Benadryl, consisting of the active ingredient diphenhydramine, is classified as the first-generation Antihistamine drug. It used to treat allergy symptoms. It works by decreasing the effect of a natural chemical known to be histamine responsible for generating allergic symptoms like sneezing, itching, watery eyes, and a runny nose.

Benadryl can make you sleepy; that's why it is also known as a drowsy or sedating antihistamine. Benadryl inhibits the body's serotonin (a natural mood stabilizer) reuptake by blocking H-1 receptors and resulting in sedating and drowsy effects of Benadryl. Furthermore, the first developed antihistamine to treat allergies was Benadryl.

Loratadine is the second-generation antihistamine drug used to treat hay fever, conjunctivitis, urticaria, eczema, reaction to some insect bites and stings, allergy reaction, and seasonal allergic rhinitis. In contrast, Loratadine is amongst the more recently developed class of antihistamines. Loratadine can perform its action by blocking histamine receptors (H1 receptors) positioned outside the brain, and spinal cord and thus makes Loratadine a non-drowsy or non-sedating antihistamine. You can buy loratadine otc or online through several genuine pharmacy websites.

Can Benadryl And Loratadine Be Taken Together?

Treating the same disease by administering more than one medicine from the same drug or therapeutic class category is named therapeutic duplication, which can be intentional for signified benefits.

On the other hand, therapeutic duplication can be done accidentally when more than one doctor does patient treatment and a prescription is filled at more than one pharmacy, which results in undoubtedly adverse consequences. Usually, from the drug class known as an antihistamine, the beneficial use of the number of medicines taken simultaneously is only one.

Since Benadryl cannot interact with Loratadine, and both medications belong to the antihistamine class of drugs and have overlying side effects; therefore, without a doctor's recommendation, the patient should avoid the combination of Benadryl and Loratadine in the patient.

Under Which Condition Can Loratadine Be Combined with Benadryl?

The following are the few situations under which doctors combine Loratadine with Benadryl;

During Longer Hours Gap

Furthermore, without the addition of potential benefits, their combination could intensify the side effects of both medicines, for example, dry mouth, headache, and sleepiness. Because of the longer half-life, Loratadine remains in the body for an extended period, and taking Benadryl 12 hours after taking Loratadine might be harmful. Patients are advised to only take Benadryl and Loratadine together within 24 hours with a doctor's recommendation. An equally vital thing to be worried about is the addition of drowsiness when both are taken together.

Whereas, in some circumstances, the practitioner usually suggests the combination of two antihistamines. Second-generation Loratadine should be given during the day, and first-generation antihistamine Benadryl should be used at night. Meanwhile, people can use this combination for a short period under the observation of a physician. And particularly, the combination of both drugs is mainly used for allergic reactions or hives.

During Hay Fever and Serious Allergy

Compared with Loratadine, Benadryl is more productive for blocking an allergic reaction. In the case of seasonal allergies, if you are taking Loratadine and suffer a severe allergic response before going to the hospital, with a doctor's recommendation, the addition of Benadryl is more suitable to add to the therapy.

In other conditions, the over-the-counter antihistamine is insufficient to treat the symptoms of horrible hay fever. In such cases, the doctor adds two antihistamines, Benadryl and Loratadine, to manage the itchy rash skin or other intense conditions caused by hay fever.

In brief, if a doctor recommends the combination, using different antihistamines for potential benefits is better. Another point to be noted, the doctor's recommendation is a must before taking a variety because it can cause serious side effects.

Side Effects Of Combination

Besides the beneficial effects of using the combination, some side effects are caused by using a variety of Benadryl and Loratadine. The side effects that may occur using the combination of both medicines include;

  • Sedation
  • Drowsiness
  • Dry mouth
  • Constipation
  • Blurred vision
  • Neurocognitive decline with early onset of dementia.

In addition, their combination can cause antihistamine poisoning, which has severe and life-threatening side effects, including gastrointestinal agitation, fast heartbeat, blood pressure disturbance, issues with balance and coordination, and behavioral changes.

Limitation for Intake And Non-Intake of Benadryl and Loratadine

Some boundaries are set for medications, and an Expert or patient can monitor some parameters thoroughly before giving medicine to patients.

Most commonly, Benadryl can be given to adults and young people with an age limit of 16 years or above. With pharmacist and doctor recommendations, Benadryl can be given to children according to age and symptoms. But in the case of children younger than two years, Benadryl is not the right choice for them. Patients should avoid using Benadryl and tell the pharmacist or doctor if they have any allergic reaction to diphenhydramine, lung problems, angle closure glaucoma, blockage in the stomach or gut, and kidney and liver problems.

Like Benadryl, using Loratadine should be avoided in children younger than two years. For children 2 to 5 years old, Loratadine is effective in syrup dosage form, and for patients above six years, a variety of liquid capsules and tablets are available. Avoid using Loratadine if you are allergic to it, have an allergy to food additives, or have epilepsy. In addition, you must inform the pharmacist or doctor if you have any problem, as mentioned above.


To conclude, the combination of Benadryl and Loratadine is not suitable for patients because of the increased chance of side effects using the combination. As described earlier, Benadryl is more effective for treating allergic reactions, so with the doctor's recommendation, Benadryl can be used with Loratadine but for a short period under supervision. You can buy 


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