Lisinopril is a member of the ACE inhibitors (Angiotensin Converting Enzyme Inhibitors) drug class, which treats heart failure, hypertension (high blood pressure), and myocardial infarction.

Angiotensin I is changed into the vasoconstrictor angiotensin II by ACE, which Lisinopril inhibits. The kidney's adrenal glands are stimulated by angiotensin II, which also causes aldosterone to be secreted. High blood pressure is the effect of both narrowing the blood vessels.

Lisinopril lowers blood pressure by blocking ACE, which prevents the release of aldosterone and causes the blood vessels to relax, all of which assist in lowering blood pressure. As a first-line therapy for high blood pressure, it is also used in cases of Heart failure and kidney diseases.

Tylenol (Acetaminophen) is a fever reducer and painkiller. It is believed to reduce minor aches and pains by raising the body's overall pain threshold, so you experience less pain. It also supposedly decreases fever by assisting the body in releasing extra heat.

The main ingredient in Tylenol medicine is acetaminophen, one of the most widely used active pharmaceuticals. Both prescription and over-the-counter (OTC) medications include it. Acetaminophen is most frequently used to treat minor aches and pains, such as headaches, backache, toothache, muscular aches, premenstrual and menstrual cramps, and mild arthritis pain. It is frequently used to lower fever momentarily.

Is It Useful/Harmful To Mix NSAIDS and Antihypertensives?

No, it is not helpful to mix NSAIDs and antihypertensives. NSAIDs can raise blood pressure (BP) and may lessen the effectiveness of several antihypertensive medications. Because regulating blood pressure (and renal function) is more PG-dependent than other medicines, such as diuretics, beta-blockers, and ACE inhibitors, the principal mechanism of action for NSAIDs is likely the inhibition of prostaglandin (PG) synthesis.

Contrarily, NSAIDs have no interactions with calcium antagonists or medicines with central effects, which appear to have no bearing on the renal or extrarenal generation of PG. It has been suggested that NSAID pressure effects in hypertension individuals treated with them could be explained by suppression of natriuretic PGs.

Does Tylenol And Lisinopril Interact With Each Other?

There are no known interactions between Lisinopril and Tylenol. This does not imply that there are no interactions, though. Always get advice from your doctor.

ALWAYS AVOID: Some people on angiotensin-converting enzyme (ACE) inhibitors may develop hyperkalemia from consuming moderate to high amounts of potassium. Some of the afflicted individuals were taking a salt substitute high in potassium. Through suppression of the renin-aldosterone-angiotensin (RAA) pathway, ACE inhibitors can cause hyperkalemia.

Is There Any Effect Of Tylenol On Blood Pressure?

Formerly, Sources reported that Tylenol does not affect blood pressure and is compatible with blood pressure medications. This is due to acetaminophen, which is Tylenol's principal active ingredient. Unlike NSAIDs, this painkiller does not cause blood pressure to rise.

The most popular alternative painkillers for patients with high blood pressure (hypertension) are acetaminophen (Tylenol). At the same time, nonsteroidal anti-inflammatory medicines (NSAIDs) like ibuprofen (Motrin, Advil) and naproxen (Naprosyn, Aleve) can also cause blood pressure to increase. However, a study published in the Circulation journal on February 8, 2022, reveals acetaminophen might have a similar impact.

According to the findings, those who took high doses of acetaminophen saw an elevation in systolic blood pressure (the top number) of roughly five points greater than those who took a placebo.

This does not imply that those with high blood pressure should never take acetaminophen for pain relief. People should use the lowest effective dose, which should not exceed two regular-strength (325 mg) or two extra-strength (500 mg) tablets every six or eight hours. Regular users of acetaminophen should reduce their dosage or talk to their doctor if they experience higher blood pressure readings.

What Pain Killer You Can Take With High Blood pressure?

Those with high blood pressure and those using prescriptions to treat elevated blood pressure tend to do better when taking over-the-counter drugs like acetaminophen (Tylenol). Aspirin and other painkillers like naproxen are also secure.

Having said that, monitoring your blood pressure readings is a good idea. You can check your blood pressure at home. Or, if you have new-onset hypertension and they are changing your blood pressure meds, your doctor could urge you to visit and have your blood pressure tested frequently. Remember that high blood pressure has no symptoms and can jeopardize your health if you are unaware of it.

How Should You Take Tylenol And Lisinopril Together?

Tylenol is compatible with blood pressure medications. This is due to acetaminophen, which is Tylenol's principal active ingredient. Unlike NSAIDs, this painkiller does not cause blood pressure to rise.

Acetaminophen, like all medications, can have adverse effects. Therefore if you have severe liver issues, you shouldn't use Tylenol. The patient shouldn't take Tylenol and other over-the-counter drugs for longer than ten days without consulting a healthcare professional.


It is generally safe to take Tylenol and Lisinopril together. With blood pressure medications, you can take Tylenol. This is so because acetaminophen, the active component of Tylenol, doesn't affect blood pressure. This type of painkiller is distinct from NSAIDs.

Acetaminophen can have adverse effects like any medication, so you shouldn't take Tylenol if you have severe liver issues. You shouldn't take over-the-counter medicines, including Tylenol, for longer than ten days.

Additionally, it is essential to keep in mind that in addition to over-the-counter painkillers, other drugs used to treat common conditions, including colds, the flu, sinus issues, and heartburn, may also include active chemicals that might raise blood pressure. Therefore, before taking a bottle of an over-the-counter pain reliever or other medication, ask your doctor if it might affect your ability to control your blood pressure.


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