Can You Take Tylenol And Meloxicam Together?

Can You Take Tylenol And Meloxicam Together?

Tylenol and meloxicam are NSAIDs medication that treats pain and inflammation-related issues. Both Tylenol and meloxicam can be taken together as these drugs do not lead to any drug interactions.

Can Meloxicam be taken with Tylenol?

Meloxicam and Aleve (naproxen) are both nonsteroidal anti-inflammatory medications (NSAIDs) that are used to treat pain, fever, and inflammation. They’re used to relieve mild to severe Pain from things like headaches, menstruation, migraines, arthritis, sprains and strains, and toothaches.

For moderate discomfort that is not controlled by NSAIDs alone, NSAIDs can be used with Tylenol (acetaminophen). It’s advised to avoid taking more than one NSAID at a time because you’ll increase your chances of suffering negative effects. Both Tylenol and meloxicam being NSAIDs can lead to some harmful effects. 

GI distress such as bloating, diarrhea, constipation, irritation of the stomach lining, nausea, and vomiting are the most prevalent side effects. NSAIDs also have an impact on renal function, slowing blood flow through the kidneys. They may induce salt and water retention, resulting in edema and excessive potassium levels. 

Some nonsteroidal anti-inflammatory drugs (NSAIDs) have a significant risk of cardiovascular thrombotic events such a heart attack or stroke. NSAIDs can also cause asthma, headaches, sleeplessness, and hives.

It is safer to take Tylenol with either meloxicam, but meloxicam and Tylenol should not be used together. Consult your doctor if the discomfort persists or worsens.

Study on Tylenol and Meloxicam Together

Research: this study was conducted by aRice University, Houston bU.S. Army Institute of Surgical Research, JBSA – Fort Sam Houston, Texas, USA. Aim: The effects of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples were studied in this study. Results: the results detected that Acetaminophen or meloxicam had no effect on PT or any Rotem measures. Platelet aggregation and aPTT were harmed by acetaminophen and meloxicam. Characterizing the effects of acetaminophen and meloxicam on bleeding in vivo requires more research (Martini AK, Rodriguez CM, Cap AP, Martini WZ, Dubick MA).

What is Meloxicam, and How does it Work?

Meloxicam, marketed as Mobic, is a nonsteroidal anti-inflammatory medicine used to treat pain and irritation caused by inflammation and enlargement, and hardness in the joints. This medication can be either orally or injected into the veins. This medication works by preventing the synthetic Cyclooxygenase protein from doing its job, resulting in pain and edema are caused by prostaglandins (Noble, S. and Balfour, J.A., 1996).

What is Tylenol, and How does it Work?

Tylenol is a pain reliever, a nonsteroidal anti-inflammatory drug used to treat a variety of ailments, including muscular pain, headaches, sore throat, flu, arthritis, and more. It includes acetaminophen, an active chemical that recognizes the source of the Pain. It produces prostaglandins, which send a message to the brain and prevent Pain (AMEER, B. and GREENBLATT, D.J., 1977).

Forms and Strengths of Meloxicam 

Form: This medication’s dose can come in the form of capsules, pills, or an injection

Strength: Suppository; 120 mg, 125 mg, 325 mg, 650 mg; Chewable tablets; 80 mg; Junior tablets: 160 mg; Regular strength: 325 mg; Extra strength: 500 mg (Noble, S. and Balfour, J.A., 1996).

Form and Strength of Tylenol

Form: This drug is available in tablet, caplet, capsule, and other forms and is suitable for adults and children.

Strength: Tablets 325mg, 500mg; Caplets containing 325 mg and 500 mg; Capsules 325 mg 500 mg 650 mg (AMEER, B. and GREENBLATT, D.J., 1977).

How to take Meloxicam? 

However, one can consume meloxicam with or without food under the doctor’s guidance and surveillance. It is advised to take meloxicam at the same time every day (Noble, S. and Balfour, J.A., 1996).

How to take Tylenol? 

When symptoms remain, take 2 caplets every 6 hours. If not advised by a doctor, do not take more than 6 caplets in 24 hours. Unless instructed by a doctor, do not take for longer than 10 days (AMEER, B. and GREENBLATT, D.J., 1977).

Meloxicam Dosage                

The drug’s dose for children must be discussed with a doctor since safety is paramount. Adults, on the other hand, should take their medications as follows:

In General Dosage

The recommended dosage for this drug is 15mg, which can be raised to 25mg with a doctor’s approval.

  • In the case of hemodialysis

In the condition of hemodialysis, the dose is around 7.5mg.

  • In the case of adults with osteoarthritis

If diagnosed with osteoarthritis, the oral dose is around 7.5mg.

  • When it comes to rheumatoid arthritis

The recommended dose is 7.5mg.

Meloxicam medicine must be used exactly as recommended because an overdose of this drug can be fatal (Noble, S. and Balfour, J.A., 1996).

Tylenol Dosage 

Dosage in Tablets: This medication’s recommended dosage ranges from 325mg to 500mg when taken orally.

Dosage in Caplets: This medication’s recommended dosage ranges from 325mg to 600mg when taken orally.

Dosage in the Form of Capsule: Tylenol may be taken orally in doses ranging from 325mg to 500mg, much like tablets (AMEER, B. and GREENBLATT, D.J., 1977).

Meloxicam Overdose

Overdosage on this medication can be lethal and can lead to side effects such as drowsiness, dizziness, fatigue. Other than that can also be adverse, including gastrointestinal bleeding, renal failure, coma, which is considered to be a rare case (Noble, S. and Balfour, J.A., 1996).

Tylenol Overdose

Tylenol overdosage can be harmful. According to the US Food and Drug Administration (FDA), taking too much acetaminophen can harm your liver and lead to loss of appetite, nausea, vomiting, and loss of breath (AMEER, B. and GREENBLATT, D.J., 1977).

Side Effects of Meloxicam 

The side effects that occur may be common but, in rare cases, can be adverse. The symptoms are as follows:

Common Side Effects ​

The common symptoms that may occur are: 

  • Fatigue 
  • Diarrhea
  • Abdominal Pain 
  • Nausea

These are the side effects one may or may not experience.

Adverse effects

These symptoms are rare but can lead to severe effects. The symptoms areas 


  • Heart attack 
  • Stroke 
  • Epilepsy
  • Liver damage 
  • Increased blood pressure

Side effects of Tylenol 

The side effects can be standard or can even be adverse. The common symptoms can be as follow: 

Common symptoms             

  • Loss of appetite 
  • Vomiting or nausea 
  • Rashes

Adverse symptoms  

Adverse side effects can be a rare situation; however, in any case, consult the doctor. 

  • Breathlessness 
  • Stomach ache 
  • Allergy

Who cannot take Meloxicam? 

  • Suffer from Difficulty in breathing 
  • Fever or any flu 
  • Skin blisters 
  • Swelling in any part of the body
  • Hives 
  • This medication can be considered as a high-risk drug as it can increase the potential of heart attacks, strokes, etc., and can be deadly if one is suffering from a heart-related issue.
  • It can be dangerous for persons who have certain cardiac or renal illnesses or drinking problems.

Who cannot take Tylenol? 

  • Liver problems: Do not take this medication if you have liver problems
  • Alcohol consumption: Do not use# this medication with alcohol or if you consume alcohol regularly.
  • Children under the age of two: If you are under the age of two, you should not take this medication.
  • Pregnancy: If you’re expecting a child, talk to your doctor before using this drug.
  • Do not take any acetaminophen-containing medicine since it can lead to overdosing.
Tylenol vs Paracetamol

Tylenol vs Paracetamol

What is Tylenol? 

Acetaminophen is marketed under the brand name Tylenol. Tylenol is a pain reliever and fever reducer as well. Colds and flu, headaches, muscle pains, arthritis, menstrual cramps, and fevers are treated with Tylenol to decrease fever and relieve moderate pain (Douglas, D.R., Sholal, J.B. and Smilkstein, M.J., 1996).

What is Paracetamol?

Paracetamol is also another name for acetaminophen. It is a mild pain medication with few adverse effects. Sciatica, Muscle Pain, Fever, and Pain are among the conditions for this medication (Prescott, L.F., 2000).

two people conversation on tylenol comparing with paracetamol

Forms and Strengths


Tylenol adult acetaminophen medications come in three strengths:

  • regular strength (325 mg)
  • extra strength (500 mg)
  • extended-release Tylenol 8 HR (625 mg)

Tablets (325 mg) and liquid gel capsules are both available in Tylenol Regular Strength (325 mg)


The following forms and strengths of paracetamol are available:

  • Tablets: 325mg – 500mg
  • Extended-release caplets: 650mg
  • Capsules: 500mg
  • Gel caps / gel tabs: 500mg
  • Oral suspension or solution: 160mg or 5ml
  • Liquid (oral): 500mg or 5ml
  • Oral-disintegrating tablets: 80mg – 160mg
  • Caplets: 325mg, 500mg and 650mg
  • Syrup: 160mg or 5ml
  • Suppositories: 125mg, 250mg and 500mg
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For Tylenol

The typical dose of Tylenol Regular Strength is two tablets or capsules of 650 mg every four to six hours.

Adults and adolescents aged 12 and above should not take more than 10 Tylenol pills (3,250 mg) in 24 hours. Use for no more than ten days.

Children between 6 and 11 can take regular strength Tylenol (325 mg). Tylenol should only be given to children under the age of six under the supervision of a doctor or other healthcare expert. 

When providing Tylenol to young children, the appropriate dose is determined by the child’s weight and age (Lesko, S.M. and Mitchell, A.A., 1999).

For Paracetamol

Adults and children aged 16 and above should take 500 mg to 1 g every 4-6 hours, up to a maximum of 4 g per day.

The standard dose for children aged 12-15 years is 480-750 mg every 4-6 hours, up to a maximum of four doses per day.

If needed, a dosage of paracetamol can be taken every 4-6 hours, up to four times each day. Remember that you should wait at least four hours between doses and that you should not take more than four paracetamol doses in 24 hours (Cranswick, N. and Coghlan, D., 2000).

Are Tylenol and Paracetamol the same thing?

In the United States, paracetamol is known as acetaminophen. It comes in a variety of brands, including Tylenol, Mapap, and Panadol, as well as generics and store-specific brands.

Although suggested doses and available strengths may vary significantly between nations, there are no changes in the chemical structure or therapeutic usage of Tylenol and paracetamol.

Tylenol is commonly referred as to as paracetamol in various parts of the world, including Europe, Australia, India, and New Zealand.

Side Effects

Tyleno Side Effects

Although acetaminophen has negative effects, most people do not notice them. The majority of people well tolerate this medicine. It has caused allergic reactions in a few persons. Severe liver damage is the most concerning adverse effect. 

Acetaminophen has the following common side effects:

  • Loss of appetite
  • Itching
  • Rash
  • Headache
  • Dark urine
  • Clay-colored feces
Paracetamol Side Effects

Some people have suffered adverse reactions to acetaminophen in very uncommon situations. Contact your healthcare professional right away if you have any of the following symptoms after taking acetaminophen.

  • Skin itching
  • Peeling of skin
  • Difficulty breathing
  • Swelling of your face, lips, throat, or tongue
  • Skin blistering 
  • severe dizziness
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How does it work?

Acetaminophen belongs to the analgesics (pain relievers) and antipyretics pharmacological classes (fever reducers). Acetaminophen’s specific method of action is unknown. 

Prostaglandin production in the brain may be reduced by this medication. Prostaglandins are inflammatory and swelling-causing substances. Acetaminophen alleviates pain by raising the pain threshold, which means that a person must experience more pain before feeling it. 

It works by reducing fever by affecting the brain’s heat-regulating region. When the body’s temperature rises, it instructs the center to lower the body’s temperature (Graham, G.G. and Scott, K.F., 2005. Mechanism of action of paracetamol)

Can you take Tylenol (Acetaminophen) on an Empty Stomach?

Can you take Tylenol (Acetaminophen) on an Empty Stomach?

Tylenol (acetaminophen) is a pain reliever as well as a fever reducer. Tylenol is an over-the-counter medicine used to treat and reduce the symptoms of pain and fever caused by conditions such as colds or flu, headaches, muscle aches, arthritis, mensuration cramps, or fever.

We all think that medications should only be taken after eating some food, but some medicines can be consumed without food and are completely safe, like Tylenol.


Many people often confuse Tylenol with a non-steroidal anti-inflammatory drug (NSAIDs) like ibuprofen or Mortin, which leads them to stereotype Tylenol and consider it unsafe without being aware of the facts and working of the drug. Unlike NSAIDs, Tylenol is entirely safe to take on an empty stomach as it does not cause gastric or ulcer diseases. Tylenol may take up to twice as long to take effect if taken on full stomach, depending on the preparation. (Bushra, R., Aslam, N. and Khan, A.Y., 2011).

conversation of two people on tylenol to take on empty stomach

Interaction of Food with Tylenol

Interaction of Food with tylenol

Tylenol can be taken on a glass of water, as an empty stomach absorbs Tylneol much faster since there is no food. Food in our stomach deters the absorption process of Tylenol. However, many people might feel ill or uncomfortable after taking Tylenol on an empty stomach; these people might have a sensitive gastrointestinal tract. Taking Tylenol with some food might turn out to be better and much more comfortable (Bushra, R., Aslam, N. and Khan, A.Y., 2011).

How long does it take Tylenol to start working?

The time it takes for Tylenol to start working depends on the dose. Oral tablets must first dissolve in the stomach and get absorbed into the bloodstream before affecting the body. Tylenol liquid takes about 20 minutes to start working, whereas oral tablets take about 30 to 45 minutes. Tylenol taken on a full stomach may take up to double the time to affect the body, depending on the preparation. It takes more time for Tylenol to reduce fever while it is faster in relieving pain.
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Side effects of Tylenol

Tylenol can cause some side effects which create discomfort. These are some of the rare side effects, which include.

• Rash
• Itching or swelling on face, tongue, or throat
• Dizziness
• Trouble in breathing in some cases

Some widespread side effects of Tylenol are

• Nausea
• Loss of appetite
• May feel like hungover
• Dark urine

It is essential to go to a doctor if you have any side effects that bother you and are not ready to go away.

Precautions to be taken before Consuming Tylenol

Precautions to be taken before Consuming Tylenol
  • You should not take Tylenol if you are allergic to acetaminophen or if you have severe liver conditions.
  • Do not consume this medicine until and unless it is recommended or prescribed by your doctor if you ever had liver disease or if you drink more than two alcoholic beverages per day. It is because alcohol combined with Tylenol can be hazardous and can cause severe side effects and discomfort.
  • Acetaminophen can pass to breast milk and may harm a nurturing baby. Asking a doctor is mandatory before using this medicine if you are pregnant.
  • This medicine is not be given to children younger than two years old without the advice of a doctor.


In the end, you have now learned facts about Tylenol that you might not have known before, and this blog may have cleared the stereotypes like taking Tylenol will destroy your liver, it a drug used to get high, and that if taken on an empty stomach it will damage your internal organs, that was clouding your judgment to take Tylenol on an empty stomach. Do you now know that what is the correct way to consume Tylenol? And who all can consume it? And the fact that Tylenol is completely safe to be consumed on an empty stomach. 

How long does Tylenol (Acetaminophen) Stay in your System?

How long does Tylenol (Acetaminophen) Stay in your System?

Tylenol tablets contain acetaminophen. Acetaminophen is an analgesic (pain reliever) and antipyretics (fever reducers). This drug works quickly to relieve off the pain caused due to medical conditions like headaches and osteoarthritis and reduce fever caused by infections. Tylenol can be used by itself or even with other medication for the treatment of several medical conditions.

Acetaminophen, although it doesn’t help in treating swelling or inflammation. It works by blocking out the brain from releasing chemicals that cause the feeling of pain.

The usual dosage of acetaminophen for adults is around 325mg to 650mg every 4 to 6 hours. One shouldn’t take more than 4000mg in a 24 hour period. The dosage may also be affected by factors like body weight, medical conditions, and other medications. However, these tablets shouldn’t be used for longer than five days in a row for pain and three days in a row for fever. Tylenol relieves minor aches and pain from the following medical conditions:

tylenol in your system
  • Sore throats
  • Body or muscle aches   
  • Arthritis   
  • Toothaches
  • Menstrual cramps
  • Cold
  • Headache and migraine
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Two People talking on how long does tylenol stay in your system

How Long Does Tylenol Stay in your Body?

Each Tylenol tablet contains 300mg of acetaminophen. Acetaminophen is broken down by the liver in your body, which helps it to enter the bloodstream, and it exits the body through the urine. A typical dose of Tylenol can take up to a few hours to leave the body completely when taken orally. The effects of Tylenol take 4 to 6 hours to wash away thoroughly. However, factors like how much acetaminophen you have taken and how regularly you take the drug also affect the stay of your medicine in your system. 

Suppose you suffer from no medical conditions and take acetaminophen at recommended doses; In that case, it will take on average 10 to 12 hours for the drug to completely leave your system after your last dose. 

Although if you are taking more than the amounts prescribed, it will take at least a day or two to entirely leave your body (Calhoun, P., Johnson, T.K., Hughes, J., Price, D. and Balo, A.K., 2018).

Half-life of Tylenol

When one takes a Tylenol tablet, the acetaminophen starts acting within the first hours. The pain-relieving effects of the drug begin and may last for a few hours, depending on your dosage. The absorption is rapid, and it provides a therapeutic level within the first 40 to 120 minutes after consumption. The peak level is achieved within 2 to 4 hours after ingestion. The half-life of a drug refers to the amount of time it takes for the drug’s active ingredient in your body to reduce by half. On average, the half-life of Tylenol is around 2 to 4 hours. Generally, it will take approximately 24 hours for the drug to leave the body through urine. However, it may take even longer, depending on the health of your liver (Shively, C.A. and Vesell, E.S., 1975).

However, there are several other factors that may affect the stay of the drug, which are as follows,

  • The dosage of the drug
  • Medical conditions
  • Frequency of use
  • Body mass
  • Gender
  •  Presence of other drugs.
  • Alcohol

Possible Side effects of Tylenol

Side effects of tylenol

The common side effects of Tylenol include:

  • Headache
  • Loss of appetite
  • Dark urine
  • Clay-colored stool
  • Yellowing of skin or eyes (jaundice)
  • Nausea 
  • Stomach pain

The above-stated Side effects are the most common ones, and there are many more than this. If you feel like the symptoms are not going away and bothering you too much, then contact your healthcare provider immediately.

Tylenol can also cause some severe side effects like,

  • Severe dizziness
  • Trouble breathing
  • Itching and swelling
  • Rash 

Get medical help right away if you see any of the above symptoms.


Tylenol is an excellent drug for relieving pain. However, one should always monitor their Tylenol doses and shouldn’t take the medication on a frequent basis as regular use of the drug can affect the health of your liver and, in some cases, may prove to be fatal. So it is recommended to always call a doctor before taking Tylenol to treat your medical conditions.

Does Tylenol Help with Cramps?

Does Tylenol Help with Cramps?

Tylenol is also known by the generic name Acetaminophen is a pain reliever and a fever reducer. There are several brands and forms of Acetaminophen available, and Tylenol is one of them. Tylenol is used commonly among people since it’s an over-the-counter drug. Tylenol can be used for the following reasons:

  • Headache.
  • Arthritis.
  • Backache.
  • Toothache.
  • Sore throat.

These were a few common conditions for which Tylenol gives us relief. Tylenol isn’t meant for children below 12 years of age without a doctor’s recommendation, and an adult shouldn’t exceed 4000mg of Acetaminophen in a day. An irregular dose could result in a hazardous overdose.

conversation of two people on Cramps

How does Tylenol work?

Research is ongoing to know how Tylenol actually works. We know how it reacts with the human body, however. It is considered a Non-opioid analgesic.  A Non-opioid analgesic works by impeding an enzyme known as cyclooxygenase (COX). COX works as a catalyst for converting fatty acids stored in cell walls-arachidonic acid- to substances called Prostaglandins. Prostaglandins serve various protective functions in the body that can also cause pain, inflammation, and fever. After a cell injury, the prostaglandin causes pain by several mechanisms. The impairment occurs in the peripheral nervous system, where the nerves are outside the brain, spinal cord, and central nervous system. They increase one’s body temperature by affecting the brain’s heat-regulating region, also called the hypothalamus. During any injury, prostaglandin causes us pain. Still, the Tylenol blocks the COX, which stops the subsequent production of prostaglandins in the central and peripheral nervous system (Botting, R.M., 2000. Mechanism of action of acetaminophen)

How does Tylenol help with Menstrual Cramp?

According to a study by the wright state University School of Medicine and College of Science and Engineering, Dayton, Ohio, USA. It was a four-month study where 90 women participated. No pain relievers were given to them in the first two periods; however, during the last two periods, they were given a dose of 2 x 325 mg aspirin, Acetaminophen (Tylenol), or an identically packed placebo. These medicines were given to them every 4 hours to a total of eight tablets during the first 24 hours of their periods, beginning with spots. For a statistical analysis period, 1 and 2 were combined on an average and then compared to the average of periods 3 and 4. The number of days of flow, total menstrual loss in grams, pain were examined by MANOVA for the three treatment groups. An ANOVA type of analysis was also done for each of these variables for the first 3 menstrual days. The MANOVA reading failed to show any significant differences from all 3 variables. The same was for the ANOVA reading except for the variable pain of cramps. To see the difference in the measurement of cramps, the Duncan’s Multiple Range Test for pain was used, which showed us that the average pain of the placebo group was higher than the average pain of the aspirin group and Tylenol (Acetaminophen) group. This concludes that neither aspirin nor Acetaminophen (Tylenol) given in the doses changes either total menstrual loss or the pattern of loss during the first 3 menstrual days. But, when it came to cramps, both the drugs proved to be an effective means to alter the pain (Pendergrass, P.B. Effect of small doses of aspirin and acetaminophen on total menstrual loss and pain of cramps).

Tylenol dosages for Cramps

Tylenol dosages for Cramps

Tylenol is an over-counter drug available in:

  • Capsules,
  • Gel caps,
  • Chewable,
  • Liquid,

Adults and teenagers weighing at least 110 pounds (50kgs) should not take more than 1000mg at one time and not more than 4000mg per day.

Why Ibuprofen is better for Menstrual Cramps?

Menstrual cramps take a toll on women and are a significant concern for them. One out of two people suffers from extreme menstrual cramps. Although menstrual cramps are really intense from the age of 20-24, they weaken as a women ages. Many analgesics help relieve menstrual cramps like ibuprofen and Tylenol. When we compare the 2, ibuprofen is similar to Tylenol, which helps relieve pain and fever. Still, Ibuprofen has inflammatory properties, which makes it a better drug to relieve menstrual cramps. The recommended dosage is 400 mg of ibuprofen taken every six to eight hours for the initial days of the period. Any queries regarding the drug, dosage, or uses, the pharmacist will assist you (Chan, W.Y., Dawood, M.Y. and Fuchs, F., 1979).
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Although menstrual cramps are a typical symptom of menstruation, they can be dealt with using the correct medication and can be under control. Consult your General Practitioner regarding the same and drug usage.