Losartan Erectile Dysfunction – Is It The New Gig In Sexual Medicine?

losartan erectile dysfunction
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Erectile dysfunction is a sexual disorder in men characterized as the inability to maintain or develop an erection. This male sexual dysfunction is highly prevalent in men with hypertension, or in other words, it is an after-effect of anti-hypersensitive activity. Moreover, its prevalence also increases progressively with age. 

The present studies dictate the effectiveness of losartan, an angiotensin receptor blocker, in improving erectile function by supporting the blood flow mechanism. Below is a detailed discussion about it.  

What Is The Connection Between Blood Pressure And ED?

High blood pressure is a common phenomenon among men as they turn old, making them more prone to erectile dysfunction. Studies reveal that onset of ED among men with hypertension is one-third. For instance, the likelihood of erectile dysfunction is almost twice in men with high blood pressure compared to their male counterparts having normal blood pressure. 

High blood pressure or hypertension also leads to impaired penile blood flow. It’s because of the strain placed by high blood pressure on tissues and organs, causing retardation in blood flow and, in return, affecting the ability of men to maintain an erection. 

Reasons for Increasing Erectile Dysfunction In Hypertensive Patients

Hypertension can contribute to erectile dysfunction by changing smooth muscles and blood vessels surrounding the penis. This is how hypertension takes the lead in causing ED. Furthermore, the two most common methods through which hypertension contributes to ED include;

Arteries– At first, it causes gradual hardening of the walls of arteries over time, thus affecting their ability to dilate the vessels that carry blood toward the penis.

Smooth Muscles– Secondly, hypertension stiffens the smooth muscle inside the penis, consequently impeding blood movement in the penis. The forces remain rigid and unable to carry enough blood required for normal functioning.

Does Blood Pressure (hypertensive) Medication Helps Or Cause Erectile Dysfunction?

Studies report that blood pressure medicines work both ways. These can help encourage recovery from ED or contribute to ED. Here are a few blood pressure medications that can help cause ED.

Blood Pressure Medications Helping Erectile Dysfunction

These medications are discussed below;

Angiotensin-Converting Enzyme Inhibitors (ACE-Is)– ACE-I are blood pressure-lowering medications blocking the conversion of angiotensin | to angiotensin || and, in response relaxing arteries and veins that get contract due to angiotensin || hormones. 

As a result, ACE-Is improve blood to certain areas of the body, including the penis, and reduce the workload on the heart, thereby increasing stamina and sexual performance. Among various ACE-Is, lisinopril is discovered to be the most unlikely to cause ED.

Vasodilators– Vasodilators improve blood flow by relaxing blood vessels. Since they are involved in stimulating blood, they are found to have a secondary impact on regulating ED.

Angiotensin || Receptor Blockers (ARBs)- ARBs are medications to treat high blood pressure and block the blood vessel narrowing action of angiotensin. Studies dictate ARBs’ beneficial effect on erectile function.

Alpha Blocker- Alpha-blockers are a class of drugs that block the effect of adrenaline and noradrenaline hormones. Both hormones leave a small space for blood flow by narrowing the blood vessels and do not perform their action when they get blocked by alpha-blockers. However, at the same time, both are fundamental mediators of sexual performance and the development of an erection. That’s why any decrease in their effect also stimulates the risk of ED.

Blood Pressure Medications Increasing the Risk of ED

Following are a few medications that take part in triggering erectile dysfunction.

Diuretics– Diuretics help lower blood pressure by increasing urine output, thus releasing excess salt and water from the body. However, the mechanism of diuretics in affecting erectile function is not well known, but some researchers favor their involvement in causing an increase in erectile dysfunction. 

Beta Blockers– Like alpha-blocker blockers, beta-blockers also block the effect of adrenaline but do not affect noradrenaline. However, they decrease blood pressure and reduce blood flow in the penis, resulting in erectile dysfunction. 

Calcium Channel Blockers– Calcium channel blockers deal with high blood pressure by restricting calcium entry into the arteries and heart cells. A recent literature analysis evaluates that CCBs do not have any positive effect in promoting erectile functioning.

How Does Losartan Help In Getting Back The Confidence?

Although some medications either promote or retard erectile functioning, a beneficial relationship has been found to exist between losartan and ED. Losartan is an oral drug listed in the class of angiotensin || receptor blockers and thus has a role in blocking angiotensin from attaching to its receptor site. When performing its action, angiotensin causes high blood pressure due to vasoconstriction. 

Losartan prevents angiotensin from performing its action, eventually lowering blood pressure and improving blood flow in the penis during sexual arousal. It also induces positive effects on mood that further enhance sexual functioning. Thus, losartan plays a part in gaining confidence in having an improved sexual life after ED.

Can You Take Viagra With Losartan?

Viagra is used along with losartan to enhance the blood pressure-lowering effect of losartan. The mild blood pressure-lowering effect of sildenafil combines with the losartan effect, eventually causing a significant drop in blood pressure. Because of their combined usage, a drug interaction is expected to present in both. 

Acute respiratory failure is a typical interaction among females and males with chronic kidney disease. However, it is recommended as best to take the combination of drugs under the supervision of your doctor to avoid any severe side effects. 

The drug advised not to take with Viagra is nitroglycerine or nitrate-containing medications because they can cause adverse interaction. There is also a detailed info on Viagra With losartan.

Can Losartan Be The Next Prime Solution For ED?

A study based upon the survey of men with uncontrolled hypertension as subjects demonstrates the drug effect of losartan on patients with erectile dysfunction. It spotlights that after the consumption of losartan, sexual satisfaction of issues increased from 7.3% to 58.5% within 12 weeks of usage. 

Also, there has been a 21.8% upswing in sexual activity. Moreover, 73.7% of subjects experienced an improvement in their quality of life. At the same time, the implementation of losartan did not affect the sexual activity of a group of people with no erectile dysfunction. 

In light of the experimental data evaluated by research, losartan functions are apparent in making erection better and sharpening the frequency of sexual activity alongside improving quality of life. As Erectile dysfunction already has sildenafil type of medications making losartan a prime solution for ED is not so digestive.

(Llisterri JL, Lozano Vidal JV, Aznar Vicente J, Argaya Roca M, Pol Bravo C)

Conclusion

For maintaining long-term erectile health, it is essential to keep blood pressure within normal limits. Moreover, you should not stop or start any kind of blood pressure medication without a doctor’s prescription. If you have any doubts or concerns about the drug, discuss it with your physician.

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