Can Celebrex Raise Blood Pressure?

Can Celebrex Raise Blood Pressure?

Celebrex belongs to the family of the nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, swelling, and tenderness caused by arthritis. Other Celebrex uses include acute pain, menstrual cramps, and FAP (Familial Adenomatous Polyposis). With the generic name Celecoxib, this medicine is available only by prescription.

Yes, being an NSAID, Celebrex can raise the blood pressure and lower the effects of some hypertension drugs like angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, and diuretics.

In a study conducted at the Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, Iran, the effects of NSAIDs like Celecoxib over blood pressure were observed. It was noted that Celecoxib reduced the Hypotensive effects while it did not interfere with the heart rate. No major rise in blood pressure was noted at the prescribed dosage—however, the effects of hypotensive medications led to a rise in blood pressure. (Solomon, S.D., Pfeffer, M.A., McMurray, J.J., Fowler, R., Finn, P., Levin, B., Eagle, C., Hawk, E., Lechuga, M., Zauber, A.G. and Bertagnolli, M.M., 2006)

can celebrex raise blood pressure

Mechanism Of Celebrex

Celebrex is categorized as a non-selective inhibitor of the cyclooxygenase (COX) enzyme. The enzyme COX is involved in prostaglandin and thromboxane synthesis arachidonic acid pathway for mediation of pain and fever and stimulation of blood clotting, respectively. This inhibition of COX (COX-1 and COX-2) activity decreases the synthesis of prostaglandins involved in the mediation of inflammation, pain, fever, and swelling while it could cause gastrointestinal ulceration, respectively.

Half-Life Of Celebrex

The half-life of Celebrex is on an average of 7.8 hours. In cases such as mild hepatic impairment and moderate-severe hepatic impairment, the half-life extends to 11 and 13 hours, respectively. (Dilger, K., Herrlinger, C., Peters, J., Seyberth, H.W., Schweer, H. and Klotz, U., 2002)

How Long Does Celebrex Take To Work?

It takes about 3 hours for Celebrex to reach its peak concentration. You experience the relief effect for up to 12 hours, depending upon the conditions.

Forms And Strengths

Celebrex is available in the form of capsules and oral suspension.

The capsules are available in the strengths of 50, 100, 200, and 400mg, while the oral suspension is available in the strength of 25 mg/ 1 mL or 120mg/4.8mL.

The oral suspension is available only for adults.

Dosage

For Acute Pain or Primary Dysmenorrhea-

Standardized adult dosage: 400 mg initially, adding 200 mg on the first day when needed, dividing it in a 12-hour cycle.

For Ankylosing Spondylitis-

Standardized adult dosage: 200mg initially, divided into a 12-hour cycle. It might increase to 400 mg/day if the improvement isn’t noted in 6 weeks. 

Note: If no changes are to be seen even after the consumption of 400 mg/day, consult your doctor as you might be advised to discontinue the medication.

For Osteoarthritis-

Standardized adult dosage: 200mg/day divided into a 12-hour cycle.

For Rheumatoid Arthritis-

Standardized adult dosage: 100-200 mg divided into a 12-hour cycle.

Standardized pediatric dosage (Juvenile Rheumatoid Arthritis): Not prescribed for children below two years of age.

For those above two years and weighing 10-25kg- 50 mg divided into a 12-hour cycle.

For those above two years and weighing above 25 kg- 100 mg divided into a 12-hour cycle.

How To Consume Celebrex?

Celebrex consumption is totally dependent upon your age, condition, medical history, and response to the initial dosage. Celebrex liquids are available for those who find it difficult to swallow tablets and also for children. While using the liquid, use the measuring spoon that comes along with it. Do NOT use a kitchen spoon at any cost.

How Long Should You Take Celebrex For?

The dosage might only be for a few days or a week for acute cases such as back pain, menstrual cramps, or pain following surgery.

However, consulting your doctor for a longer course of medication would be needed for any chronic symptoms or cases.

It is to be noted that Celebrex is not advised to be taken for too long under any circumstances as it might lead to adverse side effects or an overdose. Make sure your doctor keeps track of your medication and progress. 

Who Should Not Take Celebrex?

In case you have or have had the following conditions and/or symptoms, consult your doctor before consuming Celebrex:

  • Dehydration
  • Systemic mastocytosis
  • Anemia
  • An increased risk of bleeding
  • Alcoholism
  • High blood pressure
  • A heart attack
  • Chronic heart failure
  • Hemorrhagic stroke
  • A blood clot
  • Asthma
  • An ulcer from too much stomach acid
  • Stomach or intestinal ulcer
  • Liver problems
  • Bleeding of the stomach or intestines
  • Kidney transplant
  • Visible water retention
  • Abnormal liver function tests
  • Pregnancy
  • A rupture in the walls of the stomach or intestine
  • Tobacco smoking
  • Increased cardiovascular event risk
  • The time immediately after coronary bypass surgery
  • CYP2C9 poor metabolizer
  • Chronic kidney disease stage 4 (severe)
  • Chronic kidney disease stage 5 (failure)
  • Kidney disease with likely reduction in kidney function
  • Aspirin-exacerbated respiratory disease
  • History of gastric bypass surgery
  • CYP2C9 intermediate metabolizer (AS 1)
  • History of kidney donation

Side Effects Of Celebrex

Some of the common side effects of Celebrex include:

  • Tobacco smoking
  • Increased cardiovascular event risk
  • CYP2C9 poor metabolizer
  • The time immediately after coronary bypass surgery
  • Chronic kidney disease stage 4 (severe)
  • Chronic kidney disease stage 5 (failure)
  • Kidney disease with likely reduction in kidney function
  • Aspirin-exacerbated respiratory disease
  • History of gastric bypass surgery
  • CYP2C9 intermediate metabolizer (AS 1)
  • History of kidney donation

In case these symptoms elevate from mild to moderate, consult your doctor.

Warnings

Seek immediate medical attention and help if you face any of the following symptoms:

  • Chest pain or heart attack
  • Sudden weakness in any part or side of your body
  • Slurred speech
  • Drooping on one side of your face
  • Blurred vision
  • Sudden dizziness or trouble walking
  • Very severe headache with no other cause
  • High blood pressure
  • Edema
  • Swelling in your arms and legs, hands and feet
  • Unusual weight gain
  • Bleeding and ulcers in your stomach and intestine
  • Blood in urine
  • Vomiting
  • Bloody stools
  • Black and sticky stools
  • Skin reactions, including rash or blisters
  • Allergic reactions
  • Itching and hives
  • Swelling of your face or throat
  • Liver problems
  • Sudden yellowing of the skin or the whites of eyes
  • Asthma attacks

Interaction Of Celebrex With Other Drugs

If not taken cautiously, Celebrex can react dangerously with certain medicines. To prevent this, carefully read the leaflet of the medicines to check whether or not it is complimentary with Ibuprofen. In case you are confused or unsure, consult your local pharmacist or doctor.

Since Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug), it is not advised to take more than one kind of them simultaneously. It is suggested to consult your doctor in case you are consuming any of the medicine.

What To Do If You Missed A Dose?

Ibuprofen is used only when needed unless prescribed otherwise. Skip the dose that is missed if you are close to the next dosage. Do NOT consume a double dose to even it out.

What Happens If You Overdose?

Seek emergency attention in case you overdose or call the poison helpline. Overdosing symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, shallow breathing, coughing up blood, fainting, or belly pain.

Conclusion

Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) used for conditions like pain, fever, swelling, and tenderness caused by arthritis. Other Celebrex uses include acute pain, menstrual cramps, and FAP (Familial Adenomatous Polyposis).

Being an NSAID, Celebrex can raise blood pressure and lower the effects of some hypertension drugs.

Can You Take Tylenol With Celebrex?

Can You Take Tylenol With Celebrex?

Tylenol is a medication used for the treatment of pain. Acetaminophen is the generic name of Tylenol. It is a member of the drug class called Analgesics. It works against the pain caused due to cold and fever, headaches, and menstrual cramps.

Tylenol and Celebrex are both medications used to treat pain caused due to various reasons in the body. There are no significant drug interactions observed between these two medications. One can take Tylenol with Celebrex to treat pain after consulting the medical practitioner. (Gunasingha, R.M., Niloy, I.L., Wetstein, B.B., Learn, P.A. and Turza, L.C., 2021)

tylenol with celebrex

Study Of Effectiveness Of Taking Tylenol With Celebrex

A study was conducted by Tijani Issioui et al. to compare the individual efficacy of Tylenol and Celebrex and take it together against pain after surgery.

The total number of participants was 112, and the study was divided into 4 groups:

  • Group 1. Placebo (500 mg)
  • Group 2. Tylenol (2000 mg)
  • Group 3. Celebrex (200 mg)
  • Group 4. Tylenol and Celebrex (2000 mg and 200 mg respectively).

It was observed that Group 4 was more effective in reducing the pain compared to the other groups. Taking Tylenol with Celebrex was observed more effective in reducing the pain after the surgery.

It can be observed that Tylenol can be taken with Celebrex and get effective results.

How It Works

Tylenol Tylenol blocks the prostaglandin-producing enzymes. Prostaglandin is the chemical that gives the feeling and sensation of pain in the body. The level of prostaglandin decreases due to the blocking of enzymes. It helps to reduce the pain. Celebrex Celebrex blocks COX-2 enzymes and relieves pain. COX-2 enzymes produce prostaglandins that cause pain and inflammation in the body. This helps to decrease the level of prostaglandin and provides relief from pain and inflammation. (Chiang, P.C., Ran, Y., Chou, K.J., Cui, Y., Sambrone, A., Chan, C. and Hart, R., 2012)
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Forms And Strengths

 Tylenol

Tylenol is available as tablets, capsules, caplets, chewable tablets, and liquid forms.

Capsule: 325 mg, 500 mg

Tablet: 325 mg, 500 mg

Chewable tablet: 80 mg

Liquid solution : 160 mg/5 ml

Caplet extended release: 650 mg

Tablet oral-disintegrating: 80 mg, 160 mg

Caplet 325 mg, 500 mg, 650 mg

Celebrex

Celebrex is an oral medication available as capsules. It comes in the strengths of 50,100,200 and 400 mg capsules.

How To Take

Tylenol

Tylenol can be taken with water before or after a meal. Do not crush or break the tablets. For oral Tylenol, one should use a proper measuring spoon.

It should be taken only as directed and not change the dose without consulting the doctor. Take medical help if you face a problem while taking medicine.

Celebrex

Celebrex can be taken with or without eating food. If you face the problem of stomach upset, it is better to take it with food. It should be taken only as per the directions of a medical practitioner. This medication can be taken at any time, but one should take it regularly.

Dosage

Tylenol

The normal adult dose of Tylenol extended-release is 1300 mg every 8 hours.

The maximum daily dose should not be more than 3900 mg.

Regular tablets dose is 325-650 mg taken 4 hours daily.

The maximum dose is 3250-4000 mg daily.

Celebrex

The initial adult daily dose is 200 mg, taken twice daily.

The maximum daily dose is 400 mg twice daily.

Who Should Not Take It?

Tylenol

One should not take Tylenol if:

  1. Cirrhosis
  2. Diabetes
  3. Allergic to acetaminophen
  4. Addicted to alcohol

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.

Celebrex

One should not take Celebrex if:

  1. Allergic to Celecoxib
  2. Asthma
  3. Heart diseases like stroke and high blood pressure
  4. Liver and kidney problems
  5. Bleeding and stomach ulcers
  6. Allergic to NSAIDs

It can be taken by pregnant and breastfeeding women only if prescribed by the doctor in an emergency and necessary conditions.

Side Effects

Tylenol

Following are some common side effects of Tylenol:

  1. Nausea- make you feel uneasy
  2. Stomach pain- discomfort in the abdomen.
  3. Headaches- severe headache leading to disturbance in sleep.
  4. Constipation- leading to digestion problems
  5. Loss of appetite- may lead to weakness

These are severe side effects associated with the medication of Tylenol:

  1. Jaundice- pale yellow urine and weakness
  2. Swelling – complicating some muscle movements
  3. Difficulty in breathing- suffocation, and restlessness
  4. Redness of the skin- constant feeling of itching

Celebrex

Following are some common side effects of Celebrex:

  1. Dizziness- feeling sleepy most of the time
  2. Nausea- feeling like vomiting.
  3. Heartburn- pain in the chest after eating.
  4. Stuffy nose- runny nose and cough problems.
  5. Stomach pain- unable to eat as discomfort in the abdomen.
  6. Constipation- problem in stools.

These are some adverse side effects after using Celebrex:

  1. Signs of heart attack- chest pain, sweating.
  2. Difficulty in breathing- restlessness, suffocation.
  3. Stomach bleeding- vomiting blood, blood in urine and stools.
  4. Anaemia- cold hands, pale skin, weakness.
  5. Swelling- restricting muscle movements.

Take immediate medical help if you face these side effects to prevent further risks.

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Other Precautions While Taking These Medications

  1. Drinking alcohol can lead to more dizziness and bleeding problems. Thus, it is advised not to consume alcohol.
  2. Other medicines for pain and fever can interact and have a negative impact on health. Therefore, do not consume or ask your medical health practitioner before taking such medicines.
  3. Do consult your doctor before taking Tylenol with Celebrex, as it might affect your health and lead to severe side effects.

Conclusion

Tylenol and Celebrex are medications for pain and fever. It is observed that Tylenol can be taken with Celebrex as no major drug interaction was observed between them. Take precautionary medical help before taking it.

Treatment of Migraine with Celebrex (Celecoxib)

Treatment of Migraine with Celebrex (Celecoxib)

Celebrex is the brand name of the drug Celecoxib. Celecoxib belongs to the class of NSAIDs (non-steroidal anti-inflammatory drugs). Celebrex is mainly used to reduce pain and inflammation in diseases like rheumatoid arthritis, painful menstruation, osteoarthritis, etc. but it can also be used in treating headaches particularly those associated with migraine.

Although Celebrex is used in treating headaches, it is not considered as a first-line pharmaceutical agent to treat headaches. NSAIDs like Acetaminophen, Ibuprofen, Diclofenac, etc are generally preferred in the management of headaches.

Additionally, Celebrex can also be used in individuals with a family history of familial adenomatous polyposis (FAP) as it can reduce the risk of colorectal adenomas. The role of Celebrex in psychiatric conditions like depression, bipolar disorder, and schizophrenia is also being researched as these conditions have an underlying inflammatory process and Celebrex is effective in reducing inflammation (McCormack, P.L., 2011. Celecoxib).

conversation of two people on celebrex for headache

Is Celebrex Effective For Headaches?

Celebrex is an important drug in managing headaches, particularly those associated with migraine. Its relatively fewer side effects on the gastrointestinal tract as compared to other non-selective NSAIDs make Celebrex a better drug in treating headaches in patients who experience side effects like gastrointestinal bleeding with non-selective NSAIDs like Ibuprofen. Thus, in spite of not being the most effective drug for treating headaches, Celebrex is used in headaches due to its relatively fewer side effects on the gastrointestinal tract and better tolerability. Due to its effectiveness in reducing inflammatory processes, the role of Celebrex is thoroughly investigated in psychiatric illnesses like depression and schizophrenia and it is showing promising evidence (Taghdiri, F., Togha, M., Razeghi Jahromi, S. and Paknejad, S.M.H., 2015).

Scientfic Study on Celebrex

Patients with a diagnosis of migraine were chosen based on the International Headache Society revised criteria in a randomized open-label, controlled experiment. Celecoxib 400 mg (30 patients) or naproxen sodium 550 mg (30 patients) were given to 60 patients (30 patients). Patients took the study drug for the first acute migraine episode that occurred during the trial period, and based on a visual analog score, reported a headache reduction (VAS). After a month, patients were reassessed to compare VAS at one and two hours to baseline. Any drug adverse effects were also documented. In comparison to naproxen sodium, celecoxib was equally efficient in reducing pain in acute migraine and caused much less stomach pain, according to the study (Celecoxib in the treatment of acute migraine).
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How does Celebrex work?

Celebrex selectively inhibits COX2 form of cyclo-oxygenase enzyme thereby preventing the conversion of arachidonic acid to prostaglandins. Prostaglandins are the main mediators of inflammation and thus by reducing the production of prostaglandins, Celebrex reduces the inflammation. Non-selective NSAIDs like Acetaminophen, Ibuprofen, Diclofenac, etc inhibit both isoforms of cyclo-oxygenase enzyme (COX1 and COX2).  COX1 enzyme is essential in maintaining the gastrointestinal lining and the mucus covering of the gastrointestinal tract and thus by inhibiting COX1, non-selective NSAIDs can induce gastrointestinal bleeding, ulceration, and perforation. Contrary to this, Celebrex has less likelihood of gastrointestinal side-effects as it selectively inhibits only the COX2 enzyme (Loo, C.Y., Tan, H.J., Teh, H.S. and Raymond, A.A., 2007).

What are the Contraindications?

Celebrex is contraindicated (not given) in pregnant females and women who are breastfeeding.

Celebrex is also not given in patients with a past history of stroke, in individuals taking blood thinners like aspirin as it might increase the risk of bleeding and can potentially be fatal. 

In individuals who have had any allergic reactions to NSAIDs in the past, Celebrex is not preferred. 

There is increasing evidence of the use of Celebrex and increased risk of cardiovascular accidents hence it should not be given in individuals with any ongoing cardiovascular diseases or past history of cardiovascular accidents.

Side effects of celebrex

Side effects of celebrex

The most common side effects encountered with the use of Celebrex are gastrointestinal complaints like diarrhea and flatulence. Other side effects which can be seen are:

  • Flu-like symptoms
  • difficulty in breathing
  • dizziness.

In some cases, gastrointestinal bleeding and perforation can also occur with Celebrex just like with other non-selective NSAIDs (Stollberger, C. and Finsterer, J., 2004).