Carisoprodol with Hydrocodone

What is Carisoprodol (Soma)

Carisoprodol (Soma) is a strong muscle relaxant that restricts pain sensations in the brain’s nerves. It is prescribed during resting and physiotherapy to treat conditions of the skeletal muscles, such as pain or injury. It can also be used for recovery, physical therapy, and other measures to relax muscle strains and sprained muscle injuries. The Drug Enforcement Administration (DEA) lists Carisoprodol as a Schedule IV controlled substance. Due to its sedative nature, Soma can be addicting. If Soma is ingested in high doses, it can intensify its effects and result in the patient feeling the same after-effects that drugs cause.

Due to its sedative, relaxing and euphoric effects, Carisoprodol can be addictive, especially in higher doses and with prolonged use. People who consume it regularly, even if they take prescription drugs, can develop an addiction over time.

Carisoprodol is the most active and important substance in Soma. As Soma creates a calming effect in mind, other Central Nervous System drugs like alcohol, benzodiazepines, opioids, and tricyclic antidepressants may result in addiction.

The sedative and relaxed feeling caused by the medication may be addictive for some patients who later misuse Soma in recreational ways to experience increased euphoria. This can be detrimental to health as it would later cause life-threatening complications, which would require prolonged therapy and rehab.

What is Hydrocodone (Vicodin)

Hydrocodone (Vicodin) is a painkiller and an antitussive that falls under the category of opioid painkillers. Antitussives are prescribed as cough suppressants .it is prescribed for severe pain caused after surgery or injury. It functions by blocking pain receptors in the brain and increases the sensation of euphoria, which can be addictive and compels users to misuse or abuse it.

To be more precise, hydrocodone is a semi-synthetic Schedule II opioid pain medication. Semi-synthetic drugs are drugs that are synthesized chemically from a naturally existing compound. The Drug Enforcement Administration (DEA) considers hydrocodone a Schedule II controlled substance because it tends to abuse and addiction.

Schedule II consists of drugs with a high risk of addiction and causes psychological conditions and severe dependence. Some schedule II drugs are oxycodone, methadone, hydromorphone, etc.

Opioids and drugs that fall under the class of opioids are powerful narcotics prescribed for relief from moderate to severe pain from surgery. Opioids function by stimulating the brain to increase the production of dopamine. Hazardous risks of opioids include abuse, addiction, overdosing, and death. Opioids possess a high risk of addiction with their strong side effects.

Can Hydrocodone and Carisoprodol be taken together?

The combination of Hydrocodone and Carisoprodol, when taken together, is subject to abuse, addiction, coma, and even death. When narcotics or cough suppressants like hydrocodone interact with a medication used for pain relief like Carisoprodol, it induces heightened effects and side effects. Since both these drugs work on the Central Nervous System, it may cause Central Nervous System Depression, leading to severe conditions. This combination induces a high that is usually experienced after taking drugs. The combination of hydrocodone and Carisoprodol is potent and is not advised for consumption by professionals.

Houston Cocktail

The lethal combination of hydrocodone, Carisoprodol, and alprazolam is known as ‘Houston cocktail’ and ‘the Holy Trinity. The combination (Carisoprodol, hydrocodone, and alprazolam) is made up of components that belong to the class of muscle relaxers, opioids, and benzodiazepines, respectively.

Houston cocktail is sought illegally by people who practice substance abuse and have an addiction.

Houston cocktails are usually provided at social settings like raves, parties, clubs, etc. They are consumed by teenagers or adults who are eager to abuse drugs and experience euphoric feelings.

Houston cocktails are also used for harmful purposes. They have similar properties that are present in date rape drugs.

Side effects caused by Hydrocodone with Carisoprodol

The risky combination of controlled substances that work as Central Nervous System (CNS) depressants is bound to bring about twice the normal side effects experienced, which are:

  • Dizziness
  • Drowsiness
  • Convulsions (seizures)
  • Instability
  • Respiratory problems
  • Intense sedation
  • Impairment in thinking and action
  • Hypersensitivity to noise and light
  • Hallucinations
  • Coma
  • Death

Warnings and Precautions of Carisoprodol and Hydrocodone

Initially, this combination is not advised because of its severe side effects that sometimes lead to coma and death. However, suppose consumption is required for treatment for any illness or condition. In that case, professional doctors should hold proper supervision, and dosages should be appropriately adjusted according to the patient’s medical needs. Some precautions and warnings to keep in mind when consuming this combination are:

  • Dosages should be kept minimal as sudden withdrawal may lead to severe withdrawal symptoms.
  • This medication should not be used for a long duration. Do not try to tamper with the doses, frequency, or duration of consumption; only do so if the doctor advises.
  • As the medication affects the patient’s stability and thinking, avoid driving or operating heavy machinery to avoid unnecessary injury.
  • Grapefruit or grapefruit juice should be avoided for consumption as grapefruit increases the concentration in hydrocodone which may cause harmful side effects.

References Accessed on 1/08/2021

Forrester MB. Ingestions of hydrocodone, carisoprodol, and alprazolam in combination reported to Texas poison centers. J Addict Dis. 2011 Apr;30(2):110-5. doi: 10.1080/10550887.2011.554778. PMID: 21491292. Accessed on 1/08/2021 Accessed on 1/08/2021

Dayong Lee, Peter Stout, Donald Egdorf, Houston Cocktail: Driving under influence of hydrocodone, alprazolam, and carisoprodol,
Forensic Science International, Accessed on 1/08/2021 Accessed on 1/08/2021

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