprofen and placebo. This study shows that Tizanidine is more effective and works well on back pains. It can rely on curing back pains from moderate to mild (Berry H, Hutchinson DR)

study of tizanidine explained in infographics

How and When to take Tizanidine for Back Pain?

As Tizanidine comes in two forms: capsules and tablets, both have the same similarity of taking medicine orally. Medicine can be consumed without food and can be taken with food.

Tizanidine is a medicine that can be consumed at any time. But with a time gap of at least 6-8 hours. Tizanidine should be consumed as per the doctor’s recommendation (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

Dosage

Adults

  • At the Start of the dose- The doctor may prescribe you to take 2mg at every 6-8 hours of interval.
  • Continuity of dose- The doctor may prescribe you to increase the dosage by 2 to 4mg. Until the symptoms are controlled, you need to be under the doctor’s guidance.
  • Highest dose- A person should not exceed 3 doses within 24 hours

Pediatric

  • People below 18 years should not consume Tizanidine. It may cause side effects if consumed.

Senior citizen (65 years and more)

  • The doctor does not always recommend it to consume Tizanidine as it is a powerful drug that might affect the kidneys more than the age of 65. It is a risk to give it to people who already have kidney issues that cannot be worked as other normal adults. Their kidneys might get weak to process the medicine.
  • If required, only after the doctor’s consultation, the doctor might prescribe to take the dose at the lowest power possible.

Every medication should be taken under the doctor’s guidance only. Otherwise, there could be worse situations build-up would not be suitable for health (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

What if I Skipped a Dose or Overdose?

It is ok if you skip the dose or miss a dose. An important thing to keep in mind, you should not have two doses at one time to cover up the previously missed dose.

There would be some of the effects found within you, such as fainting or having lightheadedness which can lead to headaches or getting confused about what you are doing, your body can get weak, and the biggest reason could be slow heart rate.

Who should avoid taking Tizanidine?

These people should avoid taking Tizanidine

  • If the person is already using fluvoxamine (medicine which is used for treating obsessive-compulsive disorder)
  • If the person is consuming ciprofloxacin (medication which is used in treating bacterial infections)
  • If the person is in the process of toning the muscles
  • If the person uses antidepressant medicines.
  • Before consuming medicine, you should inform the doctor about
  • If the person has any kidney-related issues
  • If the person has any liver-related issues
  • If the person has any heart-related issues

Pros and Cons

  • It helps in curing the muscles
  • It helps in making the muscle lose
  • It helps in taking off spasms
  • It helps in curing the spinal problems
  • People below 18 are not recommended to consume Tizanidine.
  • There might be a liver injury.
  • Psychotic symptoms can make the person more brain drained.
  • There might be allergies to the body.

Warnings

There are different medicines that affect the body if you take Tizanidine with it. There are possibilities of Tizanidine acting as a tool for death if taken with other drugs. It can also make the person feel sleepy a lot, which can also be unsuitable for body function.

You need to inform the doctor if you are using medication like:

  • Acyclovir: This medicine is used to treat different infections, as it’s an antiviral medicine
  • Ticlopidine: – This medicine is used to treat strokes and coronary stents.
  • Zileuton: This medicine is used in the treatments of asthma
  • Birth control pills: this medicine is used for not having babies and to control the birth of a child.
  • Antibiotics: These medicines are used for treating different bacterias in the body.
  • Blood pressure: These medicines are used to control blood pressure problems.
  • Heart rhythm medicine: These medicines are used for treating when the heart causes slow blood flow
  • Stomach acid medicine: These medicines are used for treating stomach-related issues.

Conclusion

Tizanidine works more efficiently for the back pains and cures them in the safest way possible. There are side effects too, which always have to be kept in mind; it might get a reaction if consumed without the doctor’s prescription. It works well for curing muscles and pains.

Diclofenac For Back Pain

Diclofenac For Back Pain

Diclofenac is classified as a nonsteroidal anti-inflammatory drug (NSAID) with the generic name Diclofenac sodium. It is used to treat conditions like mild to severe pain, fever, inflammation of tissues (red, swollen, and tender tissues), rheumatoid arthritis, back pain, and gout.

As Diclofenac can be used for any type of joint, muscle, and bone problems, it can be used to treat back pain (Todd, P.A. and Sorkin, E.M., 1988).

A Study on the Efficacy of Diclofenac in the Treatment of Back Pain

A study was conducted in the Department of Health Policy and Management/iMTA, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands, to determine the effect of Diclofenac over back pain. The patients were given Diclofenac (immediate-release) 2 doses daily of 75 mg, placebo paracetamol four daily doses. It was observed that Diclofenac is relatively effective and fast-acting in cases of back pain (Efficacy of paracetamol, diclofenac and advice for acute low back pain)
Conversation of patient and doctor on diclofenac for back pain

Mechanism Of Diclofenac

Diclofenac is responsible for the inhibition of cyclooxygenase-1 and -2, the enzymes that are responsible for the production of prostaglandin (PG) G2, the precursor to other prostaglandins. These are related to the activity in pain and inflammation, inhibition of which by Diclofenac relieves the pain.

This inhibition of COX (COX-1 and COX-2) activity decreases the synthesis of prostaglandins involved in the mediation of inflammation, pain, and swelling while it could cause gastrointestinal ulceration, respectively (Todd, P.A. and Sorkin, E.M., 1988).

Half life and how long does it take Work?

The half-life of Diclofenac on a general basis is of 2 hours. However, depending upon the condition and medical history, it could be extended to 25-33 hours. Consumed orally, Diclofenac takes about 20 to 30 minutes to initiate its action, and in about one to two hours, the full effect is observed.

In the case of Diclofenac gel, it takes approximately 1 to 2 days to start working. To reach peak concentration, it could take up to 7 days, depending upon how severe the condition is (Todd, P.A. and Sorkin, E.M., 1988).

Forms And Strengths

Diclofenac is available in the forms of packets, regular tablets, delayed and extended-release tablets, and capsules.

Diclofenac sodium is available in the strengths of 25, 50, and 75mg delayed-release tablets, 100 mg extended-release tablets, and 18 and 35 mg capsules.

Diclofenac potassium is available in the strengths of 50mg single dose packet, 50 mg generic tablets, and 25mg capsules (Todd, P.A. and Sorkin, E.M., 1988).

Dosage

For Rheumatoid Arthritis

Standardized adult dosage:

  • Diclofenac sodium- 50 mg divided into an eight-hour cycle or 75 mg divided into a 12-hour cycle.
  • Diclofenac potassium- 50 mg divided into 8-12 hour cycle.
  • Extended-release tablets- 100 mg once a day, can be increased to 100mg divided into a 12-hour cycle.

For Osteoarthritis

Standardized adult dosage:

  • Diclofenac sodium- 50 mg divided into an eight-hour cycle or 75 mg divided into a 12-hour cycle.
  • Diclofenac potassium- 50 mg divided into 8-12 hour cycle.
  • Extended-release tablets- 100 mg once a day, can be increased to 100mg divided into a 12-hour cycle.
  • Capsule (Zorvolex)-35 mg three times a day

For Ankylosing Spondylitis

Standardized adult dosage:

  • Diclofenac sodium- 25 mg to be taken four to five times a day
  • Diclofenac potassium- 50 mg divided into a twelve-hour cycle.

For Dysmenorrhea

Standardized Adult Dosage: 100 mg once a day, increasing by 50mg divided into an eight-hour cycle depending upon the condition.

For Acute Pain

Standardized adult dosage:

  • Regular tablets- 100 mg, increasing by 50 mg when required divided into an eight-hour cycle.
  • Extended-release tablets- 25 mg four times a day of Zipsor or 18-35 mg three times a day for Zorovolex.

NOTE: Diclofenac is advised in the acute pain cases for mild to moderate pain in adults

How To Consume Diclofenac?

Swallow Diclofenac capsules and tablets with water, juice, or milk. In case of consumption with water, consume Diclofenac after a snack or meal. Consumption of juice or milk is less likely to upset your stomach or irritate it. Do not chew, crush, or break the capsules. Consume the whole (Todd, P.A. and Sorkin, E.M., 1988).

What To Do If You Missed A Dose?

Diclofenac is used only when needed unless prescribed otherwise. Skip the dose that is missed if you are close to the next dosage. Do NOT consume a double dose to even it out.

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, shallow breathing, coughing up blood, fainting, or stroke.

Who Should Not Take Diclofenac?

If any of the below conditions sound relatable and familiar, it is not advised for you to consume Diclofenac. However, consulting the doctor before the decision would prove of help.

  • Allergy to aspirin
  • Allergy to any NSAIDs
  • Allergy to Diclofenac
  • Faced any side effects to NSAID such as wheezing, asthma, skin allergy
  • Suffered stomach ulcers
  • Have or had hypertension
  • Heart failures
  • Liver disease 
  • Kidney disease
  • Crohn’s disease
  • Ulcerative colitis
  • Lupus
  • Blood clotting disorder

If you are either pregnant or are breastfeeding, it is advised NOT to consume Diclofenac. Consult your doctor if you face any confusion.

Side Effects Of Diclofenac

Common side effects of Diclofenac include:

  • Gas
  • Indigestion
  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Constipation
  • Headache
  • Dizziness
  • Drowsiness
  • Abnormality in lab tests
  • Itching
  • Sweating
  • Stuffy nose
  • Increase in blood pressure
  • Swelling or pain in arms or legs

Consult your doctor or seek immediate attention in case you notice any of the following side effects to Diclofenac:

  • Skin rash, even if mild
  • Flu or flu-like symptoms
  • Heart problems such as shortness of breath, swelling, or rapid weight gain
  • Little or no urinating
  • Stinging or difficult urination
  • Stomach pain
  • Dark urine
  • Excessive fatigue
  • Jaundice
  • Bloody or tarry stools
  • Coughing up blood
  • Coffee ground look-alike vomit
  • Slurred speech
  • Burning eyes

Conclusion

Diclofenac is an NSAID (nonsteroidal anti-inflammatory drug) that is used for conditions like mild to severe pain, fever, inflammation of tissues (red, swollen, and tender tissues), rheumatoid arthritis, back pain, gout, and period cramps. It is useful and effective for both acute and chronic back pain problems. However, the visible effect may vary depending upon the condition.

Methocarbamol For Anxiety

Methocarbamol For Anxiety

Methocarbamol, a muscle relaxant, is used along with physiotherapy to treat conditions of skeletal muscles such as pain and injury. It is a type of central nervous system (CNS) depressant approved by the FDA in July 1957. Methocarbamol works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. Methocarbamol can be used for anxiety. In addition, the medication can affect the symptoms of depression (Jung, H. and Chae, H.K., 2019).

Study of Methocarbamol in the Treatment of Depression

In a study conducted to observe the effect of Meprobamate and Methocarbamol over anxiety and depression, it was noted that Methocarbamol was more suited for the treatment of depression than Meprobamate. A likely cause for depression could be stiff and tense muscles, especially the skeletal muscles. As Methocarbamol is a muscle relaxant, it also eases the CNS into a slightly light-headed mood, in turn helping an individual relax. Therefore, by easing the skeletal muscles, it is noted to be effective in diminishing the symptoms of depression (Numazawa, T. (2016) Treating Depression with the Mephenesin Analog Skeletal Muscle Relaxant Methocarbamol).

Mechanism Of Methocarbamol

Although the exact mechanism of Methocarbamol is unknown, it is observed to be dependent upon the CNS depressant activity. This could be mediated by inhibiting or blocking spinal polysynaptic reflexes, inhibiting nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the muscle cells’ refractory period.

It is observed that Methocarbamol does not affect the contraction of nerve and muscle fibers and motor endplates (Jung, H. and Chae, H.K., 2019).

Half life and how long does it take to work?

For an average human, the half-life of Methocarbamol is 1.14 hours. For patients with renal insufficiency, the half-life extends to 1.24 hours, and for older adults, 1.6-2.15 hours.

The effects of Methocarbamol are seen within 30 minutes of consumption, and its peak concentration is reached within 2 hours (Jung, H. and Chae, H.K., 2019).

How To Consume Methocarbamol?

The consumption of Methocarbamol is totally dependent upon your age, condition, medical history, and your response to the initial dosage.

Methocarbamol is generally available in the form of tablets to be taken by mouth. The usual dosage is four times a day initially, and then it may change to three to six times a day. In case of any doubts, you could consult your doctor (Jung, H. and Chae, H.K., 2019).

Side Effects Of Methocarbamol

Common side effects of the consumption of Methocarbamol include:

  • Dizziness
  • Headache
  • Drowsiness
  • Fever
  • Confusion
  • Interruption in memory
  • Vomiting 
  • Nausea
  • Bad stomach
  • Pixelated vision
  • Blurred vision
  • Insomnia
  • Flushing feeling
  • Lack of coordination

Seek urgent medical attention in case you observe any of the given side effects to Methocarbamol:

  • The feeling of passing out
  • Decreasing heartbeats
  • Seizures
  • Jaundice
  • Pain, swelling, bruising, stiffening, or skin reactions in the area where the medicine was injected

Who Should Not Take Methocarbamol?

Do not use Methocarbamol if you are allergic to it.

Consult your doctor if you are facing or have undergone any of the following conditions:

  • Seizures
  • Kidney failure
  • Kidney disease
  • Myasthenia gravis

Warnings

Consumption of Methocarbamol can cause severe skin allergies. In case you notice any of the following symptoms or conditions, report to your doctor at once:

  • Rash 
  • Hives
  • Swelling up of either tongue, throat or both
  • Trouble breathing

Note: Do not consume Methocarbamol again if you have ever had any of such allergies before. In case you are pregnant or are planning to, consult your doctor before the consumption of Methocarbamol.

If you are a breastfeeding mother, there are chances that the drug might pass on through milk into the infant, leading to adverse side effects. Consult your doctor before the consumption (Jung, H. and Chae, H.K., 2019).

What To Do If You Missed A Dose?

Methocarbamol is used only when needed unless prescribed otherwise. Skip the missed dose if you are close to the next dosage. Do NOT consume a double dose to even it out (Jung, H. and Chae, H.K., 2019).

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing symptoms may include nausea, blurry vision, drowsiness, seizures, and /or coma (Jung, H. and Chae, H.K., 2019).

Conclusion

Methocarbamol is a type of muscle relaxant that works by inhibiting the pain sensations (peculiar nerve impulses) that are received by the brain. It helps with anxiety and depression by soothing out the root cause of the symptoms, i.e., the tension in the skeletal muscles.

Is Methocarbamol a Blood Thinner?

Is Methocarbamol a Blood Thinner?

Methocarbamol is a drug that used for making the muscle normal. It is used as a muscle reliever. It helps in making the pain less effective on the body muscles. It treats the symptoms such as muscle spasms, injury, or tetanus, with a generic name, whereas the familiar brand is Robaxin. It has a drug class of muscle relaxers.

Relieving blood clots is done by blood thinners. Blood thinners are medicines that substantially impact blood clots to make them accessible. It also acts as a solution for the clots to get bigger (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Is Methocarbamol a Blood Thinner?

No, Methocarbamol is used to relieve pain in the muscles. It is used in different physical therapy, which works as a muscle reliever. Methocarbamol can be used alone without other medicines if the person wants to get rid of muscle pain. Another drug (aspirin) or (methocarbamol plus) works as a blood thinner (Jildeh, T.R., Khalil, L.S., Abbas, M.J., Moutzouros, V. and Okoroha, K.R., 2021).

Why is Methocarbamol used?

Methocarbamol is a drug used as a muscle reliever and used for muscle spasms. A muscle spasm occurs when the muscle is overused or any stress built up. Muscle pain is even caused due to over-exercising as well, and the problems related to muscle pain and stiffness (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Ways to take Methocarbamol?

For the very first, you should read the ways of having medicine on the package or even get a recommendation from a doctor.

There are two forms of drugs in this

  • Tablet form which has to be eaten orally
  • The injection form has to be taken under medical practitioner guidance.

Forms

Strengths

1- Tablet form

500mg, 700mg

2- Injection form

100mg (per ml)

Side effects for Methocarbamol

Types of side effects:

  • Normal effects which can be seen after consuming
  • The person might feel a headache
  • The person might feel fainting out or sleepy
  • A slight feeling of the head being heavy
  • Feeling sober

Serious effects

  • If the person has any allergic reactions such as rashes over the body, itching, face getting swollen up, breathlessness, Chest might have mild pain.
  • Suppose the person is facing symptoms of Angioedema. This includes swelling at specific places on the face or other parts of the body, swelling on the throat, and pain in the abdomen.
  • If the person is facing a slow heartbeat, lower blood pressure.
  • If the person faces a swelling on the muscle or where the injection has been injected.
  • Jaundice, which means the eyes and skin getting yellowish.
  • If the person is fainting or feels lazy, it can lead to low white blood count, which will not fight against the medicine injected.
  • If the person feels like memory loss.
  • If the person is facing vision issues, the person starts to get his vision blurred or doubled vision.
  • Eyes might become watery, and the eyes would get itchy.
  • If the person is facing any brain-related issues such as seizures.

If the person faces any severe issues, they should quickly contact their doctor before making the situation worse. You should always consult the doctor, which can be easy to not get into some serious trouble (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

What if you Overdose?

If you have overdosed or have a feeling of passing out, or any other severe happenings with your body, then you should consult a doctor as soon as possible (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

What if you missed a Dose?

You should not panic or have any other thoughts in your mind; it’s okay if you miss a dose. You should remember that you should not double up the amount if one is forgotten (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Pros of having a Methocarbamol

  • You can have an intense relief
  • You can feel that your muscle pains getting low
  • Muscle spasm can state in relief mode.

Cons of having methocarbamol

  • The person might feel to sleep every time
  • The person might get a fever
  • Heartbeats could be a little low
  • The vision could be effected
  • Not valid for the people who have allergies, which can be taken only after a doctors prescription 

Conclusion

Methocarbamol is not used as a blood thinner. Other variants of medicines add to the methocarbamol, which can be used in a blood thinner process.

The Efficacy of Naproxen on Headaches

The Efficacy of Naproxen on Headaches

Naproxen is a medication used for relieving pain. Naproxen can be used for the treatment of headaches, back pains, and muscle pain. Naproxen is the generic name of Aleve, and it belongs to the drug class Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). It can also be used to treat fever and menstrual discomfort in women.

As it is used to tackle pain, Naproxen is an effective medicine for headaches and migraine. Aleve can be used to treat headaches and give better results (Todd, P.A. and Clissold, S.P., 1990).

Effectiveness of Naproxen for Headache

infographic on the study of naproxen for headaches

A research was conducted by Simon Law et al. to study the effectiveness of Naproxen on people suffering from headaches and migraine. 6 studies from about 2700 participants were collected by assigning 275mg, 500mg, and 825 mg doses. The participants were given doses of Naproxen and a placebo.

It was observed that Naproxen was more effective in relieving headaches and migraine. People relived after taking Naproxen was more than people taking placebo. There were adverse effects with mild intensity observed when high doses were administered. Thus, Naproxen with lower doses can better effective results against headaches and migraines (Naproxen with or without an antiemetic for acute migraine headaches in adults).

How does Naproxen Work?

Naproxen affects the enzymes which produce prostaglandins- substances causing inflammation and pain. Aleve restricts the prostaglandin-producing enzymes and thus reduces the headache (Todd, P.A. and Clissold, S.P., 1990).

Forms and strengths of Naproxen

Aleve, also known as Naproxen, is an oral medication available in the form of tablets, gel caps, and caplets. The Aleve tablets and caplets are available in the strength of 220 mg (Todd, P.A. and Clissold, S.P., 1990).

How to Administer Naproxen?

Aleve should be taken as prescribed by the doctor only. Taking a higher dose to tackle headaches quickly should not be done as it will lead to severe side effects and create a threat to life.

The medicine can be taken with or without food. One can take it with milk or food to prevent stomach upset. One should not consume alcohol while taking Aleve. It may lead to stomach bleeding. Taking antacids along with Aleve can act as a barrier in the working of Aleve (Todd, P.A. and Clissold, S.P., 1990).

Dosage of Naproxen

Type Of Dosage

Dose Amount

Initial Dose

220-440 mg

Standard Dose

220 mg every 8-12 hours

Maximum Dose

440 mg every 8-12 hours OR

660 mg every 24 hours

Most of the time, Aleve doesn’t follow a specific schedule. But one should take the dose at the time prescribed by the doctor. One should not take a double dose to compromise the missed dose. Some people take a higher amount to get more effectiveness. But it will cause harm. 

If observed overdose, one should seek emergency medical help to prevent further risk. Difficulty in breathing, seizures, and stomach pain are some of the overdosage symptoms (Todd, P.A. and Clissold, S.P., 1990).

Who should not take Naproxen

One should not take Naproxen if:

  • Used MAO inhibitor in past 2 weeks
  • Allergic to Naproxen
  • Asthma attack
  • Below the age of 12
  • Blood pressure and other heart diseases
  • Stomach ulcers and bleeding issues
  • Kidney and liver disorders
  • Addicted to alcohol

It is advised for breastfeeding and pregnant women not to take Aleve as it can harm the woman and child both. It can be taken only if prescribed by the doctor.

Side effects of Naproxen

Following are the common side effects which one can experience after taking Aleve:

  • Heartburn
  • Swelling
  • Dizziness
  • Nausea
  • Ringing in ears
  • Abdominal pain

There are some severe side effects associated too with the medication of Aleve, which require emergency medical help or even termination of drugs. Following are the severe side effects:

  • Anemia
  • Breathlessness
  • Chest pain or stroke symptoms
  • A quick change in weight
  • Skin rashes
  • Stomach bleeding

Conclusion

Naproxen is an effective medicine for headaches if taken in smaller dosages. Aleve can be taken for other pains too. Proper medical guidance should be taken before taking Aleve in order to prevent the risk of adverse effects.

Can You Take Tylenol With Celebrex?

Can You Take Tylenol With Celebrex?

Tylenol is a medication used for the treatment of pain. Acetaminophen is the generic name of Tylenol. It is a member of the drug class called Analgesics. It works against the pain caused due to cold and fever, headaches, and menstrual cramps.

Tylenol and Celebrex are both medications used to treat pain caused due to various reasons in the body. There are no significant drug interactions observed between these two medications. One can take Tylenol with Celebrex to treat pain after consulting the medical practitioner. (Gunasingha, R.M., Niloy, I.L., Wetstein, B.B., Learn, P.A. and Turza, L.C., 2021)

tylenol with celebrex

Study Of Effectiveness Of Taking Tylenol With Celebrex

A study was conducted by Tijani Issioui et al. to compare the individual efficacy of Tylenol and Celebrex and take it together against pain after surgery.

The total number of participants was 112, and the study was divided into 4 groups:

  • Group 1. Placebo (500 mg)
  • Group 2. Tylenol (2000 mg)
  • Group 3. Celebrex (200 mg)
  • Group 4. Tylenol and Celebrex (2000 mg and 200 mg respectively).

It was observed that Group 4 was more effective in reducing the pain compared to the other groups. Taking Tylenol with Celebrex was observed more effective in reducing the pain after the surgery.

It can be observed that Tylenol can be taken with Celebrex and get effective results.

How It Works

Tylenol Tylenol blocks the prostaglandin-producing enzymes. Prostaglandin is the chemical that gives the feeling and sensation of pain in the body. The level of prostaglandin decreases due to the blocking of enzymes. It helps to reduce the pain. Celebrex Celebrex blocks COX-2 enzymes and relieves pain. COX-2 enzymes produce prostaglandins that cause pain and inflammation in the body. This helps to decrease the level of prostaglandin and provides relief from pain and inflammation. (Chiang, P.C., Ran, Y., Chou, K.J., Cui, Y., Sambrone, A., Chan, C. and Hart, R., 2012)
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Forms And Strengths

 Tylenol

Tylenol is available as tablets, capsules, caplets, chewable tablets, and liquid forms.

Capsule: 325 mg, 500 mg

Tablet: 325 mg, 500 mg

Chewable tablet: 80 mg

Liquid solution : 160 mg/5 ml

Caplet extended release: 650 mg

Tablet oral-disintegrating: 80 mg, 160 mg

Caplet 325 mg, 500 mg, 650 mg

Celebrex

Celebrex is an oral medication available as capsules. It comes in the strengths of 50,100,200 and 400 mg capsules.

How To Take

Tylenol

Tylenol can be taken with water before or after a meal. Do not crush or break the tablets. For oral Tylenol, one should use a proper measuring spoon.

It should be taken only as directed and not change the dose without consulting the doctor. Take medical help if you face a problem while taking medicine.

Celebrex

Celebrex can be taken with or without eating food. If you face the problem of stomach upset, it is better to take it with food. It should be taken only as per the directions of a medical practitioner. This medication can be taken at any time, but one should take it regularly.

Dosage

Tylenol

The normal adult dose of Tylenol extended-release is 1300 mg every 8 hours.

The maximum daily dose should not be more than 3900 mg.

Regular tablets dose is 325-650 mg taken 4 hours daily.

The maximum dose is 3250-4000 mg daily.

Celebrex

The initial adult daily dose is 200 mg, taken twice daily.

The maximum daily dose is 400 mg twice daily.

Who Should Not Take It?

Tylenol

One should not take Tylenol if:

  1. Cirrhosis
  2. Diabetes
  3. Allergic to acetaminophen
  4. Addicted to alcohol

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.

Celebrex

One should not take Celebrex if:

  1. Allergic to Celecoxib
  2. Asthma
  3. Heart diseases like stroke and high blood pressure
  4. Liver and kidney problems
  5. Bleeding and stomach ulcers
  6. Allergic to NSAIDs

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.

Side Effects

Tylenol

Following are some common side effects of Tylenol:

  1. Nausea- make you feel uneasy
  2. Stomach pain- discomfort in the abdomen.
  3. Headaches- severe headache leading to disturbance in sleep.
  4. Constipation- leading to digestion problems
  5. Loss of appetite- may lead to weakness

These are severe side effects associated with the medication of Tylenol:

  1. Jaundice- pale yellow urine and weakness
  2. Swelling – complicating some muscle movements
  3. Difficulty in breathing- suffocation, and restlessness
  4. Redness of the skin- constant feeling of itching

Celebrex

Following are some common side effects of Celebrex:

  1. Dizziness- feeling sleepy most of the time
  2. Nausea- feeling like vomiting.
  3. Heartburn- pain in the chest after eating.
  4. Stuffy nose- runny nose and cough problems.
  5. Stomach pain- unable to eat as discomfort in the abdomen.
  6. Constipation- problem in stools.

These are some adverse side effects after using Celebrex:

  1. Signs of heart attack- chest pain, sweating.
  2. Difficulty in breathing- restlessness, suffocation.
  3. Stomach bleeding- vomiting blood, blood in urine and stools.
  4. Anaemia- cold hands, pale skin, weakness.
  5. Swelling- restricting muscle movements.

Take immediate medical help if you face these side effects to prevent further risks.

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Other Precautions While Taking These Medications

  1. Drinking alcohol can lead to more dizziness and bleeding problems. Thus, it is advised not to consume alcohol.
  2. Other medicines for pain and fever can interact and have a negative impact on health. Therefore, do not consume or ask your medical health practitioner before taking such medicines.
  3. Do consult your doctor before taking Tylenol with Celebrex, as it might affect your health and lead to severe side effects.

Conclusion

Tylenol and Celebrex are medications for pain and fever. It is observed that Tylenol can be taken with Celebrex as no major drug interaction was observed between them. Take precautionary medical help before taking it.

Does Methocarbamol Make You Sleepy?

Does Methocarbamol Make You Sleepy?

Methocarbamol is a muscle relaxant medication sold under the brand name Robaxin. Robaxin is used along with rest and physical therapy for short-term musculoskeletal pain.

It relaxes muscles and relieves pain and discomfort caused by sprains, strains, and other muscle injuries/conditions. It works by slowing down the activity in the nervous system to allow the body to relax (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Does Methocarbamol Make You Sleepy?

Yes, methocarbamol can make you sleepy if taken in huge quantities and if taken with other sedative medication. Drowsiness/sleepiness is a common side effect of methocarbamol.

It is not advisable to take alcohol or other central nervous system depressant medication along with methocarbamol as it can enhance the side effect of drowsiness and can affect your concentration and focus.

Muscle relaxers are often suggested to be taken at night due to their high sedative effects. Driving and taking other important decisions should be avoided by patients if they are taking any muscle relaxers (Jung, H. and Chae, H.K., 2019).

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Does It Affect Sleeping Patterns?

Robaxin can influence your sleeping pattern. Almost all muscle relaxants have drowsiness as their side effects and cause sleepiness in patients. People suffering from muscle pain usually face difficulty getting sleep at night due to pain.

Methocarbamol is usually prescribed to be taken at night due to its sedative effects and can help a patient sleep well.Taking methocarbamol during the day is not advised as it can cause a person to lose their concentration and focus and also affect their sleeping patterns (Jung, H. and Chae, H.K., 2019).

Does-methocarbamol-cause-sleep

How Does Methocarbamol Work?

The exact mechanism of methocarbamol is not known. However, it is presumed that Methocarbamol works by depressing the central nervous system. This leads to the relaxation of muscles.

Although the drug isn’t an opioid drug, it does produce effects of drowsiness and dizziness, which users mistake for a high. Methocarbamol causes sleep problems such as insomnia during the initial stages of treatment as your body adjusts to this medication.

For light sleepers, they find it hard to sleep with muscle pain. Methocarbamol is prescribed for such patients as it can induce sleep. For deep sleepers, methocarbamol can enhance the drowsiness effect; hence it is usually prescribed to take during the night or when they aren’t going to engage in activities that require focus and concentration (Jung, H. and Chae, H.K., 2019).

Withdrawing From Methocarbamol

Stopping any medication abruptly can cause dangerous side effects. Speak with your healthcare provider before discontinuing methocarbamol. Methocarbamol has little to no evidence of withdrawal symptoms; however gradual decrease in the medication is advised for discontinuing the drug to prevent severe side effects.

As mentioned, Robaxin does not cause any withdrawal symptoms; however, methocarbamol abusers and addicts who take the medication in large quantities for recreational purposes can find it hard to discontinue the medication. Professionals have facilitated a methocarbamol detox program to provide a safe and effective transition to sobriety (Jung, H. and Chae, H.K., 2019).

Methocarbamol Levels of Usage and Effects

Methocarbamol is usually prescribed for a short time, along with rest and physical therapy to treat musculoskeletal conditions.

For beginners or initial users, methocarbamol usage in low dosages can cause insomnia (difficulty in sleeping).
For mild to average users, methocarbamol can produce effects of drowsiness/ sleepiness and can cause impaired motor controls if mixed with alcohol or other CNS depressant/sedative medication.

Methocarbamol usually isn’t prescribed for long-term use or in heavy doses. However, methocarbamol abusers take the drug in high dosages, which causes extreme drowsiness and sleepiness, which the users misunderstand for a high. Although Methocarbamol abuse is not very common.

Conclusion

Methocarbamol is a muscle relaxant medication that calms the central nervous. Methocarbamol does make a user sleepy. Drowsiness is a common side effect of methocarbamol.

Methocarbamol causes insomnia in the initial stages of treatment as the body tries to adapt to the drug. Methocarbamol shouldn’t be used with alcohol or other sedative medications as it can double the drowsiness side effect. Methocarbamol is usually prescribed at night because of the drowsiness side effects.

Methocarbamol causes loss of focus and concentration. Methocarbamol is usually not abused; however, users often misunderstand the drowsiness side effect of the drug as a “high.”