Aspirin

Tylenol vs. Aspirin- Which is More Effective?

Raunak Dandekar November 26, 2021December 4, 2021

Tylenol and Aspirin are the medications that are used to treat pain and fever caused in the body. People widely use both these medications, but the question is which of the medication is better than the other? Let us know more about it.

What is Tylenol?

Tylenol is a drug used as a medication for muscle pain and fever. Acetaminophen is the generic name of Tylenol. Tylenol belongs to the drug class called Analgesics and Antipyretics. IT is an oral medication available in the form of tablets (James, L.P., Mayeux, P.R. and Hinson, J.A., 2003).

What is Aspirin?

Aspirin is used for the treatment of minor pain and fever. It is generically known by the same name and available in the market by many other brand names. It belongs to the drug class called Nonsteroidal anti-inflammatory drug (NSAID), in which it was the first member of the group. It is also known as Salicylate and is available in the form of tablets (Awtry, E.H. and Loscalzo, J., 2000. Aspirin).

Which is More Effective: Tylenol or Aspirin?

Tylenol and Aspirin are both pain relievers and effective against aches and pain. These medications are also used for symptoms of Upper respiratory tract infection (URTI).

Claus Bachert Et.al; conducted a similar study to compare the effectiveness of 500 and 1000 mg Aspirin and Tylenol compared to Placebo in adult patients suffering from URTI.

The trial was conducted in Russia, where 78 people were given Aspirin doses, and 79 people were given Tylenol doses. The remaining 78 people were in the placebo group.

The primary efficacy measure was to check the reduction in body temperature from the dosage to 4 hours. The AUC values of change in temperature were as follows:

Aspirin 500 mg: 3.18
Aspirin 1000 mg: 4.26
Tylenol 500 mg: 3.13
Tylenol 1000 mg: 4.11
Placebo: 0.76

Significant reductions in temperature were observed in Aspirin and Tylenol as compared to placebos. Similar efficiency was shown by both Aspirin and Tylenol against the symptoms of fever, pain, and URTI (Bachert C, Chuchalin AG, Eisebitt R. Aspirin compared with acetaminophen in the treatment of fever and other symptoms).

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Comparison Between Aspirin and Tylenol

Acetaminophen and Aspirin can be purchased without a prescription. The dosage depends on the condition and the response to the treatment.
The working mechanism and usage of Aspirin and Tylenol are similar, and both these medications show similar side effects.

Talking about Aspirin, it may show more gastrointestinal side effects than Acetaminophen, which can badly affect people suffering from stomach ulcers. In contrast, Acetaminophen can have harmful effects on people suffering from liver diseases. Aspirin is not prescribed to pregnant women and children. At the same time, an increase in the dosage of Tylenol can be harmful to an individual.

It is observed that both Tylenol and Aspirin are equally effective. Even though both medicines are different, they are used for the same purpose and work in the exact mechanism. The selection of any of the drugs depends upon the medical history of the individual. Proper doctor consultation should be taken before taking medication in order to reduce the risk (Tarlin, L., Landrigan, P., Babineau, R. and Alpert, J.J., 1972).

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Can you take Aspirin and Tylenol together?

Raunak Dandekar November 20, 2021December 2, 2021

Tylenol is a drug used for medication as a pain reliever and fever reducer. It belongs to the drug classes named Analgesics and Antipyretics. Acetaminophen is the generic name of Tylenol. It is an oral medication available in the form of tablets. Aspirin is used as a medication for minor pains and aches caused in the body. Aspirin is a part of the drug class named Nonsteroidal anti-inflammatory drug (NSAID). It was the first member of the NSAID drug group. Aspirin is also known as Salicylate and helps reduce the human body’s pain, ache, and fever. Being generically known by the same name, it is available by other brand names in the market. It is an oral medication available in the form of tablets (Liew, Z., Ritz, B., Rebordosa, C., Lee, P.C. and Olsen, J., 2014).

Is it Safe to consume Tylenol and Aspirin together?

Tylenol and Aspirin are both used to treat the pain and ache caused in the body. Tylenol is generally considered a better choice than the other aspirins available in the market. The answer to the question is that there is no harm involved in taking Tylenol and Aspirin together as there is no such interaction between these two drugs. Generally, an NSAID drug can be given with Aspirin to get an anti-inflammatory effect to get relief. Tylenol, which may not cause severe significant side effects, is considered along with Aspirin (D’Lugos, A.C., Patel, S.H., Ormsby, 2018. Prior acetaminophen consumption).

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How does Both the Medications Work?

The combination of Tylenol and Aspirin works on reducing the fever and soothing the pain caused in the body. Tylenol and Aspirin work on their specific parts and provide better results. Tylenol works by affecting the production of chemicals that cause pain and swelling inside the body. Tylenol reduces the Prostaglandin production and thus enables to reduce the pain and swelling. It works against the fever by informing the heat-regulating center of the brain to lower the body temperature when it gets high. Thus, it balances the temperature. While on the other hand, Aspirin also works by affecting the substances that cause pain and ache in the body. It tries to reduce their production and helps the body to overcome pain. It reduces the signals sent by these pain-causing chemicals to the brain and provides relief from fever and pain. This combination works by working together by performing each of their tasks and helps in reducing fever and pain (Botting, R.M., 2000. Mechanism of action of acetaminophen).

Warnings of Aspirin and Tylenol together?

Whenever a combination of the drug is used for medication, it has some exceptions associated with it. People should not take Tylenol and Aspirin combination if they are:

Allergic to Tylenol or Aspirin
Heart disease
Kidney disorders
Asthma
Diabetes
Blood clotting disorders
Serious Liver Diseases
Addiction of daily alcohol consumption
Under the age of 12

It can cause harm to pregnant women and breastfeeding women to take the Tylenol-Aspirin combination as it can affect the baby. This combination can be taken only if advised by the doctor.

People using herbal products and over-the-counter vitamins can face problems using this combination. Thus, a proper doctor consultation should be taken before any medication to prevent any further risk.

Dosages

This combination of Tylenol and Aspirin should only be taken as prescribed by the doctor. As both of the medications are oral medications, they should be taken with a glass of water. An adult should follow the equal distribution rule while taking the combination dose. An adult dose should include 250 mg Tylenol and 250 mg Aspirin together. Initially, the medication should be taken in 2 caplets every 6 hours. An adult should not increase the dosage by more than 8 caplets in a single day or 24 hours. The dosage will remain the same if you are using the combination to treat pain, backache, and Rheumatoid Arthritis. Talking about the Paediatric dosage, this combination can only be taken by children above 12. The pediatric dose should be 250 mg Aspirin and 250 mg Tylenol in 2 caplets every 6 hours. Similar to adult dosage, this dose should also not exceed 8 caplets in a day (Divoll, M., Abernethy, D.R., Ameer, B. and Greenblatt, D.J., 1982).

Side effects of Aspirin and Tylenol

Unlike other medications, there are side effects associated when Tylenol and Aspirin are taken together.
Following are some common side effects that can be observed after the medication of this combination:

Drowsiness
Nausea
Upset stomach
Ringing in ears

There are severe side effects associated with the consumption of Tylenol and Aspirin together, which might require emergency medical help or even termination of medication. Following are some serious side effects:

Redness of the skin
Skin allergies and rashes
Breathlessness
Difficulty in hearing
Stomach bleeding

Conclusion

Tylenol and Aspirin can be taken together as a combination of medication for pain and aches. But proper doctor consultation should be carried before taking such a combination as it may affect the body’s normal working and may cause serious issues.

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Aspirin for Toothache | Is it the Right Choice?

Raunak Dandekar November 13, 2021December 2, 2021

Aspirin is an NSAID (nonsteroidal anti-inflammatory drug. It was the first NSAID to be ever discovered. NSAID’s are a class of drugs that help relieve pain, lower inflammation, and reduce fever.

Aspirin contains a salicylate compound that is found in plants such as myrtle and willow tree. Aspirin is used to treat many conditions, especially to manage pain and swelling, while also reducing the dangers of heart attack and strokes in patients with high risk. In general, aspirin is used to treat mild to moderate pain and swelling and health issues such as,

Tylenol for Cold and flu
Tylenol for Migraine and Headaches
Tylenol Menstrual cramps
Arthritis and migraine
Sprains and strain

How does Aspirin Work?

Aspirin is an antipyretic (fever reducer), analgesic (pain reliever), and anti-inflammatory (fights swelling and inflammation). As mentioned before, aspirin is an NSAID. Like other NSAIDs, aspirin also chemically addresses the nerve signals by blocking the effects of certain enzymes that create prostaglandins, meaning less pain and minor swelling. In addition to this, aspirin can also reduce the risk of heart attack and strokes. Aspirin works to stave off the platelets in your blood from clumping and clotting your arteries, escalating the blood flow to your brain and heart. (Vane, J.R. and Botting, R.M., 2003. The mechanism of action of aspirin)

Can Aspirin be used for Toothache?

The leading cause of toothache is swelling inside the tooth. However, unlike other swellings on your body, the swelling inside your tooth hurts more. This is because the surrounding tooth structure is rigid and not flexible/ expandable. This means that the swelling inside your tooth has got nowhere to go. This pressure that you feel inside your tooth is what you call toothache and is the thing that makes you feel like your tooth is about to explode.

People often think aspirin can cure your toothache. It is pretty accurate, but this common misconception is that placing an aspirin on your tongue can relieve your pain. Placing aspirin on your tooth or gums only allows the aspirin to dissolve into your bloodstream slowly. This is an inferior way to ingest aspirin into your system.

The generic name of aspirin is Acetylsalicylic Acid, which explains the corrosive effects that the tablets possess. Placing aspirin on your gum causes chemical burns to take place. Being an acid, it will start to attack your enamel. If this process is repeated, severe erosions may occur. The aspirin begins to burn your gums as well as your cheeks if placed on the gums. It will usually look like some of the gums and cheek tissues have turned white, which in reality is burn damage. (Seymour, R.A., 1983. The efficacy of self-prescribed analgesics in the treatment of toothache)

The proper way to take aspirin to treat a toothache is by swallowing it. Aspirin works by being ingested. Once the tablet is in the stomach, it starts to make its way through the body and bloodstream. Aspirin relieves the aches by blocking the pain signals from being sent to the brain. The way it helps is by interrupting the pain chemicals in the bloodstream.

Doctors prescribe a 600mg dosage of aspirin every two hours to treat toothache. This would mean you will have a four-hour gap between each dosage; however, do not take more than the daily dose as recommended on the box. New research has found out that aspirin holds a few dental benefits despite its concerns. Taking low dosages of aspirin repairs damaged cavities in the tooth. A research team in British found that aspirin can enhance the function of stem cells located in the teeth. Aspirin also increases the expression of genes that work to form dentin (the primary structure of the teeth damaged by decay). (Faisal, M.D: a potential plant for treatment of toothache)

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Conclusion

So yes, aspirin can help deal with toothache but only if swallowed and not by placing it on your tongue. There are also many other treatments available to treat toothache. You should see a dentist if your tooth starts aching too much. To take proper care of your teeth, book a dental checkup appointment every six months to ensure your oral health.

Does Aspirin Help with Lower Blood Pressure?

Raunak Dandekar November 12, 2021December 2, 2021

How does Aspirin Work?

Aspirin is a drug commonly used to get relief from minor aches, pains, and fevers. It is also used as a blood thinner or an anti-inflammatory medication. Without a prescription, aspirin can be purchased over-the-counter. Aspirin is the world’s first nonsteroidal anti-inflammatory medication (NSAID). An Aspirin is not a steroid but has similar properties. Aspirin isn’t suitable for everyone and could have undesired side effects when a person is in pain; the nerves present in their damaged tissue signal the brain. The brain, in return, sends a message to the damaged tissue to release certain chemicals called prostaglandins which is a hormone that makes the tissue swell up. This process also intensifies the signal process to the brain, which results in feeling more pain. Here is where aspirin comes into the picture. The drug is used to block the signals hence reducing the pain. Aspirin also helps thin the blood, which reduces the swelling to an extent. (Vane, J.R. and Botting, R.M., 2003. The mechanism of action of aspirin)

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What is High Blood Pressure?

When the force of your blood pushing against the walls of your veins is constantly high, it is called Hypertension (high blood pressure). Our tissues and organs need oxygenated blood. The nerves supply the oxygenated blood to our body parts. When our heart beats, it creates pressure that pushes the blood through our nerves, reaching our organs. This pressure is our blood pressure, which contains two forces, the systolic pressure, which pumps out the blood out of the heart to the arteries, and the diastolic pressure, where the heart rests between heartbeats. These two pressures represent the blood pressure in numbers. (American Heart Association, 2017. What is high blood pressure?)

Aspirin for High Blood Pressure

High blood pressure, also known as Hypertension, is a problem that quite some people face. If not treated immediately, high blood pressure can cause nerve damage, heart damage and affect your brain. A Spanish study shows that taking aspirin at night is more effective than taking one in the morning. This study included 328 people with stage 1 high blood pressure; the patients were 44 years old. The patients were divided into three groups, group 1 was given no aspirin, group 2 was given 100mg of aspirin in the morning, and group 3 was given 100mg of aspirin in the night. All patients’ blood pressure was monitored every 20 minutes during the day and every 30 minutes at night. The results were as follow: • When you take aspirin at night, your blood pressure drops significantly. • When you take aspirin first thing in the morning, your blood pressure rises somewhat. • Without aspirin, blood pressure is somewhat lower. (Hermida, R.C., Ayala, D.E., Calvo, C. and López, J.E., 2005)

Aspirin for Lower Blood Pressure

Low blood pressure, also known as Hypotension, can seem desirable, and for some people, it may not cause any problem. But abnormally low blood pressure can cause dizziness and feel weariness. In extreme cases, low blood pressure can be life-threatening. Aspirin is a drug that is used to relieve pain, fever, etc. The drug can also be used as an anti-inflammatory or a blood thinner. When a person has low blood pressure, their heart doesn’t pump the blood to the organs via the veins with much force, causing them to feel dizzy or lightheaded. According to a study done by the population health sciences of the University of Wisconsin medical school, published by the National Library of Medicine, Nonsteroidal anti-inflammatory drugs usually are taken to increase blood pressure. Still, it has been recently proven that aspirin lowers blood pressure. Trials conducted suggest that aspirin taken at bedtime lowers blood pressure in a controlled and unmasked way. It also opposes past studies by showing an 18% increase in the risk of Hypertension among regular users. Short-term use of aspirin isn’t harmful and doesn’t seem to interfere with other antihypertensive medication. Hence stating the benefits of aspirin is undesirable for high blood pressure. (Effects of intensive blood-pressure lowering and low-dose aspirin in patients)

What are the Other ways to Cope up with Low Blood Pressure?

Low blood pressure isn’t much of a significant concern normally but should be taken care of to avoid other complications that it may cause later on. Following are a few ways to cope with low blood pressure:
• Using more salt.
• Drinking more water.
• Medications.
• Wearing compressed stockings.
• Implementing lifestyle changes.
• Getting a good night’s sleep.
• Exercising regularly.

Side effects of Aspirin

All medicines have their share of side effects, and aspirin also has side effects, although not everyone may experience them. Following are a few side effects:

Common Side Effects:

Slight Indigestion.
Bleeding more than usual. Since aspirin thins your blood, it can make you bleed more easily.

Serious Side Effects:

Rashes, peeling of the skin.
Coughing up blood.
Blood in your stools.
Liver problems.
Swollen limbs.
Serious allergic reaction.

It is advisable to seek immediate medical care if one experiences such symptoms. Consult a doctor before taking any medications and be thorough with your symptoms for a speedy recovery.