Combining medicine in order to increase the potential has happened for many years, as it gives the stats and a method to heal the pain, disease in a new and effective manner. Simultaneously the same combination can also result in interaction and can cause dreadful situations, hence an experimental method but don’t worry experiment makes life better as it helps us to not repeat or use the unhealthy combinations of medicines.


Metaxalone belongs to the group of medicines called muscle relaxants. It is used to treat muscle spasms and stiffness. It is not a general painkiller rather treats pain that occurs due to muscle spasms, sprains, and strain.


Tramadol is a powerful painkiller and belongs to the class of medicines called opioid analgesics or narcotics.

It is a controlled drug and is only available on the prescription of a registered healthcare professional.

A controlled drug is a medicine that has the potential to be misused or can cause physical or mental dependence or you can say serious addictions.

Their sale is tightly controlled by government regularities and is only available on the prescription of a registered healthcare practitioner.

How Does Metaxalone Work?

It works by directly acting on the central nervous system (brain), and blocks pain sensations due to skeletal muscle spasms and stiffness.It usually uses the sedation or depression method and cuts down the pain signals from reaching the brain. Thus it relaxes the muscles not directly relaxing the actual muscles.

How does Tramadol work?

It mimics the action of opioid receptors and inhibits the pain sensations originating from the central nervous system (brain). Tramadol contains synthetic opioid which are metabolized and perform its action in the opioid receptors in them and also act on the central nervous system to relieve pain.

Uses of Metaxalone

Metaxalone is a skeletal muscle relaxer used along with rest and physical therapy to treat pain due to muscle spasms, sprains, and stress.

Uses of Tramadol

Tramadol is used when other painkillers fail to relieve pain. Tramadol is a strong painkiller. It is used to relieve moderate to severe pain such as postsurgical pain or for the ones who are unable to bear the extreme traumatic pain.

Combination Of Medication Is Good Or Bad?

Combination of medicine can’t be elaborated on whether it is always good or always bad. Some combinations increase the overall potential or some can make it worse in the form of interactions and side effects.

Combining Tramadol with metaxalone is not a good idea. Both medications depress the central nervous system (brain) and cause respiratory depression (difficulty in breathing), coma, and even death.

Can Metaxalone And Tramadol be Taken Together?

According to drug interaction classification, the interaction between Metaxalone and Tramadol is major and in a wise advice it should not be done.

When the drug interaction is major, according to guidelines we should avoid such combinations because the risk between them outweighs the benefit. The risk appears in intense side effects which is of course a combined side effect of a combined medicine interaction.

What Are The Side Effects Of The Combination Of Metaxalone And Tramadol?

The side effects of the combination are:

  • Dizziness
  • Drowsiness
  • Difficulty concentrating
  • Respiratory distress
  • Cognitive impairment
  • Coma

Interactions also happen with the food or beverages, medicines you consume.


Tramadol is a powerful painkiller used to treat moderate to severe pain while Metaxalone is a skeletal muscle relaxant used to treat pain or injury due to muscle stiffness and spasms. Although both are differently used, it is hazardous to take them together as both act on the central nervous system. The output will be disturbing side effects that can land you in hospital or emergency centers.

A combination of both medicines is generally avoided due to serious and life-threatening side effects.


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