Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces certain chemicals that cause pain and inflammation in the body. It reduces fever and treats pain or inflammation caused by headache, back pain, toothache, arthritis, or minor injury. It is safe for use in adults or children six months or older.

Naproxen is also a nonsteroidal anti-inflammatory drug. Like Ibuprofen, it works by blocking the chemicals that cause pain and inflammation in the body. It is used to treat inflammation or pain caused by arthritis, tendinitis, bursitis, gout, or menstrual cramps. It is safe for use in children 12 years and older.

Ibuprofen is a short-acting drug, while naproxen is a long-acting drug. Naproxen is more likely to cause an upset stomach. Both these drugs are NSAIDs and are similar in many ways, but there are some differences. It is generally not advised to take Ibuprofen with Naproxen or with any other NSAIDs.

What Happens When You Take Ibuprofen And Naproxen Together?

Combining these two medications may increase the risk of side effects. It can affect the gastrointestinal tract and cause bleeding, inflammation, ulcer, and in some rare cases, can also cause perforation.

Gastrointestinal perforation can be fatal, which causes holes in your stomach and intestine. We suggest you take these drugs with food to reduce any risks.

You can always talk to your doctor if you have any questions or concerns. Your doctor may prescribe other medications that may not interact with these medications. You can order  Naproxen online from a certified online pharmacy as it is available over the counter.

Seek immediate medical attention if you experience any symptoms of bleeding such as:

  •  Dizziness
  •  Lightheadedness
  •  Red or Black Stools
  •  Coughing or Vomiting blood 
  •  Headache and Weakness

Do not stop using any medications without consulting your doctor first.

Avoid taking Aspirin, Ibuprofen, or Naproxen within 8 to 12 hours of each other. These NSAIDs may be taken in combination with acetaminophen for additional pain relief. If you have pre-existing medical conditions, tell your doctor (Polat, O., Karaman, A.I. and Durmus, E., 2005).


A study published by the department of pharmacology at the University of Bordeaux, France, studied NSAID drugs, their safe and effective use, and adverse side effects due to drug-drug reactions.

The study reported adverse drug reactions (ADRs), including gastrointestinal bleeding and cardiovascular and renal effects due to NSAID use. In many cases, ADRs may occur due to drug-drug interaction between the NSAID and other medications. When assessing potential risks of ADRs, it is crucial to consider the dose and duration of NSAID use and the type or class of comedication administered (Pacheco, D.P., Manrique, Y.J. and Martinez, F., 2007).

Health care professionals can be crucial in educating patients to use the lowest effective dose for the shortest required duration for good balance and safety. Refer to the link to read the entire study.


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