Loratadine vs Cetirizine

Loratadine vs Cetirizine


Loratadine is used to treat allergies, itchings, runny nose, watery eyes, sneezing from hay fever, urticaria, food allergies. It is the 2nd generation in the drug class.

It acts as an antihistamine for treating hives. Hives are red bumps on the skin formed due to allergies and skin reactions.

Claritin is the brand name, and Loratadine is the generic name for this medicine. It was developed by Schering plough.

Claritin is an over the counter medication you can also buy Claritin online from certified pharmacy. Medicine sent it for approval in 1993 and for commercial sale in 2002. (Haria, M., Fitton, A. and Peters, D.H., 1994.)


Cetirizine is an antihistamine that helps treat allergic rhinitis, runny nose sneezing, inflamed nose, urticaria, and allergies. It is a second-generation antihistamine.

It was approved in 2007 by FDA as the over counter. Cetirizine is effective in decreasing the possible effect of sedatives.

Cetirizine is under the brand name Zyrtec. The generic name is Cetirizine. (Spencer, C.M., Faulds, D. and Peters, D.H., 1993)

Yeah, but What is Antihistamine?

Before understanding antihistamine, first, understand “Histamine.” Histamine is a chemical present in your body that helps whenever your immune system poses a threat from foreign substances like dust, molds, pet hairs, etc.

It’s a defense mechanism and makes the body sneeze a runny nose to kick the allergens out of the system. Antihistamine is a type of drug that helps treat reactions caused by various substances, termed an allergy.

It blocks the use of histamines to prevent the symptoms of sneezing, red eyes, runny nose as the body is in the symptoms stage. Histamines overreact towards the allergy, whereas antihistamine prevents the allergy symptoms and makes it tolerable and preventable.

Which Brands do they belong to?

Both are available over-the-counter medicine. Loratadine was approved in 2002, and Cetirizine was approved in 2007 by FDA.

Loratadine was branded under the name Claritin.Cetirizine was branded under the name Zyrtec. These two medicines brand are commonly used to treat allergies conjunctivitis.

They are also generic medicines for aller-tec,aller-tec D, quzyttir, reactine for Cetirizine and Alavert, Alavert D, loradamed.

Is it OTC or prescribed?

The FDA has approved both the medicines to be over the counter; the loratadine can be prescribed through a doctor for some conditions.

Loratadine vs Cetirizine

A study was conducted about the effectiveness of Cetirizine and loratadine. The study was born on 80 children aged 2 to 6 years with rhinitis allergies caused by house dust and plant pollens.

The children were studied parallelly and were monitored by the experts; they were given about 0.2mg/kg per day in the morning both the drug for 28 days; on the 28th day, the results displayed in which Cetirizine was proven significantly more significant as compared to loratadine.

Cetirizine helped to lower the histamine as compared to loratadine. Hence it proved effective and tolerable to the symptoms of allergies.Cetirizine comes under the brand Zyrtec, and loratadine comes under Claritin.

In Cetirizine, i.e., the Zyrtec contains Cetirizine which has a more effective time; a usual time for effect for Zyrtec is 1 hour. Both Cetirizine and loratadine have similar uses, but the drug also depends on the conditions, some people feel drowsiness by taking Cetirizine, but it depends on the person.

Are Cetirizine and Loratadine Safe to use While Pregnancy and Breastfeeding?

Loratadine and cetirizine are both antihistamine and used to treat allergy caused by outer substance. It is ok to take these medications if you are facing allergies, inflamed nose and other symptoms.

As it makes the day more frustrating, during breast feeding a minute amount of it is released but it does not have any effect on your infant. So, it safe to take these medics.

Mechanism (How it works)

Loratadine does create a block on one type of histamine receptor, i.e., the H1 receptor, and stops the activation of cells that histamine does. The loratadine does not enter the brain’s blood barrier; hence, like other antihistamines, loratadine doesn’t let the user feel sleepy or tired. (Crumb, W.J., 2000)

Cetirizine has a quick one set of actions than another antihistamine. It blocks the H1 receptors to stop the generation of cells, decreasing allergic symptoms like runny nose, skin itchiness, and watery eyes. Yet the Cetirizine has some drowsy effect, but it depends on its body. (Dyakonov, T., Muir, A., Nasri, H., Toops, D. and Fatmi, A., 2010)

Age Preferred

Loratadine can be taken by children of 2 years and older; adults can prefer this medicine dosage directed by the physician or as per the package description.Cetirizine can be taken by children starting from 1 year under the guidance of a physician.

Age 6 and older can take tablets and liquid. Twelve and above can prefer both tablets, drink, and capsules also. The option in Cetirizine is more than another antihistamine as it has a quick effect.

Forms and Dosages

Loratadine comes in tablets, chewable tablets, syrup tablets can be taken once a day before the food. Don’t take more dosage without guidance.

The standard tablets should be entirely swallowed through water; the chewable tablet should be thoroughly chewed and swallowed.

10 mg once a day

For 2 to 5 years, 5 mg once a day

Six years and older 10mg once a day

The maximum dose is 10mg a day.

Cetirizine comes in tablets that melt in the mouth, chewable tablets, syrup, and solutions.

For adult 

  • It should be 5 mg to 10 mg

For children

  • Not preferred under two years
  • 2-6 years 2.5 mg oral solution can be increased to 5 mg as per the symptoms but should not exceed 5 mg

More than six years 5-10 mg orally each day, not to exceed 10 mg per day.

Offer On Loratadine Will End Soon

Side Effects

Loratadine’s common side effects include

  • Fast heart rate
  • Dry mouth
  • Drowsiness
  • Headache
  • Vomiting and stomach pain
  • Hyperactive

Cetirizine side effects include

  • Sleepiness or drowsiness
  • Common headaches
  • Fatigue
  • Mouth drying out
  • Diarrhea
  • Breathing problems
  • Vomiting
  • Nose Bleed
  • Hallucinations
  • Blood pressure.


Loratadine interactions consist of

  • Lactation (it is a theoretical explanation that this medicine has decreased the breastfeeding compatibility of women)
  • Alcohol
  • Liver related diseases ( consult before taking the medication)
  • Abametapir topical
  • Belzutifan

Cetirizine interactions consist of

  • Alcohol
  • Hypersensitivity towards allergy
  • Benadryl
  • Cymbalta
  • Lyrica


Loratadine and Cetirizine are both used to treat allergy, conjunctivitis, urticaria, itching, skin allergies, food allergies, runny nose, watery nose, sneezing, etc. There are side effects involved in both medicines.

Cetirizine proves effective due to its quick factor; it feels tired for some people who avoid taking this medication while driving or having mental alertness activity.

Loratadine vs Fexofenadine

Loratadine vs Fexofenadine

Loratadine And it's overview

Loratadine is a medication that is a second gen antihistamine medication. It came into life and was patented in the year 1980. The medicine came into the market for people to use in 1988. Later the FDA gave approval for the medicine on 27th November 2002.

Loratadine has different brand names known as Claritin, Alavert, Claritin Reditab, ohm Allergy relief, Tavist ND, Wal-itin.

Loratadine has a drug class of Antihistamines. Loratadine is an over the counter medication, you can also buy Loratadine online from certified pharmacy.

With the help of loratadine you can improve your effects on your body of running nose, sneezing, watery eyes, skin rashes, itching, cold, and hives. Loratadine can make your health well and take off from the issues you are facing. It also helps people in curing the effects of chronic skin reaction. (Haria, M., Fitton, A. and Peters, D.H., 1994.)

Fexofenadine And it's overview

Fexofenadine came into life and was patented in 1979. It came into the market for the people to use in the year 1996. Later it got an approval from FDA on 25th February 2000.

Fexofenadine has a brand name known as Allegra, Aller- Ease, Mucinex allergy, Wal-fex and many others.

Fexofenadine has a drug class of Antihistamine.

Fexofenadine helps you overcome allergies which are caused by fever or flu. It is also used in treating symptoms related to skin such as hives and rashes which is caused from a condition known as chronic idiopathic urticarial older than 6 years of age.

It can also help you with symptoms of sneezing, watery eyes, throat infection, and running nose. (Simpson, K. and Jarvis, B., 2000.)

Loratadine vs Fexofenadine

Loratadine and fexofenadine both can be used for the same purposes of treating allergies. You will definitely be at a cause of treating it through medication but you have options to choose between the two because you can’t take both the medicines at a time that might create problems for you.

Both medications have similarities which can work safely on your body and make you fit. Loratadine and Fexofenadine can help you with several other causes as well.

It is said that Loratadine works more efficiently compared to Fexofenadine.

There was a study made by the researchers B M Prenner et al. In which they have observed the efficiency of two medicines working styles and quick healing for the body.

It was observed by having 659 volunteer patients for the testing process. These patients were distributed in 2 different groups whereas one group was provided with fexofenadine 60mg and the other group was given loratadine 10mg. They were observed for 2 weeks straight by giving one dose for a day.

As a conclusion they found out that Loratadine worked better in terms of relieving the allergic reaction safely and the response time for the medication was fast compared to Fexofenadine. (Clin Ther. 2000 Jun;22)

How Does Loratadine work?

Loratadine works by blocking the negative substances which produce allergies in the body. There are various allergies that are produced in the body due to various reasons and that can be cured with the formula of Loratadine.

How Does Fexofenadine Work?

You might be allergic to different reactions that are produced within the body. This blocks the histamines that are generated in the body and create positive cells through Fexofenadine. Allergy symptoms are very irritable and can be solved through medicine.

Age Restrictions for Loratadine

Children and adults who are more than 2 years of age can use loratadine. But Loratadine is not acceptable by many people due to its effects on the body.

Age Restrictions for Fexofenadine

Children with the age of 6-11 have mild reactions which can be healed. People who are more than 6 years of age can consume the medicine.

Find Assured Bargains On Loratadine

Availability and cost of Loratadine

Loratadine is available in many countries and even in the USA. You can get this at a price of 25.46 dollars for 20 medicines.

Availability and cost of Fexofenadine

Fexofenadine is available in the USA and other countries. You can get the medication at the price range of 13.99 dollars for 30 tablets.

OTC or prescription (Loratadine)

You can have loratadine directly from Over the counter and for a safer medication for your life you can have a prescription too from a doctor.

OTC or Prescription (Fexofenadine)

At First fexofenadine was sold as an Over the counter medicine for sneezing and itchy nose. Later due to its sleepy effects seen on people, it changed as a prescription based medicine.

How to Take Loratadine

Loratadine should be taken by mouth. You can have the medicine with or without food as per your convenience and even suggested by the doctor.  If you are advised to use chewable tablets you should chew the whole tablet fully and then swallow it.

If at all you are advised to take the medicine in a liquid form, then use a proper measuring cup for the dosage suggested by your doctor. (Haria, M., Fitton, A. and Peters, D.H., 1994.)

How to Take Fexofenadine

You should not consume the medicine with any juices, it can create problems for you. Fexofenadine should be taken by mouth with a glass of water and consumed. You should take the medication at an allotted time. (Simpson, K. and Jarvis, B., 2000.)

Side Effects

There are many side effects for medicines. These side effects can harm your health and sometimes it can be more harmful for you if taken without the advice of a medical practitioner.

There are two types of effects seen after consuming the medicine which are known as normal effects that can be caused in common (it should be reported to your doctor) for a better suggestion for not getting severely affected.

Then there comes the severe effects that can harm your health fully. Severe effects can cause you harm and you might need a medical assistant in an emergency.

Normal effects that can be seen on your body with Loratadine

  • You might get mild headache
  • You might get a mild stomach ache
  • Your mouth can get dried up
  • You might get too tired and feel of sleeping throughout the day
  • Your mindset would get in a nervous mode.

Normal effects that can be seen on your body with Fexofenadine

  • You might have a mild headache
  • You might get cold
  • You might get sinus pain
  • You might get back pain in a mild way
  • Your throat might get sore

Severe effects that can be seen on your body with Loratadine

  • You might have breathlessness
  • You might have severe headache
  • Your heart rate might get low or fast
  • You might have severe headache
  • You might faint out

Severe effects that can be seen on your body with Fexofenadine

  • You might get feels of uneasiness
  • Your cough would get severe
  • You would have pains
  • You might get your ears blocked for some while.
  • You may get severe allergic reactions.

These are not the only side effects which you might face after consuming. There can be other side effects as well which are not mentioned here. Always have a discussion before taking a tablet for your betterment and not getting yourself into problems. Always try not to opt for medicine which is not prescribed.

Forms and Strength






Chewable Tablets


Orally disintegrating tablet

5mg, 10mg








30mg, 60mg, 180mg

Oral Suspension


Oral Disintegrated tablets




Allergic Rhinitis and Urticaria


10 mg once a day

Highest dose: 10 mg/day


2 to 5 years

5 mg consumed once a day

-Highest dose: 5 mg/day

Six years and more

10 mg once a day

-Highest dose: 10 mg/day



Allergic Rhinitis and Urticarial

Adult Dosage

180mg (Once a day)

60mg (two times a day)

Maximum Dose

180 mg per day

Pediatric Dose

6 years to 2 years

15mg (2 times a day)

2 years to 11 years

30mg (2 times a day)

12 years and older

180mg (once a day)

60mg (2 times a day)

Drug Interactions














Loratadine and Fexofenadine both medications have similar working processes and are effective for any body type. Both the drug should be purchased with guidance from a doctor to be safe.

Always have a third eye for the medicine to observe its consequences, which should not create a mess for your body throughout your life. Be safe with the medicine choice you want to opt for and have a greater life ahead.

Claritin vs Benadryl

Claritin vs Benadryl

Claritin came into existence in 1950 and was approved by the FDA in 2002. The clarity comes under the drug class name second-generation antihistamine, and Loratadine is sold under the brand name Claritin, which is used to treat allergies. It is an over the counter medication, you can also buy Claritin online from certified pharmacy.

Claritin is also known as Loratadine. It is the medication (medicine) used in itchy, runny nose, watery eyes, sneezing, and other allergies. It also helps to relieve the itching from hives. (Genovese, A., Patella, V., De Crescenzo, G., De Paulis, A., Spadaro, G. and Marone, G., 1997)

Benadryl came into existence in 1943 and was approved by FDA in 2000. It belongs to the classes of drugs called antihistamine (first-generation antihistamine)

Benadryl is a brand name, and it is a prescription medicine used to treat the symptoms of an allergic reaction, insomnia, motion sickness, vomiting.

Benadryl is known by its generic name Diphenhydramine. It is also used to treat symptoms of Parkinson’s disease, such as stiffness and tremors. (Loew, E.R., MacMillan, R. and Kaiser, M.E., 1946. )

The Mechanism of Claritin and Benadryl?

Claritin or Loratadine is medicine for allergies such as sneezing, runny nose, and itchy eyes that won’t make you sleep as fast as other treatments make you fall asleep more quickly.

The second-generation antihistamine is an over-the-counter drug taken once a day.

Diphenhydramine is the brand name for Benadryl, and it is the first generation antihistamine that can treat allergy symptoms, insomnia, motion sickness, and Parkinson Parkinson’s. It is usually taken after 4-5 hours.

Claritin and Benadryl are not identical. These might be used for allergy, but Benadryl works differently and has different side effects than Claritin.

Benadryl is also helpful in mild Parkinson’s, but Claritin only works on nose, eyes, and throat simple allergy. Benadryl is better for allergies.

It provides quick relief for both kids and adults, but Claritin shows mild effect and Benadryl makes you sleepy, and you can take a gap between 4-5 hours so that results are not long-lasting and Claritin doesn’t make you feel tired, and the allergy can bother you all the night.

Which Age Groups can use Claritin and How to take it?

Claritin is taken once a day, and you should consult a doctor before using it and don’t give this medicine to the child who is younger than two years without medical advice.

The children who are older than six years to eleven years and an adult can use one tablet a day and not more than one tablet a day.

People suffering from liver or kidney disease should ask a doctor first. Pregnant ladies or breastfeeding mothers should not use it and should consult a doctor. (Genovese, A., Patella, V., De Crescenzo, G., De Paulis, A., Spadaro, G. and Marone, G., 1997 )

Which Age Groups can use Benadryl, and How to take it?

Benadryl is a strong medicine that shows promising effects on our body, but children under six years of age must consult a doctor.

The children who are older than six years who come in the category from six to twelve age groups can use the tablets once, and adults can also use two to three capsules a week and if pregnant and breastfeeding mothers or the one who is consuming alcohol should consult the doctor.

A typical dose of Benadryl is 25-50 mg every 4-6 hours. (Loew, E.R., MacMillan, R. and Kaiser, M.E., 1946 )

Is Claritin OTC or prescribed medicine?

Claritin (Loratadine) is available in most states as OTC and as a prescription, but for better results, we should consult a doctor before using it.

Is Benadryl OTC or prescribed medicine?

Benadryl (Diphenhydramine) is available in both generic form and over-the-counter and is also known as a prescription. But Benadryl is used to treat allergies and insomnia, Parkinson and many mild diseases, so we should consult a doctor.

In Which Forms can we take Claritin?

The Claritin is available in any form or type, which can be pills or tablets, chewable tablets, dissolving tablets, and in liquid form.       

In Which Forms can we take Benadryl?

Benadryl is also available in many forms and provides users the choice, pills, oral solution, cream, gel, or syrup.

Find Loratadine At Rock Bottom Prices

Side Effects of Claritin (Loratadine)

Common side effects-

  • Headache
  • Dry mouth
  • nose bleed
  • Sore throat
  • mouth sores
  • Difficulty falling asleep or staying asleep
  • Nervousness weakness, stomach pain diarrhea
  • Red or itchy eyes

Severe side effects-

  • Rash
  • Hives
  • Itching
  • Swelling of eyes, face, lips, tongue, throats, arms, legs, and feet.
  • Hoarseness
  • Wheezing
  • Difficulty in breathing or swallowing

These are some side effects of Claritin, so you do not forget your intake of a dose, and if you find the above symptoms, consult your doctor about it.

Side Effects of Benadryl (Diphenhydramine)

Most common side effects-

  • Dizziness
  • Drowsiness
  • Loss of coordination
  • Dry mouth, nose, or throat
  • Constipation
  • upset stomach
  • Dry eyes
  • blurred vision
  • Daytime drowsiness or feeling hangover

Severe side effects-

  • mental/mood changes
  • Difficulty in urination or no urination
  • Tightness in your neck or jaw
  • Uncontrollable movements of your tongue
  • Irregular heartbeats or fluttering in the chest

Additional information

As we know the medication, we should take proper precautions while using it and consult a doctor. We should store the medicine in four months and always check the manufacture date and expiry date.

Keep it in a cool place and keep it away from children. Also, dispose of the medicine in the right way to not harm anyone.


So now we are aware of the allergy and which medication we should use, and the effect of that on our body. So we should take proper precautions and consult a doctor.

Especially the person that already is a consumer of disease should be aware and careful about their health and then use these medications.

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