Differentiating between medicines is one of the confusing work. Various factors are involved in this process.

It becomes more complicated when we have to compare and decide between two medications which work the same. The same thing has happened between Gabapentin and Pregabalin.

A Brief About Gabapentin And Pregabalin

Gabapentin Vs Pregabalin- Who Wins?

The difference lies in the metabolism or bioavailability rate of medicine. As per the comparison, Pregabalin gets absorbed much faster, leading to an immediate effect (Cross AL, Viswanath O, Sherman Al).

The bioavailability of Pregabalin is 60 percent. Gabapentin has a slow absorption rate, awarding Pregabalin a winning position (Yasaei R, Katta S, Saadabadi A).

A dose of 50 mg per day is equally effective as 300mg per day of Gabapentin. Pregabalin reaches the maximum level in blood about 1.5 hours, whereas Gabapentin reaches its peak level in about 2 to 4 hours.

Gabapentin is not available over the counter in the United States without a prescription. You can buy gabapentin over the counter with a valid prescription  from a certified online pharmacy.

Gabapentin and Pregabalin are anticonvulsants, medicines that are prescribed for seizures and nerve pain. In a broad view, Gabapentin And Pregabalin are effective medicines, so which med wins the battle? (Yasaei R, Katta S, Saadabadi A).

Gabapentin and Pregabalin work similarly. Both influence the neurotransmitter called GABA, and its drowsy effect helps decrease pain (Cross AL, Viswanath O, Sherman Al).

The kidney metabolises Antoconsulvant hence these medicines do not stay for a more extended period of time. So what makes the difference?

Gabapentin Vs Pregabalin Dosage

Gabapentin Dosage:

For Adults: 50 mg and three times a day, should not exceed 300 mg per day

For Children: The medical expert will provide a prescription according to the examination (Yasaei R, Katta S, Saadabadi A).

Extended-release tablet: 

Adult: 165 mg once a day, should not exceed 330 mg per day

Pregabalin Dosage:

For Adults: 300mg one time on 1st day, 300mg 2 times on 2nd day, 300mg 3 times on 3rd day. The time between two doses should not exceed more than 12 hours (Cross AL, Viswanath O, Sherman Al).

For Children: Health experts can consult dosages.

Precautions For Gabapentin Vs Pregabalin

Precautions Of Gabapentin

People having below mentioned problems should avoid gabapentin

  • Breathing issues (Breathlessness)
  • Kidney problems
  • Any drug addictions
  • Liver issues
  • Chest pains or any heart-related problems
  • Mood swings, depression and anxiety

Precaution Of Pregabalin

Precautions that you should keep in mind before consuming Pregabalin and for conditions that you are facing, such as:

  • Heart or chest pains
  • Allergy to the medicine
  • Suffering from kidney or liver issues
  • Diabetes
  • Depression

These medicines should not be given to children. Consuming medication without the doctor's consent can lead you to severe troubles.

Medicines have their positives and negatives that help your body heal from the conditions you face.

Side effects of (Gabapentin vs Pregabalin)

Side Effects Of Gabapentin Side Effects Of Pregabalin
Dry mouth Drowsiness
Constipation Lack in concentration
Swelling Difficulty in speaking
Blurriness in your vision Breathlessness
Rapid weight gain Panic attacks

(Yasaei R, Katta S, Saadabadi A).

(Cross AL, Viswanath O, Sherman Al).

Above mentioned side effects are a small gist of side effects that you might get affected by Gabapentin and Pregabalin medicines. 

Can I Take Gabapentin Vs Pregabalin During Pregnancy And Breastfeeding?

Gabapentin and Pregabalin have adverse effects on the fetus and can result in death. You should call your health expert immediately if you have taken the dose.

During breastfeeding, a small amount of medicine is released into the milk. Please avoid using both mentioned medicines.

Is There Any Danger While Switching From Gabapentin To Pregabalin Or Vice Versa?

There is no mishap involved while switching from Gabapentin to Pregabalin. Doctors can prescribe you a lower dose of Gabapentin before switching just as a beginning process. Do consider a healthcare professional to supervise you.

Are Gabapentin And Pregabalin Controlled Drugs?

Some countries or states have declared these medicines as controlled drugs.

Pregabalin is classified as a schedule 5 controlled substance in the US. States like Kentucky, Virginia, Michigan, etc., classify Gabapentin as a controlled substance.

What If Gabapentin And Pregabalin Taken Together?

There are combinations done with Gabapentin and Pregabalin for effective results. If both these medicines are mixed, it can result in addiction or other toxic effects.

The absorption time of Pregabalin is higher than Gabapentin. When absorbed, they can increase a mixture of unknown consequences.


The match result is clear. Pregabalin wins this battle against Gabapentin. Higher metabolism is the key factor behind Pregabalin's win.

According to the whole scenario between them, we can specify that medicine having the exact working mechanism can differ in some aspects and that factors making them a choice for health recovery.

Another point is that prescription is better application to good health.


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