Ibuprofen belongs to a non-steroidal anti-inflammatory drug (NSAID) class that treats disorders such as toothache, pain, headache, migraine, menstrual cramps, fever, and inflammation caused by rheumatoid arthritis. It also helps in healing minor injuries and aids in closing the patent ductus arteriosus in a premature baby.

The drug works by producing substances that diminish inflammation and aches causing hormones in the body. Ibuprofen can be consumed orally or injected through veins. The medicine shows its effects typically within an hour.

Whats The Working Pattern Of Ibuprofen?

When you have an injury, your immune system continues to perform its action to prevent infection. In the body's inflammatory response, the damaged cells, after injury, begin to release arachidonic acid (a natural chemical that bolts cyclooxygenase enzyme). Arachidonic acid and cyclooxygenase enzymes together create essential substances for blood flow, and as a result, they produce prostaglandin H2.

During a headache, injury, or bruise, prostaglandins are created in those areas, producing a throbbing feeling or sometimes warming the room. Prostaglandins help to form or remove blood clots in these areas, which is also a painful process.

Ibuprofen helps in stopping the formation of prostaglandins before it commences. The medicine enters the blood, circulates through the body, and restricts cyclooxygenase. In this process, only a few prostaglandins will be left that cause pain. That's the reason most patients end up having less pain and inflammation.

Moreover, ibuprofen blocks two forms of cyclooxygenase, one of which aids digestion, and the other helps in the body's activities, like blood flow. This can make a patient feel nauseous sometimes after consuming it. Generally, it is safe to take if taken according to the prescription.

Is Ibuprofen A Fast Acting NSAID In the Market?

Ibuprofen is a fast-acting NSAID compared to other NSAIDs (aspirin, naproxen, etc.). According to a medicine review, this drug works more effectively when you intake it with paracetamol. The recommended dose strength of ibuprofen is 100 - 200mg and of paracetamol is 60-125mg. The combination is well known for treating acute and chronic pain. You can also take ibuprofen with caffeine, which works well with caffeine.

When ibuprofen is taken with food, the absorption rate is slightly slower than the drug taken on an empty stomach. It works faster to relieve symptoms when you take it on an empty stomach; however, this method could increase the risk of stomach disorders like indigestion. That's why it is better to take it with food. Did You Ever Wonder How Long Does Ibuprofen Take To Leave System?

How Long Does Ibuprofen Take To Work?

The timeframe Ibuprofen takes to work in a patient's body varies from situation to situation. It generally takes 25-30 minutes to start working and ultimately shows its effects within an hour. After taking medicine, your fever and pain will decrease. In contrast, inflammatory diseases take a long time to recover. 

But in some patients (suffering from pain and inflammation for weeks or months), ibuprofen (after regular dosing) will take a few days to recover from the disorders.

The effects of ibuprofen will last for about six hours, and the results will be eliminated from the body after 9-10 hours. Young children (below the age of 16) bodies expel the effects of medicines much faster than adults (above 16 years).

Do Conditions Or Factors Affect The Time Of Ibuprofen To Work?

Some patients show quick reassurance, while others' bodies take a long period to recover after taking medicine. Before taking ibuprofen, certain factors should be considered as they will impact how long the drug will take to show its effects. These conditions include:

  • Strength of dosage taken
  • Weight of patient
  • Age of patient
  • Health history
  • Stomach condition - if your stomach has food in it or is empty

If you're taking any other drug at the time or not.

Can Interactions Affect The Half-Life Of Ibuprofen?

The half-life of medicine refers to how much time it takes to metabolize half of its dose and remove it from the bloodstream. Some drugs affect the half-life of ibuprofen; therefore, you should ask your doctor before taking any medicine with ibuprofen. Following are some medicines prescribed by doctors as these will least affect the half-life of ibuprofen after the interaction.

  • Lithium
  • Warfarin
  • Diuretics
  • Methotrexate
  • Beta-blockers

This is not a complete list of medicines, but if you take any of them with ibuprofen, your doctors must know about them.

Is There Any Difference Between Branded And Generic Working Time Of Ibuprofen?

There is no difference between the branded and generic working times of ibuprofen because the chief ingredient is present in both versions. The active ingredient is paracetamol which treats the disorders (mentioned above), so both function similarly and have the same working time.

Does Ibuprofen Make You Drowsy Due to Excessive Dose? 

Excessive doses of ibuprofen can make you drowsy. This is one of the side effects of taking ibuprofen in larger quantities and with solid strength (i.e.600 or 800 mg). If you feel tired or sleepy, you shouldn't stop taking medicine; instead, reduce the power of your dose (i.e., 100, 300, or 400mg max) and monitor your situation if you feel the same after lowering the strength. In that case, get your check-up done immediately and stop taking it.

Does The Quantity Decide The Working Of Ibuprofen?

The quantity of ibuprofen determines how effectively the medicine works and how much your body recovers from various diseases. 100mg - 400mg tablet is recommended for treating acute pain three times daily, and 200mg 3 times daily for treating rheumatoid arthritis.

But if you intake ibuprofen in bulk, you can face adverse side effects such as liver problems, anemia, shortness of breath, kidney disorders, and sudden weight gain. So it is better to take the recommended quantity of ibuprofen to prevent other health complications.


You can get ibuprofen over the counter with and without a prescription, but it is better to consult your doctor first. In case of overdosing, visit your doctor. He may insert a tube through your mouth to look for internal bleeding. You will be prescribed medications that make you throw up the overdose drugs, and your stomach will be decontaminated with activated charcoal.


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