Can you take Ibuprofen and Robaxin Together?

Can you take Ibuprofen and Robaxin Together?

Ibuprofen is the medication used to treat pain, fever, and inflammation. The drug was discovered in the year 1961 by Stewart Adams and John Nicholson. The drug is also listed in the World Health Organization’s Essential Medicines. The drug is manufactured by IOLCP, the only manufacturer of Ibuprofen in India.

Robaxin is a brand name of Methocarbamol. It is a medication used for the short-term treatment of musculoskeletal pain. It is used together with rest, physical therapy, and pain medication. It was adopted in the United States for medicinal usage in the year 1957. The drug is being manufactured by Unnati Pharmaceuticals Pvt Ltd from India.

Studies have shown that methocarbamol and ibuprofen in combination are more effective than taking the two classes of drugs separately. In fact, it is not uncommon for health care providers to prescribe both together or do both at the same time. The combined effects of Robaxin and Ibuprofen work together because they release muscle tension and reduce pain and inflammation.

Uses of both the Medications

Ibuprofen is primarily used to treat fever. It is also used to tackle mild pain and may be used post-surgery. It also helps in relieving painful menstrual periods, migraines, rheumatoid arthritis, dental pain, and kidney stones.

Robaxin is used to manage a variety of musculoskeletal conditions like bone fractures, tendinitis, osteoarthritis, and many more.

Dosages and Side effects include

Quantity-
Usual adult dose for muscle spasm-
• Mild symptoms- 1 g IV or IM once, then switch to oral.
• Severe symptoms or postoperative conditions: 1 g IV or IM every 8 hours.
• Maximum Dose can go around 3 g in 24-hours
• The maximum period can be 3 consecutive days; it may recur after a drug-free interim of 48 hours.

Side effects shared by both the drugs-

• Nausea
• Vomiting
• Bleeding
• Headache
• Dizziness

The Differences between Ibuprofen and Robaxin

  • Ibuprofen works by reducing the hormones that cause inflammation in the body. Robaxin works by blocking the pain sensations that are sent to the brain.
  • Ibuprofen comes under the drug class called “Nonsteroidal anti-inflammatory drugs” and Robaxin comes under the drug class called “Skeletal muscle relaxants”.
  • The average cost of Ibuprofen 30 tablets of 800 mg cost may be around $11.99 and the price of Robaxin for 20 quantities costs around $80.72.
  • Ibuprofen comes in the form of an oral capsule, oral suspension, oral tablet, oral tablet, and chewable on the other hand Robaxin comes in the form of Injection and tablets.

Warnings and Precautions

  • Ibuprofen can enhance the uncertainty of fatal heart attack or stroke. Do not utilize this medication just before or after a heart bypass operation.
  • Do not take any of the medications if you are allergic to them.
  • Before using Robaxin, inform your doctor if you have myasthenia gravis.
  • Take the amount of medication to what your health care experts have advised you. Do not overdose or abuse the drugs.
  • Robaxin can impair your thinking so, make sure you do not involve in any activity that demands mental alertness.
  • Avoid consumption of alcoholic beverages while on the medications.

Pregnancy and Breastfeeding

The drugs are not recommended for either of the activity. If the physician feels that benefit of the medicine can overweight the risk, in that case, only the medicine should be given to the pregnant women. Similarly, if the medicine is given when breastfeeding, the infant should be observed for any changes.

Conclusion

Your health care provider may prescribe a comparatively lower dosage of both medications for added effectiveness. If the drugs do not show positive results, visit your health care provider. Your physician may give you another medicine or may change the quantity of dosage.
Do not stop the medication on your own it may cause withdrawal symptoms, always consult your health care service provider if you have any doubts regarding the drugs.

Robaxin vs Flexeril

Robaxin vs Flexeril

The generic name for Robaxin is Methocarbamol, Cyclobenzaprine, being the generic name of Flexeril. Methocarbamol and Cyclobenzaprine are examples of skeletal muscle relaxants (SMRs) that your doctor might prescribe if you have muscle pain. Robaxin and Flexeril are both effective treatments for musculoskeletal pain and muscle spasms.

Robaxin vs. Flexeril are classified as antispasmodic agents and effective in treating acute painful musculoskeletal disorders that cause discomfort and muscle spasms.

What are the differences between Flexeril and Robaxin?

• Flexeril was approved for medical use in the United States in 1977, Robaxin was approved by FDA on 16 July 1957.
• The precise mechanism of Flexeril is still not entirely determined. Still, the drug seems to initially act at the brain stem to lessen tonic somatic motor activity, affecting both gamma and alpha motor neurons, leading to decreased muscle spasms. The mechanism of Robaxin is still not been confirmed.
• The dosage form of Flexeril is tablet and capsule. Robaxin comes in the dosage form of a tablet and injectable solution.

Difference between their Side Effects

General side effects of Robaxin are-
· Stomach upset
· Nausea
· Vomiting
· Flushing
· Constipation

General side effects of Flexeril-
· Dry mouth or throat
· Headache
· Blurred vision
· Drowsiness
· Dizziness

Differences between their Warnings

Flexeril-
• People experiencing thyroid disorder, heart block, congestive heart failure, a heart rhythm disorder, or have recently had a heart attack should not consume the medicine.
• Do not use the drug if you have taken an MAO inhibitor in the past 14 days.
• The drug is not approved for people younger than 15-year-old.
• Brief your doctor about your past and current medical conditions and medicines if you are consuming any.
• Older people may be more sensitive to the effects of this drug.

Robaxin-
• Do not take the drug if you have an allergy to methocarbamol.
• The drug may impair your thinking. Be alert or avoid driving or activities that require mental alertness.
• Avoid taking alcohol when on this medication.
• The drug is not approved for people younger than 16-year-old unless to treat tetanus.

Robaxin and Flexeril during Pregnancy and Breastfeeding?

• For Robaxin, there are no adequate studies that can determine the safety and effectiveness in pregnancy. Pregnant ladies should avoid muscle relaxers as it may cause harm to the unborn.
• Likewise, in breastfeeding, it is still not known whether the drug enters breast milk. The medicine should also be avoided in nursing mothers.
• No adequate studies of Flexeril in the pregnant woman. However, animals suggest no important effect on the fetus. Therefore, Flexeril can be used only when your health provider feels it is necessary.
• It is not known that Flexeril is secreted in milk. Caution is recommended in using this drug while breastfeeding.

Robaxin vs. Flexeril: who is more Effective?

Flexeril is the most studied drug and hence has more supporting proof of its effectiveness. According to the experiment done on patients, they felt slightly sounder improvements in local pain with Cyclobenzaprine (48% vs. 40%).
Methocarbamol is the best-known brand, while Roboxin is an effective muscle relaxant recommended as a pain reliever for short-term muscle pain and muscle spasms. Methocarbamol is helpful in the treatment of seizures and muscle spasms as a result of the ingestion of toxic substances in cats and dogs.

Conclusion

Robaxin is for short-term treatment as prescribed by your physician. Similarly, Flexeril is not used for more than 2-3 weeks. Both Flexeril and Robaxin are used as muscle relaxants. It depends on your condition and medical history, which will be more effective for you. Take guidance from your health provider; they will direct the best suitable drug for you after examining your condition.

Another option is to select a specific muscle relaxant (such as methocarbamol or other drugs of the same class) based on the quality of the drug and the condition of the patient. When considering skeletal muscle relaxants for use in the elderly, as an aid to treat chronic pain, or in patients with multiple comorbidities who receive polypharmaceutical therapy that includes opioids and skeletal muscle medications, the medication selection for each patient needs careful consideration of these factors.

FAQ's

Robaxin is a CNS depressant with sedative and musculoskeletal relaxant properties.

Methocarbamol is mistaken as a narcotic due to its side effects of drowsiness, but it isn’t a narcotic. It is a CNS depressant and muscle relaxant to treat pain.

Both Robaxin and Flexeril drugs are muscle relaxants utilized to manage skeletal muscle conditions such as injury or pain. They are used mutually with rest and physical therapy.

According to the list released, Robaxin is the best muscle relaxant.

References

TOURAY, T. and SOLWAY, S., 2003. Muscle relaxants for nonspecific low back pain: a systematic review within the framework of the cochrane collaboration. Spine28(17), pp.1978-1992. Available at: https://ci.nii.ac.jp/naid/10017370724/ Accessed on 14/09/2021

Post, R.E. and Dickerson, L.M., 2010. Dizziness: a diagnostic approach. American family physician82(4), pp.361-368. Available at: https://www.aafp.org/afp/2010/0815/p361.html? Accessed on 14/09/2021

 

Soma while Pregnant and Breastfeeding

Soma while Pregnant and Breastfeeding

Soma is a medication used as a muscle relaxant. The generic name of the drug is Carisoprodol. It belongs to the drug class called Skeletal Muscle Relaxants. It is practiced together with rest and other physical therapy. It can be utilized with other drugs as well.
Soma is converted into meprobamate, which is believed to relieve anxiety and cause sedation.
A review of studies from 2004 states that there is adequate evidence that Soma, Carisoprodol, and Robaxin are effective in treating acute back and neck pain compared to placebo. Still, there are only conflicting data on the effectiveness of Robaxin and Soma.

Can I take Soma while Pregnancy?

Pregnant women are now taking medication during pregnancy more often than their mothers ever were. Pregnant women assume that a drug is safe if their doctor prescribes it.
The FDA classifies medicines based on safety for use during pregnancy.
Five sections: A, B, C, D, and X, are used to distinguish the potential dangers to an unborn baby when a medicine is taken during pregnancy. Carisoprodol falls into category C.
Though the drug is not recommended for the woman during pregnancy, it is used only if your health care provider thinks that the benefit may surpass the risk.

Is Carisoprodol Safe for Breastfeeding?

Soma is not suitable for Breastfeeding. One report explained that the nursing infant is a little sleepier than expected, according to two case reports. It can let troublesome effects on infants.
A safety level of 3 indicates that the use of Soma in breastfed babies may cause minor side effects. Soma Breastfeeding Side Effects A mother who took Soma (700 mg, propoxyphene 70 mg, and paracetamol 900 mg three times a day) while breastfeeding her baby noticed unusual behavior and side effects in her baby. Studies from various scientific studies suggest that Soma can cause moderate side effects in breastfeeding mothers.

After one week, the mother nursed an infant 2 hours after breastfeeding and 3.5 hours after her previous dose with immeasurable serum concentrations of Carisoprodol (2 mg / l) and Meprobamate (4 mg / l). Light sedation was observed in short-term infants with a birth weight below the 10th percentile for gestation and Breastfeeding, and signs and withdrawal symptoms were observed after breastfeeding.
New mothers are prescribed safe drugs, but there are medications that new mothers should never take. Taking Soma while Breastfeeding can lead to permanent injuries or even the death of your baby.

What Side Effects does Soma have while Pregnant?

Soma is not recommended for a woman who is pregnant.
Its sedative properties may impair the mental or physical abilities required to perform potentially hazardous tasks such as driving a motor vehicle or operating machinery. If the drug has still been consumed, they may have withdrawal symptoms such as irritability, abnormal or persistent crying, vomiting, or diarrhea.

Are Muscle Relaxers Safe while Pregnant and Breastfeeding?

When it comes to Soma vs. Flexeril for pregnancy and Breastfeeding, Flexeril is recommended by doctors. It is a pregnancy B category drug and can be utilized in pregnancy only if needed. The drug has been examined in rats, mice, and rabbits at a dose up to 20 times the human dose and have reported no such evidence that will diminish fertility or harm the fetus. There is no enough research on pregnant women. Because animal reproduction examinations are not always imminent of human response, this drug should be practiced during pregnancy only if required.
While breastfeeding, the drug appears in the milk in a very small amount, and two infants tolerated it in the milk well. If a mother requires Flexeril, then there is no reason to stop breastfeeding. It can be used with proper care.

Conclusion

Taking Carisoprodol along with certain medications may increase the risk of side effects of these medications. If you are taking the medication Carisoprodol, your doctor will monitor you for possible side effects. And if you are already taking the medication, they may increase your dose of the medication.
Certain drugs are prescribed for specific conditions only. The benefits and risks may differ from person to person, according to their age, health, medical history, etc.

Consult your health provider before using any medications. Follow their advice and directions. If you find any difficulties, do not avoid them or try to manage them on your own; see your doctor immediately. While taking any medicine, the patient should be monitored closely.

References

Briggs GG, Ambrose PJ, Nageotte MP, Padilla G. High-dose carisoprodol during pregnancy and lactation. Ann Pharmacother. 2008 Jun;42(6):898-901. doi: 10.1345/aph.1L042. Epub 2008 May 6. PMID: 18460586. https://pubmed.ncbi.nlm.nih.gov/18460586/ Accessed on 25/08/2021

https://medlineplus.gov/druginfo/meds/a682514.html Accessed on 25/08/2021

U.S. Department of Health and Human Service, Food and Drug Administration. (2010). Medicine and Pregnancy.  Retrieved from http://www.fda.gov/ForConsumers/ByAudience/ForWomen/ucm118567.htm Accessed on 25/08/2021

Spencer, J, Gonzales III, L, and Barnhart, D. (2001). Medications in the breast-feeding mother. American Family Physician, 64(1), Retrieved from http://www.aafp.org/afp/2001/0701/p119.html Accessed on 25/08/2021

The Effects Of Mixing Soma With Alcohol

The Effects Of Mixing Soma With Alcohol

Soma is the name of the prescription drug carisoprodol, a muscle relaxant prescribed to relieve pain from muscle injuries and cramps. It is prescribed for injuries that cause pain and discomfort in the muscles. Doctors often prescribe Soma together with rest and physical therapy to relieve muscle tension and pain associated with injuries such as sprains and strains. Still, some people abuse Soma due to the feelings of relaxation and sedation it induces.
Soma was approved for prescription use by the FDA in 2007.

Recreational users often mix Soma with Flexeril and alcohol to enhance the calming and relaxing properties of the substance. Alcohol, diazepam, hydrocodone, meprobamate, and propoxyphene are frequently abused in combination with Soma. Side effects of mixing Soma and alcohol include- memory problems or loss, increased physical weakness, Increased risk of seizures, etc.

How Is Soma Supposed to Be Used?

Soma belongs to the class of drugs called Skeletal muscle relaxants and is used as a muscle relaxant. The drug is used with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. It should be used for the short-term only, that is only up to two or three weeks.
The longer a person continues the use of Soma, the higher chances that they will become addicted to it or abuse it. Severe sedation is also likely with more powerful doses. Soma is not recommended for long-term treatment in patients.

Why Do People Mix Soma with Alcohol?

Some people combined Soma and alcohol because it produces a relaxing euphoria or high. While it is possible to cause the person to pass out, since the combination intensifies slowed brain activity and sleepiness, it may also make the person feel much great when the two drugs are combined.

Soma drugs should not be combined with depressants, including alcohol. Mixing Soma drugs with alcohol can exacerbate undesirable and dangerous side effects such as dizziness and judgment. You should avoid or limit the use of alcohol to treat carisoprodol.

Signs of Soma and Alcohol Addiction

Combining alcohol with prescription painkillers can have undesirable and harmful effects. Those who consume alcohol with painkillers such as carisoprodol may perceive a pleasant effect, but they may not recognize the associated dangers, including prescription drugs and alcohol addiction.
Signs that indicate addiction is-

  • Regular consumption of Soma and alcohol.
  • Suffer the effects of withdrawal.

Increase in the amount of consumption.
Some more signs are-

  • There is a failure to manage the amount of the substance consumed.
  • Signs of withdrawal are encountered after cessation of consumption.
  • There is a rise in unsafe behavior, such as driving while intoxicated.
  • Poor performance at school, home, or work.
  • There is reduced interest in exercises other than using the substance
  • Financial and/or legal difficulties arise related to the consumption of the substance.

Dangers of Mixing Alcohol and Soma

The combination of Soma and alcohol can be dangerous or deadly. Soma and alcohol are considered to influence the central nervous system and specific brain chemicals.
Following are the warnings that need to be considered-

  • The combination can lead to coordination problems.
  • The risk of accidents and falling is high.
  • It can cause a fatal overdose.
  • It can slow down the body’s main function.
  • Due to the mixture, the CNS can slow down to the point where it will dangerously affect heart rate and breathing.

Treatment for Soma and Alcohol Addiction

If you or your loved one has been addicted to carisoprodol or become addicted to SOMA, reflecting centers, prescription drug detoxes, and treatment programs can help you recover. The recovery process includes using other medications to relieve withdrawal symptoms and various psychotherapies to help the person understand his addiction to SOMA and alcohol, develop coping skills, and prevent relapses. Contact us for help in finding a professional who can discuss the effects of Soma fusion with alcohol and help in treating addiction.

References

Is Soma a Barbiturate?

Is Soma a Barbiturate?

Barbiturates are a class of drugs derived from barbituric acid, which act as depressants in the central nervous system. These are CNS depressants, which are also used as sedatives and hypnosis drugs. The drug is used to treat insomnia, seizures, and headaches.
Barbiturates are sedatives that have a calming and relaxing effect compared to alcohol’s effect. They are used to treat certain conditions such as seizuresanxiety and as an anesthetic during surgery. They can also be used to alleviate the negative withdrawal effects of illegal drugs when used similarly to benzodiazepines such as diazepam and clonazepam.

Soma is a muscle relaxer drug that blocks pain sensation between the nerves and the brain. It is used as a short-term treatment for muscle pain. It is practiced unitedly with rest and physical therapy to heal skeletal muscle conditions like soma for backpain and injury
The drug should only be practiced for the short course (up to two or three weeks) because there is no proof of its effectiveness in long-term utilization and most skeletal muscle injuries are generally of a short span.

Are Soma and barbiturate the same thing?

Soma works as a muscle relaxer that blocks pain sensation between the nerves and brain. It is prescribed to offer relief from pain.

Barbiturates are synthetic drugs. The chief mechanism of action of barbiturates is inhibition of the central nervous system. It is prescribed to cure insomnia (sleeping disorder), seizures, and headaches. Barbiturates are also used in the treatment of epilepsy, where short-acting molecules are used for anesthesia. Long-acting barbiturates such as phenobarbitalluminalmephobarbital, and Mebaral are classified as class I drugs and are used as anticonvulsants.

What are the differences between Soma and barbiturate?

Generic name for soma is carisoprodol. Barbiturate is sold under many brand names like amobarbital, secobarbital, butabarbital, pentobarbital, etc.

Soma is used to treating muscle pain, whereas barbiturate is used to treat extreme cases of insomnia, seizures that are unresponsive to other, less toxic agents, etc.

The difference between their Half-life, Dosages and Side effects

Soma takes 30 minutes to kick in. on the other hand, barbiturates have various onsets of action. Oral varies from 20 to 60 minutes, and intravenous can vary from almost immediate to 5 minutes.
The half-life of Soma is around 2 hours; it may vary from 1-3 hours in some people. The half-life of barbiturate varies from 4-38 hours.
Soma comes in tablet form. The dosage of barbiturates depends upon the drug and its uses.

Side effects-
Common side effects for Soma are-

  • Drowsiness
  • Dizziness
  • Headache

Allergic reactions from this medication are – hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Common side effects for Barbiturates are-

  • Confusion
  • Diarrhea
  • Irritability

Severe side effects are- Abnormally slow breathing, Coma, Unsettling, Fainting, Hallucinations, and Temporary breathing cessation.

How long does Soma and Barbiturate stay in your system?

Soma would take an average of 11 hours to eliminate from your body after consumption. Soma leaves back metabolites as well. The meprobamate metabolite can take around four days to be excluded from the body, even after the original drug has been fully eliminated.

Barbiturate stays up to 72 hours after consumption.
The effect of interacting barbiturates such as butobarbital sodium lasts between 6 and 12 hours and is used to treat insomnia. However, the effects of longer-acting barbiturates such as barbital and phenobarbital can last up to 24 hours, making them useful with other active ingredients to prevent seizures in epilepsy. The effects of these medications can last up to 24 hours, and they can be used in conjunction with other medications in the treatment of epilepsy as they have a long-lasting depressive effect that helps prevent convulsions.

Conclusion

Many people stopped taking barbiturates when word spread of their high potential for abuse, and less addictive drugs replaced them in the benzodiazepine’s family.
Frequent barbiturate users can experience severe withdrawal symptoms up to 8 to 15 hours after stopping the drug. The more a person takes the drug, the greater the difference between the doses that can cause the desired effect and the fatal overdose.
Soma is the most preferred drug for muscle relaxants. The quality and effectiveness of the drug make it a priority for doctors to prescribe them for patients.

References

Richards, C.D., 1972. On the mechanism of barbiturate anaesthesia. The Journal of physiology227(3), pp.749-767. Available at: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1972.sp010057 Accessed on 20/08/2021

https://www.sciencedirect.com/topics/neuroscience/carisoprodol Accessed on 20/08/2021

Gonzalez, L. A., Gatch, M. B., Forster, M. J., & Dillon, G. H. (2009). Abuse Potential of Soma: the GABA(A) Receptor as a Target. Molecular and cellular pharmacology1(4), 180–186. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858432/ Accessed on 20/08/2021

Is Robaxin (Methocarbamol) a Controlled Substance?

Is Robaxin (Methocarbamol) a Controlled Substance?

Robaxin was approved on 6th October 1959 by the FDA (Food and Drug Administration). The effect of the drug generally begins within half an hour after consumption. One can take it by mouth or by injection. Geriatric patients should not take the drug. FDA labels the medication as a pregnancy C category.

Methocarbamol interacts with other central nervous system depressants (prescription painkillers, cough and cold medications, sedatives, sleeping pills, and anxiety medications) to enhance their effect when taken orally. Methocarbamol is not an opioid, benzodiazepine, or other prescription medicines used to treat pain or convulsions. Methocarbamol is not a controlled substance in the United States, so its potential for abuse or addiction is low. Like any substance, however, it can be misused and used in ways that are not intended.

Diseases such as kidney or liver disease can also influence the metabolic processes of methocarbamol. A 2014 review of skeletal muscle relaxants found that the first-line drugs were not as effective as muscle relaxants at first. Muscle relaxants were more effective than placebos for short-term relief, but the risk of side effects was 50%.
In 2018, it was the 120th most commonly directed medicine in the United States, with higher than 5 million prescriptions.

Robaxin and Carisoprodol is schedule IV drug used to relieve pain in muscles and relax them. Robaxin got approval in the year 1959 by FDA (Food and Drug Administration).

What kind of drug is Robaxin?

Robaxin belongs to the drug group called Skeletal Muscle Relaxants. It is sold under the brand names of other medicines and is used for short-term musculoskeletal pain.
The medicine is prescribed to treat the symptoms of muscle spasms caused by pain or injury. It is used along with some rest, physical therapy, and other treatment to support it. It acts to relax the muscles to relieve the pain.
It can be injected intravenously and has positive effects in controlling neuromuscular spasms caused by tetanus.

Robaxin injection is at times utilized in the treatment of tetanus, which produces painful tightening of the muscles.
The mechanism of action in humans is not yet established. It is assumed to operate, depressing the central nervous system, leading to the relaxation of muscles.
It is not beneficial in chronic neurological diseases, such as cerebral palsy or different dyskinesia’s.

Does Robaxin make you high?

According to studies, and observation under clinic trials, the drug can induce dizziness and drowsiness as they are some of its general side effects and can be misinterpreted as high. Considering the dizziness, one should take care that after using Robaxin, the person should not be involved or get included in any task that demands mental alertness, for example, driving or activity on any hazardous machine.
The medicine is not frequently abused.
People with a history of substance abuse or addiction are more likely to be abused and become dependent on Robaxin. Such as Snorting or smoking Carisoprodol can increase their effectiveness and deliver a strong high. Patients with a history of substance abuse are more likely to be addicted. Robaxin can be purchased without a prescription, and it can be misused to make a habit.

Is Robaxin a Narcotic?

Robaxin is not a narcotic. It is a muscle relaxant and is used to cure pain. According to studies and proven clinical trials, the drug can make you dizzy and drowsy, which can be misunderstood as high on the drug.

Conclusion

Robaxin is utilized to treat the symptoms of muscle spasms caused by pain. The safety and effectiveness of the drug in kids older than 16 years have not been authenticated yet.
Every drug has its benefits and limitations. Likewise, every drug has specific side effects; some get improved on time, but some get worse; in such cases, medical help should be taken, and conditions should not be taken for granted. Drug abuse should not be done as it may lead to a serious impact on the body. Never share or take medicine from other people, even if there is a similarity in symptoms. Use the drugs only when prescribed by doctors.
For some, the drug may not be the fittest option. Talk to your doctor about your concerns and brief them about your medical conditions. After conducting a proper check-up and examination, the physician will direct the most suitable prescription for you.

References

Witenko, C., Moorman-Li, R., Motycka, C., Duane, K., Hincapie-Castillo, J., Leonard, P., & Valaer, C. (2014). Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P & T: a peer-reviewed journal for formulary management39(6), 427–435. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103716/ Accessed on 14/08/2021

https://en.wikipedia.org/wiki/Methocarbamol Accessed on 14/08/2021

Soma (Carisoprodol) For Anxiety – Is it the Right Option?

Soma (Carisoprodol) For Anxiety – Is it the Right Option?

Soma belongs to the class of drugs known as centrally acting skeletal muscle relaxants. It belongs to the group of muscle relaxants known as carbamates.
Soma can help relieve pain, lower muscle tension, and reduce anxiety when prescribed but is often used as a recreational drug due to its potent effects. Alcohol consumption is a dangerous synergy that increases soma effects, which makes the combination a risky combination.
The FDA (Food and Drug Administration) has not approved Soma to help with anxiety.

Why is Soma not Good for Anxiety?

Soma is the brand name for the prescription carisoprodol a muscle relaxer with sedative properties that dampens central nervous system activity.
Though Soma reduces anxiety is not recommended for a longer span as it is not approved for anxiety by the administration.
If you have anxiety trouble communicate to your doctor, they will prescribe the most suitable drug for you.

What is Soma originally intended to be used for?

The medication works by affecting the communication among the nerves in the central nervous system. It is a drug prescribed to relax the muscles and relived the pain from it—injuries caused by sprains and strains. The drug may be addictive if misused and can be caused dependency. It acts in the brain and doesn’t relax the muscles directly.
Mixing the Soma drug with alcohol can exacerbate undesirable and dangerous side effects such as dizziness and judgment. The risk of abuse of Soma pill comes from taking more carisoprodol than prescribed and from drowsiness or dizziness. These side effects can be exacerbated in cases where the pill is abused.

If not Soma, what are some other drugs one can take to Calm Anxiety?

There are a total of four major classes of drugs used to calm anxiety;
they are –
• Selective Serotonin Reuptake Inhibitors (SSRIs): This class of drugs can ease average to severe depression symptoms and are relatively safe.
• Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): This class of drugs treats depression and can cure anxiety disorder and long-term pain.
• Benzodiazepines: These drugs are used to calm a person by raising the level of the inhibitory neurotransmitter GABA in the brain.
• Tricyclic Antidepressants: these are second-line drugs next to SSRI. They are primary used as antidepressants to manage depression.
• Ketamine (Eskatimine): This drug is used before surgery to put you to sleep.
• Consult your doctor before taking any medications. Your physician will observe your situation and will prescribe the right drug for you.
• Remember that drugs usually take around 4-8 weeks to work to become fully effective.
• Sometimes, one will need a combination of antidepressants.
• Side effects may vary as it depends on the drug you are consuming, and once your body gets to adjust to the drug, it will improve.

What are some Natural Remedies to Calm Anxiety?

  • Get some sleep: get quality sleep for yourself. Avoid sleeping late, watching tv in bed, using gadgets on the bed, etc.; try sleeping early so that you will appear fresh in the morning.
  • Meditate: The primary goal of mediation is to eliminate negative thoughts from your mind and replace them with peace, positivity, and mindfulness. Meditating every day can benefit you in a great way.
  • Eat healthily: Monitor your eating habits. Exclude processed foods from your menu. Stay hydrated and consume stuff rich in complex carbohydrates, fruits and vegetables, and thin proteins.
  • Avoid consuming alcohol: Alcohol is a natural sedative. It may calm you down for a while but then will hit you vigorously. It may also develop alcohol dependence.
  • Stay active: Hit the gym, walk around, exercise, do yoga, or meditate but keep yourself active as much as possible. It is not a short-term fixture, but it will serve you hours later too.

FAQs

Muscle relaxers can help relieve pain, lower muscle tension and reduce anxiety due to its calming effects when prescribed by doctors, but is often used as a recreational drug due to its potent effects.

The maximum recommended dose of some is 350 mg. The drug is prescribed for people undergoing muscle pain affected by a sprain

The drug generally works within 30 minutes and lasts for 4-6 hours.

Though Soma can be an adequate cure for Facial flushing, sleeplessness, nausea, and abdominal discomfort, it may be addictive and carries the potential for abuse. Misuse of the drug can cause a heart attack or stroke and can also cause sudden death.

Benzodiazepines support in managing many anxiety disorders, including panic dysfunction, generalized anxiety dysfunction, etc. Some examples of these drugs are- alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Valium), and lorazepam (Ativan).

References

Dean L. Carisoprodol Therapy and CYP2C19 Genotype. 2017 Apr 4. In: Pratt VM, Scott SA, Pirmohamed M, et al., editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK425390/ Accessed on 10/08/2021

Carisoprodol with Hydrocodone: The Deadliest Combination

Carisoprodol with Hydrocodone: The Deadliest Combination

What is Carisoprodol (Soma)

Carisoprodol (Soma) is a strong muscle relaxant that restricts pain sensations in the brain’s nerves. It is prescribed during resting and physiotherapy to treat conditions of the skeletal muscles, such as pain or injury. It can also be used for recovery, physical therapy, and other measures to relax muscle strains and sprained muscle injuries. The Drug Enforcement Administration (DEA) lists Carisoprodol as a Schedule IV controlled substance. Due to its sedative nature, Soma can be addicting. If Soma is ingested in high doses, it can intensify its effects and result in the patient feeling the same after-effects that drugs cause.

Due to its sedative, relaxing and euphoric effects, Carisoprodol can be addictive, especially in higher doses and with prolonged use. People who consume it regularly, even if they take prescription drugs, can develop an addiction over time.

Carisoprodol is the most active and important substance in Soma. As Soma creates a calming effect in mind, other Central Nervous System drugs like alcohol, benzodiazepines, opioids, and tricyclic antidepressants may result in addiction.

The sedative and relaxed feeling caused by the medication may be addictive for some patients who later misuse Soma in recreational ways to experience increased euphoria. This can be detrimental to health as it would later cause life-threatening complications, which would require prolonged therapy and rehab.

What is Hydrocodone (Vicodin)

Hydrocodone (Vicodin) is a painkiller and an antitussive that falls under the category of opioid painkillers. Antitussives are prescribed as cough suppressants .it is prescribed for severe pain caused after surgery or injury. It functions by blocking pain receptors in the brain and increases the sensation of euphoria, which can be addictive and compels users to misuse or abuse it.

To be more precise, hydrocodone is a semi-synthetic Schedule II opioid pain medication. Semi-synthetic drugs are drugs that are synthesized chemically from a naturally existing compound. The Drug Enforcement Administration (DEA) considers hydrocodone a Schedule II controlled substance because it tends to abuse and addiction.

Schedule II consists of drugs with a high risk of addiction and causes psychological conditions and severe dependence. Some schedule II drugs are oxycodone, methadone, hydromorphone, etc.

Opioids and drugs that fall under the class of opioids are powerful narcotics prescribed for relief from moderate to severe pain from surgery. Opioids function by stimulating the brain to increase the production of dopamine. Hazardous risks of opioids include abuse, addiction, overdosing, and death. Opioids possess a high risk of addiction with their strong side effects.

Can Hydrocodone and Carisoprodol be taken together?

The combination of Hydrocodone and Carisoprodol, when taken together, is subject to abuse, addiction, coma, and even death. When narcotics or cough suppressants like hydrocodone interact with a medication used for pain relief like Carisoprodol, it induces heightened effects and side effects. Since both these drugs work on the Central Nervous System, it may cause Central Nervous System Depression, leading to severe conditions. This combination induces a high that is usually experienced after taking drugs. The combination of hydrocodone and Carisoprodol is potent and is not advised for consumption by professionals.

Houston Cocktail

The lethal combination of hydrocodone, Carisoprodol, and alprazolam is known as ‘Houston cocktail’ and ‘the Holy Trinity. The combination (Carisoprodol, hydrocodone, and alprazolam) is made up of components that belong to the class of muscle relaxers, opioids, and benzodiazepines, respectively.

Houston cocktail is sought illegally by people who practice substance abuse and have an addiction.

Houston cocktails are usually provided at social settings like raves, parties, clubs, etc. They are consumed by teenagers or adults who are eager to abuse drugs and experience euphoric feelings.

Houston cocktails are also used for harmful purposes. They have similar properties that are present in date rape drugs.

Side effects caused by Hydrocodone with Carisoprodol

The risky combination of controlled substances that work as Central Nervous System (CNS) depressants is bound to bring about twice the normal side effects experienced, which are:

  • Dizziness
  • Drowsiness
  • Convulsions (seizures)
  • Instability
  • Respiratory problems
  • Intense sedation
  • Impairment in thinking and action
  • Hypersensitivity to noise and light
  • Hallucinations
  • Coma
  • Death

Warnings and Precautions of Carisoprodol and Hydrocodone

Initially, this combination is not advised because of its severe side effects that sometimes lead to coma and death. However, suppose consumption is required for treatment for any illness or condition. In that case, professional doctors should hold proper supervision, and dosages should be appropriately adjusted according to the patient’s medical needs. Some precautions and warnings to keep in mind when consuming this combination are:

  • Dosages should be kept minimal as sudden withdrawal may lead to severe withdrawal symptoms.
  • This medication should not be used for a long duration. Do not try to tamper with the doses, frequency, or duration of consumption; only do so if the doctor advises.
  • As the medication affects the patient’s stability and thinking, avoid driving or operating heavy machinery to avoid unnecessary injury.
  • Grapefruit or grapefruit juice should be avoided for consumption as grapefruit increases the concentration in hydrocodone which may cause harmful side effects.

References

https://www.uofmhealth.org/health-library/d00960a1 Accessed on 1/08/2021

Forrester MB. Ingestions of hydrocodone, carisoprodol, and alprazolam in combination reported to Texas poison centers. J Addict Dis. 2011 Apr;30(2):110-5. doi: 10.1080/10550887.2011.554778. PMID: 21491292. Accessed on 1/08/2021

https://en.wikipedia.org/wiki/Carisoprodol Accessed on 1/08/2021

Dayong Lee, Peter Stout, Donald Egdorf, Houston Cocktail: Driving under influence of hydrocodone, alprazolam, and carisoprodol,
Forensic Science International, https://doi.org/10.1016/j.forsciint.2021.110819. Accessed on 1/08/2021

https://medlineplus.gov/druginfo/meds/a601006.html Accessed on 1/08/2021

446 PILLS (CARISOPRODOL 350MG)

446 PILLS (CARISOPRODOL 350MG)

A pill with imprint 446 is White, circular in shape, and identified as Carisoprodol 350 mgSun Pharmaceutical Industries Inc supplies the medication. It is exercised in the therapy of muscle spasms and connected to the drug group skeletal muscle relaxants. Uncertainty cannot be eliminated during pregnancy.

Soma is a muscle relaxant used to relieve pain, stiffness, muscle cramps, discomfort, strains, and sprains. After many years, we realized that the so-called therapy provided a complex amount of permanent help for cancer patients.

Carisoprodol is a central nervous system depressant that works as a medicine and skeletal muscle relaxant. Carisoprodol interrupts neuronal communication within the reticular development and spinal cord, resulting in calming and modification in pain perception.

Carisoprodol is absorbed and begins to have results after 30 minutes and the outcomes last for 4 to 6 hours. Both Carisoprodol and its metabolite meprobamate medications are expelled in the urine and can be recognized for various days after the highest dose.

What are the Side Effects, Dosages, and Warnings of 446 pills?

Caution should be exercised when administering Soma to patients with reduced CYP2C19 activity. After the market launch, cases of abuse and dependence on Carisoprodol (the active ingredient in Soma) were reported in patients with prolonged use and substance abuse. While most of these patients have taken other abuse medications, some patients have abused Carisoprodol.

Common side effects-
· Drowsiness
· Dizziness
· Headache

Side effects that need prompt medical help-
– Seizure
– High levels of serotonin
– Hallucinations
– Fever
– Sweating
– Shivering

Dosage-
– The duration of this dosage can go around 2- 3 weeks.
– The dose can go around 250 to 350 mg orally three times a day and at sleep time.
– Take your pill as directed by your physician.
– If you mistakenly miss a dose, take it immediately. but do not take the dose if it is almost time for your next dose.
– If you, overdose, seek urgent therapeutic help.

Warnings-
– Avoid consuming alcohol.
– Never stop taking the medications on your own this can lead to unpleasant withdrawal symptoms.

Call your doctor if the symptoms do not improve or worsen.

Carisoprodol Abuse and Addiction.

Developing some degree of tolerance does not mean that the person is addicted to Carisoprodol, while they are related to that. A person who has an addiction or dependence on the drug will continue talking about it despite physical, social, or psychological problems.

  • Someone may be diagnoses with addiction if they experience at least 2 signs of the following over a period of 12 or fewer months.
  • Someone who is consuming for a longer time.
  • Consuming greater amount than recommended
  • Craving for the drug strongly.
  • Poor concentration in work or school, neglecting the responsibilities.
  • Using Soma even in a dangerous situation.
  • Withdrawal symptoms when stopped using the drug.
  • Consuming it even after having issues related to that.

Treatment of Carisoprodol Addiction.

The addiction can be treated. There are various ways to treat the individual and take them away from soma addiction. They are taken into rehab and get exposure to some of the things like-

Detox: This is the first step in the rehab program. In this process, the drug has been cleaned from the body under the professional staff of detox. In addition to that, the patient is being monitored if he undergoes any medical complications; most of the programs include social and emotional support as the individual is experiencing drug-free living.

Cognitive behavior therapy: This is the form of behavioral therapy in which the patients learn to change their thinking pattern, recognize situations that lead them to take the drugs, and control it and avoid using the drugs.

Motivational speech: In this, the patient is being motivated and encouraged to have control over themselves and guide them towards a new life.

It solely depends upon how much an individual is addicted to the drug.do they need deep therapy or just mild therapy.

Conclusion

Information on the effects of Carisoprodol on mother and fetus during birth. Information suggests that maternal intake of this drug may result in reduced effective infant nutrition due to sedation and reduced milk production. However, their use during pregnancy has the potential benefit of justifying the risks to the fetus. Caution should be taken when administering Carisoprodol to breastfeeding women.

Carisoprodol is an abusive medication, and you should be aware of this if you are taking it without a prescription. It is not approved for use by persons under 16 years of age.
The medications have their own pros and cons. It depends on how long and how much your doctors prescribed it. Always consult your doctor while consuming medications.

References

Duoflex Pills (DICLOFENACO / CARISOPRODOL)

Duoflex Pills (DICLOFENACO / CARISOPRODOL)

Duoflex, a carisoprodol tablet, is indicated to relieve discomfort associated with acute painful musculoskeletal disorders. Duoflex can be used for a short period (two to three weeks), but sufficient evidence of efficacy after prolonged use has not been provided for these conditions due to the short duration between dosage and administration.

Carisoprodol is an oral muscle relaxant used for recovery, physical therapy, and short-term relief of acute painful muscles and skeletal disorders in adults. The intensity of the side effects of carisoprodol tends to decrease as the therapy continues as is the case with many other medications. However, for patients undergoing therapy, it can have a range of calming side effects that can affect patients’ ability to operate firearms, motor vehicles, and other machinery of various kinds, to take alcoholic medicines, and, in some cases, to consider Carisoprodol alternative medicines.

What are the Active ingredients of Duoflex Pills?

It comprises Bisacodyl as its active ingredient. It belongs to the group of stimulant laxatives that help to treat constipation. It operates by stimulating the action of the intestinal walls, making them incur and defecate easily. These are usually recommended to stop and manage short-term constipation. Carisoprodol, Diclofenac, Chlorzoxazone are the active ingredients in Duoflex pills.

What are the Side effects of Duoflex Pills?

If you are concerned about side effects, discuss the risks and benefits of each medication with your doctor. Your doctor may need to change the dose of your medication or monitor you closely. Side effects are adverse reactions to the drug when taken in normal doses. The following side effects have been reported in up to 1% of people taking the drug. The side effects of a drug are determined by several factors, such as the severity of the disease or the condition of the individual patient. In a common condition such as fever, the same dose of paracetamol (500 mg) as the drug is used for the patient, but the drug may be available in different doses.

Some common side effects are-

  • Dizziness
  • Drowsiness
  • Headache
  • Constipation
  • Diarrhea
  • Gas
  • Mild stomach pain or heartburn
  • Vomiting
  • Nausea

If you are experiencing some different side effects then it is recommended to visit to your physician.

Warnings and Precautions for Duoflex pills.

Take care of these things while taking the medications: –

  • The medications may cause dizziness so make sure you don’t drive and do activities that involve machinery which involves alertness until you know how to react to it. 
  • Avoid consuming alcohol while you are on this medication. 
  • Consult your physician or pharmacist if you have any doubts or issues. 
  • As the medicines will make you dizzy and it may increase in fever, alcohol or hot weather. To prevent this, sit and stand slowly especially in the morning. 
  • Take the medicines as recommended by the doctor. Never raise your dosage on your own.  
  • If elderly people are treated with these medications, then they have to be more cautious as they can be more sensitive to it. 
  • The medication should be used with extreme caution in children below 16 years old, the safety of the medication is still not been established. 
  • Women in pregnancy or breastfeeding should discuss with the physician about the risks and benefits before taking the medication. 
  • Severe stomach ulcer or bleeding can occur with the use of Diclofenac. Taking it for a longer time, smoking, or consuming alcohol can increase the risk of side effects. 
  • Do not use aspirin while you are taking Diclofenac unless your doctor tells you to. 
  • Check with your physician or pharmacologist before you take acetaminophen while you are using Diclofenac. The uncertainty of liver difficulties may be increased.
  • Do not switch between different forms of Diclofenac unless your physician tells you to.
  • Some brands of Diclofenac include gelatin and should not be consumed by individuals who are allergic to bovine proteins.
  • It is important to consult a doctor regarding medication and pills. No, it is not recommended to take tablets with milk. 
  • The prolonged or excessive intake of these tablets may expose you to the risk of extreme dehydration in severe cases.

How much Consumption of Duoflex is Safe?

Do not increase your dose or use any medication longer than prescribed. The risk is higher if you have a substance use disorder, such as overuse or drug or alcohol dependence. Tell your doctor if you or someone in your family drink or consume large amounts of alcohol, take or use street drugs, take prescription drugs excessively, have an overdose, or suffers from depression or other mental illness.

The recommended dosage is 200 mg and Diclofenac Sodium 50 mg. In the ingestion of a 50 mg tablet, the mean plasma concentration is 1.5 mcg /ml (5 mcmol / H) which is reached on average at 2 hours.
Drinking alcohol or taking any of these medications, especially Soma and Tramadol, increases the risk of serious or life-threatening side effects.

References

https://en.wikipedia.org/wiki/Carisoprodol Accessed on 31/07/2021

https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Dulcoflex_PI.pdf?la=en\ Accessed on 31/07/2021

DailyMed. “DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information.  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=DICLOFENAC+EPOLAMINE Accessed on 31/07/2021

FDA/SPL Indexing Data. “144O8QL0L1: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).  https://www.fda.gov/industry/fda-resources-data-standards/fdas-global-substance-registration-system Accessed on 31/07/2021