Naproxen came into existence in 1994, whereas the first drug was sold with a prescription in 1976.

FDA approved it on 17th February 2006.Naproxen is a drug used in the mediation process to deal with inflammation and different pains.

Different pains include headaches, toothache, period cramps, and muscle pains.It also helps overcome pains such as swelling in the body and muscle stiffness.

It helps in relieving arthritis problems. It makes it possible for people to heal fever and cold.It is a nonsteroidal anti-inflammatory medicine that helps in curing inflammation.Naproxen can be found over the counter and as a prescription-based medication.

It is an over the counter medication which you can buy without prescription, even you can buy Naproxen onine from certified pharmacy.

Naproxen is a generic name, whereas Aleve, EC-Naprosyn,Aleve Easy Open Arthritis, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium, Aleve Caplet, Aleve Gel Cap,Anaprox, Anaprox-DS, Flanax Pain Reliever are the brand names.

Non antiinflammatory drug is a drug class for Naproxen.Prednisone helps keep the immunity levels in control and a track on it. Prednisone is a drug used in curing problems such as cancer, arthritis, and breathing issues.

It is used as a solution in treating various conditions. It helps many people who suffer from immunity and keep it normal.It treats different conditions such as allergies, skin problems, and eye-related problems (Todd, P.A. and Clissold, S.P., 1990. Naproxen. Drugs40(1), pp.91-137).

Prednisone helps keep the inflammation in control. It is an immunosuppressant medication.Prednisone is a prescription-based medicine only; it cannot be purchased over the counter without a prescription.

Prednisone came into existence in the 1950s, whereas it got FDA approval on 26th July 2012.  Deltasone, Sterapred, Rayas are the brand names, whereas Prednisone is a Generic medicine.Corticosteroid is a drug class of Prednisone (Tannock, I.F., De Wit, R., Berry, W.R., Horti, J., Pluzanska, A., Chi, K.N., Oudard, S., Théodore, C., James, N.D., Turesson, I. and Rosenthal, M.A., 2004).

Can you take Naproxen and Prednisone?

If you take Naproxen and Prednisone there are interactions found, of getting a serious stomach ache.

This stomach ache may include bleeding, inflammation, ulceration, and gastrointestinal toxicity.

Due to two different drug classes (Corticosteroid and nonsteroidal antiinflammatory drug) may increase side effects.

There are relative risks found on people who are older than 60, facing issues such as peptic ulcer disease and GI hemorrhage (Beck, C., Morbach, H., Beer, M., Stenzel, M., Tappe, D., Gattenlöhner, S., Hofmann, U., Raab, P. and Girschick, H.J., 2010).

Caution- It is recommended that people consuming Naproxen and Prednisone together consume after the food.

Observe your body; if there are any problems, you should immediately call your doctor and report your signs and symptoms.

If you feel any effects such as sleepiness, headache, or any abdominal pain, you should inform your doctor for quick action to be taken.


Many people in the world suffer from inflammation. Roughly around 350 million people in the world are suffering from it.

There is a possibility of people dying due to inflammation.

20% of people in the United States of America suffer from it.

Most people are suffering from issues such as arthritis and joint diseases.

More than 60 million people can exceed in the upcoming years.

How does Naproxen work?

Naproxen is a drug for anti-inflammatory that works by stopping the natural substance produced after consuming Naproxen and acts against inflammation.

It helps by lowering the hormones, which causes pains and inflammation in the body (Valjakka-Koskela, R., Kirjavainen, M., Mönkkönen, J., Urtti, A. and Kiesvaara, J., 1998).


The study was made to know how the medication of Naproxen and Prednisone work together.

This study was taken from, where FDA collected the data.

The data was collected by observing 5405 people who took Naproxen and Prednisone.

 The results showed interactions found in people who have consumed Naproxen and Prednisone. In males, drugs were ineffective, and women had pains with common interactions.

Naproxen Forms and Strengths




250mg, 375mg and 500mg.

Fast Absorbing tablets and Capsules

220mg (OTC)


275mg and 550mg (With prescription)



Prednisone Forms and Strengths




1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg

Delayed release tablets

1mg, 2mg, 5mg.



Naproxen (Dosage)


Adult (18 and older)

Immediate release tablet

Dosing at start : 750mg

Continuity dose : 250mg

(It should be taken at 8 hours of interval)

Delayed release oral tablet

Dosing at start : 100mg to 1500mg

(Daily once)

Naproxen sodium

Immediate release tablet

Dosing at start : 825mg

Continuity Dose : 275mg

( Should be taken at every 8 hours of interval)

Child Dosage (Younger than 18)

There is no relevant dosage for people below 18 years of age, Do consult a doctor.

Dosage (Prednisone)

(Stomach Disease)

Adult (18-64)

Dosing at start : 5mg (60mg per day can be consumed)

Immediate Release-

Alternate day therapy can be used only after doctors advice.

Child (0-17)

Dosage will depend on weight of the child

Senior Citizen (65 and older)

Lower dose can be advised only by a doctor if needed.

 Dosage (Prednisone)

(Allergies and Asthma)

Adult (18-64)

Dosing at start- 5mg (60mg per day can be consumed)

Immediate release

Alternate day therapy can be used only after doctors advice.

Child (0-17)

Dosage will depend on weight of the child

Senior Citizen (65 and older)

Lower dose can be advised only by a doctor if needed.

The dosage provided is a common dose that a person can use.

It should be consulted by the medical practitioner for getting a proper dose as per the severity of your health condition.

This will prevent you from not getting severe effects.

Your previous medical history should be shared with your doctor so that no drug can interact with other drugs which you are consuming.

Side effects

Get an emergency medical if you find any of the severe side effects such as:

  • Chest pain: If you ever feel like having a heart attack.
  • Lack of oxygen: If you are feeling breathlessness
  • Reaction: If you get severe skin rashes.
  • Kidney problem: If you are feeling pain or swelling in your stomach area
  • Stomach bleeding: If you are puking blood

These are severe issues; there can be more even. When you observe any severe conditions, you should get emergency help.

Normal effects which can be seen, such as :

  • Mild headache
  • Stomach pain
  • Lumps seen in any part of the body.
  • Itching
  • It Feels like acidity.

Normal effects can be seen; observe the symptoms, and do not forget to inform your doctor

Side Effects (Prednisone)

Get emergency help if you observe any severe side effects such as :

  • If you feel your stamina getting low
  • If you are feeling breathlessness
  • If your vision gets blurred
  • If you are getting into depression and anxiety
  • If you are puking blood

Do consult a doctor if you see any severe effects and not get yourself into trouble.

 Normal effects were seen after consuming Prednisone, such as :

  • If your stomach gets bloated.
  • Mild headache
  • Over sweating
  • If your skin gets acne
  • If your mood starts getting changed.

Normal effects should be known to the doctor for not getting into severe situations and making yourself not get affected.







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Naproxen and Prednisone have various elements that work differently. They work individually well on different problems.

It has the same elements which work for inflammation. There are side effects that have been seen that can harm your health if both are taken together.

These side effects are mild, yet you should be smart enough not to get into severe troubles without consulting a doctor, even after the research proves interactions.


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