Medications have different varieties, and each has its effectiveness for the condition. When medications are combined or taken together, it can increase strength regarding the issue or vice versa. 

Diclofenac and Tylenol have different mechanisms of action and are also used to treat various conditions. What if it is combined and used? Let's see, but first, a short teaser of them.

Diclofenac And Tylenol ( A short teaser)

Diclofenac is NSAID(Non-steroidal Anti-inflammatory drug) used to treat pain from arthritis, rheumatoid arthritis etc.

It blocks the production of pain-inducing hormones called COX1 and COX2 and relieves the pain. Diclofenac is also available over the counter (Todd, P.A. and Sorkin, E.M., 1988).

Tylenol also known as Acetaminophen is a pain reliever which helps in menstrual pain, headaches, fever etc. It blocks the enzymes that produce prostaglandin in the brain(a pain chemical) and stops the pain signals from reaching the brain. You can buy Tylenol over the counter online from a trusted and reputed online pharmacy (Ameer, B. and Greenblatt, D.J., 1977).

Observing keenly, we get to know that the medicines can stop pain arising from different conditions. So We can make a combination to increase the power of medicine. Is it possible?

Diclofenac And Tylenol: Useful Or Not?

Firstly, let’s clear your doubts about interaction. This mixture found no interaction in this combination. However, it doesn't mean it cannot affect your health. You should notify your healthcare consultant before usage.

Mixing Diclofenac and Tylenol can be compared to two machines working for a single cause in their respective mechanism. Diclofenac relieves the pain by stopping cox one and cox2, which helps in decreasing the inflammation and swelling of the muscles and bones.

In contrast, Tylenol inhibits the prostaglandin in the brain to reduce the body's temperature. Together they make an effective way to treat conditions or issues. We can say that the combination is successfully treating pain.

Can We Use Diclofenac And Tylenol For Long Term Purpose?

When you decide on its long term use, ask yourself and your doctor is it essential?. Generally, it is not recommended for long term usage as it can cause stomach bleed, ulcers, diarrhea, and increased unknown side effects.

Any medicine or combination of medication should be thoroughly discussed and consumed as per the prescription. Remember, you are a patient, not a self expert.

Who Cannot Use This Combination Of Diclofenac And Tylenol?

People who are allergic to painkillers have sensitive guts, heart conditions etc., should not use this medicine. This combination is prescribed to selected ones due to their condition and examined circumstances.

Some people still use it to escape their issues quickly without observing their effects on themselves. It can increase the weakness and strengthen the side effects on the body.

Does Diclofenac + Tylenol Interact With Each Other Or Other?

There were no severe interactions found in this combination, but they can interact with other medications and can harm the system

If you are consuming Tylenol and Diclofenac together, the medicines you should not consume with these two are mentioned below:

  • Aspirin
  • Antipsychotic drug
  • Blood thinners
  • Anti- Gout
  • Anti Cancer medicines 
  • Alcohol
  • Hypertensive drugs
  • Anti-Diabtetes medicines
  • Side Effects Of Diclofenac Plus Tylenol
  • Diarrhea
  • Intestinal bleed
  • Ulcers
  • Headaches
  • Irregular heartbeat
  • Breathing difficulties
  • Skin rashes
  • Dizziness
  • Hepatitis (Todd, P.A. and Sorkin, E.M., 1988)

Forms And Dosages Of Diclofenac


  • Tablet- 50mg
  • Delayed release tablet -25mg, 50mg, 75mg
  • Extended release tablets-100mg
  • Capsules-18mg, 25mg, 35mg
  • Oral solution-50mg
  • Injection -37.5mg

Dosage Of Diclofenac For Rheumatoid Arthritis And Osteoarthritis

  • 14 years and older:

Diclofenac Potassium

  • 50mg (Gap of 8 to 12 hours)

Diclofenac Sodium

  • 50mg (gap of 8 hours) or
  • 75mg (12 hours)


  • 100mg (per day) or
  • 200mg (per day if needed) per day (Todd, P.A. and Sorkin, E.M., 1988).

Precautions  That A Person Should Take Before Consuming Diclofenac

  • Avoid usage if you are allergic to diclofenac
  • ACE Inhibitors should be avoided
  • People who are 75 years or older in age are not recommended to use for long period
  • Alcohol and Cannabis should be avoided.
  • Notify doctor if you are consuming any hypertensive drug

Caution: Pregnant ladies should avoid using diclofenac and breastfeeding women too. They should take advice from their healthcare before using it.

Forms And Dosages Of Tylenol 

Tylenol is available in tablet and liquid form. Strengths of tablet form are 325mg, 500mg and 625mg. Whereas liquid gel consists of 325mg.

Dosage Of Tylenol


  • Two tablets of 500mg at a gap of 4 to 6 hours.
  • Max dose up to 4000mg per day.

Disclaimer: Only ten days recommended.


  • 325-650mg of 1 dose at a 4-6 hours gap.
  • Max dose up to 3250mg a day.

Disclaimer: Dosage might differ according to age and weight.

What Is The Dosage Of Diclofenac And Tylenol?

Your health expert prescribes Diclofenac and Tylenol combination doses as per your health status. Combination medicines sometimes prove effective, and the same can cause side effects.

It is better to follow the advice. For a short idea of the dose, one can take two tablets every 6 hours of a gap of 24 hours. Again the dose should be well consulted by your physician.

How Long Does Diclofenac+Tylenol Stay In Your System?

Tylenol has a half-life of 2-4 hours and gets eliminated after 24 hours. Diclofenac has a half-life of 2-3 hours and wears off in 15 hours through urine.

When combined, the peak absorption time also differs. There is no fine study about how much it stays in your system but certain studies help us know it can last for two days in the system.


The combination is the new era of increasing the strength of medicine to relieve pain. The combination can be beneficial as well as yield unwanted situations. Diclofenac and Tylenol together are helpful in pain management.

The interactions are below the possibilities. Then too, the user has to be aware of both medicines' side effects.  Always take advice before trying any mixture. And always ask the question!


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