Lisinopril belongs to ACE inhibitors (Angiotensin Converting Enzyme Inhibitors), which treat hypertension (high blood pressure), heart failure, and myocardial infarction.

How Does Lisinopril Act?

Lisinopril inhibits ACE, which converts angiotensin I to vasoconstrictor angiotensin II. Angiotensin II stimulates the adrenal glands of the kidney and secrets aldosterone as well. Both of them narrow the blood vessels, resulting in high blood pressure.

Thus, Lisinopril decreases blood pressure by inhibiting ACE, which consequently blocks aldosterone secretion. The vessels dilate, helping to lower blood pressure.

Can Blood Pressure Medication Cause Anxiety?

Not all medicines that lower blood pressure (such as beta blockers) cause Anxiety. However, these medicines help to reduce stress in many people.

In sporadic cases, people report that they have encountered Anxiety while taking blood pressure medicines which is often a side effect of that medicine.

Does High Blood Pressure Cause Mood Swings?

Many researchers have found a close connection between high blood pressure and mood swings.
It is found that high blood pressure can severely affect your mental health.
You are likely to deal with Anxiety and depression if you are hypertensive. (Having high blood pressure)

Lisinopril and Anxiety- The Side Effect Connection

One of the side effects of Lisinopril is Anxiety. Many studies have revealed that during therapy with Lisinopril, Anxiety goes away in a short time. However, if someone stops taking medicine abruptly, Anxiety may worsen.

Can Lisinopril Cause Depression?

Earlier, it was thought that Lisinopril causes depression but later on, different research studies revealed that it helps to reduce depression. But how? Here it penetrates its effect the brain very quickly and results in an antidepressant effect. It is a drug of choice when a patient is at risk of depression.

Can Lisinopril Help With Anxiety?

No, it does not help with Anxiety. Research does not provide any evidence that it helps to reduce stress.
In fact, during the treatment, the patient may feel Anxiety at the start, and then it goes away within a short time.

Types Of Medications That Can Cause Anxiety?

Many types of medicines can cause Anxiety:

  • Medication with caffeine (such as migraine medication)
  • Corticosteroids
  • Nervous system stimulators
  • Nasal decongestants
  • Thyroid medications
  • Antidepressant
  • Anti-seizure medicines
  • Drugs that are used in Parkinson’s disease

Which Medications Can Be Used To Treat Anxiety?

There is a list of medicines that treat Anxiety:

  • SSRIs such as escitalopram
  • Tricyclics, such as clomipramine and imipramine
  • Monoamine oxidase inhibitors (MAOIs), like isocarboxazid and phenelzine
  • Beta-blockers (propranolol)
  • Buspirone
  • Benzodiazepines which include alprazolam etc.
  • Selective serotonin & norepinephrine inhibitors (SNRIs), such as venlafaxine and duloxetine
  • Some anticonvulsants, such as pregabalin and gabapentin
  • Some off-label antipsychotics, such as aripiprazole


Further research and literature reviews have revealed that not all blood pressure medicines can cause Anxiety. Lisinopril can cause Anxiety, as this is one of its side effects. The study also suggests that during therapy with Lisinopril, Anxiety goes away in a short time. However, if someone stops taking Lisinopril abruptly, Anxiety may worsen.


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