Lisinopril belongs to a class of drugs referred to as angiotensin-converting enzyme inhibitors or ACE inhibitors, responsible for inducing a type of mucus-free cough named “dry cough” or “Lisinopril cough.” It is also because of Lisinopril’s ability to inhibit the kininase enzyme from breaking bradykinin.

Lisinopril has kidney-protecting properties and is used for lowering blood pressure. It is also a drug of fundamental importance for treating coronary artery disease, heart attack, and heart failure. Lisinopril is available through pharmacies online as well. You can get over the counter lisinopril.

Furthermore, it is hydrophilic, has a long half-life, and is not broken by the liver. Lisinopril is a common preference for doctors. For instance, in 2010, Lisinopril was the third most prescribed drug, with beyond 87 million prescriptions written.

Why Does Lisinopril Cough Occurs?

Being a well-known competitive inhibitor of ACE enzyme Lisinopril prevents the conversion of a potent vasoconstrictor, from angiotensin I to angiotensin II, ultimately lowering blood pressure. Scientists state that angiotensin-converting enzymes instigate the breakdown of cough-producing substances in the liver.

To this extent, when a person consumes Lisinopril, they may develop chronic dry cough because of blockage of the angiotensin-converting enzyme that leads to a solid local accumulation of cough-triggering substances. The cough may be intermittent or constant and non-productive– at times, tickle-like.

To add further, Lisinopril is also a bradykinesia (Slowness of movement) inhibitor preventing the breakdown of bradykinin, which reduces histamine levels. This additional histamine increase also causes a constant or intermittent dry cough. So to put it in a nutshell, dry cough, also named hacking cough, is one of the potential side effects caused by Lisinopril.

How To Eliminate the Cough Produced by Lisinopril?

Lisinopril’s half-life is 12 hours, and the drug roughly takes 60 hours or five half-lives to clear your system. The coughing effect of Lisinopril disappears the moment the drug ingestion is stopped; however, the duration for the cough to fade away varies from person to person. Anyhow, 14 days is a standard time for the cough to go away.

Researchers report that Patients should avoid taking iron supplements and ACE inhibitors to prevent the side effects and complications caused by the combination. The addition of iron with Lisinopril may worsen the condition. It is because the iron interferes with the drug absorption into the individual system prescribed the drug.

Risk Factors For Lisinopril 

Dry cough is a common phenomenon caused by Lisinopril but does not affect everyone. Studies reveal that around 5% to 20% of people taking ACE inhibitors suffer persistent dry cough. Moreover, the dry cough pops up after taking Lisinopril’s first dose. Most often, it takes weeks or months to develop and sometimes takes even longer. Also, most people do not develop coughs at all. The reason behind these various responsive actions is not yet known.
However, here are a few of the risks factors that increase the risk of a person developing dry cough;

  • Old age
  • Being non-smoker
  • Females sex
  • Hyperactivity of airways
  • Sensitive cough reflex

To summarize, people getting coughs because of Lisinopril intake generally have multiple risk factors. Having one or two risk factors does not contribute enough to the onset of a cough.


It is observed that sometimes a lower dose of Lisinopril does not show any dry cough side effects among people, whilst the opposite exists for increased dosage. Although harmless, it sometimes turns severe.

And because of this, people might think to quit the medication to relieve the cough. But it might be or might not be suitable for your health. Correspondingly, people consuming it to cope with their blood pressure may experience some adverse health effects.

That’s why discussing the issue with your therapist or physician is wise before changing or stopping the Lisinopril consumption. They will prescribe you a better alternative based on your condition. Despite this, it is advisable not to skip the medication at once.


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