Flexeril vs Baclofen

Flexeril vs Baclofen

What is Flexeril?

Flexeril is a muscle relaxant that is used in conjunction with rest, physical therapy, and other treatments to relieve pain and suffering caused by muscle strains, sprains, and other injuries. Cyclobenzaprine belongs to the skeletal muscle relaxant class of drugs. It works by allowing the muscles to relax by acting on the brain and nerve system (RELAXANT, S.M., 1981. FLEXERIL).

What is Baclofen? 

Baclofen is a prescription pain reliever that is used to treat pain and spasticity caused by spinal cord injuries, multiple sclerosis, and other spinal cord illnesses. Baclofen belongs to the skeletal muscle relaxant class of drugs. Baclofen works by acting on the nerves in the spinal cord, reducing the amount and intensity of muscular spasms caused by multiple sclerosis or other spinal disorders. It also helps with pain relief and muscle movement (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Forms and Strength

For Flexeril

  • Tablet for adults and children – 5mg, 7.5mg, 10mg
  • Capsule, extended use for adults only – 15mg, 30mg

For Baclofen

Oral Tablet – 10mg, 20mg


For Flexeril

The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets (RELAXANT, S.M., 1981. FLEXERIL).

For Baclofen

For people with spasticity, the usual starting dose of oral baclofen is 5 mg three times daily. The amount can be increased by 5 mg every three days, up to a maximum of 80 mg/day in divided doses, depending on the reaction (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Side Effects


  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision


  • Vomiting
  • Low blood pressure (hypotension)
  • Respiratory depression
  • Weakness
  • Seizures
  • Inability to sleep (insomnia)
  • Increased urinary frequency or urinary retention

Drug Interactions


  • MAO inhibitors and FLEXERIL may have life-threatening interactions. 
  • Alcohol, barbiturates, and other CNS depressants may be amplified by Flexeril.
  • Antihypertensive effects of guanethidine and related substances may be blocked by tricyclic antidepressants. 
  • Tricyclic antidepressants may amplify the risk of seizures in tramadol users (RELAXANT, S.M., 1981. FLEXERIL).


  • The use of baclofen plus MAO inhibitors can lead to a decrease in brain function and a drop in blood pressure.
  • Anti-diabetic medicine doses may need to be modified when baclofen is started because it can raise blood sugar.
  • The use of baclofen and tricyclic antidepressants combined may produce muscle weakness, in addition to the danger of reducing brain function.
  • Baclofen with monoamine oxidase inhibitors can cause brain function to be depressed as well as low blood pressure (Ghose, K., Holmes, K.M. and Matthewson, K., 1980).

Which one is better?

If you have acute back or neck pain due to a musculoskeletal injury or fibromyalgia, cyclobenzaprine is the best treatment option. If you have spasticity or persistent pain as a result of neurological disease or injury, such as multiple sclerosis or a spinal cord injury, baclofen may be the best option for you.

Always talk to your healthcare professional about your medical history to figure out which medications are the safest for you to use. Any medication’s apparent benefits should always outweigh the potential hazards.

Robaxin vs Baclofen Which is better?

Robaxin vs Baclofen Which is better?

Robaxin and Baclofen are the medication that is used for skeletal muscular relaxation. Robaxin and Baclofen are medications accustomed to healing any muscle pain or muscle injury. Therefore, to know which one of these drugs is better, let’s post-mortem both the drugs.

two people conversation about robaxin is better or baclofen

What is Robaxin and Baclofen?

Robaxin is a medication that belongs to the skeletal muscle class that is mainly used for treating muscular pain, muscle spasms, or any muscular injury and is also used for tetanus used primarily in or during the process of recovery, physical therapy, or any other treatment. (Sibrack, J. and Hammer, R., 2020. Methocarbamol)
Baclofen is another muscle-relaxing drug that comes under the brand Lioresal, which is primarily used for treating muscle pain due to injury or pain in general amongst people who suffer from spinal-related issues or multiple sclerosis. (Penn, R. and Kroin, J., 1985))Now that we are well versed in this drug let’s see how it works. Now that we are aware of the purpose of this medication let’s look further at how does both the muscle relaxer works?

How Both the Medication Works?

As previously mentioned, Robaxin is a muscle-relaxing medication used to tame muscular injuries and tetanus. This muscle relaxer medication blocks the nerve impulses or painful sensations that lead to almost nil feeling of the pain. Thus, it is useful when injured. (Forsyth, H.F., 1958. Methocarbamol) Therefore, this is how Robaxin works. Now, let’s scrutinize intake or the dosage of this medication.
Baclofen is the medication that can be consumed orally or directly injected into the spinal cord; this thus, acts on the spinal cord nerves and decreases the pain and number of muscle spasms or the pain in the spinal cord. (Merino, M., Peris‐Ribera, J.E.,1989)Now that we know about the working of both the medication, let’s look at other factors such as the dosage, side effects, etc.

Dosages for Robaxin vs Baclofen

  • Robaxin Dosage in the form of Tablet– in the case of adults, this medication’s oral dosage can be from 500-750mg, depending upon the factors such as the extent of pain, injury, etc.
  • Injection for adults and pediatrics: In the case of injection, the dosage of this medication is about 100mg for both adults and pediatrics.
  • For Tetanus in Adults: The dosage of this medication is about 300mg which may or may not increase.
  • Pediatrics: The dosage in the case of pediatrics is 15mg for three days. (Ferslew, K.E., Hagardorn, A.N. and McCormick, W.F., 1990)
Thus, this was the dosage description. Do not consume more than what is recommended by the certified doctor or physician, or it can be hazardous.
This medication should be consumed only when prescribed and in the recommended amount by the doctor. Do not overdose or use it without any prescription. Baclofen in the case of adults: Baclofen tablet comes in about 10mg. However, the recommended dosage is about 60mg per day which can be increased according to the doctor’s consultation. This medication is started by providing 5 mg, which is then increased o 15 or 20 mg in one day. Pediatric: In the case of children above eight years, the daily dosage consumption orally is 40mg per day. (Lubsch, L., Habersang, R., Haase, M. and Luedtke, S., 2006) Now that we are well versed with dosage let’s see the side effects of consumption of both the medication.
For heavily discounted Robaxin and Baclofen

Side Effects of both the Medication

There are several common side effects of Robaxin Therefore, let’s have a look at them. 

Common Side effects

  • Drowsiness or feeling sleepy
  • Nausea or vomiting 
  • Blurred or doubled vision 
  • Insomnia 
  • Lack of brain functioning like; loss of memory, confusion, etc.

Thus, there are a few common symptoms that you need not worry about as it only lasts for a few days; either way, consult your doctor if you undergo any of these symptoms. However, there is a possibility of facing severe symptoms; however, it is a rare case. Thus, let’s have a look at them. 

Adverse Effects 

  • Fever or flu 
  • Light-headedness
  • Slower heartbeats
  • Jaundice 

These are a few adverse symptoms; if you undergo any, consult your doctor as quickly as possible. Now that we are conscious of all these symptoms, let’s look at a few key factors that are a few things to remember.


  • Do not consume this medication if suffering from any of these:
  • Kidney diseases 
  • Epilepsy or seizures 
  • Myasthenia gravis (a long-term condition that causes adverse muscle weakness)
  • In the case of Pregnancy, consult the doctor before consumption, as it can be unsafe for the unborn baby.
  • This medication can be interactive, and thus before consuming other medicines, consult your doctor, or it can be hazardous to health. 
  • Do not consume this medication if not prescribed by a certified doctor or physician. 
  • 16 years or younger are not suggested to consume this medication; however, consult the doctor before consumption. 
Baclofen, like every drug, has its side effects which can vary from being common or minor to extreme or adverse, and thus, one must consult the doctor in either of the cases.
Robaxin vs Baclofen Which is better

Common Side effects

  • Headache 
  • Nausea 
  • Insomnia 
  • Increased urination 
  • Drowsiness 

Thus, these are the common symptoms of Baclofen with is similar to that of Robaxin. Therefore, let’s look at the extreme symptoms. 


Adverse Effects 

  • Severe fever 
  • Breathlessness 
  • Seizure 
  • Tingling sensation within the body 

Thus, these are some adverse symptoms. Therefore, in case you undergo any, do consult with your doctor or physician. Do not try to solve it on your own, and with this, we come to the next factor that is the key points that one must follow.


  • Do not consume this medication if you suffer from any of these 
  • Epilepsy or seizure might make it worse. 
  • Kidney diseases 
  • Mental disorder 
  • Stroke 
  • Blood clot 
  • Nerves system disorder

Strictly, do not indulge in taking this medication if you suffer from any of the issues mentioned above.

  • If pregnant or breastfeeding, consult your doctor before consuming this medication as it can lead to withdrawal symptoms. 
  • Do not consume this medication If not prescribed by a certified professional 
  • Children below 8 years are not recommended to consume the medication.

Thus, these are the key points to remember in any case, consult the doctor before taking any risk. Therefore, now that we are aware of both these medications, the main question arises which one is better? Let’s disclose the answer.

Which one is better? Robaxin or Baclofen

Now that we are well aware of the essential properties of both these medications, Both of these medications have similar properties but at the same time different uses. Yes, it is a muscle relaxer; however, Robaxin is mainly used for skeletal muscle tissues, and Baclofen is used primarily for the distress in the spinal cord and, thus, is beneficial and effective in both their separate cases. Therefore, remember to consult the doctor before consuming these drugs.