Does Naproxen Make You Sleepy?

does naproxen make you sleepy
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Naproxen is a nonsteroidal anti-inflammatory drug(NSAID). Naproxen is used to treat:

  • headaches
  • dental aches
  • muscle aches
  • muscle cramps

It also reduces pain, swelling, and stiffness in joints for those who have arthritis. It can also help treat insomnia in some cases.

A study conducted at the Bowling Green State University (Ohio) demonstrated that some nonsteroidal anti-inflammatory drugs (NSAIDs) have adverse effects on sleep. Thirty-seven male and female subjects slept in a sleep laboratory for two nights, recorded on a polygraph.

The study stated that the mechanisms of sleep disruption after taking NSAIDs might relate to direct or indirect consequences of prostaglandin synthesis resulting in changes in body temperature and suppression of nighttime melatonin levels.

Melatonin is a sleep hormone and is an essential part of the body’s sleep-wake cycle. The prostaglandin synthesis, which causes melatonin suppression, can make you feel tired or sleepy. However, the study did not specifically test Naproxen; the two drugs used were aspirin and ibuprofen (Brown, G.M., 1994).

Another study in the International Journal of Clinical Practice Published by John Wiley & Sons Ltd evaluated sleep aid and analgesic combination of Naproxen sodium and diphenhydramine in dental pain with patients with transient insomnia. The study aimed to demonstrate the added benefit and optimal dosages of the mixture of Naproxen and Diphenhydramine over individual ingredients alone in improving sleep and pain. 

There were two studies conducted, and the subjects were randomized, double-blind, and double-dummy trialed. The subjects in both studies were given a combination of Naproxen and Diphenhydramine in different dosages. The primary end-points in both studies were wake time after sleep onset and sleep latency which was measured by actigraphy. Other sleep and pain end-points were also assessed. There were no serious or unexpected events reported in the study besides 1 type of dosage (NS 440 mg/ DPH 50 mg)improving sleep quality (Simpson, K. and Jarvis, B., 2000).

It is generally advised to take medicine at nighttime before going to bed. You can get Naproxen online from a certified online pharmacy as it is available over the counter but you should contact your health care before consuming these medications.

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Things You Shouldn’t Do Under The Influence Of Naproxen


Avoid drinking alcohol. It may increase the risk of stomach bleeding. Consult your doctor if you get the symptoms of stomach or intestine bleeding. Some of the signs to look for are black or bloody stools, coughing up blood, or vomiting.

Use of Heavy Machinery/ Drive:

You shouldn’t operate heavy machinery or drive when under the influence of Naproxen as it causes fatigue and drowsiness. Also, try to avoid other activities that require alertness and attention, especially outdoors. 

In short, there is no concrete evidence of Naproxen showing adverse effects on sleep-cycle, but some other NSAIDs are found to affect sleep negatively up to some degree. Naproxen may cause drowsiness and fatigue, and hence you shouldn’t operate on heavy machines or drive (Thomas, R.G. and Thal, L.J., 2003).

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