Tylenol(Acetaminophen) and Mobic (Meloxicam) are the two types of analgesic and antipyretic medications.


Acetaminophen is an OTC analgesic and antipyretic drug widely used to relieve pain.

It is associated with arthritis, headache, muscular aches, sore throat, and toothache and reduces fever.

It may be given to infants.

Available as a pill, chewable tablet, liquid, or suppository.


Meloxicam is a non-steroidal anti-inflammatory drug (NSAID). It is used to treat pain, swelling, or stiffness caused by osteoarthritis( breakdown of the lining of joints) and rheumatoid arthritis(swelling of the lining of joints).

It has been clinically proven effective in relieving acute, surgical, and chronic pain.

It has a favorable gastrointestinal tolerability profile at recommended doses.

It works by reducing hormones that produce inflammation in the body.

Can We Take Mobic With Ibuprofen?

Meloxicam and Ibuprofen are both Non-Selective Non-Steroidal Anti Inflammatory Drugs and are used to treat pain and inflammation by blocking prostaglandins. They work by inhibiting cyclooxygenase enzymes COX1 and COX2, which protect the stomach lining from acidic enzymes. Doctors recommend Mobic for moderate to severe arthritis and Ibuprofen for mild arthritis. You should take one pain reliever at a time.

Never take Mobic with a combination of other NSAIDs because it causes severe adverse reactions to the gastrointestinal tract. It can cause stomach ulcers and bleeding. Mobic is much stronger than Ibuprofen, so it should take once a day, while Ibuprofen can take four times a day. There is no additional benefit to taking both drugs together, so we should avoid this combination and make sure to use NSAIDs according to the prescription of our healthcare provider.

Effects Of A Combination Of Tylenol and Mobic

A combination of Tylenol and Mobic can provide more significant pain relief than the drug alone. Taking acetaminophen and an NSAID may provide equivalent pain relief with lower doses of both and minimize their side effects. A variety of both drugs is effectively used to treat

  • Gout
  • Pain
  • Fever
  • Menstrual cramps
  • Rheumatoid arthritis
  • Osteoarthritis

Side Effects Of Taking Mobic with Ibuprofen

  • Painful urination
  • Loss of appetite
  • Ringing in ears
  • Pain in the upper portion of your stomach
  • Headache
  • Gas or bloating
  • Blood in the urine
  • Swelling of the feet, abdomen, legs, or ankles

What is the difference between NSAID (Meloxicam) and Acetaminophen (Tylenol)?

NSAIDs are Non-Steroidal Anti Inflammatory Drugs that have analgesic and anti-inflammatory properties. At the same time, acetaminophen is an analgesic, an excellent pain-relieving drug without anti-inflammatory properties.

Acetaminophen actions work by changing the way the body senses pain by cooling the body temperature, while NSAIDs are well known to halt the enzyme called cyclooxygenase-2.

NSAID can cause side effects on GIT if taken for a long time, while acetaminophen has few side effects and usually is safe to use for more extended periods.

Drug Interaction of Tylenol And Mobic

There is no significant interaction between both drugs. Tylenol doesn't reduce inflammation, but Meloxicam does so. It is generally used together to increase the effectiveness and reduce the symptoms of pain and inflammation in arthritis. Still, Meloxicam has some interaction with other drugs that has a significant effect on the gastrointestinal tract if combined.

Other drugs interactions

  • Mobic should not be used with antihypertensive drugs because it may impact blood pressure and cause a negative effect.
  • Mobic should not be used with prednisolone because it increases the gastrointestinal side effects of NSAIDs.
  • Mobic and hydrocodone can cause peptic ulcers, gastrointestinal perforation, and other complications.
  • Tylenol has no severe interactions with other drugs but avoids using other drugs containing acetaminophen.


Combining Mobic with Tylenol is safe if you aim to reduce inflammation and pain primarily associated with osteoarthritis and rheumatoid arthritis. Always take the correct dose of both drugs and consult your healthcare provider before taking any medication. Medicines are combined for effective treatment but vice versa there are also interactions to be taken care of.


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