Metaxalone vs Tizanidine

Metaxalone vs Tizanidine

Human life is full of challenges; and with challenges comes pain. The same applies in medical condition also, there is always a medicine which is efficient  in their qualities to treat.


Metaxalone is used to relax muscles and prescribed for short-term pain like spasms, musculoskeletal pain, and acute pain, menstrual cramps. It is one of the widely used muscle relaxers.

FDA approved Metaxalone in 1962. It comes under the Skeletal Muscle relaxants drug class. Its sedative effects block muscle pain receptors in the brain and thus relax the muscles.

Metaxalone is both available in brand as well as generic. It is a prescribed drug. You can buy Metaxalone online from the certified online pharmacy with a doctor’s prescription before consuming any medications. (Cacace, J., Reilly, E.E. and Amann, A., 2004)

Brands of Metaxalone

How does Metaxalone Works in your Body?

Metaxalone relaxes the muscle pain. The mechanism of Metaxalone is not properly documented, it is observed that its sedative effects block the pain receptors’ impulses from reaching the brain. Thus, the pain is decreased in the human body.


FDA approved Tizanidine in 1996. Tizanidine is used as a short-acting muscle relaxer for the pains like acute low pain, drug withdrawal, headache, insomnia, migraine.

Technically speaking, Tizanidine is an Alpha-2 adrenergic receptor that reduces spasticity. It is used as a short-acting muscle pain relaxer.

It comes under a skeletal muscle relaxant. Just as the Metaxalone. It is a prescription-based drug. (Wagstaff, A.J. and Bryson, H.M., 1997)

Brand of Tizanidine

How does Tizanidine Work?

 Tizanidine reduces spasticity through neurotransmitters. Neurotransmitter causes the firing of neurons that promote muscle spasm. It stops the firing of neurons that causes pain in muscles.

Hence the working of the Tizanidine mechanism depends on the Nervous system and spinal cord of the body.

You can order Tizanidine online from a certified online pharmcacy, but always contact your health care before consuming these medicines.

Metaxalone Vs Tizanidine

The drug comes under the same class  (what?), so what is the actual difference between them?

According to the sources, Tizanidine is not the first choice as muscle relaxers due to its short-lasting effects. In the case of Metaxalone, it uses the sedating method to relax the muscles, mainly used to treat short pains that last more. Metaxalone quite works as a CNS depressant than Tizanidine.

Study shows Tizanidine is not a muscle relaxer; it’s used in sclerosis and mental-related pains or injuries on the spinal cord. Tizanidine is less fast and takes about 3 hours to activate. The side effects of Metaxalone are low as compared to Tizanidine. The addiction rate is higher in Tizanidine. Hence Metaxalone is effective and fast as compared to Tizanidine. (Richards, B.L., Whittle, S.L. and Buchbinder, R., 2012.)

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How should you consume it?

There are age boundaries while taking this drug, plus you should also consult your doctor for references.

Metaxalone comes in tablet form, and Tizanidine comes in Tablet, capsule form. The capsule can be opened up and used with food for some patients.

For Metaxalone: 

  • 2-12 years: Must take consultation from doctor
  • 13 to 65+ years: 400 mg and 800 mg 3 to 4 times a day.

For Tizanidine:

  • 12 years and adult: 2mg 4mg for the tablet form
  • 12 years and adult: 2mg 4mg 6mg for the capsule form
  • Under 12 years: Not recommended; requires examination of the doctor.

How Should you Prepare Yourselves before taking the Dose?

For Metaxalone:

  • Confirm you had an allergy or not
  • Consult a doctor when an ongoing medication is in progress
  • Have a prescription if you are pregnant
  • Avoid driving, traveling
  • Don’t consume alcohol

For Tizanidine

  • Avoid if you are allergic to Tizanidine 
  • See a doctor if you are using medic like Cipro, fluvoxamine
  • Have a prescription if your vitamins and other supplements are in progress
  • Avoid mental alertness activity

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Side Effects

For Metaxalone:

  • You can feel dryness in the mouth
  • Dizziness and sedative feeling
  • Your stomach can get upset
  • You can feel tiredness and weakness

For Tizanidine:

  • You can feel Nausea
  • Stomach pain
  • Your eyes can become yellow
  • Rashes
  • Depression
  • Nervousness


Metaxalone is a muscle relaxer medicine, and Tizanidine is used to treat sclerosis and spinal cord injury; The mechanism differs based on sedation method and neurotransmitter method.

There are age barriers in drug consumption, and doctor consultation is also mandatory in cases. Overall, as a muscle relaxer, Metaxalone performs better than Tizanidine.

Zanaflex for Headaches

Zanaflex for Headaches

Zanaflex is a medication used in working on various pains related to muscles. Zanaflex is a brand name, whereas Tizanidine is a generic name. you can also find Zanaflex online from certified onine pharmacy.

Zanaflex came into existence on 29th August 2002.The drug class of Zanaflex is a skeletal muscle relaxant.

It helps the body relax and relieve pain. Muscle spasms are caused due to contraction of the muscles and creating pain within. It will make the pain more severe as per the contraction between the muscles.

Various issues can cause muscle spasms or muscle pains. There are different effects on the body, which can even tear the muscle.

Muscle spasms mostly happen due to cramps within the muscle. Zanaflex works on stiffness related to neurological and cerebral palsy disorder conditions (Wagstaff, A.J. and Bryson, H.M., 1997).

How does Zanaflex Work?

Zanaflex is a medication mostly used in treating muscle issues, which can also be used in pain. Zanaflex works by stopping the pain in the body.

This medicine works by acting in nerves and slowly getting into the spinal cord, and acting as a tool for the person to cure.

Pain is the foremost thing that is hurt by people, for which you opt for medicine like Zanaflex for relaxing your body from the painful moments.

When the pain gets low in the body, the person relaxes. It also works by obstructing the painful cells in the body, in contrast, to relieve the pains and help the person be fit (Wagstaff, A.J. and Bryson, H.M., 1997).

conversation of two people on zanaflex for headaches

Connection of Brain and Zanaflex

Every action you do happens through the brain. It has different internal organs that work on the command given by the brain. It helps people do all the things which a brain suggests.

Zanaflex acts as an obstructing tool to which a person can let go of the headaches. Headaches are usually common between people around, but Zanaflex acts as a tool to which the nervous system breaks the process of pain.

Zanaflex is used as a Headache Regime

Dosages are the real ones for which the person gets cured, and Zanaflex is a medication that helps in curing headaches. There will be a continuation in the medicine as per the doctor’s advice, but it should always be taken after the guidance only. Otherwise, there can be issues building up.

Dosing for Headaches

Dosing power increases after starting from a small amount of mg. Mg is the main thing to be focused on before consuming the medication. Otherwise, it can affect your body system.

Starting dose starts from 2 mg, which gradually increases as per the requirement and only after the doctor’s prescription. It can even increase to 8 mg per dose three times a day.





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A Study on Curing Chronic Migraines with Zanaflex

The study was done by R. Khan et al. to observe the pains and the curability of the person after consuming Zanaflex.

Method: There was a 40-year-old patient who was taken to observe the severity of the headache pains; this has made it possible for the moment of the patient suffering from it. It was observed for four weeks in total. That patient has been given 2- 8 mg of Zanaflex at every interval, three doses a day, to observe the medicine.

Results: The researchers have found that it successfully treated the Zanaflex medicine for headaches. They tend to believe that it can cause easier and work on headaches as well.

Observation made clear that 24mg of Zanaflex used per day made the patient suitable for treating the headache more quickly. It also showed some side effects such as drowsiness and dizziness to which the person was feeling low (Khan, R., Nicolas, J. and Sachdeva, H., 2012)

Overview of Chronic Cluster Headaches and Zanaflex Drug

People who have consumed it have the correct and experienced form of saying that Zanaflex is a medication that can be used for headaches.

It was shown that people who have opted for consuming Zanaflex are cured with different types of pains, such as mild to severe. If extra severe situations are seen within you, you should consult a doctor before worsening the situation.

Different side effects are also seen according to the body type, whereas some people didn’t have any side effects, and some did have mild side effects such as headache and drowsiness.

Overall there are situations where people believe that it can cure headaches and relax the mind of the people.

How to Administer Zanaflex?

There are two types of medicines, such as tablets and capsules, which have the same form of consuming method.

This medication should be taken every 6 to 8 hours of the gap so that there won’t be any issues in the body. For proper functioning of the medicine, you should have a proper dosage accordingly from the doctor (Wagstaff, A.J. and Bryson, H.M., 1997).

Precautions before consuming Zanaflex

There are various things a person should be aware of and avoid if any things are consumed or any other medications. The person should inform all the medication they have been taking to the doctor for proper guidance to which the person can be on a safer side.

There are precautions such as:

  • If the person is allergic to Zanaflex, then it should be avoided.
  • If the person is already consuming the antidepressant drugs, they should avoid
  • If the person is facing any kidney problems, they should avoid
  • If the person is facing any liver problems, they should avoid it.
  • If the person is facing any heart issues, they should avoid it.
  • If the person is in the process of toning, the muscles should avoid.
  • If the person is consuming medications used to treat infections, they should avoid it.
  • If the person is using medicines related to any disorders such as obsessive-compulsive disorder.

Side effects of Zanaflex

Every medication has a different reaction to the body. These reactions to the body are known as side effects. Two types of side effects cause problems within people and make them unhealthy. These things should be kept in mind, and inform the doctor as soon as possible to avoid getting yourself into more trouble.  

Normal effects which can be seen in the body after consuming Zanaflex are as follows.

  • The person might feel sleepy.
  • The person might get the vision blurred.
  • The person might get anxiety issues
  • The person might get their mouth dried
  • The person might feel confused in talking.
  • The person might get a runny nose or cold.
  • The person might get into a situation where they might get a problem during urinating.
  • The person might get the feel of puking.

These normal effects should be known to the doctor, to which there won’t be other effects seen. To not get affected by the medicine, you should always be cautious about the self and the health reaction to the medicine.

Severe effects should be the first thing known to the doctor. This might even get your life into a risky stage, and you cannot understand what is happening within you. So speak to the doctor and get the desired medication or tips accordingly.

Severe effects which can be seen in the body after consuming Zanaflex are as follows.

  • The person might feel a burning sensation in the urinary.
  • The person is unable to pee properly.
  • The person might get their breathing level too low and have trouble breathing properly.
  • The person might get a hint of falling to which no energy is seen within the body.
  • The person might get into a confusing state of mind which can create problems in focusing.
  • The person might see things that are not present or a sensation of watching something not present.

These are the severe issues, which can be harmful to the body, for which you should inform the doctor. Informing a doctor is the correct option to save your life and have a healthy life. You should contact an immediate purpose for the doctor’s visit and get the following suggestions accordingly.


It is always advised not to take in a larger form of dose. Zanaflex helps in relaxing headaches. It will affect your body if not taken without a prescription. It is a prescription-based medication. It is an effective one for you to take for a headache.

Can you take Tizanidine and Alcohol Together?

Can you take Tizanidine and Alcohol Together?

Tizanidine is a relaxer for muscles. It relaxes the spasms in the muscle. It helps in treating different muscle pains. It is a powerful drug used in making the muscle relax with the body. If the person is facing muscle spasms, then Tizanidine can be used.

It makes the muscle relax and cure spasms. It works on different muscles and acts as a solution to resolve the muscle issue. It works on tightness in the muscles, stiffness, and pains. It also treats issues such as brain injury, stroke, or any spinal problems.

The drug class of Tizanidine is skeletal muscle relaxants. The brand name for Tizanidine is Zanaflex, whereas Tizanidine is a generic name. The FDA approved tizanidine medicine on 29 August 2002. You can buy Flexeril online from certified online pharmacy but recommended to get doctor’s advice before consuming any medications. (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

Tizanidine and Alcohol Together

Alcohol (ethanol) and Tizanidine cannot be taken together. It has different side effects which can affect the person.

If both are taken together, there are symptoms such as dizziness, Drowsiness, Creating confusion scenarios in the mind to which the person cannot focus, and concentrating power gets low to which the person can’t talk or react to anything or have a proper mindset for a thought.

As per the data collected by based on FDA data, study about the Tizanidine hydrochloride and Alcoholism, this study shows that it has various effects of Tizanidine taken, Alcohol is one of it.

Tizanidine and Alcohol have various side effects if taken together. Only a few people show side effects by taking Tizanidine and Alcohol. It differs from person to person; it has normal effects if Tizanidine and Alcohol are taken

Side effects

Normal effects can be seen after consuming Tizanidine

  • Your vision might get blurred
  • You might get flooding nose
  • Your urination might get changed in color.
  • Your speaking senses would get low, and you might not be able to talk properly
  • You might feel anxious about things around you
  • Your mouth would lack of saliva; you might feel your dry mouth
  • You might feel puking every time
  • Your muscles might lose control over your body.

These kinds of normal effects should be informed to the doctor for not getting severely affected. Getting advice from the doctor and its treatment accordingly if needed.

Severe effects can be seen after consuming Tizanidine

  • You might have a feeling of fainting or collapsing.
  • You might feel breathlessness, or your breathing level gets too low.
  • You might feel losing your mind and being in a totally confused state.
  • You might feel the things that are not available around (hallucination)
  • You might feel burning when urinating

Severe effects should immediately get into the doctor’s notice and not get onto the person’s nerves severely. You should take the necessary treatment as soon as possible.

Side effects (If Tizanidine and alcohol taken)

  • Your thinking capacity is getting low
  • You might have a low blood pressure
  • You might feel a headache
  • Your body might feel weak
  • You might fall off or be unable to stand.
  • Your heart rate might differ or fluctuate a lot.

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Who should Avoid taking Tizanidine?

Some people should avoid not taking Tizanidine unless and until the doctor prescribes it, after telling you other medications or other issues.

  • If the person is having fluvoxamine (this drug is used in treatments for obsessive-compulsive disorder)
  • If the person is having ciprofloxacin (This drug is used in treatments of infections)
  • If you are in the process of making your muscle tone
  • If you are using antidepressants
  • Not using heavy machines or lifting heavyweights
  • A person should inform the doctor about previous health conditions such as:
  • Kidney related issues
  • Liver related issues
  • Heart-related issues

There are two different side effects that can be seen before or after taking medicines.

  • Blood levels can increase if Tizanidine is taken after food consumption
  • Blood levels can decrease if Tizanidine is taken without food consumption.


You should be aware of taking Tizanidine, which can be harmful if taken more than the prescribed form. You should have a proper prescription and dosage for taking this medicine under the doctor’s guidance. Tizanidine can also take the patient’s life if taken more than prescribed.

Tizanidine can differ from person to person and different body types. It’s necessary to tell the doctor about all the medications, even its herbs or vitamins, for safer medicine usage (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).


Taking Tizanidine and alcohol can lead to side effects that you can feel through your body. Tizanidine and alcohol don’t work together. However, you can use Tizanidine alone as a medicine for muscle relaxation.

Can Zanaflex be Highly Addictive?

Can Zanaflex be Highly Addictive?

Zanaflex is a medication used to treat muscle pain and muscle spasms that are caused due to spinal injuries. Tizanidine is the generic name of Zanaflex.

Zanaflex is a member of the drug class called Skeletal muscle relaxants. It is a quick-acting pain reliever drug.

Zanaflex is an oral medication available as capsules and tablets. You can also buy zanaflex online from certified pharmacy with doctor’s advice. It can be used alone or with other medication as a combination medication (Wagstaff, A.J. and Bryson, H.M., 1997)

Is Zanaflex Addictive?

Zanaflex is a muscle relaxer that helps to reduce muscle pain and spasms. Following proper medication and doctor’s advice can lead to effective results of Zanaflex and provide pain relief.

But it is observed that Zanaflex can be addictive.It is an effective medicine, but some individuals may develop an addiction to Zanaflex.

People with a previous history of drug abuse or dependence have a high chance of getting addicted to Zanaflex. Addiction may start if the daily dose goes beyond 20 mg and 36 mg (Spiller, H.A., Bosse, G.M. and Adamson, L.A., 2004).

Why is Zanaflex Addictive?

Zanaflex relieves pain by affecting the nerve impulses in the spinal cord. It acts on the CNS and creates a tranquilizing effect on people taking it.

Thus, it might lead to addiction and withdrawal symptoms when someone stops taking Zanaflex suddenly.

But it is observed that Tizanidine can’t be highly addictive unless consumed in higher doses.

Overdosage and using it for a long time can lead to dependence and addiction.

Also, Zanaflex can be used as an off-label treatment for migraine headaches and insomnia.

Hence, using Zanaflex for these reasons might also contribute to the addiction to get better results quickly.

This can also lead to people consuming Zanaflex in higher doses (Koyuncuǒglu, H., Ariciǒglu, F., Üresin, Y., Dizdar, Y. and Esin, Y., 1992).

Signs of Zanaflex Addiction

Zanaflex is not highly addictive, but if taken in higher doses for a longer time, it can be addictive. If you are taking higher doses and experiencing some changes or side effects in the body, you might be addicted to Zanaflex.

Following are some signs of overdose and addiction of Zanaflex:

  • Severe dizziness
  • Difficulty in breathing- sometimes quick while sometimes slow and shallow.
  • Chest pain
  • Hallucinations and Delusions
  • Nervousness
  • Urination and kidney problems
  • Problem in muscle movements
  • Severe dry mouth
  • Flu symptoms like runny nose and fever
  • Constant craving for consumption

One should stop taking Zanaflex if any of the symptoms are observed, as it can lead to other harmful risks, which can be fatal.

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Withdrawal symptoms of Zanaflex

Withdrawal symptoms can be observed when an individual consumes Zanaflex for a very long time or takes higher doses and stops taking it suddenly. Following are some of the withdrawal symptoms that one can experience:

  • Anxiety
  • Hypertension/ high blood pressure
  • Muscle problems like Hypertonia
  • Irregular heartbeats called Tachycardia.
  • Tremor

These withdrawal symptoms may trouble an individual that may lead to consuming the medicine again. Proper treatment and consultation can help tackle these symptoms.

Is Zanaflex a Narcotic/Controlled Substance?

Zanaflex can be highly addictive only if it is consumed in higher doses. Though Zanaflex is addictive, it is not a controlled or narcotic substance as it doesn’t have a high potential for getting abused.

One needs a valid medical prescription to get Zanaflex due to its addictive ability, but it is not a narcotic medicine.

How to Overcome Zanaflex Addiction?

Addiction to any drug can negatively impact the body and lead to many severe side effects. Similarly, it is essential to overcome if you are addicted to Zanaflex. Following are some of the steps which can be helpful to overcome the addiction:

  • Follow the medicine dosage and take the exact dose guided by the doctor.
  • If you experience any difficulty while taking the prescribed doses, don’t stop or change the dose independently. Consult your doctor.
  • If you feel like you are getting addicted to Zanaflex and taking extra doses, immediately contact the doctor in the first place to prevent the situation from getting worst.
  • One can take medical help and prefer medical detoxification, which can help against the withdrawal symptoms and take the toxins out of the body.
  • Join support groups or indulge in hobbies.
  • Exercising and meditation can help work against withdrawal symptoms like nervousness and help overcome dependency.


Contact the following helplines to get emergency medical help against overdose and addiction.

  1. For the UK
  • For ambulance, call 999.
  • To connect to NHS UK, call 111.
  1. For the USA
  • 911
  • 1-877-474-0883.

If you are not residing in the UK or USA, there are separate helplines for every region or country which can provide medical help after contacting.

Zanaflex is an effective muscle relaxer that helps with muscle pain and spasms. It is not highly addictive but can be addictive if taken for a longer time or consumed in higher doses.

Thus, it is essential to follow proper instructions while taking Zanaflex. Before taking Zanaflex, please discuss with your doctor to get effective results by following the correct dosage without getting addicted.

Baclofen vs Tizanidine

Baclofen vs Tizanidine

What is Baclofen?

Baclofen is a drug used for the treatment of muscle pain and spasms caused due to multiple sclerosis or spinal injuries. Baclofen belongs to the drug group called Skeletal muscle relaxants. Lioresal is the brand name. It can be used for hiccups also as an off-label treatment (Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., Parke, B. and Kroin, J.S., 1989).

What is Tizanidine?

Tizanidine is a muscle relaxer drug used to treat muscle pain and spasms. Tizanidine is a member of the drug class named Skeletal muscle relaxants. It is sold under the brand name Zanaflex and can be used with other medicines as a combination medication. You can get zanax online easy from certified online pharmacy. (Wagstaff, A.J. and Bryson, H.M., 1997).

How does Baclofen vs Tizanidine Works?


Baclofen works by affecting neurotransmitters. Neurotransmitters are the chemicals that communicate the signal to the brain. The activity of these transmitters is blocked by the GABA (Gamma-aminobutyric acid), and Baclofen works by acting like GABA.

This helps to control the skeletal muscles and relaxes the muscle resulting in pain relief Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., Parke, B. and Kroin, J.S., 1989).


Tizanidine affects the nerve impulses in the body. It blocks the route of these nerve impulses from reaching the brain. This results in reducing the nerve activity in the spinal cord, which helps relax the muscle and reduce the pain (Wagstaff, A.J. and Bryson, H.M., 1997).

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Who is more Effective?

Baclofen and Tizanidine help to relieve pain caused due to muscle spasms and other injuries. These medicines are similar in many ways and work for a similar cause. But it is observed that in some scenarios, Baclofen is more effective and considered better than Tizanidine, while in other circumstances, Tizanidine is better than Baclofen.

These medicines are effective for muscle pain and spasms and can be selected considering the health conditions and side effects to get effective results.

A study was conducted by B Bass et al. to compare the efficacy of Baclofen and Tizanidine for the treatment of spasticity in people suffering from multiple sclerosis.

The treatment was conducted into 2 phases- a 3-week titration period and dose for 5 weeks. 66 patients participated in the study, while 48 completed the entire treatment.

It was observed that Baclofen perceived more efficacy and tolerance than Tizanidine, where 24 % of participants found Tizanidine effective and 39% of participants found Baclofen effective. Also, it was noted that muscle weakness was the common side effect of both the medicines, but the intensity and effect were more due to Baclofen (Tizanidine versus baclofen in the treatment of spasticity in patients with multiple sclerosis)

But a similar study was conducted by M C Hoogstraten et al. to observe the same topic where 16 patients who suffered from spasticity due to sclerosis participated in the study.

It was observed that both the medicines were equally effective with no major difference in efficacy. But Baclofen led to severe muscle weakness while Tizanidine helped patients with mobility (Hoogstraten MC, van der Ploeg RJ, vd Burg W, Vreeling A, van Marle S, Minderhoud JM).

Thus, it can be seen that in both the studies, the common thing is both the medicines are effective against spasticity, and no major difference was there in their efficacies. There was a difference in effectiveness due to the impact of side effects.

Hence, Baclofen and Tizanidine are effective medicines and can be used after consulting with your doctor.

conversation of two people on baclofen and tizanidine

Forms and Strengths


Baclofen is an oral medication available as tablets and liquid solutions.

The Baclofen tablets are available in the strength of 5,10, and 20 mg tablets.

The intrathecal solution is available in 500, 1000, and 2000 mcg/ml solutions.


Tizanidine is an oral medication available as tablets and capsules.

The tablet is available as 2 and 4 mg, while the capsules are available in the strength of 2,4, and 6 mg capsules.

How to take it?


Baclofen should be taken only as advised by the doctor. Baclofen can be consumed with or without a meal. It is advised to take it with milk or food to avoid the problem of stomach upset. The tablets should be consumed without crushing or breaking. An oral syringe should be used for the liquid solution to get a proper measurement.

The doctor can increase or decrease the dose depending upon the treatment response. If you experience any problem while taking it, take medical help without changing the dosage pattern on your own Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., Parke, B. and Kroin, J.S., 1989).


Tizanidine should be taken only as advised by the doctor. It can be taken with or without a meal, but the same pattern should be followed every time while taking medicine. The dosage can be varied by the doctor depending upon the treatment. The capsule and tablets should be taken as a whole without crushing or breaking.

As it is available in the form of capsules and tablets, the effect of each of the forms is different depending upon whether it is taken before or after having a meal. It is necessary to discuss with your doctor and choose the best option to get effective results (Wagstaff, A.J. and Bryson, H.M., 1997).



Dosage of Baclofen tablets

The initial dose of Baclofen can be 5 mg, taken 3 times a day. This can be continued for 3 days.

The doctor may increase your dosage by 5 mg after every 3 days up to 20 mg per dose.

80 mg is the maximum dose limit.


2 mg is the initial dose which is taken 3 times a day.

6-8 hours should be the time difference between 2 doses of Tizanidine.

The maximum dosage limit of Tizanidine is 36 mg per day.

Who should not take it?


Baclofen should not be taken if one is:

  1. Allergic to Baclofen
  2. Below the age of 12
  3. Kidney disease
  4. Seizures
  5. Taking anxiety and depression medicines

Pregnant and breastfeeding may experience withdrawal symptoms and affect the health of women and children. According to the doctor’s advice, Baclofen can be taken by pregnant and breastfeeding women only in necessary conditions Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., Parke, B. and Kroin, J.S., 1989).


Tizanidine should not be taken if one is:

  1. Allergic to Tizanidine
  2. Kidney problems
  3. Liver diseases
  4. Undergoing antidepression medicine treatment
  5. Low blood pressure

It is necessary for pregnant and breastfeeding women not to consume Tizanidine as it may affect the health of both mother and child (Wagstaff, A.J. and Bryson, H.M., 1997).

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Side Effetcs


Following are some common side effects that one might feel after taking Baclofen:

  1. Nausea
  2. Constipation
  3. Drowsiness
  4. Vomiting
  5. Problem in and while sleeping
  6. Increased urination

There are some severe side effects too that are associated with the medication of Baclofen which one may experience. Following are the severe side effects:

  1. Hallucination
  2. Confusion
  3. Seizures
  4. Allergic reactions like skin rash and itching
  5. Severe dizziness
  6. High fever

It is important to take emergency medical help on observing any of these side effects as it may lead to health risks. The doctor can give proper instructions in such situations and change or terminate the medication.


Following are some common side effects that one might feel after taking Tizanidine:

  1. Constipation
  2. Vomiting
  3. Dry mouth
  4. Drowsiness
  5. Problem in vision
  6. Sweating

There are some severe side effects too that are associated with the medication of Tizanidine which one may experience. Following are the severe side effects:

  1. Nervousness
  2. Hallucinations
  3. Breathing problems
  4. Severe abdominal pain
  5. Unusual bleeding
  6. Extreme

If you notice any side effects, immediately take medical help to prevent further risk. The doctor may change or terminate the medication depending upon the health condition and treatment.

Similarities between Baclofen and Tizanidine

  • Baclofen and Tizanidine belong to the same drug class called Skeletal muscle relaxants.
  • Both these medicines interact with antidepressants and other muscle relaxants.
  • It is advised not to take these medicines with alcohol as it can lead to more dizziness.

Difference between Baclofen and Tizanidine:

  • Baclofen stays in the body system for more time than Tizanidine. The half-life of Baclofen is 6.8 hours, and that of Tizanidine is 2.5 hours.
  • Baclofen is also available in a liquid solution, which can be taken as an injection directly into the spinal cord.
  • Baclofen can be used as an off-label treatment for hiccups and alcohol abuse, while Tizanidine can be used for back and neck pain and migraines.
  • Baclofen cannot be taken by children below 12, while Tizanidine can be taken by children.


Baclofen and Tizanidine work against muscle spasms and help for pain relief. Both medicines are effective against muscle pain. Before selecting any of these medicines, it is essential to take medical help and discuss the medical history to choose the best treatment to get effective results with minimum risk of side effects.

Tizanidine vs Methocarbamol

Tizanidine vs Methocarbamol

What is Tizanidine?

Tizanidine is a muscle relaxer that treats muscle spasms and pain caused due to spinal injuries. It is a quick-acting drug and belongs to the drug class called Skeletal muscle relaxants.

Zanaflex is the brand name of Tizanidine. It can be used with other medicines as a combination medication.

You can get Tizanidine online from certified pharmacy.(Tizanidine (Zanaflex) A Muscle Relaxant).

What is Methocarbamol?

Methocarbamol is a muscle relaxer, and it is used for muscle spasms and pain. It is a part of the drug class called Skeletal muscle relaxants.

Robaxin is the brand name of Methocarbamol. This medication is used along with the therapy to deal with muscle pain and muscle spasms.

you can also buy Methacarbamol online from certified pharmacy.(Sibrack, J. and Hammer, R., 2020. Methocarbamol).

conversation of two people on tizanidine vs methocarbamol

How does Zanaflex vs Robaxin Works?


Tizanidine works by affecting the nerve signals which travel to the brain. Tizanidine blocks these signals from reaching the brain and helps to reduce the nerve activity in the spinal cord. This helps to relieve pain and to relax the muscles (Tizanidine (Zanaflex) A Muscle Relaxant).


Methocarbamol affects the nerve signals which travel to the brain. These nerve impulses carry information and are sent to the brain. These signals are blocked due to Methocarbamol, which relaxes the muscles (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

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Tizanidine vs. Methocarbamol: Which is better?

Tizanidine and Methocarbamol are muscle relaxants used to treat muscle pain and spasms. Both the medications work against the exact cause and work in the same manner.

It is observed that both medications are effective against muscle pain and spasms. There isn’t any specific evidence denoting which is better, but both drugs give relief from muscle pain.

The selection of the medicine can be decided by the doctor depending upon the health conditions and which treatment can give you better results (Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions).

Forms and strengths


Tizanidine is an oral medication in the form of tablets and capsules.

The tablet’s strengths are 2 mg and 4 mg, while the capsule is available in the strength of 2,4 and 6 mg.


Methocarbamol is an oral medication. It is available as tablets, oral solutions, and injectable solutions.

The strength of Methocarbamol tablets is 500 mg and 700 mg, and that of the injectable solution is 100 mg/ml.

How to Administer?


Tizanidine can be consumed before or after eating food. It is advised to take medicine at the same time every day and in the same manner. The doctor may change the dose depending upon the response to the treatment.

The effect of taking capsules and tablets with food and without food is different, and thus choose the best option to get better results after consulting a doctor (Tizanidine (Zanaflex) A Muscle Relaxant).


Methocarbamol should be used as directed by the doctor. The dosage can be changed depending upon the treatment and response.

It can be used with or without food. Take the tablets without crushing or breaking. The injection should be administered carefully. If you face any problem while taking it, inform your doctor (Sibrack, J. and Hammer, R., 2020. Methocarbamol).



The initial dose of Tizanidine is 2 mg which is taken 3 times a day.

The maximum limit of Tizanidine should not be more than 36 mg in a day.

The time difference between the two doses should be about 6-8 hours.


Adult dosage of the tablet

The initial dose is 1500 mg which can be taken 4 times a day. It can be followed for 3-4 days.

The maintenance dose is 1000 mg per day which is taken 4 times.

Side Effects


Common Side Effects

Severe Side Effects








Dry mouth

Difficulty in breathing



Passing out


Vision problems

Urination problems












Blood clots


Stuffy nose

Change in heartbeats



Difficulty in breathing


Problem with memory


If you face any of the side effects, do consult your doctor to prevent further negative risks. The doctor may change the dose or terminate the medication depending upon the situation.

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Who should not take it?


  • Allergic to Tizanidine
  • Liver diseases
  • Low blood pressure
  • Taking antidepressant-like Fluvoxamine
  • Kidney disorders

Pregnant and breastfeeding women should not take Tizanidine as it can harm the child as well as the mother (Tizanidine (Zanaflex) A Muscle Relaxant).


  • Below 16 years
  • Liver diseases
  • Kidney disorder
  • Seizures
  • Neuromuscular disease like Myasthenia Gravis

Taking Methocarbamol can cause harm to pregnant and breastfeeding women. It can be taken only in necessary conditions after the doctor’s advice (Sibrack, J. and Hammer, R., 2020. Methocarbamol).

Similarities between Tizanidine and Methocarbamol

  1. Tizanidine and Methocarbamol are both muscle relaxers and belong to the same drug class, Skeletal muscle relaxants.
  2. Both these medicines work by blocking the nerve signals from reaching the brain.
  3. Similar side effects of Tizanidine and Methocarbamol are dizziness, constipation, vomiting, and drowsiness.
  4. Both medicines may interact with antidepressant medications and alcohol.
  5. Pregnant and breastfeeding should not take any of these medicines.

Differences between Tizanidine and Methocarbamol

  1. Methocarbamol is also available as tablets and injections, while Tizanidine is available as tablets and capsules.
  2. One might experience withdrawal symptoms after stopping the consumption of Tizanidine suddenly.
  3. Nervousness and back pain are some side effects of Tizanidine that are different from Methocarbamol.
  4. Memory problems, blood clotting, insomnia are some side effects of Methocarbamol different from Tizanidine.


Tizanidine and Methocarbamol are muscle relaxers used for muscle spasms and pain. Both are effective pain medicines and can be used for treatment.

It is essential to discuss with the medical health practitioner before taking any medicine to prevent any harmful effects on the health and get effective results.  

Tizanidine for back pain

Tizanidine for back pain

Tizanidine is a medicine used as a muscle relaxant. It works on different muscle pains. It tends to make the drug more powerful to use it. Muscle spasms are more painful for people; they act as a reliever for them. It has a drug class of skeletal muscle relaxants.

Tizanidine is a Generic name, whereas the brand name is Zanaflex that you can also buy Tizanidine online from certified pharmacy, it is also recommended to get doctor’s advise before consuming medication.

The drug is a muscle relaxant; it works as a pain reliever and is the cure for the pain. It works by obstructing the sensation of pain, which creates and passes to the brain. It helps block the pain through the spinal cord and makes the person more comfortable in the senses of pain (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

conversation of two people on tizanidine for backpain

Study on the Effectiveness of Tizanidine for Back Pain

Study: A study was conducted by H Berry et al. to observe the back pain relief with Tizanidine and placebo with ibuprofen.

Aim: The study aims at observing the process of medicines and their safety and effectiveness for back pains.

Method: This study was conducted for 7 days, including 105 patients., They were divided into different groups to observe the effectiveness of Tizanidine and placebo with ibuprofen. Half the patients were given 4mg tizanidine 3 times a day and 400mg of ibuprofen 3 times a day. This process was observed on the 3rd day and the 7th day to strictly observe the reliever’s comments on the process of getting them cured. This was followed by giving a daily diary to the patients to note down their pain levels. Patients who were there as volunteers were already having back pains, which helped the researcher know efficiently.

Results: After the two intervals of observation, the outcome came as Tizanidine working more efficiently and quicker than ibuprofen and placebo. This study shows that Tizanidine is more effective and works well on back pains. It can rely on curing back pains from moderate to mild (Berry H, Hutchinson DR)

study of tizanidine explained in infographics

How and When to take Tizanidine for Back Pain?

As Tizanidine comes in two forms: capsules and tablets, both have the same similarity of taking medicine orally. Medicine can be consumed without food and can be taken with food.

Tizanidine is a medicine that can be consumed at any time. But with a time gap of at least 6-8 hours. Tizanidine should be consumed as per the doctor’s recommendation (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).



  • At the Start of the dose- The doctor may prescribe you to take 2mg at every 6-8 hours of interval.
  • Continuity of dose- The doctor may prescribe you to increase the dosage by 2 to 4mg. Until the symptoms are controlled, you need to be under the doctor’s guidance.
  • Highest dose- A person should not exceed 3 doses within 24 hours


  • People below 18 years should not consume Tizanidine. It may cause side effects if consumed.

Senior citizen (65 years and more)

  • The doctor does not always recommend it to consume Tizanidine as it is a powerful drug that might affect the kidneys more than the age of 65. It is a risk to give it to people who already have kidney issues that cannot be worked as other normal adults. Their kidneys might get weak to process the medicine.
  • If required, only after the doctor’s consultation, the doctor might prescribe to take the dose at the lowest power possible.

Every medication should be taken under the doctor’s guidance only. Otherwise, there could be worse situations build-up would not be suitable for health (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

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What if I Skipped a Dose or Overdose?

It is ok if you skip the dose or miss a dose. An important thing to keep in mind, you should not have two doses at one time to cover up the previously missed dose.

There would be some of the effects found within you, such as fainting or having lightheadedness which can lead to headaches or getting confused about what you are doing, your body can get weak, and the biggest reason could be slow heart rate.

Who should avoid taking Tizanidine?

These people should avoid taking Tizanidine

  • If the person is already using fluvoxamine (medicine which is used for treating obsessive-compulsive disorder)
  • If the person is consuming ciprofloxacin (medication which is used in treating bacterial infections)
  • If the person is in the process of toning the muscles
  • If the person uses antidepressant medicines.
  • Before consuming medicine, you should inform the doctor about
  • If the person has any kidney-related issues
  • If the person has any liver-related issues
  • If the person has any heart-related issues

Pros and Cons

  • It helps in curing the muscles
  • It helps in making the muscle lose
  • It helps in taking off spasms
  • It helps in curing the spinal problems
  • People below 18 are not recommended to consume Tizanidine.
  • There might be a liver injury.
  • Psychotic symptoms can make the person more brain drained.
  • There might be allergies to the body.


There are different medicines that affect the body if you take Tizanidine with it. There are possibilities of Tizanidine acting as a tool for death if taken with other drugs. Tizanidine make the person feel sleepy a lot, which can also be unsuitable for body function.

You need to inform the doctor if you are using medication like:

  • Acyclovir: This medicine is used to treat different infections, as it’s an antiviral medicine
  • Ticlopidine: – This medicine is used to treat strokes and coronary stents.
  • Zileuton: This medicine is used in the treatments of asthma
  • Birth control pills: this medicine is used for not having babies and to control the birth of a child.
  • Antibiotics: These medicines are used for treating different bacterias in the body.
  • Blood pressure: These medicines are used to control blood pressure problems.
  • Heart rhythm medicine: These medicines are used for treating when the heart causes slow blood flow
  • Stomach acid medicine: These medicines are used for treating stomach-related issues.


Tizanidine works more efficiently for the back pains and cures them in the safest way possible. There are side effects too, which always have to be kept in mind; it might get a reaction if consumed without the doctor’s prescription. It works well for curing muscles and pains.

Flexeril vs Zanaflex

Flexeril vs Zanaflex

Muscle relaxants such as Flexeril (cyclobenzaprine) and Zanaflex (tizanidine) are used to relieve muscle tension and cramping (spasm) caused by acute, painful musculoskeletal diseases.

Flexeril is used to treat muscle spasms as an addition to rest and physical therapy, whereas Zanaflex is used to treat disorders like multiple sclerosis or spinal damage(Dickerson, L.M., 2010).

Strength and Dosage for Zanaflex

Zanaflex is available in three strengths: 2.29 mg, 4.58 mg, and 6.87 mg.

The initial dose is recommended to be 2 mg. Because Zanaflex’s efficacy peaks at around 1 to 2 hours after a dose and fades between 3 and 6 hours after a dose, treatment can be repeated as needed at 6 to 8 hour periods, up to a maximum of three doses in 24 hours.

To achieve a sufficient reduction in muscle tone, the amount can be steadily increased by 2 mg to 4 mg at each dosage, with 1 to 4 days between dosage increases. The daily intake should not be more than 36 mg.

You can buy Flexeril online from the certified online pharmacy taking a doctor’s prescription before consuming any medications (Barnes, M., 2000).

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Strength and Dosage for Flexeril

Tablet for adults and children – 5mg, 7.5mg, 10mg Capsule, extended use for adults only – 15mg, 30mg The suggested cyclobenzaprine dose is 5 or 10 mg three times per day in immediate release pills or 15 or 30 mg once per day in extended-release tablets(Zegarra, M., 2010).

Side Effects for Zanaflex

  • dry mouth
  • drowsiness
  • dizziness
  • muscle weakness
  • back pain
  • increased muscle tone or spasms
  • sweating
  • nervousness
  • numbness or tingling
  • stomach pain
  • diarrhea
  • constipation
  • vomiting

Side Effects for Flexeril

Zanaflex vs Flexeril
  • Unpleasant taste
  • Nervousness
  • Acid reflux
  • Abdominal pain or discomfort
  • Dry mouth
  • Fatigue
  • Blurred vision

Drug Interactions for Zanaflex

  • Zanaflex is mostly metabolized in the liver by the CYP1A2 enzyme. Zanaflex levels in the body can be increased by drugs that block or inhibit this enzyme. 
  • Increased medication levels might cause sleepiness and dizziness, among other side effects. 
  • CYP1A2 inhibitors like ciprofloxacin and cimetidine and birth control pills containing Ethinyl estradiol should be avoided when taking Zanaflex.
  • Zanaflex may interact with drugs that depress the central nervous system. Barbiturates, opioids, and benzodiazepines are examples of these medications. 
  • Zanaflex might intensify their effects, causing dizziness and sedation.

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Study on the effectiveness of Zanaflex and Flexeril

Cyclobenzaprine has been evaluated in most clinical trials with evidence to support its usage, according to a meta-analysis. Tizanidine has been shown to help with spasticity caused by multiple sclerosis. For musculoskeletal problems, such as acute neck or back pain, both cyclobenzaprine and tizanidine were proven to be helpful. Over 100 trials comparing muscle relaxants such as Lioresal (baclofen), Soma (carisoprodol), Robaxin (methocarbamol), Skelaxin (metaxalone), and Valium were included in the meta-analysis (diazepam). Overall, the study discovered that the efficacy and safety of these medications are equal. Muscle relaxants, according to certain guidelines, produce drowsiness and should only be used for a short period. Both Zanaflex and Flexeril are efficient muscular spasm and pain relievers. On a case-by-case basis, they are used depending on which one is most appropriate. There is currently no clinical evidence that shows a direct comparison between these two medicines (Chou R, Peterson K, Helfand M)

Is there a difference between Zanaflex and Flexeril?

Flexeril and Zanaflex are not the same things. Flexeril has an average half-life of 18 hours, while Zanaflex has a half-life of roughly 2.5 hours. Flexeril is only available in extended-release capsules, whilst Zanaflex is only available in immediate-release oral tablets and capsules(Peterson, K. and Helfand, M., 2004).

Is it better to take Zanaflex or Flexeril?

Zanaflex is a relatively new medicine that has been licensed by the FDA to treat muscle spasticity caused by multiple sclerosis and spinal cord injury. Flexeril is an older medication that has been examined extensively for musculoskeletal pain and spasms. The better medicine is the one that is most effective for your condition. Consult a doctor for assistance in determining the best course of action for you(Dickerson, L.M., 2010).

Does Tizanidine Make You Sleepy?

Does Tizanidine Make You Sleepy?

Tizanidine sold under the brand name Zanaflex possesses the effect of making the patient sleepy, dizzy, and tired, slowing down their reaction. It is not advisable to take the medicine if you are going to engage in an activity that requires you to be alert, such as driving, using tools or machines, etc.

Before consuming these medicines you should always consult for a doctor’s prescription, you can buy Zanaflex online from a certified online pharmacy.

Tizanidine belongs to a category of drugs called muscle relaxants. Drinking alcohol over Tizanidine is not recommended as it can increase the risk of side effects such as sleepiness and drowsiness. Tizanidine can also be used to treat refractory sleep disturbance (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

conversation between two people on tizanidine make you sleepy

Study on Tizanidine Used To Treat Sleep Disturbance

Purpose of the study: To study the Effects of Tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia.

Method: 21 spastic quadriplegic children with severe sleep disturbance not improved by conventional therapies were administered Tizanidine. All these patients showed abnormalities of both the induction and maintenance of sleep.

Dosage: Tizanidine was given in doses of 0.1 to 0.2 mg/kg per day, divided into two or three doses. If the drowsiness was significant during the day, Tizanidine was only given just before bedtime.

Findings: The study found that in 13 patients (61.9%), the induction and maintenance of sleep were improved. No detectable side effects were found except a facial pallor in a couple of patients (9.5%) whose treatment was discontinued.

Conclusions: The study concluded that Tizanidine directly affects the induction of sleep and promotes muscular relaxation, which promotes good sleep. It stated that Tizanidine could be used to treat refractory sleep disturbance in spastic quadriplegic patients (Tanaka H, Fukuda I, Miyamoto A, Oka R, Cho K, Fujieda K).

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When to Take Tizanidine?

The ideal time to take Tizanidine is at night, right before going to bed. The most common side effect of Tizanidine is sleepiness and can cause you to lose your concentration and focus. Users of Tizanidine have stated that they had to be in bed right after taking the drug as it kicks in your body quickly.

Mixing Tizanidine with Other Substances

Tizanidine (Zanaflex) can make you sleepy and impair your ability to concentrate and focus. If you’re over 65 or using other sedative medications, this is more likely to happen. While using this medicine, avoid drinking alcohol. Avoid tasks that need alertness, such as driving or operating machinery, until you better understand how the medication affects you.

Tizanidine has been known to interact with several drugs, including some OTC products. Some of these interactions are potentially hazardous. Before starting Tizanidine (Zanaflex), make sure to tell your healthcare provider and pharmacist about all drugs and over-the-counter products you’re taking, even if you only take them occasionally or as needed.

Common Side Effects

Common side effects include

Common side effects include,

  • dry mouth
  • urinary tract infection
  • constipation
  • vomiting
  • sore throat
  • vision problems

Serious side effects include a light-headed feeling, like you might pass out; weak or shallow breathing; confusion, hallucinations; pain or burning when you urinate. Call your doctor immediately if you notice any of these symptoms.


Tizanidine is a muscle relaxant medication sold under the brand name Zanaflex. Tizanidine’s most common Side effect is sleepiness. Tizanidine can cause you to feel drowsy and lose concentration

Mixing alcohol can increase the risk factors related to symptoms like sleepiness and drowsiness. A study found that tizanidine can be used to treat refractory sleep disturbance

Is Tizanidine the Right Option for Anxiety

Is Tizanidine the Right Option for Anxiety

Tizanidine is a muscle relaxant used to treat spasticity. It acts by interrupting the transmission of nerve impulses (pain sensations) to the brain. Tizanidine should only be used for daily tasks that require muscle spasm alleviation. Tizanidine is a pain-relieving central muscle sedative that relieves pain and relieves pain-induced anxiety (Wagstaff, A.J. and Bryson, H.M., 1997. Tizanidine).

A Study on Tizanidine Withdrawal Syndrome in Stress

A study conducted by the Pharmacy Department by IDIBELL and Hospital Universitario de Bellvitge, Barcelona, Spain, stated that; Most medicines that act on the central nervous system (CNS) require dose titration to avoid withdrawal symptoms.

Tizanidine withdrawal syndrome is marked by hypertension, reflex tachycardia, hypertonicity, and anxiety and is induced by adrenergic discharge due to its 2-agonist action.

Although Tizanidine withdrawal syndrome is a possible adverse effect of discontinuation, it is uncommon, and only a few reports have been made. We discuss the case of a 31-year-old lady who had Tizanidine withdrawal syndrome after stopping a muscular contracture treatment (Tizanidine).

With nausea, vomiting, widespread tremor, Dysthermia, hypertension, anxiety, and tachycardia, she displayed significant adrenergic activity. By beginning Tizanidine followed by a moderate downward titration, symptoms were reversed, and successful reweaning was achieved.

When medicines that target the CNS are abruptly withdrawn, withdrawal syndrome should be considered. Acute withdrawal effects should be thoroughly monitored during reducing regimens.

Hence stating that titration of Tizanidine can reverse the withdrawal symptoms that also induce anxiety. You can buy Zanaflex  online from the certified online pharmacy taking a doctor’s prescription before consuming any medications. (Management of Tizanidine Withdrawal Syndrome: A Case Report).



Tizanidine is available in 2- or 4-mg pills and 2, 4, or 6mg capsules. A single dose of 8 mg can ease spasticity for several hours. The effects are strongest 1–2 hours after the dose and fade away after 3–6 hours.

Due to the possibility of dose-related side effects, most people will begin with a lower dose of 2 or 4 mg. A doctor can gradually increase the dose by 2–4 mg every 1–4 days to achieve the best benefit with the least side effects. People can repeat the dose every 6–8 hours, but they should never take more than three doses in 24 hours, totalling 36 mg.

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What Happens If I Forget to Take a Dose?

As soon as you recall, take the missed dose. If your next scheduled dose is approaching, skip the missing dose. To make up for a missed dose, do not take more medicine.

What Happens If I Overdose?

Seek medical help right away. Overdose symptoms include light-headedness, drowsiness, disorientation, sluggish heart rate, shallow breathing, and fainting.

Who Should Not Take it

This drug shouldn’t be consumed if you have the following conditions:

  • Injured Liver
  • Hypotension
  • Kidney problems
  • Allergic reaction
Side Effects

Side Effects

Tizanidine has the potential to induce adverse effects:

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Sleepiness


You might get withdrawal symptoms (such as anxiety, tremor, elevated blood pressure/heart-rate/muscle tenseness) if you suddenly stop using this medicine. To prevent withdrawal, your doctor may gradually reduce your dose. If you’ve been using Tizanidine for a long period or in high quantities, you’re more prone to experiencing withdrawal symptoms. If you find Zanaflex highly addictive, contact your doctor or pharmacist right away. 

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